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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
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Accession:CHEBI:379896 term browser browse the term
Definition:A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Synonyms:related_synonym: 17-beta-Hydroxy-17-methylestra-4,9,11-trien-3-one;   17-methyloestra-4,9,11-trien-3-one,17beta-ol;   17alpha-Methyltrienolone;   Formula=C19H24O2;   InChI=1S/C19H24O2/c1-18-9-7-15-14-6-4-13(20)11-12(14)3-5-16(15)17(18)8-10-19(18,2)21/h7,9,11,16-17,21H,3-6,8,10H2,1-2H3/t16-,17+,18+,19+/m1/s1;   InChIKey=CCCIJQPRIXGQOE-XWSJACJDSA-N;   Methyltrienolone;   R1881;   R1881 (synthetic androgen);   SMILES=[H][C@@]12CCC3=CC(=O)CCC3=C1C=C[C@@]1(C)[C@@]2([H])CC[C@]1(C)O;   metribolona;   metribolone;   metribolonum
 alt_id: CHEBI:45313;   CHEBI:59645
 xref: Beilstein:2626053;   CAS:965-93-5;   DrugBank:DB02998;   KEGG:C14257
 xref_mesh: MESH:D015741
 xref: PDBeChem:R18;   PMID:17077481;   Patent:NL6401555



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17beta-hydroxy-17-methylestra-4,9,11-trien-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 9530057J20Rik RIKEN cDNA 9530057J20 gene increases expression ISO Metribolone results in increased expression of POTEM mRNA CTD PMID:17010196 NCBI chr 8:20,478,979...20,510,931
Ensembl chr 8:20,478,993...20,501,314
JBrowse link
G AA986860 expressed sequence AA986860 increases expression ISO Metribolone results in increased expression of C1ORF116 mRNA CTD PMID:17010675 NCBI chr 1:130,659,707...130,672,359
Ensembl chr 1:130,659,713...130,672,359
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 increases expression ISO Metribolone results in increased expression of ABCC4 mRNA CTD PMID:17010675 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
JBrowse link
G Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain decreases expression ISO Metribolone results in decreased expression of ACADSB protein CTD PMID:17152098 NCBI chr 7:131,012,330...131,047,940
Ensembl chr 7:131,012,330...131,050,673
JBrowse link
G Acp3 acid phosphatase 3 increases expression ISO Metribolone results in increased expression of ACP3 protein CTD PMID:17541959 NCBI chr 9:104,165,439...104,214,921
Ensembl chr 9:104,165,450...104,214,947
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to ACSL3 protein]
Metribolone results in increased expression of ACSL3 mRNA
CTD PMID:16751804 PMID:17010675 PMID:17220478 NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460
JBrowse link
G Actb actin, beta multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to ACTB protein]
Metribolone results in increased expression of ACTB protein
CTD PMID:17152098 PMID:17220478 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
JBrowse link
G Actg1 actin, gamma, cytoplasmic 1 increases expression ISO Metribolone results in increased expression of ACTG1 protein CTD PMID:17152098 NCBI chr11:120,236,513...120,239,321
Ensembl chr11:120,236,516...120,239,368
JBrowse link
G Adam7 a disintegrin and metallopeptidase domain 7 increases expression ISO Metribolone results in increased expression of ADAM7 mRNA CTD PMID:17010675 NCBI chr14:68,734,785...68,771,138
Ensembl chr14:68,734,785...68,771,190
JBrowse link
G Aida axin interactor, dorsalization associated increases expression ISO Metribolone results in increased expression of AIDA mRNA CTD PMID:17010196 NCBI chr 1:183,078,604...183,105,356
Ensembl chr 1:183,078,134...183,106,331
JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein decreases expression ISO Metribolone results in decreased expression of AIP protein CTD PMID:17152098 NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858
JBrowse link
G Akip1 A kinase interacting protein 1 increases expression ISO Metribolone results in increased expression of AKIP1 mRNA CTD PMID:17010196 NCBI chr 7:109,302,885...109,311,393
Ensembl chr 7:109,302,897...109,311,396
JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 increases expression ISO Metribolone results in increased expression of AKR1A1 protein CTD PMID:17152098 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation
ISO bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of AKT1 protein]; Hydrogen Peroxide promotes the reaction [Metribolone results in increased phosphorylation of AKT1 protein] CTD PMID:17325745 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 increases expression ISO Metribolone results in increased expression of ALDH1A3 mRNA CTD PMID:17526768 NCBI chr 7:66,040,640...66,077,225
Ensembl chr 7:66,040,638...66,077,265
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 increases expression ISO Metribolone results in increased expression of ALDH9A1 protein CTD PMID:17152098 NCBI chr 1:167,177,560...167,196,100
Ensembl chr 1:167,177,560...167,196,101
JBrowse link
G Amh anti-Mullerian hormone multiple interactions ISO AMH protein inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA] CTD PMID:16740653 NCBI chr10:80,641,074...80,643,513
Ensembl chr10:80,641,077...80,643,482
JBrowse link
G Anxa4 annexin A4 increases expression ISO Metribolone results in increased expression of ANXA4 protein CTD PMID:17152098 NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566
JBrowse link
G Ap1m2 adaptor protein complex AP-1, mu 2 subunit multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to AP1M2 protein] CTD PMID:17220478 NCBI chr 9:21,206,753...21,223,617
Ensembl chr 9:21,205,571...21,223,633
JBrowse link
G Ap2m1 adaptor-related protein complex 2, mu 1 subunit multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to AP2M1 protein] CTD PMID:17220478 NCBI chr16:20,354,230...20,363,659
Ensembl chr16:20,354,228...20,363,659
JBrowse link
G Apmap adipocyte plasma membrane associated protein increases expression ISO Metribolone results in increased expression of APMAP protein CTD PMID:17152098 NCBI chr 2:150,425,000...150,450,487
Ensembl chr 2:150,425,000...150,450,487
JBrowse link
G Appbp2 amyloid beta precursor protein binding protein 2 increases expression ISO Metribolone results in increased expression of APPBP2 mRNA CTD PMID:16751804 NCBI chr11:85,082,134...85,125,946
Ensembl chr11:85,078,088...85,125,956
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
increases activity
increases expression
affects localization
affects binding
ISO
EXP
1,2,3,6,7,8-hexachlorodibenzodioxin inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-acetonaphthone inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-aminopyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-hydroxypyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-nitropyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; 16 alpha,17-epoxyprogesterone inhibits the reaction [Metribolone results in increased activity of AR protein]; 17 alpha,20 beta-dihydroxypregn-4-en-3-one inhibits the reaction [Metribolone results in increased activity of AR protein]; 17-(5'-isoxazolyl)androsta-4,16-dien-3-one inhibits the reaction [Metribolone binds to AR protein]; 2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2',4,5'-tetrabromodiphenyl ether inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2',4,5'-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2'-biphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; 2,2-di(4-methacryloxyphenyl)propane inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3',4,4',5-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3',4,4'-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4',6-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4,4'5-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4,5,6-pentachloroaniline inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4,7,8-pentachlorodibenzofuran inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,5,6-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,5,6-tetrachlorohydroquinone inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,4',5-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,6-trichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,5,3'-trichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,6-di-tert-butyl-4-hydroxymethylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,6-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-aminodiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-anthramine inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-chlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-tert-butylhydroquinone inhibits the reaction [Metribolone results in increased activity of AR protein]; 20-hydroximino-4,16-pregnadien-3-one inhibits the reaction [Metribolone binds to AR protein]; 3,3'-Dichlorobenzidine inhibits the reaction [Metribolone results in increased activity of AR protein]; 3,3'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 3,5-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 4,16-androstadien-3-one analog inhibits the reaction [Metribolone binds to AR protein]; 4-benzylpyridine inhibits the reaction [Metribolone results in increased activity of AR protein]; 4-methylbenzenethiol inhibits the reaction [Metribolone results in increased activity of AR protein]; 4-phenylphenol inhibits the reaction [Metribolone binds to AR protein]; 4-tert-octylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; 6-(3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)pyridine-2-sulfonic acid amide inhibits the reaction [Metribolone affects the localization of AR protein]; 9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; 9,10-dimethylanthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; 9-methylanthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; [4,4'-hexafluorisopropylidene diphenol binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [4,4'-hexafluorisopropylidene diphenol binds to and results in decreased activity of AR protein] which results in decreased susceptibility to Metribolone; [bisphenol A binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [bisphenol A binds to and results in decreased activity of AR protein] which results in decreased susceptibility to Metribolone; [iprodione binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to CNOT1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to HELZ2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOR1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to TRERF1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CHD9 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to DHX30 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GNAQ protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HR protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ITGB3BP protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to KAT2B protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MGMT protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NELFB protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NFKBIB protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PIAS2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRAME protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRIM24 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRRAP protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ZNHIT3 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to AR protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GSN protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to JMJD1C protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to LCOR protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA6 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PPARGC1A protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRDM2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RBL2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RELA protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to SLC30A9 protein modified form]; [Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein; [vinclozolin binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; Acriflavine inhibits the reaction [Metribolone results in increased activity of AR protein]; alachlor inhibits the reaction [Metribolone results in increased activity of AR protein]; alpha,alpha-dimethoxytoluene inhibits the reaction [Metribolone results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Metribolone results in increased activity of AR protein]; androsta-5,16-dien-3 beta-ol analog inhibits the reaction [Metribolone binds to AR protein]; anthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; AR mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein]; AR mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein]; AR mRNA affects the reaction [Metribolone results in increased secretion of CXCL8 protein]; AR protein affects the reaction [Metribolone results in decreased expression of MIR204 mRNA]; AR protein affects the reaction [Metribolone results in decreased expression of SESN1 protein]; AR protein affects the reaction [Metribolone results in increased abundance of Reactive Oxygen Species]; AR protein promotes the reaction [Metribolone results in increased expression of ATP7B mRNA]; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 mRNA]; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 protein]; AR protein promotes the reaction [Metribolone results in increased expression of STEAP4 mRNA]; Arsenic Trioxide inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; Benzhydryl Compounds inhibits the reaction [Metribolone results in increased activity of AR protein]; Benzo(a)pyrene inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Benzo(a)pyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; Benzo(a)pyrene metabolite inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; benzo(j)fluoranthene inhibits the reaction [Metribolone results in increased activity of AR protein]; benzo(k)fluoranthene inhibits the reaction [Metribolone results in increased activity of AR protein]; Benzophenones inhibits the reaction [Metribolone results in increased activity of AR protein]; bicalutamide inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; bicalutamide inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; bifenox inhibits the reaction [Metribolone results in increased activity of AR protein]; bisphenol A inhibits the reaction [Metribolone results in increased activity of AR protein]; bitertanol inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Bortezomib inhibits the reaction [Metribolone results in increased activity of AR protein]; Budesonide inhibits the reaction [Metribolone results in increased activity of AR protein]; Busulfan inhibits the reaction [Metribolone results in increased activity of AR protein]; Cadmium Chloride inhibits the reaction [Metribolone binds to AR protein]; carfilzomib inhibits the reaction [Metribolone results in increased activity of AR protein]; CH 5166623 inhibits the reaction [Metribolone affects the localization of AR protein]; CH4933468 inhibits the reaction [Metribolone affects the localization of AR protein]; chlorobenzilate inhibits the reaction [Metribolone results in increased