Tnrc6a (trinucleotide repeat containing adaptor 6A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Tnrc6a (trinucleotide repeat containing adaptor 6A) Rattus norvegicus
Analyze
Symbol: Tnrc6a
Name: trinucleotide repeat containing adaptor 6A
RGD ID: 1307268
Description: Predicted to enable RNA binding activity. Predicted to be involved in miRNA-mediated gene silencing by inhibition of translation and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cellular response to starvation and endoderm development. Predicted to be located in Golgi apparatus. Predicted to be part of RISC complex. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 6. Orthologous to human TNRC6A (trinucleotide repeat containing adaptor 6A); PARTICIPATES IN microRNA pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308971; Tnrc6; trinucleotide repeat containing 6; trinucleotide repeat containing 6a; trinucleotide repeat-containing gene 6A protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,992,457 - 187,146,764 (+)NCBIGRCr8
mRatBN7.21177,561,898 - 177,715,669 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,646,030 - 177,715,660 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,982,679 - 186,051,718 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01193,168,669 - 193,237,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,846,128 - 185,915,335 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,991,584 - 193,146,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1193,076,430 - 193,146,394 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01200,079,394 - 200,206,235 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,982,994 - 182,053,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,122,897 - 182,191,066 (+)NCBI
Celera1175,335,300 - 175,404,345 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
topotecan  (EXP)
triptonide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Argonaute proteins at a glance. Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:15494374   PMID:17671087   PMID:20616046   PMID:22681889   PMID:23172285   PMID:34328181  


Genomics

Comparative Map Data
Tnrc6a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,992,457 - 187,146,764 (+)NCBIGRCr8
mRatBN7.21177,561,898 - 177,715,669 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,646,030 - 177,715,660 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,982,679 - 186,051,718 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01193,168,669 - 193,237,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,846,128 - 185,915,335 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,991,584 - 193,146,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1193,076,430 - 193,146,394 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01200,079,394 - 200,206,235 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,982,994 - 182,053,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,122,897 - 182,191,066 (+)NCBI
Celera1175,335,300 - 175,404,345 (+)NCBICelera
Cytogenetic Map1q36NCBI
TNRC6A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381624,610,205 - 24,826,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1624,610,209 - 24,827,632 (+)EnsemblGRCh38hg38GRCh38
GRCh371624,621,526 - 24,837,539 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361624,648,550 - 24,745,049 (+)NCBINCBI36Build 36hg18NCBI36
Celera1623,518,894 - 23,615,357 (+)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1622,832,154 - 22,928,155 (+)NCBIHuRef
CHM1_11625,755,032 - 25,851,538 (+)NCBICHM1_1
T2T-CHM13v2.01624,887,133 - 25,103,177 (+)NCBIT2T-CHM13v2.0
Tnrc6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397122,630,324 - 122,794,519 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7122,723,108 - 122,794,519 (+)EnsemblGRCm39 Ensembl
GRCm387123,031,101 - 123,195,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7123,123,885 - 123,195,296 (+)EnsemblGRCm38mm10GRCm38
MGSCv377130,267,399 - 130,338,810 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367122,914,984 - 122,986,454 (+)NCBIMGSCv36mm8
Celera7123,004,629 - 123,075,878 (+)NCBICelera
Cytogenetic Map7F2- F3NCBI
cM Map767.42NCBI
Tnrc6a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554933,090,088 - 3,243,731 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554933,057,035 - 3,243,668 (+)NCBIChiLan1.0ChiLan1.0
TNRC6A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21826,020,802 - 26,232,707 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11630,541,876 - 30,753,579 (+)NCBINHGRI_mPanPan1
PanPan1.11624,853,809 - 25,064,998 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1624,966,474 - 25,064,998 (+)Ensemblpanpan1.1panPan2
TNRC6A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1621,247,492 - 21,454,424 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl621,248,948 - 21,420,719 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha622,816,233 - 22,917,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0621,385,360 - 21,492,387 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl621,385,944 - 21,591,644 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1621,190,299 - 21,297,275 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0621,093,728 - 21,200,685 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0621,487,588 - 21,595,440 (-)NCBIUU_Cfam_GSD_1.0
Tnrc6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,919,007 - 121,094,660 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365019,045,546 - 9,193,281 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365019,016,844 - 9,192,946 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNRC6A
(Sus scrofa - pig)		 No map positions available.
