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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:732137 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LNPEP mRNA | CTD | PMID:22079256 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LNPEP mRNA | CTD | PMID:22298810 | 2-naphthylamine | increases metabolic processing | ISO | RGD:732137 | 6480464 | LNPEP protein results in increased metabolism of 2-Naphthylamine analog | CTD | PMID:11732752 | 2-naphthylamine | increases metabolic processing | EXP | | 6480464 | LNPEP protein results in increased metabolism of 2-Naphthylamine analog | CTD | PMID:11732752 | aflatoxin B1 | affects expression | ISO | RGD:732137 | 6480464 | Aflatoxin B1 affects the expression of LNPEP protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | RGD:732137 | 6480464 | Aflatoxin B1 results in increased expression of LNPEP mRNA | CTD | PMID:21641981 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of LNPEP mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:732138 | 6480464 | Benzo(a)pyrene results in increased expression of LNPEP mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | RGD:732137 | 6480464 | Benzo(a)pyrene results in increased expression of LNPEP mRNA | CTD | PMID:21632981 | benzo[a]pyrene | multiple interactions | ISO | RGD:732138 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of LNPEP mRNA] | CTD | PMID:22228805 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of LNPEP mRNA | CTD | PMID:19167457 | cadmium dichloride | increases expression | ISO | RGD:732138 | 6480464 | Cadmium Chloride results in increased expression of LNPEP mRNA | CTD | PMID:20883709 | cyclosporin A | increases expression | ISO | RGD:732137 | 6480464 | Cyclosporine results in increased expression of LNPEP mRNA | CTD | PMID:20106945 | Delta(9)-tetrahydrocannabinol | increases expression | ISO | RGD:732137 | 6480464 | Tetrahydrocannabinol results in increased expression of LNPEP mRNA | CTD | PMID:16597638 | dibutyl phthalate | increases expression | ISO | RGD:732138 | 6480464 | Dibutyl Phthalate results in increased expression of LNPEP mRNA | CTD | PMID:21266533 | paracetamol | affects expression | ISO | RGD:732138 | 6480464 | Acetaminophen affects the expression of LNPEP mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | ISO | RGD:732138 | 6480464 | Phenobarbital affects the expression of LNPEP mRNA | CTD | PMID:23091169 | quercetin | decreases expression | ISO | RGD:732137 | 6480464 | Quercetin results in decreased expression of LNPEP mRNA | CTD | PMID:21632981 | scopolamine | multiple interactions | ISO | RGD:732137 | 6480464 | [AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine Hydrobromide | CTD | PMID:11707427 | zoledronic acid | increases expression | ISO | RGD:732137 | 6480464 | zoledronic acid results in increased expression of LNPEP mRNA | CTD | PMID:20977926 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Renin-angiotensin system |
| Pathway Interaction Database | Insulin-mediated glucose transport (PID:200196) |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Renin-angiotensin system |
| Pathway Interaction Database | Insulin-mediated glucose transport (PID:200196) |
Phenotype AnnotationsReferences - curated| 1. |
Albiston AL, etal., Trends Endocrinol Metab. 2003 Mar;14(2):72-7. |
| 2. |
Aledo JC, etal., Biochem J. 1997 Aug 1;325 ( Pt 3):727-32. |
| 3. |
Fernando RN, etal., J Comp Neurol. 2005 Jul 11;487(4):372-90. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Hamilton TA, etal., Peptides. 2001 Jun;22(6):935-44. |
| 6. |
Kalinkov D and Buchholz R, Am J Obstet Gynecol. 1980 Dec 15;138(8):1148-50. |
| 7. |
Katagiri H, etal., Mol Endocrinol 2002 May;16(5):1049-59. |
| 8. |
Keller SR, etal., J Biol Chem 1995 Oct 6;270(40):23612-8. |
| 9. |
Kramar EA, etal., Brain Res. 2001 Apr 6;897(1-2):114-21. |
| 10. |
Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23. |
| 11. |
Larrinaga G, etal., Regul Pept. 2007 Dec 4;144(1-3):56-61. Epub 2007 Jun 21. |
| 12. |
Liao H, etal., Traffic. 2006 Feb;7(2):155-67. |
| 13. |
Liu L, etal., Mol Biol Cell. 2006 Oct;17(10):4249-56. Epub 2006 Jul 26. |
| 14. |
Maianu L, etal., J Clin Endocrinol Metab. 2001 Nov;86(11):5450-6. |
| 15. |
Malide D, etal., FEBS Lett. 1997 Jun 16;409(3):461-8. |
| 16. |
Martinez JM, etal., Clin Chem. 1999 Oct;45(10):1797-802. |
| 17. |
Masuda S, etal., Eur J Biochem 2003 May;270(9):1988-94. |
| 18. |
MGD data from the GO Consortium |
| 19. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 20. |
Pilar Carrera M, etal., Anticancer Res. 2006 Mar-Apr;26(2A):1011-4. |
| 21. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 22. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 23. |
Reudelhuber TL Curr Opin Nephrol Hypertens. 2005 Mar;14(2):155-9. |
| 24. |
RGD automated data pipeline |
| 25. |
RGD automated import pipeline for gene-chemical interactions |
| 26. |
Ryu J, etal., Arch Biochem Biophys 2002 Jul 1;403(1):71-82. |
| 27. |
Savchenko ON, etal., Akush Ginekol (Mosk). 1991 Dec;(12):12-5. |
| 28. |
Shibata K, etal., Gynecol Oncol. 2004 Nov;95(2):307-13. |
| 29. |
Shibata K, etal., Gynecol Oncol. 2005 Jul;98(1):11-8. |
| 30. |
Shibata K, etal., Oncology. 2004;66(4):288-95. |
| 31. |
Stragier B, etal., J Neurochem. 2006 Aug;98(4):1100-13. Epub 2006 Jun 12. |
| 32. |
Takeuchi M, etal., Nagoya J Med Sci. 2006 Jun;68(3-4):155-63. |
| 33. |
Thoidis G and Kandror KV, Traffic. 2001 Aug;2(8):577-87. |
References - uncuratedRGD Disease Portals| Lnpep has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Lnpep (Rattus norvegicus) |
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| LNPEP (Homo sapiens) |
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| Lnpep (Mus musculus) |
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Position Markers| BF398876 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001113403 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_133574 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06003228 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01003355 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY079189 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474033 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U32990 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U76997 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_133574 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_598258 | ||||||||||||||||||||
| Peptide Label: | isoform 2 | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001113403 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001106874 | ||||||||||||||||||||
| Peptide Label: | isoform 1 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001106874 | (Get FASTA) |
| NP_598258 | (Get FASTA) | |
| GenBank Protein | AAB19066 | (Get FASTA) |
| AAB38021 | (Get FASTA) | |
| AAL86569 | (Get FASTA) | |
| EDL99798 | (Get FASTA) | |
| EDL99799 | (Get FASTA) | |
| EDL99800 | (Get FASTA) | |
| P97629 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000013082 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOG00000047387 | UniProtKB/Swiss-Prot | |
| Ensembl Protein | ENSRNOP00000017718 | UniProtKB/Swiss-Prot |
| ENSRNOP00000056519 | ENTREZGENE, UniProtKB/TrEMBL | |
| ENSRNOP00000065081 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000017718 | UniProtKB/Swiss-Prot |
| ENSRNOT00000059766 | ENTREZGENE, UniProtKB/TrEMBL | |
| ENSRNOT00000074029 | UniProtKB/TrEMBL | |
| Entrez Gene | 171105 | ENTREZGENE |
| Germonline | ENSRNOG00000013082 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 21148 | ENTREZGENE |
| InterPro | DUF3358 | UniProtKB/Swiss-Prot |
| Peptidase_M1 | UniProtKB/Swiss-Prot | |
| Peptidase_M1_N | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:100912445 | UniProtKB/Swiss-Prot |
| rno:171105 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| PANTHER | Peptidase_M1 | UniProtKB/Swiss-Prot |
| Pfam | DUF3358 | UniProtKB/Swiss-Prot |
| Peptidase_M1 | UniProtKB/Swiss-Prot | |
| PRINTS | ALADIPTASE | UniProtKB/Swiss-Prot |
| PROSITE | ZINC_PROTEASE | UniProtKB/Swiss-Prot |
| UniGene | Rn.10614 | ENTREZGENE |
| UniProt | D3ZUR9_RAT | UniProtKB/TrEMBL |
| LCAP_RAT | UniProtKB/Swiss-Prot | |
| M0R6M8_RAT | UniProtKB/TrEMBL | |
| Q8R438_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Lnpep | leucyl/cystinyl aminopeptidase | aminopeptidase Vp165 | Name updated | 10779 | APPROVED | |
| 2004-09-10 | Lnpep | aminopeptidase Vp165 | Vp165 | Symbol and Name updated | 10779 | APPROVED | |
| 2002-08-07 | Vp165 | aminopeptidase Vp165 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | localized to vesicles and upon insulin stimulation is recruited to the plasma membrane | |
| gene_domains | contains two dileucine motifs, a large extracellular catalytic domain and a single transmembrane domain |
| More on Lnpep | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621752 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.