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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:antispasmodic drug
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Accession:CHEBI:53784 term browser browse the term
Definition:A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.
Synonyms:related_synonym: antispasmodics


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alverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A affects binding EXP alverine binds to HTR1A protein CTD PMID:11697552 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO alverine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
butylscopolamine bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
clidinium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO clidinium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
darifenacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO darifenacin binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO darifenacin binds to and results in decreased activity of CHRM3 protein CTD PMID:11488427 PMID:15140916 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO darifenacin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
dicyclomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
glycycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO glycycoumarin binds to PPARG protein CTD PMID:14608046 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
nimetazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of nimetazepam CTD PMID:19005028 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
nitrazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Nitrazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Nitrazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Nitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of Nitrazepam CTD PMID:19005028 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Nitrazepam binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
oxybutynin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO oxybutynin results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO oxybutynin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of oxybutynin CTD PMID:9300133 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO oxybutynin binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO oxybutynin binds to and results in decreased activity of CHRM3 protein CTD PMID:15140916 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO oxybutynin results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Drd2 dopamine receptor D2 affects binding ISO oxybutynin binds to DRD2 protein CTD PMID:10888308 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Il24 interleukin 24 decreases expression ISO oxybutynin results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP oxybutynin results in decreased expression of JUN mRNA CTD PMID:10458442 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO oxybutynin results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO oxybutynin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO oxybutynin results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
papaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Papaverine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Papaverine results in increased expression of BDNF mRNA CTD PMID:8601816 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity		 ISO Papaverine promotes the reaction [CFTR protein affects the secretion of Chlorides]
Papaverine results in increased activity of CFTR protein		 CTD PMID:12714375 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cldn5 claudin 5 decreases expression EXP Papaverine results in decreased expression of CLDN5 protein CTD PMID:20728510 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Papaverine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Papaverine results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Papaverine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions EXP Papaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]; Papaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein] CTD PMID:10894095 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Papaverine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Papaverine results in increased expression of NTRK2 mRNA CTD PMID:8601816 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ocln occludin decreases expression EXP Papaverine results in decreased expression of OCLN protein CTD PMID:20728510 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO Papaverine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681 		JBrowse link
G Pde7b phosphodiesterase 7B multiple interactions ISO Papaverine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP		 Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]		 CTD PMID:9830022 PMID:12411423 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
pethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D affects binding
increases hydrolysis		 ISO Meperidine binds to CES1 protein
CES1 protein results in increased hydrolysis of Meperidine		 CTD PMID:10381793 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Meperidine binds to CES2 protein CTD PMID:10381793 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
pirenzepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP Pirenzepine binds to and results in decreased activity of AVPR1A protein CTD PMID:11553362 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
affects binding		 ISO
EXP		 brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]
Pirenzepine binds to and results in decreased activity of CHRM1 protein; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]		 CTD PMID:8032910 PMID:9846649 PMID:11306684 PMID:12646291 PMID:15294002 More... NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr2 early growth response 2 multiple interactions EXP Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA] CTD PMID:7968354 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
scopolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression EXP Scopolamine results in decreased expression of ABCB1 mRNA CTD PMID:12818353 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression EXP Scopolamine results in increased expression of ABCG1 mRNA CTD PMID:12818353 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Ache acetylcholinesterase multiple interactions
increases expression
affects activity
increases activity
decreases activity
decreases expression
affects response to substance
increases response to substance		 ISO
EXP		 kangshuai yizhi inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Scopolamine results in increased expression of ACHE mRNA; Scopolamine results in increased expression of ACHE protein
Scopolamine affects the activity of ACHE protein
Scopolamine results in decreased activity of ACHE protein
Ascorbic Acid inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]
Scopolamine results in decreased expression of ACHE protein
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; ajoene inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; chong-myung-tang inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts affects the reaction [Scopolamine affects the activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of ACHE mRNA]; protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]
ACHE affects the susceptibility to Scopolamine
ACHE protein results in increased susceptibility to Scopolamine		 CTD PMID:11814146 PMID:15301936 PMID:18533140 PMID:18672024 PMID:20673844 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adora3 adenosine A3 receptor multiple interactions ISO [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine CTD PMID:12672554 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine CTD PMID:11707427 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Apba1 amyloid beta precursor protein binding family A member 1 increases expression EXP Scopolamine results in increased expression of APBA1 mRNA CTD PMID:12818353 NCBI chr 1:221,363,769...221,569,496
Ensembl chr 1:221,363,778...221,566,553 		JBrowse link
G Aplp2 amyloid beta precursor like protein 2 increases expression EXP Scopolamine results in increased expression of APLP2 mRNA CTD PMID:12818353 NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855 		JBrowse link
G App amyloid beta precursor protein decreases cleavage ISO Scopolamine results in decreased cleavage of APP protein CTD PMID:16423497 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression
decreases expression 		EXP
ISO		 Scopolamine results in decreased expression of ARC mRNA
scopolamine decreases expression of Arc mRNA and protein in cerebral cortex and hippocampus		 CTD
RGD		 PMID:17540011 PMID:24012642 RGD:401938610 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Arg2 arginase 2 decreases expression EXP Scopolamine results in decreased expression of ARG2 mRNA CTD PMID:12818353 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D decreases expression EXP Scopolamine results in decreased expression of ARL4D mRNA CTD PMID:17540011 NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836 		JBrowse link
G Avp arginine vasopressin multiple interactions EXP [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:11553362 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:11553362 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Scopolamine results in increased expression of BAX mRNA; Scopolamine results in increased expression of BAX protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Donepezil inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of BAX mRNA]		 CTD PMID:17120751 PMID:26434561 PMID:34371027 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Scopolamine results in increased expression of BCAT1 mRNA CTD PMID:17540011 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Scopolamine results in decreased expression of BCL2 mRNA; Scopolamine results in decreased expression of BCL2 protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]		 CTD PMID:17120751 PMID:26434561 PMID:34371027 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression		 EXP
ISO		 Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Scopolamine results in decreased expression of BDNF mRNA; Scopolamine results in decreased expression of BDNF protein
[acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein; [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Plant Extracts inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]		 CTD PMID:8405262 PMID:8635431 PMID:22096544 PMID:26408985 PMID:26434561 More... NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D increases expression EXP Scopolamine results in increased expression of CACNA1D mRNA CTD PMID:12818353 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Scopolamine results in decreased expression of CAMKK2 mRNA CTD PMID:17540011 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Cartpt CART prepropeptide decreases expression EXP Scopolamine results in decreased expression of CARTPT mRNA CTD PMID:17540011 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions		 ISO Scopolamine results in increased expression of CASP3 mRNA; Scopolamine results in increased expression of CASP3 protein
Scopolamine results in increased activity of CASP3 protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CASP3 mRNA]		 CTD PMID:17120751 PMID:26434561 PMID:34371027 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity		 ISO acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; chong-myung-tang inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Donepezil inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein] CTD PMID:20673844 PMID:27717698 PMID:31077737 PMID:34371027 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex decreases expression EXP Scopolamine results in decreased expression of CD3E mRNA CTD PMID:17540011 NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cdkl4 cyclin-dependent kinase-like 4 increases expression EXP Scopolamine results in increased expression of CDKL4 mRNA CTD PMID:17540011 NCBI chr 6:14,449,822...14,492,568
Ensembl chr 6:14,450,681...14,492,046 		JBrowse link
G Chat choline O-acetyltransferase decreases activity
multiple interactions		 ISO Scopolamine results in decreased activity of CHAT protein
protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
kangshuai yizhi inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]		 CTD PMID:20694781 PMID:26408985 PMID:29133030 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
decreases expression
increases expression		 EXP
ISO		 [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine; Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