TNRC6A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1522,341,159 - 22,553,822 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl522,453,931 - 22,553,843 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660687,201,098 - 7,416,576 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnrc6a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247829,608,245 - 9,807,237 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnrc6a
1059 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:104
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000017885
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat

Markers in Region
RH143060  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,665,536 - 177,665,694 (+)MAPPERmRatBN7.2
Rnor_6.01193,096,168 - 193,096,325NCBIRnor6.0
Rnor_5.01200,156,000 - 200,156,157UniSTSRnor5.0
RGSC_v3.41182,003,390 - 182,003,547UniSTSRGSC3.4
Celera1175,354,216 - 175,354,373UniSTS
Cytogenetic Map1q36UniSTS
RH130254  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,715,436 - 177,715,651 (+)MAPPERmRatBN7.2
Rnor_6.01193,146,171 - 193,146,385NCBIRnor6.0
Rnor_5.01200,206,003 - 200,206,217UniSTSRnor5.0
RGSC_v3.41182,053,287 - 182,053,501UniSTSRGSC3.4
Celera1175,404,122 - 175,404,336UniSTS
Cytogenetic Map1q36UniSTS
L17913  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,683,296 - 177,683,490 (+)MAPPERmRatBN7.2
Rnor_6.01193,113,925 - 193,114,118NCBIRnor6.0
Rnor_5.01200,173,757 - 200,173,950UniSTSRnor5.0
RGSC_v3.41182,021,148 - 182,021,341UniSTSRGSC3.4
Celera1175,371,974 - 175,372,167UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 40 24 19 24 7 7 74 34 37 11 7
Low 2 17 17 17 1 4 1 4 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017885   ⟹   ENSRNOP00000017885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,683,063 - 177,714,940 (+)Ensembl
Rnor_6.0 Ensembl1193,076,459 - 193,144,362 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086492   ⟹   ENSRNOP00000071070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,683,244 - 177,715,660 (+)Ensembl
Rnor_6.0 Ensembl1193,076,430 - 193,146,394 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096111   ⟹   ENSRNOP00000083407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,646,030 - 177,714,940 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110852   ⟹   ENSRNOP00000096367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,662,260 - 177,714,940 (+)Ensembl
RefSeq Acc Id: NM_001395157   ⟹   NP_001382086
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,077,544 - 187,146,764 (+)NCBI
mRatBN7.21177,646,446 - 177,715,669 (+)NCBI
RefSeq Acc Id: XM_008759747   ⟹   XP_008757969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,992,457 - 187,146,764 (+)NCBI
mRatBN7.21177,561,899 - 177,715,669 (+)NCBI
Rnor_6.01192,991,584 - 193,146,403 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759749   ⟹   XP_008757971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,992,661 - 187,146,764 (+)NCBI
mRatBN7.21177,561,898 - 177,715,669 (+)NCBI
Rnor_6.01192,991,584 - 193,146,403 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589208   ⟹   XP_017444697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,992,661 - 187,146,764 (+)NCBI
mRatBN7.21177,561,898 - 177,715,669 (+)NCBI
Rnor_6.01192,991,584 - 193,146,403 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589209   ⟹   XP_017444698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,992,661 - 187,146,764 (+)NCBI
mRatBN7.21177,561,901 - 177,713,300 (+)NCBI
Rnor_6.01192,991,585 - 193,144,035 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078265   ⟹   XP_038934193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,020,760 - 187,146,764 (+)NCBI
mRatBN7.21177,589,654 - 177,713,300 (+)NCBI
RefSeq Acc Id: XM_063263192   ⟹   XP_063119262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,076,115 - 187,146,764 (+)NCBI
RefSeq Acc Id: XM_063263194   ⟹   XP_063119264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,088,455 - 187,146,764 (+)NCBI
RefSeq Acc Id: XM_063263199   ⟹   XP_063119269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,076,115 - 187,146,764 (+)NCBI
