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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | increases expression | ISO | RGD:1343025 | 6480464 | epigallocatechin gallate results in increased expression of COX1 mRNA | CTD | PMID:20706672 | (R)-carnitine | multiple interactions | EXP | | 6480464 | Carnitine inhibits the reaction [nickel chloride results in decreased expression of COX1 mRNA] | CTD | PMID:21419151 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:621871 | 6480464 | Ethinyl Estradiol results in increased expression of COX1 mRNA | CTD | PMID:16940010 PMID:12857939 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:621871 | 6480464 | Ethinyl Estradiol results in increased expression of COX1 mRNA | CTD | PMID:12857939 PMID:16940010 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | increases expression | ISO | RGD:1343025 | 6480464 | Metribolone results in increased expression of COX1 mRNA | CTD | PMID:17010196 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of COX1 mRNA | CTD | PMID:18172213 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | decreases expression | ISO | RGD:621871 | 6480464 | Puromycin Aminonucleoside results in decreased expression of COX1 protein | CTD | PMID:16609681 | 3H-1,2-dithiole-3-thione | increases expression | ISO | RGD:621871 | 6480464 | 1,2-dithiol-3-thione results in increased expression of COX1 mRNA | CTD | PMID:19162173 | 7,12-dimethyltetraphene | decreases expression | ISO | RGD:621871 | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of COX1 mRNA | CTD | PMID:12376462 | acetylsalicylic acid | increases expression | ISO | RGD:621871 | 6480464 | Aspirin results in increased expression of COX1 mRNA | CTD | PMID:8554334 | alpha-hexachlorocyclohexane | increases expression | ISO | RGD:621871 | 6480464 | alpha-hexachlorocyclohexane results in increased expression of COX1 mRNA | CTD | PMID:16940010 | aminoguanidine | affects activity | ISO | RGD:621871 | 6480464 | pimagedine affects the activity of COX1 protein | CTD | PMID:17936468 | aminoguanidine | affects expression | ISO | RGD:621871 | 6480464 | pimagedine affects the expression of COX1 mRNA | CTD | PMID:17936468 | chloramphenicol | decreases expression | ISO | RGD:1343025 | 6480464 | Chloramphenicol results in decreased expression of COX1 protein | CTD | PMID:15905168 | chlorogenic acid | increases expression | ISO | RGD:1343025 | 6480464 | Chlorogenic Acid results in increased expression of COX1 mRNA | CTD | PMID:20706672 | clofibrate | increases expression | ISO | RGD:621871 | 6480464 | Clofibrate results in increased expression of COX1 mRNA | CTD | PMID:8554334 | copper atom | multiple interactions | EXP | | 6480464 | Copper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased expression of COX1 protein] | CTD | PMID:12177073 | copper atom | decreases expression | ISO | RGD:621871 | 6480464 | Copper deficiency results in decreased expression of COX1 protein | CTD | PMID:16446493 | copper(0) | multiple interactions | EXP | | 6480464 | Copper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased expression of COX1 protein] | CTD | PMID:12177073 | copper(0) | decreases expression | ISO | RGD:621871 | 6480464 | Copper deficiency results in decreased expression of COX1 protein | CTD | PMID:16446493 | copper(2+) sulfate | affects response to substance | ISO | RGD:621871 | 6480464 | COX1 protein affects the susceptibility to Copper Sulfate | CTD | PMID:20582486 | dehydroepiandrosterone | increases expression | ISO | RGD:621871 | 6480464 | Dehydroepiandrosterone results in increased expression of COX1 mRNA | CTD | PMID:16940010 | Delta(9)-tetrahydrocannabinol | increases expression | ISO | RGD:621871 | 6480464 | Tetrahydrocannabinol results in increased expression of COX1 mRNA | CTD | PMID:11015613 | dexamethasone | increases expression | ISO | RGD:621871 | 6480464 | Dexamethasone results in increased expression of COX1 mRNA | CTD | PMID:7491922 | dioxygen | decreases expression | EXP | | 6480464 | Oxygen deficiency results in decreased expression of COX1 protein | CTD | PMID:19351718 | disodium selenite | multiple interactions | ISO | RGD:621871 | 6480464 | Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of COX1 mRNA] | CTD | PMID:20067779 | disodium selenite | decreases expression | ISO | RGD:621871 | 6480464 | Sodium Selenite results in decreased expression of COX1 mRNA | CTD | PMID:20067779 | disulfiram | affects activity | ISO | RGD:621871 | 6480464 | Disulfiram affects the activity of COX1 protein | CTD | PMID:17936468 | disulfiram | affects expression | ISO | RGD:621871 | 6480464 | Disulfiram affects the expression of COX1 mRNA | CTD | PMID:17936468 | doxorubicin | decreases expression | ISO | RGD:621871 | 6480464 | Doxorubicin results in decreased expression of COX1 mRNA | CTD | PMID:19217856 | doxorubicin | decreases expression | ISO | RGD:621871 | 6480464 | Doxorubicin results in decreased expression of COX1 protein | CTD | PMID:14736955 PMID:17131338 | doxorubicin | decreases activity | ISO | RGD:621871 | 6480464 | Doxorubicin results in decreased activity of COX1 protein | CTD | PMID:19747854 PMID:14568902 | doxorubicin | decreases activity | ISO | RGD:621871 | 6480464 | Doxorubicin results in decreased activity of COX1 protein | CTD | PMID:14568902 PMID:19747854 | doxorubicin | decreases expression | ISO | RGD:621871 | 6480464 | Doxorubicin results in decreased expression of COX1 protein | CTD | PMID:17131338 PMID:14736955 | ethidium | decreases expression | ISO | RGD:1343025 | 6480464 | Ethidium results in decreased expression of COX1 protein | CTD | PMID:18823003 | genistein | increases expression | ISO | RGD:1343025 | 6480464 | Genistein results in increased expression of COX1 mRNA | CTD | PMID:20706672 | lamivudine | multiple interactions | EXP | | 6480464 | [Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA | CTD | PMID:18313992 PMID:17526437 | lamivudine | multiple interactions | EXP | | 6480464 | [Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA | CTD | PMID:17526437 PMID:18313992 | malathion | decreases expression | EXP | | 6480464 | Malathion results in decreased expression of COX1 mRNA | CTD | PMID:18214912 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of COX1 mRNA | CTD | PMID:11756511 | methamphetamine | multiple interactions | EXP | | 6480464 | (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in increased expression of COX1 mRNA] | CTD | PMID:11756511 | methapyrilene | increases expression | ISO | RGD:621871 | 6480464 | Methapyrilene results in increased expression of COX1 mRNA | CTD | PMID:22484513 | nickel dichloride | multiple interactions | EXP | | 6480464 | Carnitine inhibits the reaction [nickel chloride results in decreased expression of COX1 mRNA] | CTD | PMID:21419151 | nickel dichloride | decreases expression | EXP | | 6480464 | nickel chloride results in decreased expression of COX1 mRNA | CTD | PMID:21419151 | nitric oxide | affects activity | ISO | RGD:621871 | 6480464 | Nitric Oxide affects the activity of COX1 protein | CTD | PMID:17936468 | nitric oxide | affects expression | ISO | RGD:621871 | 6480464 | Nitric Oxide affects the expression of COX1 mRNA | CTD | PMID:17936468 | perfluorooctanoic acid | increases expression | ISO | RGD:621871 | 6480464 | perfluorooctanoic acid results in increased expression of COX1 mRNA | CTD | PMID:8554334 | pirinixic acid | decreases expression | ISO | RGD:621871 | 6480464 | pirinixic acid results in decreased expression of COX1 mRNA | CTD | PMID:19162173 | pirinixic acid | decreases expression | ISO | RGD:621871 | 6480464 | pirinixic acid results in decreased expression of COX1 mRNA | CTD | PMID:19162173 PMID:22484513 | resveratrol | increases expression | ISO | RGD:1343025 | 6480464 | resveratrol results in increased expression of COX1 mRNA | CTD | PMID:20706672 | sulfur dioxide | increases expression | ISO | RGD:621871 | 6480464 | Sulfur Dioxide results in increased expression of COX1 mRNA | CTD | PMID:22677886 | trans-resveratrol | increases expression | ISO | RGD:1343025 | 6480464 | resveratrol results in increased expression of COX1 mRNA | CTD | PMID:20706672 | uridine | multiple interactions | EXP | | 6480464 | Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein] | CTD | PMID:20032772 PMID:17187420 | uridine | multiple interactions | EXP | | 6480464 | Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein] | CTD | PMID:17187420 PMID:20032772 | uridine | multiple interactions | EXP | | 6480464 | Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein] | CTD | PMID:18163507 PMID:20032772 | uridine | multiple interactions | EXP | | 6480464 | Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein] | CTD | PMID:20032772 PMID:18163507 | zalcitabine | decreases expression | ISO | RGD:1343025 | 6480464 | Zalcitabine results in decreased expression of COX1 protein | CTD | PMID:18823003 | zalcitabine | decreases expression | EXP | | 6480464 | Zalcitabine results in decreased expression of COX1 protein | CTD | PMID:17187420 PMID:20032772 | zalcitabine | multiple interactions | EXP | | 6480464 | Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein] | CTD | PMID:20032772 PMID:17187420 | zalcitabine | multiple interactions | EXP | | 6480464 | Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein] | CTD | PMID:17187420 PMID:20032772 | zalcitabine | decreases expression | EXP | | 6480464 | Zalcitabine results in decreased expression of COX1 protein | CTD | PMID:20032772 PMID:17187420 | zidovudine | multiple interactions | EXP | | 6480464 | [Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA | CTD | PMID:18313992 PMID:17526437 | zidovudine | multiple interactions | EXP | | 6480464 | Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein] | CTD | PMID:20032772 PMID:18163507 | zidovudine | increases expression | EXP | | 6480464 | Zidovudine results in increased expression of COX1 mRNA | CTD | PMID:7528833 | zidovudine | decreases expression | EXP | | 6480464 | Zidovudine results in decreased expression of COX1 protein | CTD | PMID:20032772 PMID:18163507 | zidovudine | multiple interactions | EXP | | 6480464 | Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein] | CTD | PMID:18163507 PMID:20032772 | zidovudine | decreases expression | EXP | | 6480464 | Zidovudine results in decreased expression of COX1 protein | CTD | PMID:18163507 PMID:20032772 | zidovudine | multiple interactions | EXP | | 6480464 | [Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA | CTD | PMID:17526437 PMID:18313992 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Alzheimer's disease |
| Cardiac muscle contraction | |
| Huntington's disease | |
| Metabolic pathways | |
| Oxidative phosphorylation | |
| Parkinson's disease | |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Alzheimer's disease |
| Cardiac muscle contraction | |
| Huntington's disease | |
| Metabolic pathways | |
| Oxidative phosphorylation | |
| Parkinson's disease | |
Phenotype Annotations
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References - curated
References - uncurated| PubMed | 11940593 |
| 12943672 | |
| 16449238 | |
| 16815968 | |
| 17481558 | |
| 17628447 | |
| 18469184 | |
| 18534980 | |
| 18614564 | |
| 18729827 | |
| 19175797 |
RGD Disease Portals| COX1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| COX1 (Mus musculus) |
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| MT-COI (Homo sapiens) |
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| Mt-co1 (Rattus norvegicus) |
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Position Markers| RH136213 |
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| RH136219 |
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| RH136241 |
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| RH136305 |
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| RH136337 |
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| RH136347 |
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| RH136413 |
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| RH136419 |
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| RH136461 |
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| mt-Nd2 |
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| PMC307645P1 |
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| fk25g03.x1 |
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| UniSTS:234086 |
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| UniSTS:234087 |
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| UniSTS:234088 |
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Nucleotide Sequences
Protein Sequences
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000064351 | |
| Entrez Gene | 17708 | ENTREZGENE |
| Gene3D-CATH | COX1 | UniProtKB/Swiss-Prot |
| InterPro | Cyt_c_Oxase_su1 | UniProtKB/Swiss-Prot |
| Cyt_c_Oxase_su1_BS | UniProtKB/Swiss-Prot | |
| Cyt_c_Oxase_su1_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00130376 | UniProtKB/Swiss-Prot |
| IPI00355248 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:17708 | ENTREZGENE, UniProtKB/TrEMBL |
| MGD | MGI:102504 | ENTREZGENE |
| PANTHER | COX1 | UniProtKB/Swiss-Prot |
| Pfam | COX1 | UniProtKB/Swiss-Prot |
| PRINTS | CYCOXIDASEI | UniProtKB/Swiss-Prot |
| PROSITE | COX1 | UniProtKB/Swiss-Prot |
| COX1_CUB | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | COX1 | UniProtKB/Swiss-Prot |
| UniProt | COX1_MOUSE | UniProtKB/Swiss-Prot |
| Q3TML7_MOUSE | UniProtKB/TrEMBL | |
| Q3TRT0_MOUSE | UniProtKB/TrEMBL | |
| Q3UQ58_MOUSE | UniProtKB/TrEMBL | |
| Q3UTW3_MOUSE | UniProtKB/TrEMBL | |
| Q9MD68_MOUSE | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-10-09 | COX1 | cytochrome c oxidase I, mitochondrial | Symbol and/or name change | 39860 | APPROVED | ||
| 2011-07-27 | COX1 | mt-Co1 | cytochrome c oxidase I, mitochondrial | Symbol and/or name change | 39860 | APPROVED |
| More on COX1 | |
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Entrez Gene |
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Ensembl Gene |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 736621 |
| Created: | 2004-02-06 |
| Species: | Mus musculus |
| Last Modified: | 2012-12-18 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