activity of AR protein]; chlorocresol inhibits the reaction [Metribolone results in increased activity of AR protein]; chrysene inhibits the reaction [Metribolone results in increased activity of AR protein]; Colforsin promotes the reaction [Metribolone results in increased activity of AR protein]; corticosterone acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; Corticosterone inhibits the reaction [Metribolone results in increased activity of AR protein]; Cosmetics inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyclohexylamines inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyclopentanes inhibits the reaction [Metribolone results in increased activity of AR protein]; cypermethrin inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyproterone Acetate inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; Cyproterone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]; DDT inhibits the reaction [Metribolone affects the localization of AR protein]; DDT inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; DDT inhibits the reaction [Metribolone results in increased expression of AR protein]; Deanol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dexamethasone inhibits the reaction [Metribolone results in increased activity of AR protein]; diallyl trisulfide inhibits the reaction [Metribolone affects the localization of AR protein]; Dianisidine inhibits the reaction [Metribolone results in increased activity of AR protein]; dichlone inhibits the reaction [Metribolone results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene analog inhibits the reaction [Metribolone results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone affects the localization of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of AR protein]; Dichlorvos promotes the reaction [Metribolone results in increased activity of AR protein]; dichlozolinate inhibits the reaction [Metribolone results in increased activity of AR protein]; Dicofol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dieldrin inhibits the reaction [Metribolone results in increased activity of AR protein]; Diethylstilbestrol inhibits the reaction [Metribolone results in increased activity of AR protein]; Diuron inhibits the reaction [Metribolone results in increased activity of AR protein]; Endosulfan inhibits the reaction [Metribolone results in increased activity of AR protein]; enilconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; enzacamene inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; epoxiconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Estradiol inhibits the reaction [Metribolone results in increased activity of AR protein]; Estriol inhibits the reaction [Metribolone results in increased activity of AR protein]; Ethinyl Estradiol inhibits the reaction [Metribolone results in increased activity of AR protein]; Etoposide inhibits the reaction [Metribolone results in increased activity of AR protein]; fenarimol inhibits the reaction [Metribolone results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Metribolone results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein]; Finasteride inhibits the reaction [Metribolone results in increased activity of AR protein]; fisetin inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; Flame Retardants inhibits the reaction [Metribolone results in increased activity of AR protein]; fluoranthene inhibits the reaction [Metribolone results in increased activity of AR protein]; fluoxastrobin inhibits the reaction [Metribolone results in increased activity of AR protein]; Flutamide inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Flutamide inhibits the reaction [Metribolone binds to AR protein]; Food Additives inhibits the reaction [Metribolone results in increased activity of AR protein]; galaxolide inhibits the reaction [Metribolone results in increased activity of AR protein]; gamma-Linolenic Acid inhibits the reaction [Metribolone results in increased activity of AR protein]; Hexylresorcinol inhibits the reaction [Metribolone results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone results in increased activity of AR protein]; Hydrocarbons, Chlorinated inhibits the reaction [Metribolone results in increased activity of AR protein]; hydroxyflutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; IL6 protein inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Linuron inhibits the reaction [Metribolone binds to AR protein]; Linuron inhibits the reaction [Metribolone results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; meprednisone inhibits the reaction [Metribolone results in increased activity of AR protein]; Methiocarb inhibits the reaction [Metribolone results in increased activity of AR protein]; methoxyacetic acid promotes the reaction [Metribolone results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone results in increased activity of AR protein]; Methoxychlor metabolite inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [Metribolone results in increased activity of AR protein]; metoprine inhibits the reaction [Metribolone results in increased activity of AR protein]; Metribolone binds to and affects the folding of AR protein; Metribolone binds to and results in increased activity of AR protein; Metribolone inhibits the reaction [CREBBP protein results in increased activity of AR protein]; Metribolone inhibits the reaction [NCOA1 protein results in increased activity of AR protein]; Metribolone inhibits the reaction [NCOA3 protein results in increased activity of AR protein]; Metribolone promotes the reaction [AR protein binds to ATR promoter]; Metribolone promotes the reaction [AR protein binds to CLU enhancer]; Metribolone promotes the reaction [AR protein binds to GSTE1 promoter]; Metribolone promotes the reaction [AR protein binds to IGFBP3 promoter]; Metribolone promotes the reaction [AR protein binds to KLK3 enhancer]; Metribolone promotes the reaction [AR protein binds to KLK3 promoter]; Metribolone promotes the reaction [AR protein binds to NKX3-1 enhancer]; Metribolone promotes the reaction [AR protein binds to NKX3-1 promoter]; Metribolone results in increased folding of and results in increased stability of AR protein; Metribolone results in increased localization of and results in increased activity of AR protein; Mifepristone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Mifepristone inhibits the reaction [Metribolone results in increased activity of AR protein mutant form]; Mifepristone inhibits the reaction [Metribolone results in increased activity of AR protein]; nilutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; Nitrobenzenes inhibits the reaction [Metribolone results in increased activity of AR protein]; nitrofen inhibits the reaction [Metribolone results in increased activity of AR protein]; nonylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; nootkatone inhibits the reaction [Metribolone results in increased activity of AR protein]; o,p'-DDT inhibits the reaction [Metribolone results in increased activity of AR protein]; PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Metribolone results in increased expression of AR mRNA]; pentabrominated diphenyl ether 100 inhibits the reaction [Metribolone results in increased activity of AR protein]; Pesticides inhibits the reaction [Metribolone results in increased activity of AR protein]; Plasticizers inhibits the reaction [Metribolone results in increased activity of AR protein]; Pregnadienes analog inhibits the reaction [Metribolone binds to AR protein]; prochloraz inhibits the reaction [Metribolone results in increased activity of AR protein]; procymidone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; procymidone inhibits the reaction [Metribolone binds to AR protein]; procymidone inhibits the reaction [Metribolone results in increased activity of AR protein]; Proflavine inhibits the reaction [Metribolone results in increased activity of AR protein]; Progesterone inhibits the reaction [Metribolone results in increased activity of AR protein]; propiconazole inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; propiconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; pyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; pyridaben inhibits the reaction [Metribolone results in increased activity of AR protein]; retene inhibits the reaction [Metribolone results in increased activity of AR protein]; ronnel inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; ST 1481 inhibits the reaction [Metribolone results in increased activity of AR protein]; tebuconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; tetrabromobisphenol A inhibits the reaction [Metribolone results in increased activity of AR protein]; Topotecan inhibits the reaction [Metribolone results in increased activity of AR protein]; Toxaphene inhibits the reaction [Metribolone results in increased activity of AR protein]; Trenbolone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; triadimefon inhibits the reaction [Metribolone results in increased activity of AR protein]; Triclosan inhibits the reaction [Metribolone results in increased activity of AR protein]; trifloxystrobin inhibits the reaction [Metribolone results in increased activity of AR protein]; tris(1,3-dichloro-2-propyl)phosphate affects the reaction [Metribolone affects the localization of AR protein]; tris(1,3-dichloro-2-propyl)phosphate inhibits the reaction [Metribolone results in increased expression of AR protein]; trityl chloride inhibits the reaction [Metribolone results in increased activity of AR protein]; Vehicle Emissions analog inhibits the reaction [Metribolone binds to AR protein]; vinclozolin inhibits the reaction [Metribolone results in increased activity of AR protein]; vinclozolin metabolite inhibits the reaction [Metribolone results in increased activity of AR protein]; Zearalenone inhibits the reaction [Metribolone results in increased activity of AR protein]
Metribolone results in decreased expression of AR mRNA; Metribolone results in decreased expression of AR mRNA mutant form
Metribolone results in increased activity of AR protein; Metribolone results in increased activity of AR protein mutant form
Metribolone results in increased expression of AR mRNA; Metribolone results in increased expression of AR protein
1-methylphenanthrene inhibits the reaction [Metribolone binds to AR protein]; 1-naphthaldehyde inhibits the reaction [Metribolone binds to AR protein]; 1-naphthol inhibits the reaction [Metribolone binds to AR protein]; 10,11-dihydro-5H-dibenzo(a,d)cycloheptene analog inhibits the reaction [Metribolone binds to AR protein]; 10,11-dihydro-5H-dibenzo(a,d)cycloheptene inhibits the reaction [Metribolone binds to AR protein]; 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Metribolone binds to AR protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Metribolone binds to AR protein]; 2-methylphenanthrene inhibits the reaction [Metribolone binds to AR protein]; 2-naphthol inhibits the reaction [Metribolone binds to AR protein]; 9-phenanthrol inhibits the reaction [Metribolone binds to AR protein]; Anthracenes analog inhibits the reaction [Metribolone binds to AR protein]; benzaldehyde inhibits the reaction [Metribolone binds to AR protein]; Biphenyl Compounds analog inhibits the reaction [Metribolone binds to AR protein]; decamethrin inhibits the reaction [Metribolone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [Metribolone binds to AR protein]; Flame Retardants inhibits the reaction [Metribolone binds to AR protein]; hexabromodiphenyl ether 154 inhibits the reaction [Metribolone binds to AR protein]; hydroxyflutamide inhibits the reaction [Metribolone binds to AR protein]; Linuron inhibits the reaction [Metribolone binds to AR protein]; Methiocarb inhibits the reaction [Metribolone results in increased expression of AR mRNA]; naphthalene inhibits the reaction [Metribolone binds to AR protein]; Naphthols analog inhibits the reaction [Metribolone binds to AR protein]; pentabrominated diphenyl ether 100 inhibits the reaction [Metribolone binds to AR protein]; pentabromodiphenyl ether inhibits the reaction [Metribolone binds to AR protein]; phenanthrene analog inhibits the reaction [Metribolone binds to AR protein]; phenanthrene inhibits the reaction [Metribolone binds to AR protein]; Phenols analog inhibits the reaction [Metribolone binds to AR protein]; prochloraz inhibits the reaction [Metribolone binds to AR protein]; prochloraz inhibits the reaction [Metribolone results in increased expression of AR mRNA]; Tetrahydronaphthalenes inhibits the reaction [Metribolone binds to AR protein]
AR protein promotes the reaction [Metribolone results in increased expression of FSHB mRNA]
Metribolone binds to AR protein; Metribolone binds to AR protein mutant form
CTD PMID:3695475 PMID:10053169 PMID:10188193 PMID:10771140 PMID:10910998 More... NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Arcn1 archain 1 increases expression ISO Metribolone results in increased expression of ARCN1 protein CTD PMID:17152098 NCBI chr 9:44,653,440...44,679,105
Ensembl chr 9:44,652,861...44,679,142
JBrowse link
G Arg1 arginase, liver multiple interactions
increases expression
ISO AR mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein] CTD PMID:20711410 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
JBrowse link
G Arg2 arginase type II multiple interactions
increases expression
ISO AR mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein]
Metribolone results in increased expression of ARG2 mRNA; Metribolone results in increased expression of ARG2 protein
CTD PMID:20711410 NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075
JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression ISO Metribolone results in increased expression of ARHGAP1 protein CTD PMID:17152098 NCBI chr 2:91,480,463...91,502,670
Ensembl chr 2:91,480,205...91,502,671
JBrowse link
G Asns asparagine synthetase decreases expression ISO Metribolone results in decreased expression of ASNS protein CTD PMID:17152098 NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Metribolone results in increased expression of ATF3 protein CTD PMID:16516039 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions
increases phosphorylation
ISO [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA; ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]
Metribolone results in increased phosphorylation of ATM protein
CTD PMID:23272087 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to ATP1A1 protein] CTD PMID:17220478 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions
increases expression
ISO AR protein promotes the reaction [Metribolone results in increased expression of ATP7B mRNA] CTD PMID:25320179 NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
JBrowse link
G Atr ataxia telangiectasia and Rad3 related multiple interactions
increases expression
increases phosphorylation