RefSeq Acc Id: XM_063263201   ⟹   XP_063119271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,992,661 - 187,146,764 (+)NCBI
RefSeq Acc Id: XM_063263204   ⟹   XP_063119274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,078,029 - 187,146,764 (+)NCBI
RefSeq Acc Id: XM_063263213   ⟹   XP_063119283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,076,115 - 187,146,764 (+)NCBI
RefSeq Acc Id: XM_063263221   ⟹   XP_063119291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,110,081 - 187,146,764 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008757969   ⟸   XM_008759747
- Peptide Label: isoform X1
- UniProtKB: F1M9Y8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757971   ⟸   XM_008759749
- Peptide Label: isoform X2
- UniProtKB: F1M9Y8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444697   ⟸   XM_017589208
- Peptide Label: isoform X3
- UniProtKB: F1M9Y8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444698   ⟸   XM_017589209
- Peptide Label: isoform X6
- UniProtKB: A0A8I6ASC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071070   ⟸   ENSRNOT00000086492
RefSeq Acc Id: ENSRNOP00000017885   ⟸   ENSRNOT00000017885
RefSeq Acc Id: XP_038934193   ⟸   XM_039078265
- Peptide Label: isoform X7
- UniProtKB: F1M9Y8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096367   ⟸   ENSRNOT00000110852
RefSeq Acc Id: ENSRNOP00000083407   ⟸   ENSRNOT00000096111
RefSeq Acc Id: NP_001382086   ⟸   NM_001395157
- UniProtKB: A0A8I6GAR2 (UniProtKB/TrEMBL),   F1M9Y8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119271   ⟸   XM_063263201
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063119269   ⟸   XM_063263199
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063119283   ⟸   XM_063263213
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063119262   ⟸   XM_063263192
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063119274   ⟸   XM_063263204
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063119264   ⟸   XM_063263194
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063119291   ⟸   XM_063263221
- Peptide Label: isoform X10
Protein Domains
Argonaute hook   GW182 middle   TNRC6 PABC binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZJ3-F1-model_v2 AlphaFold A0A0G2JZJ3 1-1954 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690379
Promoter ID:EPDNEW_R904
Type:initiation region
Name:Tnrc6a_1
Description:trinucleotide repeat containing 6a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01193,076,438 - 193,076,498EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307268 AgrOrtholog
BioCyc Gene G2FUF-57528 BioCyc
Ensembl Genes ENSRNOG00000024737 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017885.8 UniProtKB/TrEMBL
  ENSRNOT00000086492.2 UniProtKB/TrEMBL
  ENSRNOT00000096111 ENTREZGENE
  ENSRNOT00000096111.1 UniProtKB/TrEMBL
  ENSRNOT00000110852.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Argonaute_hook_dom UniProtKB/TrEMBL
  GW182_M_dom UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  TNRC6_PABC-bd UniProtKB/TrEMBL
  TNRC6A_RRM UniProtKB/TrEMBL
NCBI Gene 308971 ENTREZGENE
PANTHER PTHR13020:SF28 UniProtKB/TrEMBL
  TRINUCLEOTIDE REPEAT-CONTAINING GENE 6 UniProtKB/TrEMBL
Pfam Ago_hook UniProtKB/TrEMBL
  M_domain UniProtKB/TrEMBL
  TNRC6-PABC_bdg UniProtKB/TrEMBL
PhenoGen Tnrc6a PhenoGen
RatGTEx ENSRNOG00000024737 RatGTEx
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A0G2JZJ3_RAT UniProtKB/TrEMBL
  A0A8I6ASC0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GAR2 ENTREZGENE, UniProtKB/TrEMBL
  F1M9Y8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Tnrc6a  trinucleotide repeat containing adaptor 6A  Tnrc6a  trinucleotide repeat containing 6a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tnrc6a  trinucleotide repeat containing 6a  Tnrc6_predicted  trinucleotide repeat containing 6 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Tnrc6_predicted  trinucleotide repeat containing 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED