Gene: NPPA (natriuretic peptide A)  Homo sapiens Symbol: NPPA Name: natriuretic peptide A Description: The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009] Type: protein-coding RefSeq Status: REVIEWED Also known as: ANF; ANP; ATFB6; atrial natriuretic factor; atriopeptin; cardionatrin; CDD-ANF; natriuretic peptide precursor A; natriuretic peptides A; OTTHUMP00000002504; PND; prepronatriodilatin Orthologs: Mus musculus : Nppa (natriuretic peptide type A)  MGI Rattus norvegicus : Nppa (natriuretic peptide A) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 11,924,038 - 11,926,114 - NCBI Human Genome Assembly HuRef 1 11,060,823 - 11,062,905 - NCBI Human Genome Assembly GRCh37 1 11,905,766 - 11,907,840 - NCBI Human Genome Assembly Build 36 1 11,828,363 - 11,830,422 - NCBI Human Cytogenetic Map 1 p36.21   NCBI Human Genome Assembly 1 11,840,041 - 11,842,101   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Atrial Fibrillation, Familial, 6   IEA   7240710   OMIM   Brain Ischemia No_Association IAGP   1626244 DNA:polymorphism:G664A RGD   Coronary Disease   IAGP   1579982   RGD   Diabetes Mellitus, Experimental   ISS RGD:3193 1580773 protein:decreased expression:retina RGD   Diabetes Mellitus, Type 2   ISS RGD:11003 2313586   RGD   Diabetic Nephropathies No_Association IAGP   2313593 DNA:polymorphism:intron RGD   Diabetic Nephropathies   ISS RGD:3193 2313592 associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:blood RGD   Diabetic Nephropathies Disease_progression IAGP   2313590 associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism: :2238T>C (human) RGD   Diabetic Retinopathy   IEP   2313589 protein:increased expression:vitreous humor RGD   Heart Diseases   IEP   2313591 associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:plasma RGD   Hypertension   ISS   731210   RGD   Myocardial Infarction   IAGP   1579982   RGD   Stroke Susceptibility IAGP   1580137 DNA:polymorphism:TC2238 RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (R)-mevalonic acid multiple interactions ISO RGD:3193 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]] CTD PMID:16534557 (R)-noradrenaline increases expression ISO RGD:11003 6480464 Norepinephrine results in increased expression of NPPA mRNA CTD PMID:9788975 (R)-noradrenaline increases expression ISO RGD:3193 6480464 Norepinephrine results in increased expression of NPPA mRNA CTD PMID:10722803 more ... (R)-noradrenaline increases expression ISO RGD:3193 6480464 Norepinephrine results in increased expression of NPPA mRNA CTD PMID:17266992 more ... (R)-noradrenaline increases expression ISO RGD:3193 6480464 Norepinephrine results in increased expression of NPPA mRNA CTD PMID:10722803 more ... (R)-noradrenaline increases expression ISO RGD:3193 6480464 Norepinephrine results in increased expression of NPPA mRNA CTD PMID:17266992 more ... (R)-noradrenaline multiple interactions ISO RGD:3193 6480464 carvedilol inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA] CTD PMID:10722803 (R)-noradrenaline increases expression ISO RGD:3193 6480464 Norepinephrine results in increased expression of NPPA mRNA CTD PMID:16714034 more ... (R)-noradrenaline increases expression ISO RGD:3193 6480464 Norepinephrine results in increased expression of NPPA mRNA CTD PMID:14577597 more ... (R)-noradrenaline multiple interactions ISO RGD:3193 6480464 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:16714034 PMID:15240149 (R)-noradrenaline multiple interactions ISO RGD:3193 6480464 Propranolol promotes the reaction [Norepinephrine results in increased expression of NPPA mRNA] CTD PMID:17592507 (R)-noradrenaline multiple interactions ISO RGD:3193 6480464 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:15240149 PMID:16714034 (R)-noradrenaline increases expression ISO RGD:3193 6480464 Norepinephrine results in increased expression of NPPA mRNA CTD PMID:16714034 more ... 11-deoxycorticosterone increases expression ISO RGD:3193 6480464 Desoxycorticosterone results in increased expression of NPPA protein CTD PMID:2965178 17beta-estradiol increases expression ISO RGD:3193 6480464 Estradiol results in increased expression of NPPA mRNA CTD PMID:19111554 17beta-estradiol multiple interactions ISO RGD:3193 6480464 PD 98059 inhibits the reaction [Estradiol results in increased expression of NPPA mRNA] CTD PMID:19111554 17beta-estradiol multiple interactions ISO RGD:3193 6480464 fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; more ... CTD PMID:14718400 17beta-estradiol increases expression ISO RGD:3193 6480464 Estradiol results in increased expression of NPPA protein CTD PMID:14718400 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:11003 6480464 Tetrachlorodibenzodioxin results in increased expression of NPPA mRNA CTD PMID:17975115 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:3193 6480464 Tetrachlorodibenzodioxin results in increased expression of NPPA mRNA CTD PMID:19969063 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:3193 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NPPA mRNA] CTD PMID:19969063 3',5'-cyclic GMP multiple interactions EXP   6480464 Cyclic GMP affects the reaction [NPPA protein alternative form results in decreased phosphorylation of and results in decreased activity of MAP2K1 protein]; more ... CTD PMID:18225537 3',5'-cyclic GMP increases abundance ISO RGD:3193 6480464 NPPA protein results in increased abundance of Cyclic GMP CTD PMID:11696475 more ... 3',5'-cyclic GMP increases abundance ISO RGD:3193 6480464 NPPA protein results in increased abundance of Cyclic GMP CTD PMID:12972712 more ... 3',5'-cyclic GMP increases abundance ISO RGD:3193 6480464 NPPA protein results in increased abundance of Cyclic GMP CTD PMID:12972712 more ... 3',5'-cyclic GMP increases abundance ISO RGD:3193 6480464 NPPA protein results in increased abundance of Cyclic GMP CTD PMID:12972712 more ... 3',5'-cyclic GMP multiple interactions ISO RGD:3193 6480464 carvedilol promotes the reaction [NPPA protein results in increased abundance of Cyclic GMP] CTD PMID:9421401 3',5'-cyclic GMP increases abundance ISO RGD:3193 6480464 NPPA protein results in increased abundance of Cyclic GMP CTD PMID:11696475 more ... 3',5'-cyclic GMP increases abundance ISO RGD:3193 6480464 NPPA protein results in increased abundance of Cyclic GMP CTD PMID:12972712 more ... 3',5'-cyclic GMP multiple interactions ISO RGD:3193 6480464 Puromycin Aminonucleoside inhibits the reaction [NPPA protein results in increased abundance of Cyclic GMP] CTD PMID:12972712 3',5'-cyclic GMP increases abundance ISO RGD:3193 6480464 NPPA protein results in increased abundance of Cyclic GMP CTD PMID:12022755 more ... 3',5'-cyclic GMP multiple interactions ISO RGD:3193 6480464 AGT protein inhibits the reaction [NPPA protein results in increased abundance of Cyclic GMP]; more ... CTD PMID:11696475 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects metabolic processing ISO RGD:3193 6480464 Puromycin Aminonucleoside affects the metabolism of NPPA protein CTD PMID:20613715 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression ISO RGD:3193 6480464 Puromycin Aminonucleoside results in increased expression of NPPA protein CTD PMID:15590761 PMID:19885019 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression ISO RGD:3193 6480464 Puromycin Aminonucleoside results in increased expression of NPPA mRNA CTD PMID:20613715 PMID:19885019 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases response to substance ISO RGD:3193 6480464 Puromycin Aminonucleoside results in increased susceptibility to NPPA protein CTD PMID:2526952 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression ISO RGD:3193 6480464 Puromycin Aminonucleoside results in increased expression of NPPA protein CTD PMID:19885019 PMID:15590761 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression ISO RGD:3193 6480464 Puromycin Aminonucleoside results in increased expression of NPPA mRNA CTD PMID:19885019 PMID:20613715 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions ISO RGD:3193 6480464 Puromycin Aminonucleoside inhibits the reaction [NPPA protein results in increased abundance of Cyclic GMP] CTD PMID:12972712 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects expression ISO RGD:3193 6480464 Puromycin Aminonucleoside affects the expression of NPPA protein CTD PMID:20613715 3,4-methylenedioxymethamphetamine increases secretion ISO RGD:3193 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased secretion of NPPA protein CTD PMID:21827841 3-iodobenzyl-5'-N-methylcarboxamidoadenosine multiple interactions ISO RGD:3193 6480464 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:15452191 3-iodobenzyl-5'-N-methylcarboxamidoadenosine multiple interactions ISO RGD:3193 6480464 N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:15452191 PMID:19966059 3H-1,2-dithiole-3-thione increases expression ISO RGD:3193 6480464 1,2-dithiol-3-thione results in increased expression of NPPA mRNA CTD PMID:19162173 4'-epidoxorubicin increases expression EXP   6480464 Epirubicin results in increased expression of NPPA protein CTD PMID:1831809 5-azacytidine increases expression ISO RGD:11003 6480464 Azacitidine results in