ISO ATR mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]; Metribolone promotes the reaction [AR protein binds to ATR promoter]; Metribolone promotes the reaction [UXT protein binds to ATR promoter]
Metribolone results in increased expression of ATR mRNA
Metribolone results in increased phosphorylation of ATR protein
CTD PMID:19318562 PMID:23272087 NCBI chr 9:95,739,655...95,834,813
Ensembl chr 9:95,739,650...95,833,834
JBrowse link
G Atxn3 ataxin 3 increases expression ISO Metribolone results in increased expression of ATXN3 mRNA CTD PMID:16751804 NCBI chr12:101,885,160...101,928,139
Ensembl chr12:101,885,160...101,924,505
JBrowse link
G B2m beta-2 microglobulin increases expression
multiple interactions
ISO Metribolone results in increased expression of B2M mRNA
Metribolone results in increased expression of and results in increased secretion of B2M protein; resveratrol inhibits the reaction [Metribolone results in increased expression of B2M mRNA]
CTD PMID:17131305 PMID:17404077 PMID:18586690 NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564
JBrowse link
G Bcas1 brain enriched myelin associated protein 1 increases expression ISO Metribolone results in increased expression of BCAS1 mRNA CTD PMID:17010196 NCBI chr 2:170,188,911...170,270,292
Ensembl chr 2:170,188,911...170,269,765
JBrowse link
G Bglap bone gamma carboxyglutamate protein increases expression ISO Metribolone results in increased expression of BGLAP mRNA CTD PMID:19759027 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
JBrowse link
G Blcap bladder cancer associated protein increases expression ISO Metribolone results in increased expression of BLCAP mRNA CTD PMID:17010196 NCBI chr 2:157,398,282...157,408,281
Ensembl chr 2:157,398,282...157,413,194
JBrowse link
G Blvra biliverdin reductase A increases expression ISO Metribolone results in increased expression of BLVRA protein CTD PMID:17152098 NCBI chr 2:126,912,549...126,939,004
Ensembl chr 2:126,912,585...126,939,004
JBrowse link
G Brca1 breast cancer 1, early onset increases expression ISO Metribolone results in increased expression of BRCA1 mRNA CTD PMID:17010196 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781
JBrowse link
G Brca2 breast cancer 2, early onset increases expression ISO Metribolone results in increased expression of BRCA2 mRNA CTD PMID:17010196 NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794
JBrowse link
G Brd8 bromodomain containing 8 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form] CTD PMID:28751236 NCBI chr18:34,731,668...34,757,916
Ensembl chr18:34,731,668...34,757,654
JBrowse link
G Bri3 brain protein I3 affects splicing ISO Metribolone affects the splicing of BRI3 mRNA CTD PMID:17010196 NCBI chr 5:144,181,247...144,383,567
Ensembl chr 5:144,181,247...144,383,567
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 increases expression
multiple interactions
ISO Metribolone results in increased expression of BRIP1 mRNA
UXT protein affects the reaction [Metribolone results in increased expression of BRIP1 mRNA]
CTD PMID:19318562 NCBI chr11:85,948,957...86,092,041
Ensembl chr11:85,948,964...86,092,019
JBrowse link
G Brms1 breast cancer metastasis-suppressor 1 increases expression ISO Metribolone results in increased expression of BRMS1 mRNA CTD PMID:17010196 NCBI chr19:5,091,391...5,099,940
Ensembl chr19:5,091,382...5,099,945
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase increases expression ISO Metribolone results in increased expression of BUB1 mRNA CTD PMID:19318562 NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta increases expression ISO Metribolone results in increased expression of CAMKK2 mRNA CTD PMID:16751804 NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472
JBrowse link
G Canx calnexin multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to CANX protein] CTD PMID:17220478 NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500
JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 increases expression ISO Metribolone results in increased expression of CAPZA1 protein CTD PMID:17152098 NCBI chr 3:104,730,097...104,771,821
Ensembl chr 3:104,730,095...104,771,821
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta increases expression ISO Metribolone results in increased expression of CAPZB protein CTD PMID:17152098 NCBI chr 4:138,920,210...139,019,131
Ensembl chr 4:138,920,210...139,019,129
JBrowse link
G Casc3 exon junction complex subunit increases expression ISO Metribolone results in increased expression of CASC3 mRNA CTD PMID:17010196 NCBI chr11:98,700,634...98,724,633
Ensembl chr11:98,695,731...98,724,640
JBrowse link
G Cbl Casitas B-lineage lymphoma increases expression EXP Metribolone results in increased expression of CBL mRNA CTD PMID:16301331 NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Metribolone results in increased expression of CCNA2 mRNA CTD PMID:19318562 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
JBrowse link
G Cd200 CD200 molecule decreases expression ISO Metribolone results in decreased expression of CD200 mRNA CTD PMID:17010675 NCBI chr16:45,202,474...45,229,419
Ensembl chr16:45,202,498...45,229,416
JBrowse link
G Cdc6 cell division cycle 6 increases expression ISO Metribolone results in increased expression of CDC6 mRNA CTD PMID:19318562 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
JBrowse link
G Cdh1 cadherin 1 affects localization ISO Metribolone affects the localization of CDH1 protein CTD PMID:17440980 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdk2ap1 cyclin dependent kinase 2 associated protein 1 increases expression ISO Metribolone results in increased expression of CDK2AP1 mRNA CTD PMID:17010196 NCBI chr 5:124,483,502...124,492,691
Ensembl chr 5:124,483,480...124,501,145
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases expression ISO Metribolone results in increased expression of CDKN2A protein CTD PMID:23272087 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Cenpn centromere protein N increases expression ISO Metribolone results in increased expression of CENPN mRNA CTD PMID:17010675 NCBI chr 8:117,648,448...117,668,243
Ensembl chr 8:117,648,469...117,668,246
JBrowse link
G Chd9 chromodomain helicase DNA binding protein 9 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CHD9 protein modified form] CTD PMID:28751236 NCBI chr 8:91,554,930...91,781,144
Ensembl chr 8:91,554,980...91,781,144
JBrowse link
G Chek1 checkpoint kinase 1 increases expression
increases phosphorylation
ISO Metribolone results in increased expression of CHEK1 mRNA
Metribolone results in increased phosphorylation of CHEK1 protein
CTD PMID:19318562 PMID:23272087 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein
Metribolone results in increased phosphorylation of CHEK2 protein
CTD PMID:21134073 PMID:23272087 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
JBrowse link
G Cilk1 ciliogenesis associated kinase 1 increases expression ISO Metribolone results in increased expression of CILK1 mRNA CTD PMID:17010196 NCBI chr 9:78,016,425...78,079,396
Ensembl chr 9:78,016,474...78,079,389
JBrowse link
G Ckb creatine kinase, brain increases expression ISO Metribolone results in increased expression of CKB protein CTD PMID:17152098 NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
JBrowse link
G Cldn3 claudin 3 increases expression ISO Metribolone results in increased expression of CLDN3 mRNA CTD PMID:17010196 NCBI chr 5:135,015,068...135,016,330
Ensembl chr 5:135,015,068...135,016,326
JBrowse link
G Cltc clathrin heavy chain multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to CLTC protein] CTD PMID:17220478 NCBI chr11:86,585,178...86,648,637
Ensembl chr11:86,585,177...86,648,391
JBrowse link
G Clu clusterin decreases expression
increases expression
multiple interactions
ISO Metribolone results in decreased expression of CLU mRNA alternative form
Metribolone results in increased expression of CLU mRNA; Metribolone results in increased expression of CLU mRNA alternative form; Metribolone results in increased expression of CLU protein
bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU protein]; Metribolone promotes the reaction [AR protein binds to CLU enhancer]
CTD PMID:17010196 PMID:17148459 PMID:17325745 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996
JBrowse link
G Cndp2 CNDP dipeptidase 2 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to CNDP2 protein]
Metribolone results in increased expression of CNDP2 protein
CTD PMID:17152098 PMID:17220478 NCBI chr18:84,685,590...84,703,827
Ensembl chr18:84,685,590...84,703,827
JBrowse link
G Cnot1 CCR4-NOT transcription complex, subunit 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to CNOT1 protein modified form] CTD PMID:28751236 NCBI chr 8:96,445,559...96,534,741
Ensembl chr 8:96,446,079...96,534,092
JBrowse link
G Copb2 COPI coat complex subunit beta 2 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to COPB2 protein] CTD PMID:17220478 NCBI chr 9:98,445,784...98,470,428
Ensembl chr 9:98,445,774...98,470,435
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO Metribolone results in increased phosphorylation of CREB1 protein
RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of CREB1 protein]
CTD PMID:17272394 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crebbp CREB binding protein multiple interactions
decreases expression
ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; bicalutamide inhibits the reaction [Metribolone results in decreased expression of CREBBP protein]; Metribolone inhibits the reaction [CREBBP protein results in increased activity of AR protein]
Metribolone results in decreased expression of CREBBP mRNA; Metribolone results in decreased expression of CREBBP protein
CTD PMID:11981028 PMID:15378487 PMID:28751236 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861
JBrowse link
G Crls1 cardiolipin synthase 1 increases expression ISO Metribolone results in increased expression of CRLS1 mRNA CTD PMID:16751804 NCBI chr 2:132,688,557...132,708,706
Ensembl chr 2:132,688,586...132,708,705
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 affects splicing ISO Metribolone affects the splicing of CSNK1A1 mRNA CTD PMID:17010196 NCBI chr18:61,687,307...61,723,391
Ensembl chr18:61,688,345...61,723,132
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to CTNNB1 protein] CTD PMID:17220478 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Ctsb cathepsin B decreases expression ISO Metribolone results in decreased expression of CTSB protein CTD PMID:17152098 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
JBrowse link
G Ctsd cathepsin D decreases expression ISO Metribolone results in decreased expression of CTSD protein CTD PMID:17152098 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
JBrowse link
G Cwc27 CWC27 spliceosome-associated protein increases expression ISO Metribolone results in increased expression of CWC27 mRNA CTD PMID:17010196 NCBI chr13:104,767,648...104,953,649
Ensembl chr13:104,767,648...104,953,650
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
increases secretion
ISO AR mRNA affects the reaction [Metribolone results in increased secretion of CXCL8 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein] CTD PMID:20711410 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression
multiple interactions
ISO Metribolone results in increased expression of CXCR4 mRNA
Dapsone analog inhibits the reaction [Metribolone results in increased expression of CXCR4 mRNA]
CTD PMID:21440447 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to DARS1 protein] CTD PMID:17220478 NCBI chr 1:128,291,444...128,345,153
Ensembl chr 1:128,291,444...128,345,105
JBrowse link
G Dcun1d1 defective in cullin neddylation 1 domain containing 1 decreases expression ISO Metribolone results in decreased expression of DCUN1D1 protein CTD PMID:17152098 NCBI chr 3:35,946,254...35,991,626
Ensembl chr 3:35,946,254...35,991,594
JBrowse link
G Ddx1 DEAD box helicase 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to DDX1 protein] CTD PMID:17220478 NCBI chr12:13,269,308...13,299,175
Ensembl chr12:13,266,974...13,299,214
JBrowse link
G Ddx5 DEAD box helicase 5 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to DDX5 protein] CTD PMID:17220478 NCBI chr11:106,671,181...106,680,011
Ensembl chr11:106,671,181...106,680,011
JBrowse link
G Dek DEK proto-oncogene increases expression ISO Metribolone results in increased expression of DEK mRNA; Metribolone results in increased expression of DEK protein CTD PMID:23071688 NCBI chr13:47,238,243...47,261,134
Ensembl chr13:47,238,251...47,259,677
JBrowse link
G Dhx30 DExH-box helicase 30 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to DHX30 protein modified form] CTD PMID:28751236 NCBI chr 9:109,913,387...109,946,728
Ensembl chr 9:109,913,388...109,946,898
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 increases expression ISO Metribolone results in increased expression of DLG5 mRNA CTD PMID:17010196 NCBI chr14:24,184,021...24,295,988
Ensembl chr14:24,184,021...24,295,988
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to DLST protein] CTD PMID:17220478 NCBI chr12:85,157,597...85,180,865
Ensembl chr12:85,157,607...85,181,619
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions EXP Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA] CTD PMID:19587329 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377
JBrowse link
G Dynll2 dynein light chain LC8-type 2 increases expression ISO Metribolone results in increased expression of DYNLL2 mRNA CTD PMID:16751804 NCBI chr11:87,870,351...87,892,746
Ensembl chr11:87,870,351...87,878,359
JBrowse link
G Eaf2 ELL associated factor 2 increases expression ISO Metribolone results in increased expression of EAF2 mRNA CTD PMID:17010675 NCBI chr16:36,613,246...36,695,275
Ensembl chr16:36,613,246...36,695,365
JBrowse link
G Ebag9 estrogen receptor-binding fragment-associated gene 9 increases expression ISO Metribolone results in increased expression of EBAG9 mRNA CTD PMID:17010196 NCBI chr15:44,482,574...44,504,916
Ensembl chr15:44,482,571...44,504,911
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to EEF1G protein] CTD PMID:17220478 NCBI chr19:8,944,405...8,955,544
Ensembl chr19:8,944,405...8,955,843
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to EEF2 protein]
Metribolone results in increased expression of EEF2 protein
CTD PMID:17152098 PMID:17220478 NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Metribolone results in increased phosphorylation of and results in increased activity of EGFR protein CTD PMID:17272394 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Eif2s3x eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to EIF2S3 protein] CTD PMID:17220478 NCBI chr  X:93,232,315...93,256,257
Ensembl chr  X:93,232,313...93,256,468
JBrowse link
G Eif3e eukaryotic translation initiation factor 3, subunit E multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to EIF3E protein] CTD PMID:17220478 NCBI chr15:43,113,436...43,146,132
Ensembl chr15:43,113,454...43,146,115
JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K affects splicing ISO Metribolone affects the splicing of EIF3K mRNA CTD PMID:17010196 NCBI chr 7:28,670,797...28,681,322
Ensembl chr 7:28,670,797...28,681,289
JBrowse link
G Elac2 elaC ribonuclease Z 2 increases expression ISO Metribolone results in increased expression of ELAC2 mRNA CTD PMID:17010196 NCBI chr11:64,869,856...64,892,906
Ensembl chr11:64,869,864...64,892,895
JBrowse link
G Elk4 ELK4, member of ETS oncogene family multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of ELK4 mRNA] CTD PMID:21440447 NCBI chr 1:131,935,129...131,954,186
Ensembl chr 1:131,935,345...131,960,350
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO Metribolone results in increased expression of ELL2 mRNA CTD PMID:16751804 PMID:17010675 NCBI chr13:75,855,603...75,920,480
Ensembl chr13:75,854,876...75,920,483
JBrowse link
G Eno2 enolase 2, gamma neuronal decreases expression ISO Metribolone results in decreased expression of ENO2 protein CTD PMID:17152098 NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636
JBrowse link
G Entr1 endosome associated trafficking regulator 1 increases expression ISO Metribolone results in increased expression of ENTR1 mRNA CTD PMID:17010196 NCBI chr 2:26,272,810...26,279,352
Ensembl chr 2:26,272,814...26,279,328
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form] CTD PMID:28751236 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic increases expression ISO Metribolone results in increased expression of EPHX2 protein CTD PMID:17152098 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949
JBrowse link
G Eppin epididymal peptidase inhibitor multiple interactions EXP Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA] CTD PMID:19587329 NCBI chr 2:164,430,263...164,435,491
Ensembl chr 2:164,430,263...164,435,514
JBrowse link
G Erg ETS transcription factor multiple interactions ISO [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA CTD PMID:23272087 NCBI chr16:95,160,028...95,387,452
Ensembl chr16:95,160,028...95,387,452
JBrowse link
G Ergic3 ERGIC and golgi 3 increases expression ISO Metribolone results in increased expression of ERGIC3 mRNA CTD PMID:17010196 NCBI chr 2:155,849,948...155,860,199
Ensembl chr 2:155,849,965...155,860,199
JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Metribolone results in increased expression of ERP44 protein CTD PMID:17152098 NCBI chr 4:48,190,711...48,279,635
Ensembl chr 4:48,193,323...48,279,558
JBrowse link
G Evi5 ecotropic viral integration site 5 increases expression ISO Metribolone results in increased expression of EVI5 mRNA CTD PMID:16751804 NCBI chr 5:107,892,661...108,022,973
Ensembl chr 5:107,892,661...108,022,973
JBrowse link
G Ewsr1 Ewing sarcoma breakpoint region 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to EWSR1 protein] CTD PMID:17220478 NCBI chr11:5,019,687...5,049,314
Ensembl chr11:5,019,689...5,049,266
JBrowse link
G Ezr ezrin multiple interactions
increases expression
increases phosphorylation
ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of EZR mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of EZR protein]; Metribolone promotes the reaction [EZR protein binds to PRKCA protein]; PRKCA protein affects the reaction [Metribolone results in increased phosphorylation of EZR protein] CTD PMID:16873375 NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183
JBrowse link
G Fads1 fatty acid desaturase 1 increases expression ISO Metribolone results in increased expression of FADS1 mRNA CTD PMID:16751804 NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241
JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to FASN protein]
Metribolone results in increased expression of FASN protein
CTD PMID:17152098 PMID:17220478 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression ISO Metribolone results in increased expression of FDFT1 mRNA; Metribolone results in increased expression of FDFT1 protein CTD PMID:17483544 NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
JBrowse link
G Fkbp5 FK506 binding protein 5 multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of FKBP5 mRNA]
Metribolone results in increased expression of FKBP5 mRNA; Metribolone results in increased expression of FKBP5 protein
CTD PMID:16751804 PMID:17010675 PMID:17152098 PMID:21440447 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501
JBrowse link
G Fkbp8 FK506 binding protein 8 decreases expression ISO Metribolone results in decreased expression of FKBP8 protein CTD PMID:17152098 NCBI chr 8:70,980,371...70,987,978
Ensembl chr 8:70,980,374...70,987,978
JBrowse link
G Folh1 folate hydrolase 1 multiple interactions
decreases expression
ISO 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]; [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 mRNA; [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 protein; DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]; DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]
Metribolone results in decreased expression of FOLH1 mRNA; Metribolone results in decreased expression of FOLH1 protein
CTD PMID:12711008 PMID:17152098 PMID:25682698 PMID:26709203 PMID:26729308 NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151
JBrowse link
G Fshb follicle stimulating hormone beta increases expression
multiple interactions
EXP Metribolone results in increased expression of FSHB mRNA
AR protein promotes the reaction [Metribolone results in increased expression of FSHB mRNA]
CTD PMID:16675544 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
JBrowse link
G Fth1 ferritin heavy polypeptide 1 decreases expression ISO Metribolone results in decreased expression of FTH1 protein CTD PMID:17152098 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked decreases expression ISO Metribolone results in decreased expression of G6PD protein CTD PMID:17152098 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Ganab alpha glucosidase 2 alpha neutral subunit increases expression ISO Metribolone results in increased expression of GANAB protein CTD PMID:17152098 NCBI chr19:8,875,440...8,894,098
Ensembl chr19:8,875,435...8,894,036
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Metribolone results in increased expression of GDF15 mRNA CTD PMID:17010196 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 increases expression ISO Metribolone results in increased expression of GFM1 protein CTD PMID:17152098 NCBI chr 3:67,337,448...67,382,401
Ensembl chr 3:67,337,429...67,383,862
JBrowse link
G Ggct gamma-glutamyl cyclotransferase decreases expression ISO Metribolone results in decreased expression of GGCT protein CTD PMID:17152098 NCBI chr 6:54,962,080...54,969,947
Ensembl chr 6:54,959,565...54,969,935
JBrowse link
G Glod4 glyoxalase domain containing 4 decreases expression ISO Metribolone results in decreased expression of GLOD4 protein CTD PMID:17152098 NCBI chr11:76,111,221...76,134,525
Ensembl chr11:76,011,813...76,134,551
JBrowse link
G Glra2 glycine receptor, alpha 2 subunit decreases expression ISO Metribolone results in decreased expression of GLRA2 mRNA CTD PMID:17010675 NCBI chr  X:163,912,013...164,110,863
Ensembl chr  X:163,912,013...164,110,389
JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO Metribolone results in increased expression of GLUL protein CTD PMID:17152098 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
JBrowse link
G Gnai3 G protein subunit alpha i3 increases expression ISO Metribolone results in increased expression of GNAI3 mRNA CTD PMID:16751804 NCBI chr 3:108,014,591...108,053,468
Ensembl chr 3:108,014,596...108,053,462
JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GNAQ protein modified form] CTD PMID:28751236 NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827
JBrowse link
G Gnmt glycine N-methyltransferase increases expression ISO Metribolone results in increased expression of GNMT mRNA CTD PMID:17010675 NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094
JBrowse link
G Golm2 golgi membrane protein 2 increases expression ISO Metribolone results in increased expression of GOLM2 mRNA CTD PMID:17010196 NCBI chr 2:121,696,255...121,766,701
Ensembl chr 2:121,697,451...121,766,701
JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial increases expression ISO Metribolone results in increased expression of GOT2 protein CTD PMID:17626249 NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) multiple interactions EXP Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA] CTD PMID:19587329 NCBI chr15:99,615,468...99,622,895
Ensembl chr15:99,615,396...99,622,886
JBrowse link
G Greb1 gene regulated by estrogen in breast cancer protein multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of GREB1 mRNA] CTD PMID:16496412 PMID:21440447 NCBI chr12:16,720,616...16,851,395
Ensembl chr12:16,720,616...16,850,887
JBrowse link
G Gsn gelsolin multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GSN protein modified form] CTD PMID:28751236 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904
JBrowse link
G Gspt1 G1 to S phase transition 1 increases expression ISO Metribolone results in increased expression of GSPT1 protein CTD PMID:17152098 NCBI chr16:11,034,104...11,072,189
Ensembl chr16:11,037,156...11,072,189
JBrowse link
G Gss glutathione synthetase increases expression ISO Metribolone results in increased expression of GSS protein CTD PMID:17152098 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
ISO [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA; [Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]; ATR mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein] CTD PMID:21134073 PMID:23272087 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Helz2 helicase with zinc finger 2, transcriptional coactivator multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to HELZ2 protein modified form] CTD PMID:28751236 NCBI chr 2:180,869,408...180,883,851
Ensembl chr 2:180,869,408...180,883,820
JBrowse link
G Herc3 hect domain and RLD 3 increases expression ISO Metribolone results in increased expression of HERC3 mRNA CTD PMID:17010675 NCBI chr 6:58,808,440...58,897,383
Ensembl chr 6:58,808,450...58,897,383
JBrowse link
G Hexb hexosaminidase B increases expression ISO Metribolone results in increased expression of HEXB mRNA CTD PMID:17010196 NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression ISO Metribolone results in decreased expression of HIBADH protein CTD PMID:17152098 NCBI chr 6:52,523,215...52,617,285
Ensembl chr 6:52,523,213...52,617,374
JBrowse link
G Hid1 HID1 domain containing increases expression ISO Metribolone results in increased expression of HID1 mRNA CTD PMID:17010196 NCBI chr11:115,238,531...115,261,087
Ensembl chr11:115,238,533...115,258,582
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO Metribolone results in decreased expression of HMGB1 protein CTD PMID:17152098 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases expression ISO Metribolone results in increased expression of HMGCR mRNA; Metribolone results in increased expression of HMGCR protein CTD PMID:16751804 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression ISO Metribolone results in increased expression of HMGCS1 protein CTD PMID:17152098 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C decreases expression ISO Metribolone results in decreased expression of HNRNPC protein CTD PMID:17152098 NCBI chr14:52,310,834...52,341,462
Ensembl chr14:52,310,834...52,341,485
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to HNRNPF protein]
Metribolone results in increased expression of HNRNPF protein
CTD PMID:17152098 PMID:17220478 NCBI chr 6:117,877,301...117,902,583
Ensembl chr 6:117,877,285...117,902,583
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to HNRNPH1 protein] CTD PMID:17220478 NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 decreases expression ISO Metribolone results in decreased expression of HNRNPH2 protein CTD PMID:17152098 NCBI chr  X:133,501,928...133,507,809
Ensembl chr  X:133,501,928...133,507,809
JBrowse link
G Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 decreases expression ISO Metribolone results in decreased expression of HNRNPH3 protein CTD PMID:17152098 NCBI chr10:62,850,443...62,859,764
Ensembl chr10:62,850,443...62,859,996
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression ISO Metribolone results in decreased expression of HNRNPK protein CTD PMID:17152098 NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to HNRNPU protein] CTD PMID:17220478 NCBI chr 1:178,148,673...178,170,063
Ensembl chr 1:178,148,673...178,165,362
JBrowse link
G Hotair HOX transcript antisense RNA (non-protein coding) decreases expression ISO Metribolone results in decreased expression of HOTAIR mRNA CTD PMID:26411689 NCBI chr15:102,852,497...102,856,381
Ensembl chr15:102,852,494...102,856,165
JBrowse link
G Hr lysine demethylase and nuclear receptor corepressor multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HR protein modified form] CTD PMID:28751236 NCBI chr14:70,789,644...70,810,988
Ensembl chr14:70,789,652...70,810,988
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to HSD17B4 protein] CTD PMID:17220478 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
JBrowse link
G Hsf1 heat shock factor 1 decreases activity ISO Metribolone results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to HSP90AA1 protein] CTD PMID:17220478 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162
JBrowse link
G Hspa5 heat shock protein 5 affects localization
multiple interactions
increases expression
ISO Metribolone affects the localization of HSPA5 protein
Metribolone promotes the reaction [NDRG1 protein binds to HSPA5 protein]
Metribolone results in increased expression of HSPA5 protein
CTD PMID:17152098 PMID:17220478 PMID:17440980 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspb1 heat shock protein 1 increases expression ISO Metribolone results in increased expression of HSPB1 protein CTD PMID:17152098 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417
JBrowse link
G Htra2 HtrA serine peptidase 2 decreases expression ISO Metribolone results in decreased expression of HTRA2 protein CTD PMID:17152098 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254
JBrowse link
G Hus1 HUS1 checkpoint clamp component increases expression ISO Metribolone results in increased expression of HUS1 mRNA CTD PMID:19318562 NCBI chr11:8,943,137...8,961,240
Ensembl chr11:8,943,137...8,961,191
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO Metribolone results in increased expression of HYOU1 protein CTD PMID:17152098 NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666
JBrowse link
G Ide insulin degrading enzyme increases expression ISO Metribolone results in increased expression of IDE protein CTD PMID:17152098 NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010
JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble increases expression ISO Metribolone results in increased expression of IDH1 protein CTD PMID:17152098 NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase increases expression ISO Metribolone results in increased expression of IDI1 protein CTD PMID:17152098 NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
