MYH7 (myosin, heavy chain 7, cardiac muscle, beta)

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Keyword

Gene: MYH7 (myosin, heavy chain 7, cardiac muscle, beta) Homo sapiens

Symbol:

MYH7

Name:

myosin, heavy chain 7, cardiac muscle, beta

Description:

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

beta-myosin heavy chain; CMD1S; CMH1; DKFZp451F047; MGC138376; MGC138378; MPD1; myHC-beta; myhc-slow; MYHCB; myopathy, distal 1; myosin heavy chain (AA 1-96); myosin heavy chain 7; myosin heavy chain slow isoform; myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, polypeptide 7; myosin, heavy polypeptide 7, cardiac muscle, beta; myosin-7; OTTHUMP00000027949; rhabdomyosarcoma antigen MU-RMS-40.7A; SPMD; SPMM

Orthologs:

Mus musculus : Myh7 (myosin, heavy polypeptide 7, cardiac muscle, beta) MGI
Rattus norvegicus : Myh7 (myosin, heavy chain 7, cardiac muscle, beta)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	14	4,878,931 - 4,900,476	-	NCBI
Human Genome Assembly HuRef	14	3,998,386 - 4,019,919	-	NCBI
Human Genome Assembly GRCh37	14	23,881,947 - 23,903,496	-	NCBI
Human Genome Assembly Build 36	14	22,951,787 - 22,974,710	-	NCBI
Human Cytogenetic Map	14	q12		NCBI
Human Genome Assembly	14	22,951,788 - 22,974,690		NCBI