increased expression of NPPA CTD PMID:15005238 5-fluorouracil increases expression ISO RGD:11003 6480464 Fluorouracil results in increased expression of NPPA protein CTD PMID:21296659 acetic acid decreases expression ISO RGD:11003 6480464 Acetic Acid results in decreased expression of NPPA protein CTD PMID:21296659 aldosterone decreases secretion EXP   6480464 NPPA protein results in decreased secretion of Aldosterone CTD PMID:2931268 PMID:2434734 aldosterone decreases secretion EXP   6480464 NPPA protein results in decreased secretion of Aldosterone CTD PMID:2434734 PMID:2931268 aldosterone increases expression ISO RGD:3193 6480464 Aldosterone results in increased expression of NPPA mRNA CTD PMID:19966502 aldosterone multiple interactions ISO RGD:3193 6480464 Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:19966502 alprenolol increases expression ISO RGD:11003 6480464 Alprenolol results in increased expression of NPPA mRNA CTD PMID:12721106 amiodarone increases expression ISO RGD:3193 6480464 Amiodarone results in increased expression of NPPA mRNA CTD PMID:17535870 amlodipine decreases expression ISO RGD:3193 6480464 Amlodipine results in decreased expression of NPPA mRNA CTD PMID:17563544 ammonium chloride affects expression ISO RGD:3193 6480464 Ammonium Chloride affects the expression of NPPA mRNA CTD PMID:16483693 argipressin decreases response to substance ISO RGD:11003 6480464 NPPA protein results in decreased susceptibility to Arginine Vasopressin CTD PMID:8188982 arsenic atom increases expression ISO RGD:11003 6480464 Arsenic results in increased expression of NPPA mRNA CTD PMID:19654921 atenolol decreases expression EXP   6480464 Atenolol results in decreased expression of NPPA protein CTD PMID:12866806 atropine affects activity ISO RGD:3193 6480464 Atropine affects the activity of NPPA protein modified form CTD PMID:1363893 benazepril multiple interactions ISO RGD:3193 6480464 [valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA CTD PMID:11136700 benazepril decreases expression ISO RGD:3193 6480464 benazepril results in decreased expression of NPPA mRNA CTD PMID:11136700 PMID:8763405 benzo[a]pyrene increases expression ISO RGD:3193 6480464 Benzo(a)pyrene results in increased expression of NPPA mRNA CTD PMID:19889059 benzo[a]pyrene decreases expression ISO RGD:11003 6480464 Benzo(a)pyrene results in decreased expression of NPPA mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:3193 6480464 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Benzo(a)pyrene results in increased expression of NPPA mRNA] CTD PMID:21383588 benzo[a]pyrene increases expression ISO RGD:3193 6480464 Benzo(a)pyrene results in increased expression of NPPA mRNA CTD PMID:19889059 PMID:21383588 benzo[a]pyrene multiple interactions ISO RGD:3193 6480464 N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [Benzo(a)pyrene results in increased expression of NPPA mRNA] CTD PMID:19889059 betaxolol decreases expression ISO RGD:3193 6480464 Betaxolol results in decreased expression of NPPA mRNA; more ... CTD PMID:12693380 bromochloroacetic acid increases expression ISO RGD:11003 6480464 bromochloroacetic acid results in increased expression of NPPA protein CTD PMID:21296659 C60 fullerene decreases expression ISO RGD:3193 6480464 fullerene C60 results in decreased expression of NPPA mRNA CTD PMID:19167457 caffeine multiple interactions ISO RGD:3193 6480464 Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:15452191 candesartan increases expression ISO RGD:3193 6480464 candesartan results in increased expression of NPPA mRNA; more ... CTD PMID:14639023 candesartan increases secretion ISO RGD:3193 6480464 candesartan results in increased secretion of NPPA protein CTD PMID:14639023 candoxatrilat multiple interactions ISO RGD:3193 6480464 candoxatrilat inhibits the reaction [Carbon Tetrachloride results in decreased secretion of NPPA protein] CTD PMID:16449355 carbon monoxide increases expression ISO RGD:3193 6480464 Carbon Monoxide results in increased expression of NPPA mRNA CTD PMID:11781074 carvedilol increases expression ISO RGD:3193 6480464 carvedilol results in increased expression of NPPA protein CTD PMID:9421401 PMID:11206715 carvedilol increases expression ISO RGD:3193 6480464 carvedilol results in increased expression of NPPA protein CTD PMID:11206715 PMID:9421401 carvedilol increases expression ISO RGD:3193 6480464 carvedilol results in increased expression of NPPA mRNA CTD PMID:11206715 carvedilol decreases expression ISO RGD:3193 6480464 carvedilol results in decreased expression of NPPA mRNA CTD PMID:21216836 carvedilol multiple interactions ISO RGD:3193 6480464 carvedilol inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA] CTD PMID:10722803 carvedilol decreases degradation ISO RGD:3193 6480464 carvedilol results in decreased degradation of NPPA protein CTD PMID:9421401 carvedilol multiple interactions ISO RGD:3193 6480464 carvedilol promotes the reaction [NPPA protein results in increased abundance of Cyclic GMP] CTD PMID:9421401 carvedilol decreases expression EXP   6480464 carvedilol results in decreased expression of NPPA protein CTD PMID:1378157 CGS-21680 multiple interactions ISO RGD:3193 6480464 Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:15452191 CGS-21680 multiple interactions ISO RGD:3193 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:15452191 PMID:19966059 clofibrate decreases expression ISO RGD:11003 6480464 Clofibrate results in decreased expression of NPPA mRNA CTD PMID:17585979 clonidine increases expression ISO RGD:3193 6480464 Clonidine results in increased expression of NPPA protein CTD PMID:18378355 clonidine (amino form) increases expression ISO RGD:3193 6480464 Clonidine results in increased expression of NPPA protein CTD PMID:18378355 clonidine (imino form) increases expression ISO RGD:3193 6480464 Clonidine results in increased expression of NPPA protein CTD PMID:18378355 cobalt dichloride increases expression ISO RGD:3193 6480464 cobaltous chloride results in increased expression of NPPA mRNA CTD PMID:11078377 cobalt dichloride increases expression ISO RGD:3193 6480464 cobaltous chloride results in increased expression of NPPA mRNA CTD PMID:11078357 PMID:11078377 cocaine increases expression ISO RGD:3193 6480464 Cocaine results in increased expression of NPPA mRNA CTD PMID:9455993 cocaine increases expression EXP   6480464 Cocaine results in increased expression of NPPA protein CTD PMID:11377647 copper(2+) sulfate decreases expression EXP   6480464 Copper Sulfate results in decreased expression of NPPA mRNA CTD PMID:19549813 corticosterone increases expression ISO RGD:3193 6480464 Corticosterone results in increased expression of NPPA mRNA CTD PMID:16533503 corticosterone multiple interactions ISO RGD:3193 6480464 Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16533503 cortisol decreases secretion EXP   6480464 NPPA protein results in decreased secretion of Hydrocortisone CTD PMID:2931268 PMID:2434734 cortisol decreases secretion EXP   6480464 NPPA protein results in decreased secretion of Hydrocortisone CTD PMID:2434734 PMID:2931268 cortisol increases expression EXP   6480464 Hydrocortisone results in increased expression of NPPA protein CTD PMID:7473517 cyanamide multiple interactions ISO RGD:3193 6480464 [Ethanol co-treated with Cyanamide] results in increased expression of NPPA mRNA CTD PMID:10905996 cyclosporin A multiple interactions ISO RGD:3193 6480464 Cyclosporine inhibits the reaction [IGF1 protein results in increased expression of NPPA mRNA] CTD PMID:11548882 cyclosporin A affects expression ISO RGD:3193 6480464 Cyclosporine affects the expression of NPPA mRNA CTD PMID:19244478 D-glucose multiple interactions ISO RGD:3193 6480464 NPPA protein inhibits the reaction [SLC5A2 protein results in increased uptake of Glucose] CTD PMID:15127950 D-mannitol increases expression EXP   6480464 Mannitol results in increased expression of NPPA protein CTD PMID:2177369 dexamethasone multiple interactions ISO RGD:3193 6480464 Dexamethasone inhibits the reaction [nitrofen results in decreased expression of NPPA protein]; more ... CTD PMID:11584395 dexamethasone multiple interactions ISO RGD:11003 6480464 Mifepristone inhibits the reaction [[Dexamethasone co-treated with Doxorubicin] results in increased expression of NPPA mRNA] CTD PMID:19596060 dexamethasone decreases expression ISO RGD:3193 6480464 Dexamethasone results in decreased expression of NPPA protein CTD PMID:2965178 diazoxide multiple interactions ISO RGD:11003 6480464 EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA] CTD PMID:10710348 diazoxide increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:10888249 more ... diazoxide increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:11299230 more ... diazoxide increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:12224825 more ... diazoxide increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:9559417 more ... diazoxide increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:9043801 more ... diazoxide increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:11804996 more ... diazoxide increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:10997724 