Scopolamine results in increased expression of CHRM1 mRNA
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of CHRM1 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CHRM1 mRNA]		 CTD PMID:11553362 PMID:26434561 PMID:28837785 PMID:32001261 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 increases response to substance ISO CHRM4 protein results in increased susceptibility to Scopolamine CTD PMID:12729838 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 decreases response to substance ISO CHRM5 protein results in decreased susceptibility to Scopolamine CTD PMID:13679217 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions		 ISO Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]		 CTD PMID:15733544 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions		 ISO Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]		 CTD PMID:15733544 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Coch cochlin decreases expression EXP Scopolamine results in decreased expression of COCH mRNA CTD PMID:12818353 NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109 		JBrowse link
G Coro1b coronin 1B increases expression EXP Scopolamine results in increased expression of CORO1B mRNA CTD PMID:12818353 NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression EXP Scopolamine results in increased expression of COX5B mRNA CTD PMID:12818353 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions		 ISO Scopolamine results in decreased phosphorylation of CREB1 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]		 CTD PMID:26408985 PMID:31077737 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cryab crystallin, alpha B increases expression EXP Scopolamine results in increased expression of CRYAB mRNA CTD PMID:17540011 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases response to substance		 ISO IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] CTD PMID:8877002 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 decreases expression EXP Scopolamine results in decreased expression of CXCR5 mRNA CTD PMID:12818353 NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893 		JBrowse link
G Ddc dopa decarboxylase decreases expression EXP Scopolamine results in decreased expression of DDC mRNA CTD PMID:17540011 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Dguok deoxyguanosine kinase increases expression EXP Scopolamine results in increased expression of DGUOK mRNA CTD PMID:17540011 NCBI chr 4:115,987,101...116,014,733
Ensembl chr 4:115,979,094...116,014,733 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression EXP Scopolamine results in increased expression of DIO2 mRNA CTD PMID:12818353 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dusp5 dual specificity phosphatase 5 decreases expression EXP Scopolamine results in decreased expression of DUSP5 mRNA CTD PMID:17540011 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression EXP Scopolamine results in decreased expression of DUSP6 mRNA CTD PMID:17540011 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP Scopolamine results in decreased expression of EGFR mRNA CTD PMID:12818353 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 multiple interactions
decreases expression		 EXP
ISO		 [Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA; Scopolamine affects the reaction [SK&F 82958 results in increased expression of EGR1 mRNA]
Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]
Scopolamine results in decreased expression of EGR1 mRNA		 CTD PMID:8861055 PMID:17540011 PMID:29133030 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr2 early growth response 2 decreases expression EXP Scopolamine results in decreased expression of EGR2 mRNA CTD PMID:17540011 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression EXP Scopolamine results in increased expression of EIF2S1 mRNA CTD PMID:12818353 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eml1 EMAP like 1 decreases expression EXP Scopolamine results in decreased expression of EML1 mRNA CTD PMID:17540011 NCBI chr 6:127,283,968...127,457,246
Ensembl chr 6:127,284,029...127,457,246 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
increases expression		 EXP
ISO		 [Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Ro4368554 inhibits the reaction [Scopolamine results in increased expression of FOS protein]; Scopolamine affects the reaction [SK&F 82958 results in increased expression of FOS mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]
Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]
Scopolamine results in decreased expression of FOS mRNA		 CTD PMID:1393566 PMID:8281324 PMID:8861055 PMID:11337201 PMID:17540011 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 increases expression EXP Scopolamine results in increased expression of GABBR1 mRNA CTD PMID:17540011 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gap43 growth associated protein 43 decreases expression
multiple interactions		 ISO Scopolamine results in decreased expression of GAP43 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]		 CTD PMID:22096544 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
decreases expression		 ISO Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]
Scopolamine results in decreased expression of GFAP mRNA; Scopolamine results in decreased expression of GFAP protein		 CTD PMID:22096544 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP Scopolamine results in increased expression of GJB2 mRNA CTD PMID:17540011 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Gpc3 glypican 3 decreases expression EXP Scopolamine results in decreased expression of GPC3 mRNA CTD PMID:12818353 NCBI chr  X:131,868,986...132,236,824
Ensembl chr  X:131,868,990...132,236,798 		JBrowse link
G Grm4 glutamate metabotropic receptor 4 multiple interactions ISO Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions		 ISO Scopolamine results in decreased activity of GSR protein