ISO [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] results in decreased expression of IGF1 mRNA; DDT affects the reaction [Metribolone results in increased expression of IGF1 mRNA]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of IGF1 mRNA] CTD PMID:25682698 PMID:26709203 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Igf1r insulin-like growth factor I receptor increases expression
multiple interactions
ISO Metribolone results in increased expression of IGF1R mRNA
Dapsone analog inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]; resveratrol inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]
CTD PMID:18586690 PMID:21440447 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions
increases expression
ISO [Calcitriol co-treated with Metribolone] results in increased expression of IGFBP3 mRNA; Metribolone promotes the reaction [AR protein binds to IGFBP3 promoter]
Metribolone results in increased expression of IGFBP3 mRNA
CTD PMID:16825320 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923
JBrowse link
G Il6 interleukin 6 multiple interactions ISO IL6 protein inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:17219378 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to ILF3 protein] CTD PMID:17220478 NCBI chr 9:21,278,964...21,316,659
Ensembl chr 9:21,279,167...21,316,657
JBrowse link
G Immt inner membrane protein, mitochondrial increases expression ISO Metribolone results in increased expression of IMMT protein CTD PMID:17152098 NCBI chr 6:71,806,200...71,852,250
Ensembl chr 6:71,808,315...71,854,372
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Metribolone results in increased expression of INSIG1 mRNA; Metribolone results in increased expression of INSIG1 protein CTD PMID:16751804 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660
JBrowse link
G Itga2 integrin alpha 2 multiple interactions ISO Metribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:17541959 NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) multiple interactions ISO Metribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:17541959 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
JBrowse link
G Itgb3bp integrin beta 3 binding protein (beta3-endonexin) multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ITGB3BP protein modified form] CTD PMID:28751236 NCBI chr 4:99,655,643...99,717,403
Ensembl chr 4:99,653,639...99,787,010
JBrowse link
G Jmjd1c jumonji domain containing 1C multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to JMJD1C protein modified form] CTD PMID:28751236 NCBI chr10:66,932,189...67,092,105
Ensembl chr10:66,931,904...67,092,105
JBrowse link
G Jtb jumping translocation breakpoint increases expression ISO Metribolone results in increased expression of JTB mRNA CTD PMID:17010196 NCBI chr 3:90,138,904...90,143,147
Ensembl chr 3:90,138,904...90,143,145
JBrowse link
G Kat2b K(lysine) acetyltransferase 2B multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to KAT2B protein modified form] CTD PMID:28751236 NCBI chr17:53,873,802...53,979,749
Ensembl chr17:53,873,889...53,979,748
JBrowse link
G Kdm3a lysine (K)-specific demethylase 3A multiple interactions
increases expression
ISO Metribolone promotes the reaction [KDM3A protein binds to KLK3 enhancer]; Metribolone promotes the reaction [KDM3A protein binds to NKX3-1 enhancer]
Metribolone results in increased expression of KDM3A protein
CTD PMID:16603237 NCBI chr 6:71,565,954...71,609,963
Ensembl chr 6:71,565,956...71,609,974
JBrowse link
G Kif5b kinesin family member 5B multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to KIF5B protein] CTD PMID:17220478 NCBI chr18:6,201,005...6,241,524
Ensembl chr18:6,201,002...6,242,174
JBrowse link
G Knl1 kinetochore scaffold 1 increases expression ISO Metribolone results in increased expression of KNL1 mRNA CTD PMID:17010196 NCBI chr 2:118,877,600...118,940,978
Ensembl chr 2:118,877,600...118,935,982
JBrowse link
G Krt1 keratin 1 decreases expression ISO Metribolone results in decreased expression of KRT1 protein CTD PMID:17152098 NCBI chr15:101,753,861...101,759,221
Ensembl chr15:101,753,861...101,759,229
JBrowse link
G Krt10 keratin 10 decreases expression ISO Metribolone results in decreased expression of KRT10 protein CTD PMID:17152098 NCBI chr11:99,276,080...99,288,631
Ensembl chr11:99,276,080...99,280,190
JBrowse link
G Krt18 keratin 18 increases expression ISO Metribolone results in increased expression of KRT18 protein CTD PMID:17152098 PMID:17541959 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
JBrowse link
G Krt8 keratin 8 increases expression ISO Metribolone results in increased expression of KRT8 mRNA; Metribolone results in increased expression of KRT8 protein CTD PMID:17010196 PMID:17152098 NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917
JBrowse link
G Lcor ligand dependent nuclear receptor corepressor multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to LCOR protein modified form] CTD PMID:28751236 NCBI chr19:41,471,121...41,584,600
Ensembl chr19:41,471,076...41,574,975
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to LDHA protein] CTD PMID:17220478 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
JBrowse link
G Ldhd lactate dehydrogenase D increases expression ISO Metribolone results in increased expression of LDHD protein CTD PMID:17152098 NCBI chr 8:112,352,250...112,356,968
Ensembl chr 8:112,350,417...112,357,006
JBrowse link
G Ldlr low density lipoprotein receptor affects localization ISO Metribolone affects the localization of LDLR protein CTD PMID:17440980 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Lgals8 lectin, galactose binding, soluble 8 increases expression ISO Metribolone results in increased expression of LGALS8 mRNA CTD PMID:17010196 NCBI chr13:12,454,283...12,479,857
Ensembl chr13:12,454,296...12,479,825
JBrowse link
G Lhb luteinizing hormone beta decreases expression EXP Metribolone results in decreased expression of LHB mRNA CTD PMID:16675544 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase affects splicing ISO Metribolone affects the splicing of LHPP mRNA CTD PMID:17010196 NCBI chr 7:132,212,344...132,308,149
Ensembl chr 7:132,212,367...132,308,149
JBrowse link
G Lmna lamin A decreases expression ISO Metribolone results in decreased expression of LMNA protein CTD PMID:17152098 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
JBrowse link
G Lratd2 LRAT domain containing 1 increases expression ISO Metribolone results in increased expression of LRATD2 mRNA CTD PMID:17010196 NCBI chr15:60,690,845...60,697,954
Ensembl chr15:60,690,843...60,725,627
JBrowse link
G Lsm1 LSM1 homolog, mRNA degradation associated increases expression ISO Metribolone results in increased expression of LSM1 mRNA CTD PMID:17010196 NCBI chr 8:26,275,326...26,294,003
Ensembl chr 8:26,275,316...26,294,003
JBrowse link
G Lta4h leukotriene A4 hydrolase increases expression ISO Metribolone results in increased expression of LTA4H protein CTD PMID:17152098 NCBI chr10:93,289,258...93,320,758
Ensembl chr10:93,289,273...93,320,737
JBrowse link
G Mad1l1 MAD1 mitotic arrest deficient 1-like 1 decreases expression ISO Metribolone results in decreased expression of MAD1L1 protein CTD PMID:17152098 NCBI chr 5:139,994,444...140,307,346
Ensembl chr 5:139,994,444...140,307,307
JBrowse link
G Maf MAF bZIP transcription factor multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAF mRNA] CTD PMID:16751804 PMID:17010675 PMID:21440447 NCBI chr 8:116,429,992...116,433,633
Ensembl chr 8:116,409,681...116,434,533
JBrowse link
G Maged2 MAGE family member D2 increases expression ISO Metribolone results in increased expression of MAGED2 mRNA CTD PMID:17010196 NCBI chr  X:149,589,417...149,597,358
Ensembl chr  X:149,589,366...149,597,341
JBrowse link
G Mak male germ cell-associated kinase multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAK mRNA] CTD PMID:21440447 NCBI chr13:41,178,483...41,233,182
Ensembl chr13:41,178,484...41,233,182
JBrowse link
G Man1a mannosidase 1, alpha decreases expression ISO Metribolone results in decreased expression of MAN1A1 mRNA CTD PMID:17010675 NCBI chr10:53,780,881...53,952,712
Ensembl chr10:53,780,881...53,952,705
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to MAOA protein] CTD PMID:17220478 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Map7 microtubule-associated protein 7 increases expression ISO Metribolone results in increased expression of MAP7 mRNA CTD PMID:16751804 NCBI chr10:20,024,666...20,157,336
Ensembl chr10:20,024,217...20,157,336
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK1 protein] CTD PMID:17272394 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Metribolone results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK3 protein]
CTD PMID:17272394 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO Metribolone results in decreased expression of MAPRE2 mRNA CTD PMID:17010675 NCBI chr18:23,885,390...24,026,918
Ensembl chr18:23,885,390...24,026,918
JBrowse link
G Mcc mutated in colorectal cancers increases expression ISO Metribolone results in increased expression of MCC mRNA CTD PMID:17010196 NCBI chr18:44,558,127...44,945,573
Ensembl chr18:44,558,127...44,945,249
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form] CTD PMID:28751236 NCBI chr11:98,042,980...98,084,121
Ensembl chr11:98,042,980...98,084,119
JBrowse link
G Med18 mediator complex subunit 18 affects splicing ISO Metribolone affects the splicing of MED18 mRNA CTD PMID:17010196 NCBI chr 4:132,186,040...132,191,232
Ensembl chr 4:132,186,042...132,191,232
JBrowse link
G Med28 mediator complex subunit 28 increases expression ISO Metribolone results in increased expression of MED28 mRNA CTD PMID:16751804 PMID:17010675 NCBI chr 5:45,677,571...45,686,626
Ensembl chr 5:45,677,571...45,686,618
JBrowse link
G Men1 multiple endocrine neoplasia 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form] CTD PMID:28751236 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MGMT protein modified form] CTD PMID:28751236 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995
JBrowse link
G Mir204 microRNA 204 decreases expression
multiple interactions
ISO Metribolone results in decreased expression of MIR204 mRNA
AR protein affects the reaction [Metribolone results in decreased expression of MIR204 mRNA]; MIR204 mRNA inhibits the reaction [Metribolone results in increased expression of XRN1 protein]
CTD PMID:25797256 NCBI chr19:22,727,969...22,728,036
Ensembl chr19:22,727,969...22,728,036
JBrowse link
G Mme membrane metallo endopeptidase multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to MME protein] CTD PMID:17220478 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451
JBrowse link
G Mmp16 matrix metallopeptidase 16 decreases expression ISO Metribolone results in decreased expression of MMP16 mRNA CTD PMID:16751804 NCBI chr 4:17,853,072...18,117,479
Ensembl chr 4:17,852,893...18,119,145
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions ISO Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
ISO Metribolone results in increased expression of MMP2 mRNA
bicalutamide inhibits the reaction [Metribolone results in increased expression of MMP2 mRNA]
CTD PMID:16888681 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA] CTD PMID:8798622 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mphosph9 M-phase phosphoprotein 9 increases expression ISO Metribolone results in increased expression of MPHOSPH9 mRNA CTD PMID:17010675 NCBI chr 5:124,389,022...124,466,001
Ensembl chr 5:124,389,022...124,466,035
JBrowse link
G Mrps11 mitochondrial ribosomal protein S11 increases expression ISO Metribolone results in increased expression of MRPS11 mRNA CTD PMID:17010196 NCBI chr 7:78,432,879...78,442,736
Ensembl chr 7:78,432,867...78,442,737
JBrowse link
G mt-Atp6 ATP synthase 6, mitochondrial increases expression ISO Metribolone results in increased expression of ATP6 mRNA CTD PMID:17010196 NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607
JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial increases expression ISO Metribolone results in increased expression of COX1 mRNA CTD PMID:17010196 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
JBrowse link
G mt-Co3 cytochrome c oxidase III, mitochondrial increases expression ISO Metribolone results in increased expression of COX3 mRNA CTD PMID:17010196 NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390
JBrowse link
G mt-Nd2 NADH dehydrogenase 2, mitochondrial increases expression ISO Metribolone results in increased expression of ND2 mRNA CTD PMID:17010196 NCBI chr MT:3,914...4,951
Ensembl chr MT:3,914...4,951
JBrowse link
G mt-Nd4 NADH dehydrogenase 4, mitochondrial affects splicing
increases expression
ISO Metribolone affects the splicing of ND4 mRNA
Metribolone results in increased expression of ND4 mRNA
CTD PMID:17010196 NCBI chr MT:10,167...11,544
Ensembl chr MT:10,167...11,544
JBrowse link
G Mt3 metallothionein 3 increases expression ISO Metribolone results in increased expression of MT3 mRNA; Metribolone results in increased expression of MT3 protein CTD PMID:23794209 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
JBrowse link
G Mterf4 mitochondrial transcription termination factor 4 increases expression ISO Metribolone results in increased expression of MTERF4 mRNA CTD PMID:16751804 NCBI chr 1:93,228,927...93,233,601
Ensembl chr 1:93,226,933...93,233,637
JBrowse link
G Mtnap1 mitochondrial nucleoid associated protein 1 increases expression ISO Metribolone results in increased expression of MTNAP1 mRNA CTD PMID:17010196 NCBI chr11:113,574,490...113,590,201
Ensembl chr11:113,575,238...113,585,473
JBrowse link
G Myl6b myosin, light polypeptide 6B affects splicing ISO Metribolone affects the splicing of MYL6B mRNA CTD PMID:17010196 NCBI chr10:128,330,026...128,334,554
Ensembl chr10:128,330,026...128,334,554
JBrowse link
G Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit increases expression ISO Metribolone results in increased expression of NAA15 mRNA CTD PMID:17010196 NCBI chr 3:51,323,437...51,383,406
Ensembl chr 3:51,322,569...51,383,928
JBrowse link
G Nans N-acetylneuraminic acid synthase (sialic acid synthase) increases expression ISO Metribolone results in increased expression of NANS protein CTD PMID:17152098 NCBI chr 4:46,489,319...46,503,439
Ensembl chr 4:46,489,248...46,503,632
JBrowse link
G Napa N-ethylmaleimide sensitive fusion protein attachment protein alpha increases expression ISO Metribolone results in increased expression of NAPA protein CTD PMID:17152098 NCBI chr 7:15,832,127...15,851,907
Ensembl chr 7:15,832,383...15,851,900
JBrowse link
G Nav1 neuron navigator 1 decreases expression ISO Metribolone results in decreased expression of NAV1 mRNA CTD PMID:16751804 NCBI chr 1:135,362,318...135,616,082
Ensembl chr 1:135,362,318...135,615,843
JBrowse link
G Ncl nucleolin multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to NCL protein] CTD PMID:17220478 NCBI chr 1:86,272,441...86,287,177