more ... diazoxide increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:12224825 more ... diazoxide increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:19667237 more ... diazoxide increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:11804996 more ... diazoxide increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:19667237 more ... diazoxide increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:11804996 more ... diazoxide multiple interactions ISO RGD:3193 6480464 Propranolol inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:10997724 diazoxide multiple interactions ISO RGD:3193 6480464 MAP2K1 protein affects the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:10888249 diazoxide multiple interactions ISO RGD:3193 6480464 manidipine inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:9559417 diazoxide multiple interactions ISO RGD:3193 6480464 Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18851973 diazoxide increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:19667237 more ... diazoxide decreases expression ISO RGD:3193 6480464 Isoproterenol results in decreased expression of NPPA protein CTD PMID:18378355 diazoxide multiple interactions ISO RGD:3193 6480464 CREM protein inhibits the reaction [Isoproterenol results in increased expression of NPPA protein] CTD PMID:12791704 diazoxide multiple interactions ISO RGD:3193 6480464 atorvastatin inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:19136528 diazoxide multiple interactions ISO RGD:3193 6480464 ADRB1 protein promotes the reaction [Isoproterenol results in decreased expression of NPPA protein] CTD PMID:18378355 diazoxide multiple interactions ISO RGD:11003 6480464 NOS3 inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:12224825 diazoxide increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:11299230 more ... dibutyl phthalate increases expression ISO RGD:11003 6480464 Dibutyl Phthalate results in increased expression of NPPA mRNA CTD PMID:21266533 diethylstilbestrol increases expression ISO RGD:3193 6480464 Diethylstilbestrol results in increased expression of NPPA protein CTD PMID:15283993 digoxin multiple interactions ISO RGD:3193 6480464 N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of NPPA mRNA] CTD PMID:19687166 digoxin increases expression ISO RGD:3193 6480464 Digoxin results in increased expression of NPPA mRNA CTD PMID:19687166 dioxygen multiple interactions ISO RGD:3193 6480464 [Phenylephrine co-treated with Oxygen deficiency] results in increased expression of NPPA mRNA CTD PMID:11042672 doxorubicin decreases expression ISO RGD:11003 6480464 Doxorubicin results in decreased expression of NPPA mRNA CTD PMID:17531194 doxorubicin multiple interactions ISO RGD:11003 6480464 CDKN1A gene mutant form inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA] CTD PMID:21920376 doxorubicin increases expression ISO RGD:11003 6480464 Doxorubicin results in increased expression of NPPA mRNA CTD PMID:10618415 PMID:21920376 doxorubicin multiple interactions ISO RGD:11003 6480464 [Dexamethasone co-treated with Doxorubicin] results in increased expression of NPPA mRNA; more ... CTD PMID:19596060 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of NPPA protein CTD PMID:1531780 more ... doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of NPPA protein CTD PMID:1531780 more ... doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of NPPA protein CTD PMID:11724646 more ... doxorubicin multiple interactions ISO RGD:3193 6480464 NPPA protein promotes the reaction [Doxorubicin results in increased expression of PPIB mRNA] CTD PMID:8318687 doxorubicin increases expression ISO RGD:3193 6480464 Doxorubicin results in increased expression of NPPA mRNA CTD PMID:16766856 doxorubicin decreases expression ISO RGD:3193 6480464 Doxorubicin results in decreased expression of NPPA mRNA CTD PMID:19796650 doxorubicin decreases activity ISO RGD:3193 6480464 Doxorubicin results in decreased activity of NPPA protein CTD PMID:8318687 doxorubicin affects expression ISO RGD:3193 6480464 Doxorubicin affects the expression of NPPA protein CTD PMID:1533234 doxorubicin multiple interactions ISO RGD:11003 6480464 STAT3 protein promotes the reaction [Doxorubicin results in increased expression of NPPA mRNA] CTD PMID:10618415 doxorubicin multiple interactions ISO RGD:11003 6480464 Fenofibrate inhibits the reaction [Doxorubicin results in decreased expression of NPPA mRNA] CTD PMID:17531194 doxorubicin increases expression ISO RGD:11003 6480464 Doxorubicin results in increased expression of NPPA mRNA CTD PMID:10618415 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of NPPA protein CTD PMID:11466716 more ... DPCPX multiple interactions ISO RGD:3193 6480464 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:15452191 DPCPX multiple interactions ISO RGD:3193 6480464 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:19966059 edaravone decreases expression ISO RGD:11003 6480464 phenylmethylpyrazolone results in decreased expression of NPPA mRNA CTD PMID:15824197 enalapril decreases expression EXP   6480464 Enalapril results in decreased expression of NPPA protein CTD PMID:8112904 enalapril decreases expression ISO RGD:3193 6480464 Enalapril results in decreased expression of NPPA mRNA CTD PMID:2136812 PMID:21423293 enalapril decreases expression ISO RGD:3193 6480464 Enalapril results in decreased expression of NPPA mRNA CTD PMID:21423293 PMID:2136812 enalapril decreases expression ISO RGD:3193 6480464 Enalapril results in decreased expression of NPPA mRNA CTD PMID:2136812 ethanol multiple interactions ISO RGD:3193 6480464 [Ethanol co-treated with Cyanamide] results in increased expression of NPPA mRNA CTD PMID:10905996 ethanol increases expression ISO RGD:3193 6480464 Ethanol results in increased expression of NPPA mRNA CTD PMID:11181050 felodipine affects expression EXP   6480464 Felodipine affects the expression of NPPA protein CTD PMID:9264493 fenofibrate multiple interactions ISO RGD:11003 6480464 Fenofibrate inhibits the reaction [Doxorubicin results in decreased expression of NPPA mRNA] CTD PMID:17531194 fulvestrant multiple interactions ISO RGD:3193 6480464 fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; more ... CTD PMID:14718400 furosemide decreases expression EXP   6480464 Furosemide results in decreased expression of NPPA protein CTD PMID:2146706 glucose multiple interactions ISO RGD:3193 6480464 NPPA protein inhibits the reaction [SLC5A2 protein results in increased uptake of Glucose] CTD PMID:15127950 glycerol increases expression EXP   6480464 Glycerol results in increased expression of NPPA protein CTD PMID:2177369 haloperidol affects activity ISO RGD:3193 6480464 Haloperidol affects the activity of NPPA protein modified form CTD PMID:1363893 hydrogen peroxide decreases response to substance ISO RGD:3193 6480464 NPPA protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:10330004 indinavir multiple interactions ISO RGD:11003 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA CTD PMID:11706060 indomethacin multiple interactions ISO RGD:3193 6480464 Indomethacin inhibits the reaction [NPPA protein affects the activity of MPO protein]; more ... CTD PMID:17522345 indomethacin decreases expression EXP   6480464 Indomethacin results in decreased expression of NPPA protein CTD PMID:1421905 irbesartan increases expression EXP   6480464 irbesartan results in increased expression of NPPA protein CTD PMID:12035877 isoprenaline increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:11804996 more ... isoprenaline increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:10888249 more ... isoprenaline increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:11299230 more ... isoprenaline increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:12224825 more ... isoprenaline increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:9559417 more ... isoprenaline increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:9043801 more ... isoprenaline increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:11804996 more ... isoprenaline increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:10997724 more ... isoprenaline increases expression ISO RGD:11003 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:12224825 more ... isoprenaline multiple interactions ISO RGD:3193 6480464 Propranolol inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:10997724 isoprenaline multiple interactions ISO RGD:3193 6480464 MAP2K1 protein affects the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:10888249 isoprenaline increases expression ISO RGD:3193 6480464 Isoproterenol results in increased expression of NPPA mRNA CTD PMID:19667237 more ... isoprenaline multiple interactions ISO RGD:3193 6480464 manidipine inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:9559417 isoprenaline decreases expression ISO RGD:3193 6480464 Isoproterenol results in decreased expression of NPPA protein CTD PMID:18378355 isoprenaline multiple interactions ISO RGD:3193 6480464 Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18851973 isoprenaline multiple interactions ISO RGD:3193 6480464 CREM