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein]		 CTD PMID:26408985 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gypc glycophorin C decreases expression EXP Scopolamine results in decreased expression of GYPC mRNA CTD PMID:17540011 NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO 7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of HMOX1 protein] CTD PMID:32001261 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Homer1 homer scaffold protein 1 decreases expression EXP Scopolamine results in decreased expression of HOMER1 mRNA CTD PMID:17540011 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine] CTD PMID:19215234 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions EXP [[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine] CTD PMID:11640976 PMID:19215234 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Hrh3 histamine receptor H3 multiple interactions EXP [clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine CTD PMID:16488453 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression EXP Scopolamine results in increased expression of HSPA2 mRNA CTD PMID:12818353 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
increases expression 		EXP [4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine]
Scopolamine increases expression of Htr1a mRNA in amygdala, hippocampal formation; Scopolamine increases expression of Htr1a protein in amygdala, hippocampal formation		 CTD
RGD		 PMID:10578133 PMID:27760517 RGD:405850209 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression EXP Scopolamine results in increased expression of HTR2C mRNA CTD PMID:17540011 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 decreases expression EXP Scopolamine results in decreased expression of HTR6 mRNA CTD PMID:19733250 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 EXP Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IFNG mRNA] CTD PMID:21161262 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions		 ISO Scopolamine results in decreased expression of IL10 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]		 CTD PMID:31077737 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha decreases response to substance ISO IL1A protein results in decreased susceptibility to Scopolamine CTD PMID:8003924 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO
EXP		 Scopolamine results in increased expression of IL1B mRNA; Scopolamine results in increased expression of IL1B protein
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL1B mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of IL1B protein]		 CTD PMID:18357464 PMID:19426756 PMID:21161262 PMID:31077737 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] CTD PMID:8877002 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP
ISO		 Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL6 mRNA]; Scopolamine promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of IL6 mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein]
Scopolamine results in increased expression of IL6 mRNA; Scopolamine results in increased expression of IL6 protein		 CTD PMID:18357464 PMID:21161262 PMID:31077737 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP Scopolamine results in increased expression of ITPR1 mRNA CTD PMID:12818353 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 EXP
ISO		 Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]
Scopolamine results in decreased expression of JUN protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]		 CTD PMID:11337201 PMID:29133030 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Scopolamine results in decreased expression of JUNB mRNA CTD PMID:17540011 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 increases expression EXP Scopolamine results in increased expression of KCNA4 mRNA CTD PMID:12579815 NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162 		JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 increases expression EXP Scopolamine results in increased expression of KCNB1 mRNA CTD PMID:12579815 PMID:15567561 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194 		JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 decreases expression EXP Scopolamine results in decreased expression of KCND2 mRNA CTD PMID:12579815 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124 		JBrowse link
G Klf2 KLF transcription factor 2 decreases expression EXP Scopolamine results in decreased expression of KLF2 mRNA CTD PMID:17540011 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Klf4 KLF transcription factor 4 decreases expression EXP Scopolamine results in decreased expression of KLF4 mRNA CTD PMID:17540011 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase multiple interactions ISO [AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine CTD PMID:11707427 NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544 		JBrowse link
G Madd MAP-kinase activating death domain increases expression EXP Scopolamine results in increased expression of MADD mRNA CTD PMID:12818353 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701 		JBrowse link
G Map2 microtubule-associated protein 2 decreases expression
multiple interactions		 ISO Scopolamine results in decreased expression of MAP2 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]		 CTD PMID:22096544 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression EXP Scopolamine results in decreased expression of MAPT mRNA CTD PMID:12818353 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mbp myelin basic protein decreases expression
multiple interactions		 ISO Scopolamine results in decreased expression of MBP protein
Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein]		 CTD PMID:29476728 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases expression ISO
EXP		 Scopolamine results in decreased expression of MUC5AC protein CTD PMID:18357464 PMID:21161262 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nefh neurofilament heavy chain multiple interactions
decreases expression		 ISO Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein] CTD PMID:22096544 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression		 ISO 7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein] CTD PMID:32001261 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor decreases response to substance
multiple interactions
increases response to substance		 EXP
ISO		 NGF protein results in decreased susceptibility to Scopolamine
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]