Ensembl chr 1:86,272,441...86,287,122
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA1 protein modified form]; Metribolone inhibits the reaction [NCOA1 protein results in increased activity of AR protein] CTD PMID:11981028 PMID:28751236 NCBI chr12:4,297,362...4,569,452
Ensembl chr12:4,297,362...4,527,182
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; arsenic trioxide inhibits the reaction [Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]; Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter] CTD PMID:19131511 PMID:28751236 NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]; Metribolone inhibits the reaction [NCOA3 protein results in increased activity of AR protein] CTD PMID:11981028 PMID:28751236 NCBI chr 2:165,834,557...165,915,162
Ensembl chr 2:165,834,545...165,915,162
JBrowse link
G Ncoa6 nuclear receptor coactivator 6 increases expression
multiple interactions
ISO Metribolone results in increased expression of NCOA6 mRNA
[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA6 protein modified form]
CTD PMID:17010196 PMID:28751236 NCBI chr 2:155,232,585...155,315,741
Ensembl chr 2:155,232,576...155,315,814
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOR1 protein modified form] CTD PMID:28751236 NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR2 protein modified form] CTD PMID:28751236 NCBI chr 5:125,094,217...125,256,302
Ensembl chr 5:125,094,217...125,256,283
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to ACSL3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to ACTB protein]; Metribolone promotes the reaction [NDRG1 protein binds to AP1M2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to AP2M1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to ATP1A1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to CANX protein]; Metribolone promotes the reaction [NDRG1 protein binds to CLTC protein]; Metribolone promotes the reaction [NDRG1 protein binds to CNDP2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to COPB2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to CTNNB1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DARS1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DDX1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DDX5 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DLST protein]; Metribolone promotes the reaction [NDRG1 protein binds to EEF1G protein]; Metribolone promotes the reaction [NDRG1 protein binds to EEF2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to EIF2S3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to EIF3E protein]; Metribolone promotes the reaction [NDRG1 protein binds to EWSR1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to FASN protein]; Metribolone promotes the reaction [NDRG1 protein binds to HNRNPF protein]; Metribolone promotes the reaction [NDRG1 protein binds to HNRNPH1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to HNRNPU protein]; Metribolone promotes the reaction [NDRG1 protein binds to HSD17B4 protein]; Metribolone promotes the reaction [NDRG1 protein binds to HSP90AA1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to HSPA5 protein]; Metribolone promotes the reaction [NDRG1 protein binds to ILF3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to KIF5B protein]; Metribolone promotes the reaction [NDRG1 protein binds to LDHA protein]; Metribolone promotes the reaction [NDRG1 protein binds to MAOA protein]; Metribolone promotes the reaction [NDRG1 protein binds to MME protein]; Metribolone promotes the reaction [NDRG1 protein binds to NCL protein]; Metribolone promotes the reaction [NDRG1 protein binds to NDRG1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to PABPC1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to PKM protein]; Metribolone promotes the reaction [NDRG1 protein binds to PPP2R2A protein]; Metribolone promotes the reaction [NDRG1 protein binds to PSMC2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to PSMD2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPL24 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPL3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPL4 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPN2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS16 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS20 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS26 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS6 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS8 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS9 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RUVBL2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to SEC23A protein]; Metribolone promotes the reaction [NDRG1 protein binds to SHMT2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to SLC25A6 protein]; Metribolone promotes the reaction [NDRG1 protein binds to TARS1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to TLE3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to UPF1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to VCP protein]; Metribolone promotes the reaction [NDRG1 protein binds to XRCC6 protein]
Metribolone results in increased expression of NDRG1 protein
CTD PMID:17220478 NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489
JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 affects splicing ISO Metribolone affects the splicing of NDUFA3 mRNA CTD PMID:17010196 NCBI chr 7:3,620,372...3,623,162
Ensembl chr 7:3,620,372...3,623,326
JBrowse link
G Nelfb negative elongation factor complex member B multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NELFB protein modified form] CTD PMID:28751236 NCBI chr 2:25,089,724...25,101,501
Ensembl chr 2:25,089,724...25,101,501
JBrowse link
G Nemf nuclear export mediator factor increases expression ISO Metribolone results in increased expression of NEMF mRNA CTD PMID:17010196 NCBI chr12:69,358,315...69,403,975
Ensembl chr12:69,357,296...69,403,939
JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NFKBIB protein modified form] CTD PMID:28751236 NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937
JBrowse link
G Ngly1 N-glycanase 1 increases expression ISO Metribolone results in increased expression of NGLY1 mRNA CTD PMID:16751804 NCBI chr14:6,157,837...6,220,449
Ensembl chr14:6,157,837...6,220,483
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
decreases expression
increases expression
ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]; Dapsone analog inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]; Metribolone promotes the reaction [AR protein binds to NKX3-1 enhancer]; Metribolone promotes the reaction [AR protein binds to NKX3-1 promoter]; Metribolone promotes the reaction [KDM3A protein binds to NKX3-1 enhancer]; Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter]; TP53 protein inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]; UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]
Metribolone results in decreased expression of NKX3-1 mRNA
Metribolone results in increased expression of NKX3-1 mRNA; Metribolone results in increased expression of NKX3-1 protein
CTD PMID:11751618 PMID:12711008 PMID:16603237 PMID:17010675 PMID:17131305 More... NCBI chr14:69,428,141...69,432,107
Ensembl chr14:69,428,087...69,432,111
JBrowse link
G Nln neurolysin (metallopeptidase M3 family) increases expression ISO Metribolone results in increased expression of NLN protein CTD PMID:17152098 NCBI chr13:104,159,558...104,246,170
Ensembl chr13:104,159,565...104,246,122
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Metribolone results in increased expression of NNMT mRNA CTD PMID:17010675 NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor increases expression ISO Metribolone results in increased expression of NPLOC4 protein CTD PMID:17152098 NCBI chr11:120,270,624...120,328,526
Ensembl chr11:120,271,196...120,328,534
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B1 protein modified form] CTD PMID:28751236 NCBI chr  X:85,235,381...85,239,553
Ensembl chr  X:85,235,370...85,239,553
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B2 protein modified form] CTD PMID:28751236 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Metribolone binds to and results in decreased activity of NR3C2 protein; Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:17105867 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of NR4A1 mRNA] CTD PMID:21440447 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form] CTD PMID:28751236 NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715
JBrowse link
G Nucb2 nucleobindin 2 increases expression ISO Metribolone results in increased expression of NUCB2 mRNA CTD PMID:17010196 NCBI chr 7:116,103,579...116,139,823
Ensembl chr 7:116,103,604...116,139,819
JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 affects splicing ISO Metribolone affects the splicing of OAZ1 mRNA CTD PMID:17010196 NCBI chr10:80,662,490...80,665,124
Ensembl chr10:80,662,516...80,665,124
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 decreases expression ISO Metribolone results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) affects splicing ISO Metribolone affects the splicing of OGDH mRNA CTD PMID:17010196 NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Metribolone results in increased expression of ORM1 mRNA CTD PMID:16751804 NCBI chr 4:63,262,793...63,266,400
Ensembl chr 4:63,262,797...63,266,400
JBrowse link
G Osr2 odd-skipped related 2 decreases expression ISO Metribolone results in decreased expression of OSR2 mRNA CTD PMID:16751804 NCBI chr15:35,296,244...35,303,451
Ensembl chr15:35,296,244...35,303,451
JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions ISO PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Metribolone results in increased expression of AR mRNA] CTD PMID:15994225 NCBI chr10:128,393,635...128,401,803
Ensembl chr10:128,393,635...128,401,856
JBrowse link
G Pabpc1 poly(A) binding protein, cytoplasmic 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to PABPC1 protein] CTD PMID:17220478 NCBI chr15:36,595,902...36,609,825
Ensembl chr15:36,595,905...36,609,912
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 decreases expression ISO Metribolone results in decreased expression of PAK2 protein CTD PMID:17152098 NCBI chr16:31,835,108...31,898,160
Ensembl chr16:31,835,108...31,898,160
JBrowse link
G Pank4 pantothenate kinase 4 increases expression ISO Metribolone results in increased expression of PANK4 protein CTD PMID:17152098 NCBI chr 4:155,048,580...155,065,395
Ensembl chr 4:155,048,580...155,065,395
JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 increases expression ISO Metribolone results in increased expression of PARK7 protein CTD PMID:17152098 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 affects splicing ISO Metribolone affects the splicing of PCMT1 mRNA CTD PMID:17010196 NCBI chr10:7,503,608...7,556,922
Ensembl chr10:7,505,137...7,556,900
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression ISO Metribolone results in decreased expression of PDCD6IP protein CTD PMID:17152098 NCBI chr 9:113,480,812...113,537,457
Ensembl chr 9:113,480,812...113,537,327
JBrowse link
G Pdia3 protein disulfide isomerase associated 3 increases expression ISO Metribolone results in increased expression of PDIA3 protein CTD PMID:17152098 NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168
JBrowse link
G Pdia6 protein disulfide isomerase associated 6 increases expression ISO Metribolone results in increased expression of PDIA6 protein CTD PMID:17152098 NCBI chr12:17,316,590...17,334,786
Ensembl chr12:17,316,546...17,334,771
JBrowse link
G Pds5b PDS5 cohesin associated factor B increases expression ISO Metribolone results in increased expression of PDS5B mRNA CTD PMID:17010196 NCBI chr 5:150,597,178...150,734,174
Ensembl chr 5:150,597,204...150,734,155
JBrowse link
G Pdxdc1 pyridoxal-dependent decarboxylase domain containing 1 increases expression ISO Metribolone results in increased expression of PDXDC1 protein CTD PMID:17152098 NCBI chr16:13,651,025...13,721,018
Ensembl chr16:13,651,012...13,720,995
JBrowse link
G Pelp1 proline, glutamic acid and leucine rich protein 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form] CTD PMID:28751236 NCBI chr11:70,283,709...70,300,862
Ensembl chr11:70,283,709...70,300,857
JBrowse link
G Per1 period circadian clock 1 multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of PER1 mRNA] CTD PMID:21440447 NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786
JBrowse link
G Pgm2 phosphoglucomutase 2 increases expression ISO Metribolone results in increased expression of PGM2 protein CTD PMID:17152098 NCBI chr 5:64,250,258...64,285,698
Ensembl chr 5:64,250,293...64,285,694
JBrowse link
G Pgr progesterone receptor affects binding ISO Metribolone binds to PGR protein CTD PMID:15189034 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
JBrowse link
G Phb1 prohibitin 1 decreases expression ISO Metribolone results in decreased expression of PHB1 protein CTD PMID:17152098 NCBI chr11:95,557,783...95,571,599
Ensembl chr11:95,557,783...95,571,599
JBrowse link
G Phgdh 3-phosphoglycerate dehydrogenase decreases expression
increases expression
ISO Metribolone results in decreased expression of PHGDH protein
Metribolone results in increased expression of PHGDH protein
CTD PMID:17152098 NCBI chr 3:98,220,487...98,247,285
Ensembl chr 3:98,220,486...98,247,306
JBrowse link
G Pias1 protein inhibitor of activated STAT 1 increases expression ISO Metribolone results in increased expression of PIAS1 mRNA CTD PMID:16751804 NCBI chr 9:62,785,648...62,888,161
Ensembl chr 9:62,785,650...62,895,206
JBrowse link
G Pias2 protein inhibitor of activated STAT 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PIAS2 protein modified form] CTD PMID:28751236 NCBI chr18:77,152,883...77,243,406
Ensembl chr18:77,152,904...77,241,496
JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta decreases expression ISO Metribolone results in decreased expression of PIP4K2B mRNA CTD PMID:17010675 NCBI chr11:97,605,983...97,635,530
Ensembl chr11:97,605,983...97,635,530
JBrowse link
G Pkib protein kinase inhibitor beta, cAMP dependent, testis specific decreases expression ISO Metribolone results in decreased expression of PKIB mRNA CTD PMID:16751804 NCBI chr10:57,508,077...57,617,208
Ensembl chr10:57,508,077...57,617,208
JBrowse link
G Pkm pyruvate kinase, muscle multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to PKM protein] CTD PMID:17220478 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658
JBrowse link
G Plin3 perilipin 3 increases expression ISO Metribolone results in increased expression of PLIN3 protein CTD PMID:17152098 NCBI chr17:56,585,962...56,597,511
Ensembl chr17:56,584,476...56,599,873
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 affects expression
increases expression
ISO Metribolone affects the expression of PMEPA1 mRNA
Metribolone results in increased expression of PMEPA1 mRNA
CTD PMID:12711008 PMID:17010196 PMID:17010675 NCBI chr 2:173,066,251...173,118,329
Ensembl chr 2:173,066,251...173,118,326
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PPARGC1A protein modified form] CTD PMID:28751236 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Pphln1 periphilin 1 increases expression ISO Metribolone results in increased expression of PPHLN1 mRNA CTD PMID:17010196 NCBI chr15:93,296,243...93,389,794
Ensembl chr15:93,296,231...93,389,391
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha multiple interactions
decreases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to PPP2R2A protein]
Metribolone results in decreased expression of PPP2R2A protein
CTD PMID:17152098 PMID:17220478 NCBI chr14:67,251,505...67,309,920
Ensembl chr14:67,251,505...67,309,893
JBrowse link
G Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form] CTD PMID:28751236 NCBI chr19:46,044,955...46,061,348
Ensembl chr19:46,033,325...46,061,354
JBrowse link
G Pramex1 PRAME like, X-linked 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRAME protein modified form] CTD PMID:28751236 NCBI chr  X:134,513,662...134,528,437
Ensembl chr  X:134,513,751...134,528,454
JBrowse link
G Prdm2 PR domain containing 2, with ZNF domain multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRDM2 protein modified form] CTD PMID:28751236 NCBI chr 4:142,833,961...142,939,560
Ensembl chr 4:142,833,961...142,939,565
JBrowse link
G Prdx1 peroxiredoxin 1 affects splicing ISO Metribolone affects the splicing of PRDX1 mRNA CTD PMID:17010196 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Prdx3 peroxiredoxin 3 affects localization ISO Metribolone affects the localization of PRDX3 protein CTD PMID:17440980 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO Metribolone results in increased expression of PRDX6 protein CTD PMID:17152098 NCBI chr 1:161,067,682...161,078,780
Ensembl chr 1:161,067,682...161,078,789
JBrowse link
G Prkacb protein kinase, cAMP dependent, catalytic, beta affects expression ISO Metribolone affects the expression of PRKACB mRNA alternative form; Metribolone affects the expression of PRKACB protein alternative form CTD PMID:16949795 NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Metribolone promotes the reaction [EZR protein binds to PRKCA protein]; PRKCA protein affects the reaction [Metribolone results in increased phosphorylation of EZR protein] CTD PMID:16873375 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 decreases expression ISO Metribolone results in decreased expression of PRPS2 protein CTD PMID:17152098 NCBI chr  X:166,129,316...166,165,887
Ensembl chr  X:166,129,318...166,165,745
JBrowse link
G Psmc1 protease (prosome, macropain) 26S subunit, ATPase 1 increases expression ISO Metribolone results in increased expression of PSMC1 protein CTD PMID:17152098 NCBI chr12:100,076,461...100,089,623
Ensembl chr12:100,076,413...100,089,664
JBrowse link
G Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to PSMC2 protein] CTD PMID:17220478 NCBI chr 5:21,990,273...22,008,785
Ensembl chr 5:21,990,281...22,008,785
JBrowse link
G Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 increases expression ISO Metribolone results in increased expression of PSMC3 protein CTD PMID:17152098 NCBI chr 2:90,884,361...90,889,783
Ensembl chr 2:90,884,354...90,896,714
JBrowse link
G Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to PSMD2 protein]
Metribolone results in increased expression of PSMD2 protein
CTD PMID:17152098 PMID:17220478 NCBI chr16:20,469,872...20,482,164
Ensembl chr16:20,470,402...20,482,164
JBrowse link
G Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 increases expression ISO Metribolone results in increased expression of PSMD6 mRNA CTD PMID:17010196 NCBI chr14:8,348,818...8,357,578
Ensembl chr14:8,348,779...8,357,589
JBrowse link
G Psme3 proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) decreases expression ISO Metribolone results in decreased expression of PSME3 protein CTD PMID:17152098 NCBI chr11:101,206,090...101,214,363
Ensembl chr11:101,207,039...101,214,363
JBrowse link
G Pten phosphatase and tensin homolog decreases response to substance ISO PTEN protein results in decreased susceptibility to Metribolone CTD PMID:16637073 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) increases expression ISO Metribolone results in increased expression of PTGER4 mRNA CTD PMID:17010675 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668
JBrowse link
G Pthlh parathyroid hormone-like peptide decreases expression ISO Metribolone results in decreased expression of PTHLH protein CTD PMID:17676588 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681
JBrowse link
G Ptov1 prostate tumor over expressed gene 1 increases expression ISO Metribolone results in increased expression of PTOV1 mRNA CTD PMID:17010196 NCBI chr 7:44,512,491...44,523,542
Ensembl chr 7:44,512,491...44,519,212
JBrowse link
G Ptprm protein tyrosine phosphatase receptor type M increases expression ISO Metribolone results in increased expression of PTPRM mRNA CTD PMID:16751804 NCBI chr17:66,973,843...67,661,486
Ensembl chr17:66,973,942...67,661,452
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RBL2 protein modified form] CTD PMID:28751236 NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472
JBrowse link
G Rbm6 RNA binding motif protein 6 increases expression ISO Metribolone results in increased expression of RBM6 mRNA CTD PMID:17010196 NCBI chr 9:107,650,758...107,751,028
Ensembl chr 9:107,650,758...107,750,436
JBrowse link
G Rdh11 retinol dehydrogenase 11 increases expression ISO Metribolone results in increased expression of RDH11 mRNA CTD PMID:17010196 NCBI chr12:79,221,007...79,238,629
Ensembl chr12:79,221,111...79,239,067
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RELA protein modified form] CTD PMID:28751236 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rhou ras homolog family member U increases expression ISO Metribolone results in increased expression of RHOU mRNA CTD PMID:16751804 NCBI chr 8:124,380,609...124,390,622
Ensembl chr 8:124,380,668...124,390,623
JBrowse link
G Rhox5 reproductive homeobox 5 multiple interactions EXP Metribolone inhibits the reaction [Ketoconazole results in decreased expression of RHOX5 mRNA] CTD PMID:19587329 NCBI chr  X:36,891,657...36,897,305
Ensembl chr  X:36,891,636...36,897,311
JBrowse link
G Rmc1 regulator of MON1-CCZ1 increases expression ISO Metribolone results in increased expression of RMC1 mRNA CTD PMID:17010196 NCBI chr18:12,301,746...12,331,732
Ensembl chr18:12,301,774...12,323,715
JBrowse link
G Rmdn1 regulator of microtubule dynamics 1 affects localization ISO Metribolone affects the localization of RMDN1 protein CTD PMID:17440980 NCBI chr 4:19,575,036...19,606,932
Ensembl chr 4:19,575,162...19,606,932
JBrowse link
G Rpl11 ribosomal protein L11 affects splicing ISO Metribolone affects the splicing of RPL11 mRNA CTD PMID:17010196 NCBI chr 4:135,776,665...135,780,704
Ensembl chr 4:135,755,576...135,780,739
JBrowse link
G Rpl24 ribosomal protein L24 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPL24 protein] CTD PMID:17220478 NCBI chr16:55,786,638...55,791,800
Ensembl chr16:55,786,638...55,791,798
JBrowse link
G Rpl3 ribosomal protein L3 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPL3 protein] CTD PMID:17220478 NCBI chr15:79,961,993...79,967,553
Ensembl chr15:79,961,992...79,976,069
JBrowse link
G Rpl4 ribosomal protein L4 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPL4 protein] CTD PMID:17220478 NCBI chr 9:64,080,159...64,085,805
Ensembl chr 9:64,080,657...64,085,948
JBrowse link
G Rpn2 ribophorin II multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPN2 protein] CTD PMID:17220478 NCBI chr 2:157,121,018...157,168,238
Ensembl chr 2:157,120,937...157,168,239
JBrowse link
G Rps16 ribosomal protein S16 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS16 protein] CTD PMID:17220478 NCBI chr 7:28,050,114...28,052,123
Ensembl chr 7:28,050,077...28,052,580
JBrowse link
G Rps20 ribosomal protein S20 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS20 protein] CTD PMID:17220478 NCBI chr 4:3,831,334...3,835,600
Ensembl chr 4:3,831,334...3,835,665
JBrowse link
G Rps26 ribosomal protein S26 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS26 protein] CTD PMID:17220478 NCBI chr10:128,460,398...128,462,375
Ensembl chr10:128,460,403...128,462,616
JBrowse link
G Rps27l ribosomal protein S27-like affects splicing ISO Metribolone affects the splicing of RPS27L mRNA CTD PMID:17010196 NCBI chr 9:66,851,906...66,856,804
Ensembl chr 9:66,853,368...66,856,798
JBrowse link
G Rps3 ribosomal protein S3 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS3 protein] CTD PMID:17220478 NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS6 protein] CTD PMID:17220478 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649
JBrowse link
G Rps8 ribosomal protein S8 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS8 protein] CTD PMID:17220478 NCBI chr 4:117,011,033...117,013,329
Ensembl chr 4:117,011,024...117,013,440
JBrowse link
G Rps9 ribosomal protein S9 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS9 protein] CTD PMID:17220478 NCBI chr 7:3,707,035...3,709,896
Ensembl chr 7:3,706,992...3,709,896
JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Metribolone results in increased expression of RPSA protein CTD PMID:17152098 NCBI chr 9:119,956,832...119,961,435
Ensembl chr 9:119,956,755...119,961,435
JBrowse link
G Rrp12 ribosomal RNA processing 12 homolog increases expression ISO Metribolone results in increased expression of RRP12 mRNA CTD PMID:16751804 NCBI chr19:41,847,922...41,884,592
Ensembl chr19:41,851,290...41,884,612
JBrowse link
G Rrp7a ribosomal RNA processing 7 homolog A increases expression ISO Metribolone results in increased expression of RRP7A mRNA CTD PMID:17010196 NCBI chr15:83,000,047...83,007,002
Ensembl chr15:82,997,634...83,007,002
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RUVBL2 protein] CTD PMID:17220478 NCBI chr 7:45,071,320...45,084,817
Ensembl chr 7:45,071,184...45,087,520
JBrowse link
G Scp2 sterol carrier protein 2, liver affects localization ISO Metribolone affects the localization of SCP2 protein CTD PMID:17440980 NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195
JBrowse link
G Sdccag8 serologically defined colon cancer antigen 8 increases expression ISO Metribolone results in increased expression of SDCCAG8 mRNA CTD PMID:17010196 NCBI chr 1:176,642,226...176,848,004
Ensembl chr 1:176,642,226...176,848,003
JBrowse link
G Sec23a SEC23 homolog A, COPII coat complex component multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to SEC23A protein] CTD PMID:17220478 NCBI chr12:59,005,170...59,058,803
Ensembl chr12:59,005,169...59,058,803
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Metribolone results in decreased expression of SELENBP1 protein CTD PMID:17152098 NCBI chr 3:94,840,394...94,852,069
Ensembl chr 3:94,840,367...94,852,069
JBrowse link
G Selenop selenoprotein P increases expression
multiple interactions
ISO Metribolone results in increased expression of SELENOP mRNA
resveratrol inhibits the reaction [Metribolone results in increased expression of SELENOP mRNA]
CTD PMID:17131305 PMID:18586690 NCBI chr15:3,300,249...3,309,992
Ensembl chr15:3,298,029...3,309,990
JBrowse link
G Septin1 septin 1 increases expression ISO Metribolone results in increased expression of SEPTIN1 mRNA CTD PMID:17010196 NCBI chr 7:126,811,881...126,832,157
Ensembl chr 7:126,813,619...126,832,302
JBrowse link
G Septin2 septin 2 increases expression ISO Metribolone results in increased expression of SEPTIN2 protein CTD PMID:17152098 NCBI chr 1:93,406,238...93,437,455
Ensembl chr 1:93,406,686...93,437,982
Ensembl chr 1:93,406,686...93,437,982
JBrowse link
G Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 decreases expression ISO Metribolone results in decreased expression of SERPINB5 protein CTD PMID:17152098 NCBI chr 1:106,788,905...106,811,078
Ensembl chr 1:106,788,903...106,811,078
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases secretion ISO Metribolone results in increased secretion of SERPINE1 protein CTD PMID:20711410 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Sesn1 sestrin 1 multiple interactions
decreases expression
ISO AR protein affects the reaction [Metribolone results in decreased expression of SESN1 protein]
Metribolone results in decreased expression of SESN1 mRNA; Metribolone results in decreased expression of SESN1 protein
CTD PMID:16751804 NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420
JBrowse link
G Sfxn4 sideroflexin 4 increases expression ISO Metribolone results in increased expression of SFXN4 mRNA CTD PMID:17010196 NCBI chr19:60,824,747...60,850,222
Ensembl chr19:60,825,715...60,849,917
JBrowse link
G Sh3glb2 SH3-domain GRB2-like endophilin B2 increases expression ISO Metribolone results in increased expression of SH3GLB2 mRNA CTD PMID:17010196 NCBI chr 2:30,234,789...30,249,380
Ensembl chr 2:30,234,821...30,249,349
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to SHMT2 protein] CTD PMID:17220478 NCBI chr10:127,352,992...127,358,313
Ensembl chr10:127,352,992...127,358,313
JBrowse link
G Sil1 SIL1 nucleotide exchange factor increases expression ISO Metribolone results in increased expression of SIL1 protein CTD PMID:17152098 NCBI chr18:35,399,449...35,632,443
Ensembl chr18:35,399,449...35,632,833
JBrowse link
G Slc30a3 solute carrier family 30 (zinc transporter), member 3 increases expression ISO Metribolone results in increased expression of SLC30A3 mRNA CTD PMID:14662799 NCBI chr 5:31,243,450...31,265,576
Ensembl chr 5:31,243,450...31,265,581
JBrowse link
G Slc30a7 solute carrier family 30 (zinc transporter), member 7 increases expression ISO Metribolone results in increased expression of SLC30A7 mRNA CTD PMID:16751804 NCBI chr 3:115,732,622...115,801,079
Ensembl chr 3:115,732,622...115,801,055
JBrowse link
G Slc30a9 solute carrier family 30 (zinc transporter), member 9 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to SLC30A9 protein modified form] CTD PMID:28751236 NCBI chr 5:67,464,298...67,513,485
Ensembl chr 5:67,464,298...67,515,786
JBrowse link
G Slc31a1 solute carrier family 31, member 1 multiple interactions
increases expression
ISO [Metribolone results in increased expression of SLC31A1 protein] which results in increased import of Copper; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 mRNA]; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 protein]
Metribolone results in increased expression of SLC31A1 mRNA; Metribolone results in increased expression of SLC31A1 protein
CTD PMID:25320179 NCBI chr 4:62,278,821...62,310,006
Ensembl chr 4:62,278,964...62,310,006
JBrowse link
G Slc35c2 solute carrier family 35, member C2 increases expression ISO Metribolone results in increased expression of SLC35C2 mRNA CTD PMID:17010196 NCBI chr 2:165,118,442...165,129,808
Ensembl chr 2:165,118,474...165,129,789
JBrowse link
G Slc43a1 solute carrier family 43, member 1 increases expression ISO Metribolone results in increased expression of SLC43A1 mRNA CTD PMID:17010196 NCBI chr 2:84,669,196...84,693,930