protein inhibits the reaction [Isoproterenol results in increased expression of NPPA protein] CTD PMID:12791704 isoprenaline multiple interactions ISO RGD:3193 6480464 atorvastatin inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:19136528 isoprenaline multiple interactions ISO RGD:3193 6480464 ADRB1 protein promotes the reaction [Isoproterenol results in decreased expression of NPPA protein] CTD PMID:18378355 isoprenaline multiple interactions ISO RGD:11003 6480464 [Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA; more ... CTD PMID:10710348 isoprenaline multiple interactions ISO RGD:11003 6480464 NOS3 inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:12224825 labetalol decreases activity EXP   6480464 Labetalol results in decreased activity of NPPA protein CTD PMID:2524958 lamivudine multiple interactions ISO RGD:11003 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA CTD PMID:11706060 lisinopril dihydrate decreases expression EXP   6480464 Lisinopril results in decreased expression of NPPA protein CTD PMID:8393685 losartan multiple interactions ISO RGD:3193 6480464 Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA] CTD PMID:12198334 losartan decreases expression ISO RGD:3193 6480464 Losartan results in decreased expression of NPPA protein CTD PMID:12198334 lysophosphatidic acid multiple interactions ISO RGD:3193 6480464 Pertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased expression of NPPA protein] CTD PMID:15081308 manganese atom decreases expression EXP   6480464 Manganese results in decreased expression of NPPA mRNA CTD PMID:17175027 manganese(0) decreases expression EXP   6480464 Manganese results in decreased expression of NPPA mRNA CTD PMID:17175027 manganese(II) chloride decreases expression EXP   6480464 manganese chloride results in decreased expression of NPPA mRNA CTD PMID:17175027 metoprolol multiple interactions ISO RGD:3193 6480464 Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:17592507 metoprolol decreases expression ISO RGD:3193 6480464 Metoprolol results in decreased expression of NPPA mRNA CTD PMID:20353484 mevalonic acid multiple interactions ISO RGD:3193 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]] CTD PMID:16534557 mifepristone multiple interactions ISO RGD:3193 6480464 Mifepristone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NPPA mRNA] CTD PMID:16533503 mifepristone multiple interactions ISO RGD:11003 6480464 Mifepristone inhibits the reaction [[Dexamethasone co-treated with Doxorubicin] results in increased expression of NPPA mRNA] CTD PMID:19596060 monocrotaline increases expression ISO RGD:3193 6480464 Monocrotaline results in increased expression of NPPA mRNA CTD PMID:16936438 naloxone decreases expression EXP   6480464 Naloxone results in decreased expression of NPPA protein CTD PMID:11311734 nifedipine decreases expression ISO RGD:11003 6480464 Nifedipine results in decreased expression of NPPA mRNA CTD PMID:20559781 nitric oxide multiple interactions ISO RGD:3193 6480464 Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA] CTD PMID:12198334 nitric oxide increases expression ISO RGD:3193 6480464 Nitric Oxide deficiency results in increased expression of NPPA mRNA CTD PMID:10397678 more ... nitric oxide increases expression ISO RGD:3193 6480464 Nitric Oxide deficiency results in increased expression of NPPA protein CTD PMID:15177930 PMID:14700747 nitric oxide increases expression ISO RGD:3193 6480464 Nitric Oxide deficiency results in increased expression of NPPA mRNA CTD PMID:15177930 more ... nitric oxide increases expression ISO RGD:3193 6480464 Nitric Oxide deficiency results in increased expression of NPPA mRNA CTD PMID:12198334 more ... nitric oxide increases expression ISO RGD:3193 6480464 Nitric Oxide deficiency results in increased expression of NPPA protein CTD PMID:14700747 PMID:15177930 nitric oxide increases expression ISO RGD:3193 6480464 Nitric Oxide deficiency results in increased expression of NPPA mRNA CTD PMID:15177930 more ... ouabain increases expression ISO RGD:3193 6480464 Ouabain results in increased expression of NPPA mRNA CTD PMID:19687166 ouabain multiple interactions ISO RGD:3193 6480464 N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA] CTD PMID:19687166 ouabain multiple interactions ISO RGD:3193 6480464 Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:17266992 paricalcitol multiple interactions ISO RGD:3193 6480464 paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:21565836 pentobarbital decreases expression ISO RGD:3193 6480464 Pentobarbital results in decreased expression of NPPA protein CTD PMID:8464334 phenylephrine increases expression ISO RGD:11003 6480464 Phenylephrine results in increased expression of NPPA protein CTD PMID:10679475 phenylephrine multiple interactions ISO RGD:3193 6480464 CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPA protein] CTD PMID:20067472 phenylephrine increases secretion ISO RGD:3193 6480464 Phenylephrine results in increased secretion of NPPA protein CTD PMID:10642269 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:10642269 more ... phenylephrine increases expression ISO RGD:11003 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:11299230 more ... phenylephrine increases secretion ISO RGD:3193 6480464 Phenylephrine results in increased secretion of NPPA protein CTD PMID:10642269 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA protein CTD PMID:10655507 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:14718400 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA protein CTD PMID:17124262 more ... phenylephrine increases expression ISO RGD:11003 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:18502941 more ... phenylephrine multiple interactions ISO RGD:3193 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:15452191 PMID:19966059 phenylephrine increases expression ISO RGD:11003 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:16603706 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:11799083 more ... phenylephrine increases secretion ISO RGD:3193 6480464 Phenylephrine results in increased secretion of NPPA protein CTD PMID:12729799 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA protein CTD PMID:10727428 more ... phenylephrine increases secretion ISO RGD:3193 6480464 Phenylephrine results in increased secretion of NPPA protein CTD PMID:12435817 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA protein CTD PMID:16809552 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:10642269 more ... phenylephrine increases expression ISO RGD:11003 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:16690042 more ... phenylephrine increases secretion ISO RGD:3193 6480464 Phenylephrine results in increased secretion of NPPA protein CTD PMID:10642269 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:11799084 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA protein CTD PMID:19540241 more ... phenylephrine multiple interactions ISO RGD:3193 6480464 Forskolin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11470465 PMID:18851973 phenylephrine increases expression ISO RGD:11003 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:11299230 more ... phenylephrine increases secretion ISO RGD:3193 6480464 Phenylephrine results in increased secretion of NPPA protein CTD PMID:10642269 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:17592507 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA protein CTD PMID:19540241 more ... phenylephrine multiple interactions ISO RGD:3193 6480464 paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:21565836 phenylephrine increases expression ISO RGD:11003 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:11299230 more ... phenylephrine multiple interactions ISO RGD:11003 6480464 [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA CTD PMID:15201137 phenylephrine increases expression ISO RGD:11003 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:18502941 more ... phenylephrine multiple interactions ISO RGD:11003 6480464 [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein CTD PMID:11499749 phenylephrine multiple interactions ISO RGD:11003 6480464 JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16690042 phenylephrine multiple interactions ISO RGD:11003 6480464 MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:12754203 phenylephrine multiple interactions ISO RGD:11003 6480464 [NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein] CTD PMID:15939815 phenylephrine multiple interactions ISO RGD:11003 6480464 HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16603706 phenylephrine multiple interactions ISO RGD:11003 6480464 EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA] CTD PMID:10710348 phenylephrine increases secretion EXP   6480464 Phenylephrine results in increased secretion of NPPA protein CTD PMID:2847676 phenylephrine multiple interactions ISO RGD:11003 6480464 ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18502941 phenylephrine multiple interactions ISO RGD:11003 6480464 DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16380548 phenylephrine multiple interactions ISO RGD:3193 6480464 ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:15220332 phenylephrine multiple interactions ISO RGD:3193 6480464 Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11739382 phenylephrine multiple interactions ISO RGD:3193 6480464 TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:19540241 phenylephrine multiple interactions ISO RGD:3193 6480464 RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:10843871 phenylephrine multiple interactions ISO RGD:3193 6480464 RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16517124 phenylephrine increases secretion ISO RGD:3193 6480464 Phenylephrine results in increased secretion of NPPA protein CTD PMID:12729799 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA protein CTD PMID:16421291 more ... phenylephrine increases expression ISO RGD:3193 6480464 Phenylephrine results in increased expression of NPPA mRNA CTD PMID:17124262 more ... phenylephrine multiple interactions ISO RGD:3193 6480464 [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; more ... CTD PMID:12477714 phenylephrine multiple interactions ISO RGD:3193 6480464 Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter] CTD PMID:19799869 phenylephrine multiple interactions ISO RGD:3193 6480464 Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter] CTD PMID:16556869 phenylephrine multiple interactions ISO RGD:3193 6480464 Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; more ... CTD PMID:19729022 phenylephrine decreases response to substance ISO RGD:3193 6480464 NPPA protein results in decreased susceptibility to Phenylephrine CTD PMID:8188982 phenylephrine multiple interactions ISO RGD:3193 6480464 [Phenylephrine co-treated with Oxygen deficiency] results in increased expression of NPPA mRNA CTD PMID:11042672 phenylephrine multiple interactions ISO RGD:3193 6480464 PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:18790048 phenylephrine multiple interactions ISO RGD:3193 6480464 Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:17266992 phenylephrine multiple interactions ISO RGD:3193 6480464 N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16513848 phenylephrine multiple interactions ISO RGD:3193 6480464 MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:10727428 phenylephrine multiple interactions ISO RGD:3193 6480464 MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; more ... CTD PMID:14676212 phenylephrine multiple interactions ISO RGD:3193 6480464 MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11854500 phenylephrine multiple interactions ISO RGD:3193 6480464 Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:17592507 phenylephrine multiple interactions ISO RGD:3193 6480464 MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:12729799 phenylephrine multiple interactions ISO RGD:3193 6480464 MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11513749 phenylephrine multiple interactions ISO RGD:3193 6480464 JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11799083 phenylephrine multiple interactions ISO RGD:3193 6480464 KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:12403671 phenylephrine multiple interactions ISO RGD:3193 6480464 MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:10888249 phenylephrine multiple interactions ISO RGD:3193 6480464 Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:18851973 phenylephrine multiple interactions ISO RGD:3193 6480464 ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16170337 phenylephrine multiple interactions ISO RGD:3193 6480464 HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPA protein]; more ... CTD PMID:10642269 phenylephrine multiple interactions ISO RGD:3193 6480464 IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:11381115 phenylephrine multiple interactions ISO RGD:3193 6480464 [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:18701451 phenylephrine multiple interactions ISO RGD:3193 6480464 GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:16809552 phenylephrine multiple interactions ISO RGD:3193 6480464 Forskolin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18851973 PMID:11470465 phenylephrine multiple interactions ISO RGD:3193 6480464 fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein] CTD PMID:14718400 phenylephrine multiple interactions ISO RGD:3193 6480464 EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:17327491 phenylephrine multiple interactions ISO RGD:3193 6480464 Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:19966502 phenylephrine multiple interactions ISO RGD:3193 6480464 CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:11705990 phenylephrine multiple interactions ISO RGD:3193 6480464 Docosahexaenoic Acids inhibits the reaction [Phenylephrine affects the expression of NPPA protein] CTD PMID:15258898 phenylephrine multiple interactions ISO RGD:3193 6480464 Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16533503 phenylephrine multiple interactions ISO RGD:3193 6480464 BQ 788 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:15007106 phenylephrine multiple interactions ISO RGD:3193 6480464 CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:10655507 phenylephrine multiple interactions ISO RGD:3193 6480464 ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11470465 phenylephrine multiple interactions ISO RGD:3193 6480464 [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:11799084 phenylephrine multiple interactions ISO RGD:3193 6480464 2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:16787574 phenylephrine multiple interactions ISO RGD:3193 6480464 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; more ... CTD PMID:16421291 phenylephrine multiple interactions ISO RGD:3193 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:19966059 PMID:15452191 phenylephrine multiple interactions ISO RGD:3193 6480464 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:15721863 phenylephrine multiple interactions ISO RGD:3193 6480464 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; more ... CTD PMID:12513686 phenylephrine multiple interactions ISO RGD:3193 6480464 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; more ... CTD PMID:15452191 phenylephrine multiple interactions ISO RGD:3193 6480464 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; more ... CTD PMID:19966059 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:3193 6480464 MAPK8IP1 protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NPPA mRNA] CTD PMID:11513749 phorbol 13-acetate 12-myristate increases expression ISO RGD:3193 6480464 Tetradecanoylphorbol Acetate results in increased expression of NPPA mRNA CTD PMID:16533503 more ... phorbol 13-acetate 12-myristate increases expression ISO RGD:3193 6480464 Tetradecanoylphorbol Acetate results in increased expression of NPPA mRNA CTD PMID:11470465 more ... phorbol 13-acetate 12-myristate increases expression ISO RGD:3193 6480464 Tetradecanoylphorbol Acetate results in increased expression of NPPA mRNA CTD PMID:19244478 more ... phorbol 13-acetate 12-myristate increases expression ISO RGD:3193 6480464 Tetradecanoylphorbol Acetate results in increased expression of NPPA mRNA CTD PMID:11470465 more ... phorbol 13-acetate 12-myristate multiple interactions ISO RGD:3193 6480464 Mifepristone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NPPA mRNA] CTD PMID:16533503 phorbol 13-acetate 12-myristate increases expression ISO RGD:3193 6480464 Tetradecanoylphorbol Acetate results in increased expression of NPPA mRNA CTD PMID:19244478 more ... pirinixic acid multiple interactions ISO RGD:3193 6480464 [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18701451 pirinixic acid increases expression ISO RGD:11003 6480464 pirinixic acid results in increased expression of NPPA mRNA CTD PMID:17951219 PMID:20813756 pirinixic acid increases expression ISO RGD:11003 6480464 pirinixic acid results in increased expression of NPPA mRNA CTD PMID:20813756 PMID:17951219 prazosin multiple interactions ISO RGD:3193 6480464 Prazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein]; more ... CTD PMID:12513686 prazosin multiple interactions ISO RGD:3193 6480464 Prazosin inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA] CTD PMID:15240149 PMID:16714034 prazosin multiple interactions ISO RGD:3193 6480464 Prazosin inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA] CTD PMID:16714034 PMID:15240149 prazosin multiple interactions ISO RGD:3193 6480464 Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:17592507 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:11003 6480464 Pregnenolone Carbonitrile results in decreased expression of NPPA mRNA CTD PMID:22698814 propranolol multiple interactions ISO RGD:3193 6480464 Propranolol inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:10997724 propranolol affects activity ISO RGD:3193 6480464 Propranolol affects the activity of NPPA protein modified form CTD PMID:1363893 propranolol increases expression ISO RGD:3193 6480464 Propranolol results in increased expression of NPPA mRNA CTD PMID:17592507 propranolol multiple interactions ISO RGD:3193 6480464 Propranolol promotes the reaction [Norepinephrine results in increased expression