NGF protein results in increased susceptibility to Scopolamine		 CTD PMID:1661212 PMID:8635431 PMID:16405025 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:26408985 PMID:31077737 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nova1 NOVA alternative splicing regulator 1 multiple interactions EXP Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA] CTD PMID:20470870 NCBI chr 6:63,780,105...63,905,567
Ensembl chr 6:63,783,489...63,906,289 		JBrowse link
G Nova2 NOVA alternative splicing regulator 2 multiple interactions EXP Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA] CTD PMID:20470870 NCBI chr 1:78,572,253...78,613,703
Ensembl chr 1:78,572,279...78,608,021 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases expression		 ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein] CTD PMID:26408985 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 increases expression EXP Scopolamine results in increased expression of NQO2 mRNA CTD PMID:20861374 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression EXP Scopolamine results in decreased expression of NR1D1 mRNA CTD PMID:17540011 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression EXP Scopolamine results in decreased expression of NR4A1 mRNA CTD PMID:17540011 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA] CTD PMID:8635431 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
decreases expression		 EXP
ISO		 Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]
Scopolamine results in decreased expression of NTRK2 protein
[acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein]		 CTD PMID:8635431 PMID:29476728 PMID:31077737 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 multiple interactions EXP Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA] CTD PMID:8635431 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Pdcd4 programmed cell death 4 increases expression EXP Scopolamine results in increased expression of PDCD4 mRNA CTD PMID:12818353 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pdyn prodynorphin decreases response to substance
multiple interactions
increases expression		 ISO
EXP		 PDYN protein modified form results in decreased susceptibility to Scopolamine
MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine]
Scopolamine results in increased expression of PDYN mRNA		 CTD PMID:7768285 PMID:17540011 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin multiple interactions EXP Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA] CTD PMID:7637876 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression EXP Scopolamine results in decreased expression of PGAM1 mRNA CTD PMID:12818353 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Prep prolyl endopeptidase increases response to substance
increases expression
multiple interactions		 EXP PREP protein results in increased susceptibility to Scopolamine
Scopolamine results in increased expression of PREP protein
Piracetam inhibits the reaction [Scopolamine results in increased expression of PREP protein]		 CTD PMID:17244263 PMID:18318186 NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466 		JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 decreases expression EXP Scopolamine results in decreased expression of PRKRA mRNA CTD PMID:12818353 NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347 		JBrowse link
G Psen2 presenilin 2 decreases expression EXP Scopolamine results in decreased expression of PSEN2 mRNA CTD PMID:12818353 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO Scopolamine results in increased expression of PTGS2 protein
acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]		 CTD PMID:26408985 PMID:31077737 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rab14 RAB14, member RAS oncogene family increases expression EXP Scopolamine results in increased expression of RAB14 mRNA CTD PMID:17540011 NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 decreases expression EXP Scopolamine results in decreased expression of RAPGEF3 mRNA CTD PMID:12818353 NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein; timosaponin AIII inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein] CTD PMID:19182383 PMID:19426756 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rem2 RRAD and GEM like GTPase 2 decreases expression EXP Scopolamine results in decreased expression of REM2 mRNA CTD PMID:17540011 NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429 		JBrowse link
G Rgs7bp regulator of G-protein signaling 7 binding protein decreases expression EXP Scopolamine results in decreased expression of RGS7BP mRNA CTD PMID:17540011 NCBI chr 2:36,133,944...36,231,505
Ensembl chr 2:36,139,201...36,231,505 		JBrowse link
G Robo3 roundabout guidance receptor 3 decreases expression EXP Scopolamine results in decreased expression of ROBO3 mRNA CTD PMID:17540011 NCBI chr 8:37,133,542...37,151,674
Ensembl chr 8:37,133,916...37,151,315 		JBrowse link
G Rraga Ras-related GTP binding A increases expression EXP Scopolamine results in increased expression of RRAGA mRNA CTD PMID:12818353 NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510 		JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression EXP Scopolamine results in decreased expression of S100A4 mRNA CTD PMID:17540011 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases expression EXP Scopolamine results in increased expression of S1PR1 mRNA CTD PMID:12818353 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Scamp2 secretory carrier membrane protein 2 increases expression EXP Scopolamine results in increased expression of SCAMP2 mRNA CTD PMID:12818353 NCBI chr 8:57,965,612...57,992,248
Ensembl chr 8:57,965,631...57,992,646 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions ISO [2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine; [igmesine binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:12028363 NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Scopolamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Scopolamine results in increased expression of SULT1A1 mRNA CTD PMID:17540011 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Syp synaptophysin multiple interactions
decreases expression
increases expression		 EXP
ISO		 cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine results in increased expression of SYP protein]
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]		 CTD PMID:20188767 PMID:34371027 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases response to substance EXP TAC1 protein modified form results in decreased susceptibility to Scopolamine CTD PMID:20600432 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein]
Scopolamine results in increased expression of TNF mRNA
Scopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF protein		 CTD PMID:18357464 PMID:19182383 PMID:19426756 PMID:21161262 PMID:31077737 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnrc6a trinucleotide repeat containing adaptor 6A decreases expression EXP Scopolamine results in decreased expression of TNRC6A mRNA CTD PMID:17540011 NCBI chr 1:177,561,898...177,715,669
Ensembl chr 1:177,646,030...177,715,660 		JBrowse link
G Tpd52l1 TPD52 like 1 increases expression EXP Scopolamine results in increased expression of TPD52L1 mRNA CTD PMID:17540011 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109 		JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression EXP Scopolamine results in decreased expression of VGF mRNA CTD PMID:17540011 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341 		JBrowse link
G Vip vasoactive intestinal peptide decreases response to substance EXP VIP protein results in decreased susceptibility to Scopolamine CTD PMID:8208360 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
tolterodine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Tolterodine Tartrate results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of ACSL4 protein] CTD PMID:37702107 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression ISO Tolterodine Tartrate results in decreased expression of AHR mRNA CTD PMID:24316275 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Tolterodine Tartrate binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Tolterodine Tartrate binds to and results in decreased activity of CHRM3 protein CTD PMID:15140916 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
affects metabolic processing
multiple interactions		 ISO CYP2D6 protein results in increased metabolism of Tolterodine Tartrate
CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate
Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate]		 CTD PMID:10583026 PMID:28087463 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in decreased expression of FTH1 protein] CTD PMID:37702107 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of GPX4 protein] CTD PMID:37702107 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO Tolterodine Tartrate results in decreased expression of IL1B mRNA
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]		 CTD PMID:32816093 PMID:37702107 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:37702107 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein] CTD PMID:37702107 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
decreases expression		 ISO Tolterodine Tartrate inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]
Tolterodine Tartrate results in decreased expression of NR3C1 mRNA		 CTD PMID:24316275 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:37702107 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:37702107 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Tolterodine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Tolterodine Tartrate results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of TFRC protein] CTD PMID:37702107 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:37702107 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
trospium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport		 ISO valspodar inhibits the reaction [ABCB1 protein results in increased transport of trospium chloride] CTD PMID:25466967 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
increases metabolic processing		 ISO trospium chloride results in decreased activity of SLC22A1 protein
SLC22A1 protein results in increased metabolism of trospium chloride		 CTD PMID:25466967 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO trospium chloride results in decreased activity of SLC22A2 protein CTD PMID:25466967 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases metabolic processing
decreases activity		 ISO SLCO1A2 protein results in increased metabolism of trospium chloride
trospium chloride results in decreased activity of SLCO1A2 protein; trospium chloride results in decreased activity of SLCO1A2 protein alternative form		 CTD PMID:25466967 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity ISO trospium chloride results in decreased activity of SLCO1B3 protein CTD PMID:25466967 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      application 19663
        pharmaceutical 19504
          drug 19504
            neuromuscular agent 1321
              muscle relaxant 1316
                antispasmodic drug 173
                  (+-)-menthol 0
                  (-)-menthol + 0
                  3,4-secoisopimara-4(18),7,15-triene-3-oic acid 0
                  alverine 2
                  alverine citrate 0
                  alverine hydrochloride 0
                  butropium + 0
                  butropium bromide 0
                  butylscopolamine + 1
                  butylscopolamine bromide 1
                  buzepide metiodide 0
                  clidinium + 1
                  clidinium bromide 0
                  darifenacin + 3
                  dicyclomine + 1
                  dicyclomine hydrochloride 0
                  flavoxate 0
                  flavoxate hydrochloride 0
                  flutropium + 0
                  flutropium bromide 0
                  glycycoumarin 1
                  homatropine methylbromide 0
                  ipratropium bromide + 0
                  nimetazepam 4
                  nitrazepam + 8
                  oxybutynin + 12
                  papaverine 16
                  pethidine 2
                  pethidine hydrochloride 0
                  pirenzepine + 8
                  propyromazine bromide 0
                  scopolamine + 128
                  scopolamine hydrobromide trihydrate 0
                  scopolamine methobromide 0
                  tiquizium + 3
                  tiquizium bromide 3
                  tolterodine + 9
                  tridihexethyl + 0
                  trospium + 5
                  trospium chloride 5
paths to the root