Ensembl chr 2:84,669,194...84,693,938
JBrowse link
G Slc45a3 solute carrier family 45, member 3 increases expression ISO Metribolone results in increased expression of SLC45A3 mRNA CTD PMID:17010196 NCBI chr 1:131,890,653...131,910,710
Ensembl chr 1:131,890,705...131,910,707
JBrowse link
G Sms spermine synthase increases expression ISO Metribolone results in increased expression of SMS protein CTD PMID:17152098 NCBI chr  X:156,226,847...156,275,283
Ensembl chr  X:156,226,851...156,275,283
JBrowse link
G Sncg synuclein, gamma increases expression ISO Metribolone results in increased expression of SNCG mRNA CTD PMID:17010196 NCBI chr14:34,092,231...34,096,626
Ensembl chr14:34,092,231...34,096,746
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO Metribolone results in increased expression of SOCS2 mRNA CTD PMID:16751804 NCBI chr10:95,219,765...95,253,176
Ensembl chr10:95,221,224...95,253,042
JBrowse link
G Spcs3 signal peptidase complex subunit 3 homolog (S. cerevisiae) increases expression ISO Metribolone results in increased expression of SPCS3 mRNA CTD PMID:16751804 NCBI chr 8:54,973,468...54,983,033
Ensembl chr 8:54,973,468...54,983,033
JBrowse link
G Spin1 spindlin 1 increases expression ISO Metribolone results in increased expression of SPIN1 mRNA CTD PMID:17010196 NCBI chr13:51,254,523...51,306,588
Ensembl chr13:51,254,916...51,306,582
JBrowse link
G Spon2 spondin 2, extracellular matrix protein increases expression ISO Metribolone results in increased expression of SPON2 mRNA CTD PMID:17010196 NCBI chr 5:33,370,862...33,375,596
Ensembl chr 5:33,355,528...33,375,799
JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO Metribolone results in increased phosphorylation of and results in increased activity of SRC protein CTD PMID:17272394 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
JBrowse link
G Stard10 StAR related lipid transfer domain containing 10 increases expression ISO Metribolone results in increased expression of STARD10 mRNA CTD PMID:17010196 NCBI chr 7:100,966,293...100,995,833
Ensembl chr 7:100,966,293...100,995,833
JBrowse link
G Steap1 six transmembrane epithelial antigen of the prostate 1 increases expression ISO Metribolone results in increased expression of STEAP1 mRNA CTD PMID:17010196 NCBI chr 5:5,786,322...5,799,317
Ensembl chr 5:5,786,317...5,799,326
JBrowse link
G Steap2 six transmembrane epithelial antigen of prostate 2 increases expression ISO Metribolone results in increased expression of STEAP2 mRNA CTD PMID:17010196 NCBI chr 5:5,714,829...5,744,649
Ensembl chr 5:5,714,829...5,744,578
JBrowse link
G Steap4 STEAP family member 4 multiple interactions
increases expression
ISO AR protein promotes the reaction [Metribolone results in increased expression of STEAP4 mRNA] CTD PMID:25320179 NCBI chr 5:8,010,472...8,032,213
Ensembl chr 5:8,010,457...8,032,213
JBrowse link
G Stip1 stress-induced phosphoprotein 1 affects localization
increases expression
ISO Metribolone affects the localization of STIP1 protein
Metribolone results in increased expression of STIP1 protein
CTD PMID:17152098 PMID:17440980 NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335
JBrowse link
G Stk39 serine/threonine kinase 39 increases expression
multiple interactions
ISO Metribolone results in increased expression of STK39 mRNA
resveratrol inhibits the reaction [Metribolone results in increased expression of STK39 mRNA]
CTD PMID:17131305 PMID:18586690 NCBI chr 2:68,040,789...68,302,381
Ensembl chr 2:68,040,789...68,302,612
JBrowse link
G Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit increases expression ISO Metribolone results in increased expression of SUCLA2 protein CTD PMID:17152098 NCBI chr14:73,790,226...73,833,584
Ensembl chr14:73,762,759...73,833,582
JBrowse link
G Tacc1 transforming, acidic coiled-coil containing protein 1 increases expression ISO Metribolone results in increased expression of TACC1 mRNA CTD PMID:17010196 NCBI chr 8:25,644,568...25,730,901
Ensembl chr 8:25,644,568...25,746,604
JBrowse link
G Taldo1 transaldolase 1 decreases expression ISO Metribolone results in decreased expression of TALDO1 protein CTD PMID:17152098 NCBI chr 7:140,972,073...140,982,889
Ensembl chr 7:140,972,112...140,982,881
JBrowse link
G Tardbp TAR DNA binding protein decreases expression ISO Metribolone results in decreased expression of TARDBP protein CTD PMID:17152098 NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to TARS1 protein] CTD PMID:17220478 NCBI chr15:11,383,749...11,399,744
Ensembl chr15:11,382,387...11,399,751
JBrowse link
G Tbcc tubulin-specific chaperone C increases expression ISO Metribolone results in increased expression of TBCC protein CTD PMID:17152098 NCBI chr17:47,201,547...47,203,389
Ensembl chr17:47,201,610...47,202,773
JBrowse link
G Tert telomerase reverse transcriptase increases activity
multiple interactions
increases expression
ISO Metribolone results in increased activity of TERT protein
letrozole inhibits the reaction [Metribolone results in increased activity of TERT protein]; Metribolone inhibits the reaction [Estradiol results in increased activity of TERT protein]; Tamoxifen inhibits the reaction [Metribolone results in increased activity of TERT protein]
Metribolone results in increased expression of TERT mRNA
CTD PMID:19561322 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form] CTD PMID:28751236 NCBI chr 7:127,845,963...127,852,884
Ensembl chr 7:127,845,984...127,854,871
JBrowse link
G Tle3 transducin-like enhancer of split 3 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to TLE3 protein] CTD PMID:17220478 NCBI chr 9:61,279,608...61,325,779
Ensembl chr 9:61,279,665...61,325,772
JBrowse link
G Tmem50a transmembrane protein 50A increases expression ISO Metribolone results in increased expression of TMEM50A mRNA CTD PMID:16751804 NCBI chr 4:134,625,160...134,642,307
Ensembl chr 4:134,625,160...134,642,335
JBrowse link
G Tnk1 tyrosine kinase, non-receptor, 1 decreases expression ISO Metribolone results in decreased expression of TNK1 mRNA CTD PMID:17010675 NCBI chr11:69,741,389...69,749,556
Ensembl chr11:69,741,831...69,749,556
JBrowse link
G Tpx2 TPX2, microtubule-associated increases expression ISO Metribolone results in increased expression of TPX2 mRNA CTD PMID:17010196 NCBI chr 2:152,689,859...152,737,241
Ensembl chr 2:152,689,884...152,737,241
JBrowse link
G Trerf1 transcriptional regulating factor 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to TRERF1 protein modified form] CTD PMID:28751236 NCBI chr17:47,451,868...47,673,250
Ensembl chr17:47,451,801...47,672,883
JBrowse link
G Trim24 tripartite motif-containing 24 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRIM24 protein modified form] CTD PMID:28751236 NCBI chr 6:37,846,816...37,945,380
Ensembl chr 6:37,847,746...37,943,231
JBrowse link
G Trim28 tripartite motif-containing 28 decreases expression ISO Metribolone results in decreased expression of TRIM28 protein CTD PMID:17152098 NCBI chr 7:12,758,079...12,764,959
Ensembl chr 7:12,733,041...12,764,962
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; TP53 protein inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA] CTD PMID:17202838 PMID:21134073 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Trps1 transcriptional repressor GATA binding 1 decreases expression ISO Metribolone results in decreased expression of TRPS1 mRNA CTD PMID:19759027 NCBI chr15:50,518,149...50,754,027
Ensembl chr15:50,518,148...50,753,859
JBrowse link
G Trrap transformation/transcription domain-associated protein multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRRAP protein modified form] CTD PMID:28751236 NCBI chr 5:144,704,547...144,796,588
Ensembl chr 5:144,704,542...144,796,588
JBrowse link
G Tshz1 teashirt zinc finger family member 1 increases expression ISO Metribolone results in increased expression of TSHZ1 mRNA CTD PMID:17010196 NCBI chr18:84,029,752...84,105,833
Ensembl chr18:84,029,752...84,105,831
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Metribolone results in decreased expression of TUBB protein CTD PMID:17152098 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO Metribolone results in decreased expression of TXNRD1 protein CTD PMID:17152098 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression ISO Metribolone results in increased expression of UAP1 protein CTD PMID:17152098 NCBI chr 1:169,967,473...170,002,358
Ensembl chr 1:169,969,507...170,002,526
JBrowse link
G Uba6 ubiquitin-like modifier activating enzyme 6 increases expression ISO Metribolone results in increased expression of UBA6 protein CTD PMID:17152098 NCBI chr 5:86,258,579...86,320,602
Ensembl chr 5:86,257,146...86,320,662
JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2J 1 increases expression ISO Metribolone results in increased expression of UBE2J1 mRNA CTD PMID:16751804 NCBI chr 4:33,031,380...33,052,367
Ensembl chr 4:33,031,416...33,052,363
JBrowse link
G Ubl5 ubiquitin-like 5 affects splicing ISO Metribolone affects the splicing of UBL5 mRNA CTD PMID:17010196 NCBI chr 9:20,554,013...20,558,436
Ensembl chr 9:20,554,174...20,558,436
JBrowse link
G Ufd1 ubiquitin recognition factor in ER-associated degradation 1 decreases expression ISO Metribolone results in decreased expression of UFD1 protein CTD PMID:17152098 NCBI chr16:18,630,486...18,654,011
Ensembl chr16:18,630,529...18,654,011
JBrowse link
G Upf1 UPF1 RNA helicase and ATPase multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to UPF1 protein] CTD PMID:17220478 NCBI chr 8:70,784,143...70,806,418
Ensembl chr 8:70,784,175...70,805,928
JBrowse link
G Uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 increases expression ISO Metribolone results in increased expression of UQCC2 mRNA CTD PMID:17010196 NCBI chr17:27,341,639...27,352,865
Ensembl chr17:27,341,637...27,352,890
JBrowse link
G Usp5 ubiquitin specific peptidase 5 (isopeptidase T) affects localization ISO Metribolone affects the localization of USP5 protein CTD PMID:17440980 NCBI chr 6:124,791,982...124,806,404
Ensembl chr 6:124,791,982...124,806,447
JBrowse link
G Uxt ubiquitously expressed prefoldin like chaperone multiple interactions
affects response to substance
ISO Metribolone promotes the reaction [UXT protein binds to ATR promoter]; Metribolone promotes the reaction [UXT protein binds to GSTE1 promoter]; Metribolone promotes the reaction [UXT protein binds to KLK3 promoter]; Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter]; UXT protein affects the reaction [Metribolone results in increased expression of BRIP1 mRNA]; UXT protein affects the reaction [Metribolone results in increased expression of KLK3 mRNA]; UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]
UXT protein affects the susceptibility to Metribolone
CTD PMID:19318562 NCBI chr  X:20,818,162...20,828,259
Ensembl chr  X:20,807,961...20,828,256
JBrowse link
G Vcl vinculin increases expression ISO Metribolone results in increased expression of VCL protein CTD PMID:17152098 NCBI chr14:20,979,436...21,083,744
Ensembl chr14:20,979,466...21,083,744
JBrowse link
G Vcp valosin containing protein multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to VCP protein]
Metribolone results in increased expression of VCP protein
CTD PMID:17152098 PMID:17220478 NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507
JBrowse link
G Vta1 vesicle (multivesicular body) trafficking 1 decreases expression ISO Metribolone results in decreased expression of VTA1 protein CTD PMID:17152098 NCBI chr10:14,531,077...14,581,233
Ensembl chr10:14,530,499...14,581,304
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase1 increases expression ISO Metribolone results in increased expression of WARS1 protein CTD PMID:17152098 NCBI chr12:108,825,956...108,860,095
Ensembl chr12:108,825,956...108,860,100
JBrowse link
G Xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble increases expression ISO Metribolone results in increased expression of XPNPEP1 protein CTD PMID:17152098 NCBI chr19:52,919,710...53,027,093
Ensembl chr19:52,920,357...53,028,645
JBrowse link
G Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 decreases expression ISO Metribolone results in decreased expression of XRCC5 protein CTD PMID:17152098 NCBI chr 1:72,346,576...72,434,112
Ensembl chr 1:72,346,586...72,434,111
JBrowse link
G Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to XRCC6 protein] CTD PMID:17220478 NCBI chr15:81,868,805...81,924,286
Ensembl chr15:81,872,036...81,924,286
JBrowse link
G Xrn1 5'-3' exoribonuclease 1 multiple interactions
increases expression
ISO MIR204 mRNA inhibits the reaction [Metribolone results in increased expression of XRN1 protein] CTD PMID:25797256 NCBI chr 9:95,836,803...95,939,859
Ensembl chr 9:95,836,813...95,939,856
JBrowse link
G Ythdf1 YTH N6-methyladenosine RNA binding protein 1 increases expression ISO Metribolone results in increased expression of YTHDF1 mRNA CTD PMID:17010196 NCBI chr 2:180,546,170...180,562,729
Ensembl chr 2:180,546,170...180,562,742
JBrowse link
G Zbtb10 zinc finger and BTB domain containing 10 increases expression ISO Metribolone results in increased expression of ZBTB10 mRNA CTD PMID:16751804 PMID:17010675 NCBI chr 3:9,315,627...9,350,393
Ensembl chr 3:9,315,662...9,350,393
JBrowse link
G Zdhhc2 zinc finger, DHHC domain containing 2 increases expression ISO Metribolone results in increased expression of ZDHHC2 mRNA CTD PMID:17010196 NCBI chr 8:40,876,526...40,946,178
Ensembl chr 8:40,876,856...40,963,309
JBrowse link
G Znhit3 zinc finger, HIT type 3 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ZNHIT3 protein modified form] CTD PMID:28751236 NCBI chr11:84,801,776...84,807,192
Ensembl chr11:84,801,776...84,807,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22205
    role 22190
      biological role 22189
        molecular messenger 19417
          hormone 18940
            sex hormone 18752
              androgen 5675
                17beta-hydroxy-17-methylestra-4,9,11-trien-3-one 411
Path 2
Term Annotations click to browse term
  CHEBI ontology 22205
    subatomic particle 22197
      composite particle 22197
        hadron 22197
          baryon 22197
            nucleon 22169
              atomic nucleus 22197
                atom 22197
                  main group element atom 22131
                    p-block element atom 22131
                      carbon group element atom 21928
                        carbon atom 21854
                          organic molecular entity 21854
                            organic molecule 21671
                              organic cyclic compound 21276
                                organic polycyclic compound 17943
                                  steroid 14887
                                    hydroxy steroid 14621
                                      17-hydroxy steroid 14175
                                        17beta-hydroxy steroid 13393
                                          17beta-hydroxy-17-methylestra-4,9,11-trien-3-one 411
paths to the root