of NPPA mRNA]; more ... CTD PMID:17592507 prostaglandin E1 decreases expression EXP   6480464 Alprostadil results in decreased expression of NPPA protein CTD PMID:10506854 prostaglandin E2 increases expression ISO RGD:3193 6480464 Dinoprostone results in increased expression of NPPA mRNA CTD PMID:18030065 prostaglandin E2 multiple interactions ISO RGD:3193 6480464 Forskolin inhibits the reaction [Dinoprostone results in increased expression of NPPA protein] CTD PMID:18851973 prostaglandin E2 increases abundance ISO RGD:3193 6480464 NPPA protein results in increased abundance of Dinoprostone CTD PMID:3070145 prostaglandin E2 increases expression ISO RGD:3193 6480464 Dinoprostone results in increased expression of NPPA protein CTD PMID:18851973 quinapril hydrochloride increases expression ISO RGD:3193 6480464 quinapril results in increased expression of NPPA mRNA; more ... CTD PMID:14639023 quinapril hydrochloride increases secretion ISO RGD:3193 6480464 quinapril results in increased secretion of NPPA protein CTD PMID:14639023 resveratrol multiple interactions ISO RGD:3193 6480464 resveratrol inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]; more ... CTD PMID:18543488 resveratrol decreases secretion ISO RGD:3193 6480464 resveratrol results in decreased secretion of NPPA protein CTD PMID:17499237 resveratrol decreases expression ISO RGD:3193 6480464 resveratrol results in decreased expression of NPPA mRNA CTD PMID:17499237 resveratrol multiple interactions ISO RGD:3193 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NPPA mRNA] CTD PMID:19969063 resveratrol affects expression ISO RGD:3193 6480464 resveratrol affects the expression of NPPA mRNA CTD PMID:17875610 rosiglitazone increases expression ISO RGD:3193 6480464 rosiglitazone results in increased expression of NPPA mRNA CTD PMID:19397913 rosiglitazone increases expression ISO RGD:3193 6480464 rosiglitazone results in increased expression of NPPA mRNA CTD PMID:21172411 PMID:19397913 rosiglitazone increases expression ISO RGD:3193 6480464 rosiglitazone results in increased expression of NPPA mRNA CTD PMID:19397913 PMID:21172411 rosiglitazone multiple interactions ISO RGD:3193 6480464 Sirolimus inhibits the reaction [rosiglitazone results in increased expression of NPPA mRNA] CTD PMID:19397913 sildenafil multiple interactions ISO RGD:3193 6480464 sildenafil inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18790048 simvastatin multiple interactions ISO RGD:3193 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]] CTD PMID:16534557 simvastatin decreases expression ISO RGD:3193 6480464 Simvastatin results in decreased expression of NPPA mRNA CTD PMID:16029635 PMID:16534557 simvastatin decreases expression ISO RGD:3193 6480464 Simvastatin results in decreased expression of NPPA mRNA CTD PMID:16534557 PMID:16029635 sirolimus multiple interactions ISO RGD:3193 6480464 Sirolimus inhibits the reaction [rosiglitazone results in increased expression of NPPA mRNA] CTD PMID:19397913 sodium chloride multiple interactions ISO RGD:3193 6480464 simendan inhibits the reaction [Sodium Chloride results in increased expression of NPPA mRNA] CTD PMID:17325658 sodium chloride increases expression ISO RGD:3193 6480464 Sodium Chloride results in increased expression of NPPA mRNA CTD PMID:17325658 spermine increases expression ISO RGD:11003 6480464 Spermine results in increased expression of NPPA protein CTD PMID:18673383 spironolactone decreases expression EXP   6480464 Spironolactone results in decreased expression of NPPA protein CTD PMID:11300427 spironolactone multiple interactions ISO RGD:3193 6480464 Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]; more ... CTD PMID:19966502 spironolactone decreases expression EXP   6480464 Spironolactone results in decreased expression of NPPA protein modified form CTD PMID:9595286 staurosporine multiple interactions ISO RGD:3193 6480464 Staurosporine inhibits the reaction [MBF1 protein results in increased secretion of NPPA protein] CTD PMID:12729799 streptozocin increases expression ISO RGD:3193 6480464 Streptozocin results in increased expression of NPPA mRNA CTD PMID:16980342 streptozocin increases expression ISO RGD:3193 6480464 Streptozocin results in increased expression of NPPA protein CTD PMID:16409969 streptozocin multiple interactions ISO RGD:3193 6480464 Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of NPPA protein] CTD PMID:16409969 streptozocin multiple interactions ISO RGD:11003 6480464 SLC25A4 protein inhibits the reaction [Streptozocin results in increased expression of NPPA mRNA] CTD PMID:18945756 streptozocin increases expression ISO RGD:11003 6480464 Streptozocin results in increased expression of NPPA mRNA CTD PMID:18945756 tacrolimus hydrate multiple interactions ISO RGD:11003 6480464 Tacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPA mRNA] CTD PMID:15939815 tetrachloromethane multiple interactions ISO RGD:3193 6480464 candoxatrilat inhibits the reaction [Carbon Tetrachloride results in decreased secretion of NPPA protein] CTD PMID:16449355 tetrachloromethane decreases secretion ISO RGD:3193 6480464 Carbon Tetrachloride results in decreased secretion of NPPA protein CTD PMID:16449355 tetrachloromethane increases expression ISO RGD:3193 6480464 Carbon Tetrachloride results in increased expression of NPPA mRNA CTD PMID:16644059 trans-resveratrol multiple interactions ISO RGD:3193 6480464 resveratrol inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]; more ... CTD PMID:18543488 trans-resveratrol decreases secretion ISO RGD:3193 6480464 resveratrol results in decreased secretion of NPPA protein CTD PMID:17499237 trans-resveratrol decreases expression ISO RGD:3193 6480464 resveratrol results in decreased expression of NPPA mRNA CTD PMID:17499237 trans-resveratrol multiple interactions ISO RGD:3193 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NPPA mRNA] CTD PMID:19969063 trans-resveratrol affects expression ISO RGD:3193 6480464 resveratrol affects the expression of NPPA mRNA CTD PMID:17875610 trichostatin A affects expression ISO RGD:3193 6480464 trichostatin A affects the expression of NPPA mRNA CTD PMID:19729022 trichostatin A multiple interactions ISO RGD:3193 6480464 trichostatin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:19729022 UTP increases expression ISO RGD:3193 6480464 Uridine Triphosphate results in increased expression of NPPA mRNA CTD PMID:14676212 UTP multiple interactions ISO RGD:3193 6480464 Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; more ... CTD PMID:14676212 valsartan decreases expression ISO RGD:3193 6480464 valsartan results in decreased expression of NPPA mRNA CTD PMID:11136700 valsartan multiple interactions ISO RGD:3193 6480464 [valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA CTD PMID:11136700 verapamil multiple interactions EXP   6480464 [Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein CTD PMID:1457087 verapamil increases expression EXP   6480464 Verapamil results in increased expression of NPPA protein CTD PMID:11996326 verapamil affects secretion EXP   6480464 Verapamil affects the secretion of NPPA protein CTD PMID:1457087 zidovudine multiple interactions ISO RGD:11003 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA CTD PMID:11706060 zidovudine increases expression ISO RGD:11003 6480464 Zidovudine results in increased expression of NPPA mRNA CTD PMID:10701688 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cardiac muscle hypertrophy in response to stress   IEA Ensembl:ENSMUSP00000099520 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cGMP biosynthetic process   IEA Ensembl:ENSRNOP00000011005 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cGMP biosynthetic process   IDA   2290271 PMID:1672777 UniProtKB PMID:1672777 female pregnancy   ISS UniProtKB:P05125 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 female pregnancy   IEA Ensembl:ENSMUSP00000099520 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 gene expression   TAS   2290271 Reactome:REACT_71 Reactome Reactome:REACT_71 negative regulation of cell growth   IEA Ensembl:ENSRNOP00000011005 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 receptor guanylyl cyclase signaling pathway   IDA   2290271 PMID:1672777 UniProtKB PMID:1672777 regulation of blood pressure   IDA   2290271 PMID:6230082 UniProtKB PMID:6230082 regulation of blood pressure   IEA Ensembl:ENSMUSP00000099520 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of blood pressure   IDA   2290271 PMID:6547996 UniProtKB PMID:6547996 regulation of blood vessel size   IEA UniProtKB-KW:KW-0838 2290271 GO_REF:0000038 UniProtKB GO_REF:0000038 regulation of blood vessel size   IEA UniProtKB-KW:KW-0838 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 response to insulin stimulus   IEA Ensembl:ENSRNOP00000011005 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 transcription initiation from RNA polymerase II promoter   TAS   2290271 Reactome:REACT_118713 Reactome Reactome:REACT_118713 transcription initiation from RNA polymerase II promoter   TAS   2290271 Reactome:REACT_12627 Reactome Reactome:REACT_12627 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) extracellular region   NAS   2290271 PMID:14718574 UniProtKB PMID:14718574 extracellular region   TAS   2290271 Reactome:REACT_75905 Reactome Reactome:REACT_75905 extracellular region   TAS   2290271 Reactome:REACT_75876 Reactome Reactome:REACT_75876 extracellular region   TAS   2290271 Reactome:REACT_118863 Reactome Reactome:REACT_118863 extracellular space   IEA Ensembl:ENSMUSP00000099520 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 mast cell granule   IEA Ensembl:ENSRNOP00000011005 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 nucleus   IEA Ensembl:ENSRNOP00000011005 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 perinuclear region of cytoplasm   IEA Ensembl:ENSRNOP00000011005 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) hormone activity   NAS   2290271 GO_REF:0000029 UniProtKB GO_REF:0000029 hormone activity   IEA InterPro:IPR000663|InterPro:IPR002407 2290271 GO_REF:0000002 InterPro GO_REF:0000002 peptide hormone receptor binding   IEA Ensembl:ENSRNOP00000011005 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 receptor binding   IPI UniProtKB:P16066 2290271 PMID:1660465 UniProtKB PMID:1660465 receptor binding   IDA   2290271 PMID:1672777 UniProtKB PMID:1672777 receptor binding   IPI UniProtKB:P17342 2290271 PMID:1660465 UniProtKB PMID:1660465 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) atrial natriuretic peptide signaling pathway   ISS RGD:3193 1626242   RGD   atrial natriuretic peptide signaling pathway   TAS   1578335   RGD   atrial natriuretic peptide signaling pathway   ISS RGD:3193 1580001   RGD   External Database Links KEGG Pathway HIF-1 signaling pathway Vascular smooth muscle contraction Pathway Interaction Database AP-1 transcription factor network (PID:200137) Disease Annotations Atrial Fibrillation, Familial, 6  (IEA) Brain Ischemia  (IAGP) Coronary Disease  (IAGP) Diabetes Mellitus, Experimental  (ISS) Diabetes Mellitus, Type 2  (ISS) Diabetic Nephropathies  (IAGP,ISS) Diabetic Retinopathy  (IEP) Heart Diseases  (IEP) Hypertension  (ISS) Myocardial Infarction  (IAGP) Stroke  (IAGP) Gene-Chemical Interaction Annotations (R)-mevalonic acid  (ISO) (R)-noradrenaline  (ISO) 11-deoxycorticosterone  (ISO) 17beta-estradiol  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 3',5'-cyclic GMP  (EXP,ISO) 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO) 3,4-methylenedioxymethamphetamine  (ISO) 3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO) 3H-1,2-dithiole-3-thione  (ISO) 4'-epidoxorubicin  (EXP) 5-azacytidine  (ISO) 5-fluorouracil  (ISO) acetic acid  (ISO) aldosterone  (EXP,ISO) alprenolol  (ISO) amiodarone  (ISO) amlodipine  (ISO) ammonium chloride  (ISO) argipressin  (ISO) arsenic atom  (ISO) atenolol  (EXP) atropine  (ISO) benazepril  (ISO) benzo[a]pyrene  (ISO) betaxolol  (ISO) bromochloroacetic acid  (ISO) C60 fullerene  (ISO) caffeine  (ISO) candesartan  (ISO) candoxatrilat  (ISO) carbon monoxide  (ISO) carvedilol  (EXP,ISO) CGS-21680  (ISO) clofibrate  (ISO) clonidine  (ISO) clonidine (amino form)  (ISO) clonidine (imino form)  (ISO) cobalt dichloride  (ISO) cocaine  (EXP,ISO) copper(2+) sulfate  (EXP) corticosterone  (ISO) cortisol  (EXP) cyanamide  (ISO) cyclosporin A  (ISO) D-glucose  (ISO) D-mannitol  (EXP) dexamethasone  (ISO) diazoxide  (ISO) dibutyl phthalate  (ISO) diethylstilbestrol  (ISO) digoxin  (ISO) dioxygen  (ISO) doxorubicin  (EXP,ISO) DPCPX  (ISO) edaravone  (ISO) enalapril  (EXP,ISO) ethanol  (ISO) felodipine  (EXP) fenofibrate  (ISO) fulvestrant  (ISO) furosemide  (EXP) glucose  (ISO) glycerol  (EXP) haloperidol  (ISO) hydrogen peroxide  (ISO) indinavir  (ISO) indomethacin  (EXP,ISO) irbesartan  (EXP) isoprenaline  (ISO) labetalol  (EXP) lamivudine  (ISO) lisinopril dihydrate  (EXP) losartan  (ISO) lysophosphatidic acid  (ISO) manganese atom  (EXP) manganese(0)  (EXP) manganese(II) chloride  (EXP) metoprolol  (ISO) mevalonic acid  (ISO) mifepristone  (ISO) monocrotaline  (ISO) naloxone  (EXP) nifedipine  (ISO) nitric oxide  (ISO) ouabain  (ISO) paricalcitol  (ISO) pentobarbital  (ISO) phenylephrine  (EXP,ISO) phorbol 13-acetate 12-myristate  (ISO) pirinixic acid  (ISO) prazosin  (ISO) pregnenolone 16alpha-carbonitrile  (ISO) propranolol  (ISO) prostaglandin E1  (EXP) prostaglandin E2  (ISO) quinapril hydrochloride  (ISO) resveratrol  (ISO) rosiglitazone  (ISO) sildenafil  (ISO) simvastatin  (ISO) sirolimus  (ISO) sodium chloride  (ISO) spermine  (ISO) spironolactone  (EXP,ISO) staurosporine  (ISO) streptozocin  (ISO) tacrolimus hydrate  (ISO) tetrachloromethane  (ISO) trans-resveratrol  (ISO) trichostatin A  (ISO) UTP  (ISO) valsartan  (ISO) verapamil  (EXP) zidovudine  (ISO) Gene Ontology Annotations Biological Process cardiac muscle hypertrophy in response to stress  (IEA) cGMP biosynthetic process  (IDA,IEA) female pregnancy  (IEA,ISS) gene expression  (TAS) negative regulation of cell growth  (IEA) receptor guanylyl cyclase signaling pathway  (IDA) regulation of blood pressure  (IDA,IEA) regulation of blood vessel size  (IEA) response to insulin stimulus  (IEA) transcription initiation from RNA polymerase II promoter  (TAS) Cellular Component extracellular region  (NAS,TAS) extracellular space  (IEA) mast cell granule  (IEA) nucleus  (IEA) perinuclear region of cytoplasm  (IEA) Molecular Function hormone activity  (IEA,NAS) peptide hormone receptor binding  (IEA) receptor binding  (IDA,IPI) Molecular Pathway Annotations atrial natriuretic peptide signaling pathway  (ISS,TAS) External Database Links KEGG Pathway HIF-1 signaling pathway Vascular smooth muscle contraction Pathway Interaction Database AP-1 transcription factor network (PID:200137) References - curated 1. Baldini PM, etal., Mol Cell Biochem. 2005 Apr;272(1-2):19-28. 2. Bayerle-Eder M, etal., Horm Metab Res. 2003 May;35(5):301-7. 3. GOA_HUMAN data from the GO Consortium 4. Gruchala M, etal., Am Heart J. 2003 Jan;145(1):125-31. 5. Gutkowska J, etal., J Physiol. 2009 Oct 1;587(Pt 19):4725-36. Epub 2009 Aug 12. 6. Hassan A, etal., Neurology. 2001 Nov 13;57(9):1726-8. 7. Nakayama T Endocr J. 2005 Feb;52(1):11-21. 8. RGD automated import pipeline for gene-chemical interactions 9. RGD Automated Pipelines 10. Rollin R, etal., Mol Vis. 2004 Jul 15;10:450-7. 11. Rollin R, etal., Mol Vis. 2005 Mar 18;11:216-24. 12. Roussel R, etal., Diabetes. 2004 May;53(5):1394-8. 13. Rubattu S, etal., Stroke. 2004 Apr;35(4):814-8. Epub 2004 Mar 11. 14. Schmidt S, etal., Nephrol Dial Transplant. 1998 Jul;13(7):1807-10. 15. Vesely DL, etal., Metabolism. 1999 Jun;48(6):771-8. 16. Wellard J, etal., Neurochem Res. 2003 Feb;28(2):225-33. 17. Ye P and West MJ, Clin Exp Pharmacol Physiol 2003 Dec;30(12):930-6. References - uncurated PubMed 10880574   11408388   11409652   11447495   11884416   11985060   12052474   12082592   12102171   12135603   12145475   12190955   12193960   12270761   12477932   12484513   12505872   12542678   12547834   12687344   12777209   12794112   12883099   12890912   12960255   1309330   14523183   14698679   14718574   15033935   15118286   15489334   15542826   15604093   15648549   15666592   15837528   16100725   16113566   16117728   16291573   16368448   1660465   16710414   16713569   16721833   1672777   16870210   16875975   16962475   17036337   17051589   17219958   17243909   17259761   17292492   17460430   17525707   17580193   17584735   17672826   17693975   17702963   17890443   17890485   17900714   17901852   17927564   17943627   17984371   18092954   18172431   18212314   18243818   1826098   18280250   18294255   18513389   18539145   18614783   18633189   18660489   18713751   18759454   18855222   18989245   19008326   19046820   19086053   19131662   19141362   19146799   19155075   19219041   19238444   19263529   19264973   19326473   19330901   19346663   19387964   19420105   19430483   19458086   19479237   19559392   19564455   19578796   19597492   19635983   19646991   19666519   19671135   19702001   19729120   19729601   19845278   19913121   19948975   20024606   20026756   20064500   20137368   20346360   20368210   20407391   20416077   20452482   20453667   20530040   20536507   20543198   20577119   20628086   20673868   20680650   20700369   20726994   20872251   20877298   21073007   21216831   21276088   21349128   21408188   21450637   21600847   21672517   21689370   2169733   21734186   21741108   21744319   21757823   21798427   21881323   21892902   21952518   21992849   22112816   22113444   22170009   22285803   22400494   22575314   22595807   22962310   2531377   2934979   2972276   3158606   6095118   6095119   6097248   6203042   6230082   6238331   6542248   6547996   7857923   8043577   9232196 RGD Disease Portals NPPA has been annotated in the following RGD Disease Portals. Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Respiratory Pathways Genomics Comparative Map Data NPPA   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 11,924,038 - 11,926,114 - NCBI Human Genome Assembly HuRef 1 11,060,823 - 11,062,905 - NCBI Human Genome Assembly GRCh37 1 11,905,766 - 11,907,840 - NCBI Human Genome Assembly Build 36 1 11,828,363 - 11,830,422 - NCBI Human Cytogenetic Map 1 p36.21   NCBI Human Genome Assembly 1 11,840,041 - 11,842,101   NCBI Nppa   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 148,000,746 - 148,002,067 + NCBI Mouse cM Map 4 78.66   NCBI Mouse Celera Assembly 4 150,267,117 - 150,268,440 + NCBI Mouse Genome Assembly Build 37 4 147,374,855 - 147,376,176 + NCBI Mouse Genome Assembly Build 36.1 4 147,374,855 - 147,376,176 + NCBI Mouse Cytogenetic Map 4 E2   NCBI Nppa   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 5 q36   NCBI RGSC Genome Assembly v5.0 5 168,466,309 - 168,467,618 + NCBI RGSC Genome Assembly v3.4 5 165,074,518 - 165,075,827 + NCBI Rat Celera Assembly 5 156,710,885 - 156,712,194 + NCBI Genome Assembly 3.1 5 165,084,713 - 165,086,000 + NCBI RH 3.4 5 1106.6   RGD Position Markers RH80468   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 1 51.31   UniSTS Human Genome Assembly HuRef 1 11,060,831 - 11,061,090   UniSTS Human Genome Assembly GRCh37 1 11,905,774 - 11,906,033   UniSTS Human Celera Assembly 1 11,019,397 - 11,019,656   RGD Human Genome Assembly Build 36 1 11,828,361 - 11,828,620   RGD Human Cytogenetic Map 1 p36.21   UniSTS GDB:196313   Map Chr Position Strand Source Human Genome Assembly HuRef 1 11,061,074 - 11,061,205   UniSTS Human Genome Assembly GRCh37 1 11,906,017 - 11,906,148   UniSTS Human Celera Assembly 1 11,019,640 - 11,019,771   RGD Human Genome Assembly Build 36 1 11,828,604 - 11,828,735   RGD Human Cytogenetic Map 1 p36.21   UniSTS GDB:226664   Map Chr Position Strand Source Human Genome Assembly HuRef 1 11,061,074 - 11,062,430   UniSTS Human Genome Assembly GRCh37 1 11,906,017 - 11,907,365   UniSTS Human Celera Assembly 1 11,019,640 - 11,020,997   RGD Human Genome Assembly Build 36 1 11,828,604 - 11,829,952   RGD Human Cytogenetic Map 1 p36.21   UniSTS GDB:549199   Map Chr Position Strand Source Human Genome Assembly HuRef 1 11,062,809 - 11,063,015   UniSTS Human Genome Assembly GRCh37 1 11,907,744 - 11,907,950   UniSTS Human Celera Assembly 1 11,021,376 - 11,021,582   RGD Human Genome Assembly Build 36 1 11,830,331 - 11,830,537   RGD Human Cytogenetic Map 1 p36.21   UniSTS Nppa   Map Chr Position Strand Source Human Genome Assembly HuRef 1 11,062,794 - 11,063,172   UniSTS Human Genome Assembly HuRef 1 11,062,236 - 11,062,417   UniSTS Human Genome Assembly GRCh37 1 11,907,729 - 11,908,107   UniSTS Human Genome Assembly GRCh37 1 11,907,171 - 11,907,352   UniSTS Human Celera Assembly 1 11,020,803 - 11,020,984   UniSTS Human Celera Assembly 1 11,021,361 - 11,021,739   RGD Human Genome Assembly Build 36 1 11,830,316 - 11,830,694   RGD SHGC-74238   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 1 51.31   UniSTS Human TNG Radiation Hybrid Map 1 6443.0   UniSTS Human Genome Assembly HuRef 1 11,060,916 - 11,061,083   UniSTS Human Genome Assembly GRCh37 1 11,905,859 - 11,906,026   UniSTS Human Celera Assembly 1 11,019,482 - 11,019,649   RGD Human Genome Assembly Build 36 1 11,828,446 - 11,828,613   RGD Human Cytogenetic Map 1 p36.21   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 2289613 BW396_H Body weight QTL 396 (human) 2.75 Body weight BMI 1 1 16585048 Human 2289540 BW425_H Body weight QTL 425 (human) Body weight BMI 1 1 16585048 Human 1559394 SCL111_H Serum cholesterol level QTL 111 (human) 2.43 Lipid level LDL cholesterol 1 1 19962115 Human 2289215 BW344_H Body weight QTL 344 (human) .0499 Body fat amount percent fat 1 1 20142514 Human 1298433 BP17_H Blood pressure QTL 17 (human) .0162 Blood pressure hypertension susceptibility 1 1 21118041 Human 1298451 OSTEAR17_H Osteoarthritis QTL 17 (human) 2.4 .0004 Joint/bone inflammation osteoarthritis 11 1 25248168 Human 1298463 BP9_H Blood pressure QTL 9 (human) 3.9 Blood pressure hypertension susceptibility 1 1 25248168 Human 1643556 GLUCO11_H Glucose level QTL 11 (human) .77 .03 Glucose level non-insulin-dependent 1 784271 26784271 Human 1643571 GLUCO12_H Glucose level QTL 12 (human) .019 Glucose level non-insulin-dependent 1 784271 26784271 Human 2292920 PRSTS119_H Prostate tumor susceptibility QTL 119 (human) 2.13 .02 Prostate tumor susceptibility 1 784271 26784271 Human 2293430 PRSTS243_H Prostate tumor susceptibility QTL 243 (human) .077 Prostate tumor susceptibility 1 784271 26784271 Human 2292926 PRSTS121_H Prostate tumor susceptibility QTL 121 (human) 3.22 Prostate tumor susceptibility 1 2028868 28028868 Human 1331652 COPD17_H Chronic obstructive pulmonary disease QTL 17 (human) 1.28 Chronic airflow obstruction FEV1 1 3584957 17783848 Human 2293440 PRSTS240_H Prostate tumor susceptibility QTL 240 (human) .016 Prostate tumor susceptibility 1 3584957 17783848 Human 2316874 GLUCO301_H Glucose level QTL 301 (human) .001 Glucose level 1 4783758 30783758 Human 2314559 INSUL2_H Insulin level QTL 2 (human) 1 .039 Insulin level fasting 1 6026613 32026613 Human 1358848 MULTSCL16_H Multiple sclerosis susceptibility QTL 16 (human) Multiple sclerosis susceptibility 1 6267090 32267090 Human 2289594 BW463_H Body weight QTL 463 (human) 2.1 Body fat amount abdominal 1 6957083 32957083 Human 1643585 SGHRL1_H Serum ghrelin level QTL 1 (human) 3.2 .00006 Hormone level ghrelin level 1 11487038 37649865 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_012926 (Get FASTA) Search GEO for Microarray Profiles   NM_006172 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AA779538 (Get FASTA) Search GEO for Microarray Profiles   ABBA01003060 (Get FASTA) Search GEO for Microarray Profiles   AL021155 (Get FASTA) Search GEO for Microarray Profiles   AMYH01000258 (Get FASTA) Search GEO for Microarray Profiles   BC005893 (Get FASTA) Search GEO for Microarray Profiles   CH471130 (Get FASTA) Search GEO for Microarray Profiles   EU326308 (Get FASTA) Search GEO for Microarray Profiles   K02043 (Get FASTA) Search GEO for Microarray Profiles   K02044 (Get FASTA) Search GEO for Microarray Profiles   K02399 (Get FASTA) Search GEO for Microarray Profiles   M30262 (Get FASTA) Search GEO for Microarray Profiles   M54947 (Get FASTA) Search GEO for Microarray Profiles   X01470 (Get FASTA) Search GEO for Microarray Profiles   X01471 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_006172 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_006163 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 11,924,038 - 11,926,114 - NCBI Human Genome Assembly HuRef 1 11,060,823 - 11,062,905 - ENTREZGENE Human Genome Assembly GRCh37 1 11,905,766 - 11,907,840 - ENTREZGENE Human Genome Assembly Build 36 1 11,828,363 - 11,830,422 - NCBI Archive Protein Sequences Protein RefSeqs NP_006163 (Get FASTA) GenBank Protein AAA35528 (Get FASTA)   AAA35529 (Get FASTA)   AAA35669 (Get FASTA)   AAA51730 (Get FASTA)   AAB59379 (Get FASTA)   AAH05893 (Get FASTA)   ABM84041 (Get FASTA)   ABM87388 (Get FASTA)   ABW03581 (Get FASTA)   ACA05916 (Get FASTA)   CAA25699 (Get FASTA)   CAA25700 (Get FASTA)   EAW71717 (Get FASTA)   P01160 (Get FASTA) Promoters RGD ID: 6853830 Promoter ID: EPDNEW_H80 Type: initiation region Name: TMEM52_1 Description: transmembrane protein 52 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Human Genome Assembly Build 36 1 1,850,719 - 1,850,779   EPDNEW RGD ID: 6850072 Promoter ID: EP11132 Type: single initiation site Name: HS_NPPA Description: Pronatriodilatin, Atrial natriuretic factor, NPPA or PND gene. SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Notes: homology_group=Homology group 83; Mammalian pronatriodilatin Tissues & Cell Lines: cardiac atrium Experiment Methods: Primer extension with homologous sequence ladder Position: Map Chr Position Strand Source Human Genome Assembly Build 36 1 11,830,425 - 11,830,485   EPD RGD ID: 6785355 Promoter ID: HG_KWN:711 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: HeLa_S3,   Lymphoblastoid,   NB4 Transcripts: ENST00000376476,   OTTHUMT00000006852 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 1 11,830,654 - 11,831,154 - MPROMDB Additional Information External Database Links Database Acc Id Source(s) COSMIC NPPA COSMIC Ensembl Genes ENSG00000175206 ENTREZGENE Ensembl Protein ENSP00000365663 ENTREZGENE Ensembl Transcript ENST00000376480 ENTREZGENE Entrez Gene 4878 ENTREZGENE Germonline ENSG00000175206 HGNC ID 7939 ENTREZGENE HomoloGene Group ID 4498 ENTREZGENE HPRD ID 00164 ENTREZGENE InterPro Natr_peptide UniProtKB/Swiss-Prot   Natriuretic_peptide_atrial UniProtKB/Swiss-Prot IPI IPI00221279 UniProtKB/Swiss-Prot   IPI00644997 UniProtKB/TrEMBL KEGG Report hsa:4878 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 108780 OMIM   612201 OMIM Pfam ANP UniProtKB/Swiss-Prot PharmGKB PA256 PharmGKB PRINTS ANATPEPTIDE UniProtKB/Swiss-Prot   NATPEPTIDES UniProtKB/Swiss-Prot PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot SMART NAT_PEP UniProtKB/Swiss-Prot UniGene Hs.75640 ENTREZGENE UniProt ANF_HUMAN UniProtKB/Swiss-Prot   B0ZBE8_HUMAN UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 NPPA  natriuretic peptide A  NPPA  natriuretic peptide A  Symbol and/or name change 39860 APPROVED 2011-07-27 NPPA  natriuretic peptide A  NPPA  natriuretic peptide precursor A  Symbol and/or name change 39860 APPROVED

More on NPPA Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 730878 Created: 2003-12-10 Species: Homo sapiens Last Modified: 2013-04-30 Status: ACTIVE