Shmt2 (serine hydroxymethyltransferase 2 (mitochondrial)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Shmt2 (serine hydroxymethyltransferase 2 (mitochondrial)) Mus musculus
Analyze
Symbol: Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
RGD ID: 1318438
MGI Page MGI
Description: Enables glycine hydroxymethyltransferase activity. Involved in regulation of mitochondrial translation; regulation of oxidative phosphorylation; and tetrahydrofolate interconversion. Located in mitochondrial inner membrane. Is active in nucleus. Is expressed in several structures, including future brain; hepatic primordium; placenta; skeleton; and submandibular gland primordium. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2700043D08Rik; AA408223; AA986903; glycine hydroxymethyltransferase; serine hydroxymethyltransferase, mitochondrial; serine methylase; SHMT
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm15544  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,352,992 - 127,358,313 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,352,992 - 127,358,313 (-)EnsemblGRCm39 Ensembl
GRCm3810127,517,123 - 127,522,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,517,123 - 127,522,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,954,195 - 126,959,491 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,920,088 - 126,925,384 (-)NCBIMGSCv36mm8
Celera10129,908,893 - 129,914,189 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
arsenite(3-)  (EXP,ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
buspirone  (ISO)
butan-1-ol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
carnosic acid  (EXP)
chlordecone  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dioxygen  (EXP)
diuron  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
epoxiconazole  (EXP)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
gentamycin  (ISO)
glyphosate  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
lead diacetate  (EXP,ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
N(4)-hydroxycytidine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
neomycin  (EXP,ISO)
nickel dichloride  (ISO)
O-methyleugenol  (ISO)
omeprazole  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tanespimycin  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Affinity purification and characterization of serine hydroxymethyltransferases from rat liver. Masuda T, etal., J Biochem. 1987 Mar;101(3):643-52.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Trafficking of intracellular folates. Stover PJ and Field MS, Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/¿an.111.000596. Epub 2011 Jun 28.
10. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.
11. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:12865426   PMID:12904583   PMID:14610273   PMID:14681479   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:17309103   PMID:17937387   PMID:18228065   PMID:18614015   PMID:18799693   PMID:19513116   PMID:21267068   PMID:21873635   PMID:27434733   PMID:29323231  
PMID:29452640   PMID:30333037   PMID:30550785   PMID:30964837   PMID:31690790   PMID:31828098   PMID:32330411   PMID:34702858   PMID:35212811   PMID:35237793   PMID:36114006   PMID:37839992  
PMID:38171330   PMID:38171331   PMID:38183387   PMID:38347107   PMID:38355793  


Genomics

Comparative Map Data
Shmt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,352,992 - 127,358,313 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,352,992 - 127,358,313 (-)EnsemblGRCm39 Ensembl
GRCm3810127,517,123 - 127,522,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,517,123 - 127,522,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,954,195 - 126,959,491 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,920,088 - 126,925,384 (-)NCBIMGSCv36mm8
Celera10129,908,893 - 129,914,189 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.51NCBI
SHMT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,229,711 - 57,234,935 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,229,573 - 57,234,935 (+)EnsemblGRCh38hg38GRCh38
GRCh371257,623,494 - 57,628,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,909,819 - 55,914,981 (+)NCBINCBI36Build 36hg18NCBI36
Build 341255,909,818 - 55,914,981NCBI
Celera1257,277,587 - 57,282,945 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,662,237 - 54,667,595 (+)NCBIHuRef
CHM1_11257,591,454 - 57,596,816 (+)NCBICHM1_1
T2T-CHM13v2.01257,197,949 - 57,203,173 (+)NCBIT2T-CHM13v2.0
Shmt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,244,247 - 65,249,580 (-)NCBIGRCr8
mRatBN7.2763,358,961 - 63,364,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,358,961 - 63,364,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,248,234 - 65,253,554 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,450,661 - 67,455,981 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,251,885 - 67,257,207 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,824,718 - 70,829,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,824,715 - 70,829,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,998,103 - 71,003,197 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,494,470 - 67,499,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,515,199 - 67,520,270 (-)NCBI
Celera760,498,180 - 60,503,250 (-)NCBICelera
Cytogenetic Map7q22NCBI
Shmt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,957,602 - 4,962,691 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,957,614 - 4,962,691 (+)NCBIChiLan1.0ChiLan1.0
SHMT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,106,967 - 37,112,419 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,103,737 - 37,108,804 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,692,451 - 31,697,727 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,944,787 - 31,950,138 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,944,785 - 31,950,138 (-)Ensemblpanpan1.1panPan2
SHMT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,357,347 - 1,362,511 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,356,706 - 1,362,305 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,421,107 - 1,426,256 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,367,808 - 1,372,957 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,367,831 - 1,372,939 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,344,398 - 1,349,547 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,586,394 - 1,591,543 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,711,303 - 1,716,453 (+)NCBIUU_Cfam_GSD_1.0
Shmt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,442,306 - 57,447,426 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,422,817 - 1,429,037 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,422,844 - 1,427,929 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHMT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,532,894 - 22,540,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,535,780 - 22,540,322 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,368,828 - 24,374,450 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SHMT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,141,435 - 53,146,625 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,141,462 - 53,147,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,825,670 - 192,831,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shmt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,713,276 - 10,719,253 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,713,276 - 10,718,391 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Shmt2
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:245
Count of miRNA genes:191
Interacting mature miRNAs:202
Transcripts:ENSMUST00000026470
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse

Markers in Region
RH126912  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,517,236 - 127,517,485UniSTSGRCm38
MGSCv3710126,954,292 - 126,954,541UniSTSGRCm37
Celera10129,908,990 - 129,909,239UniSTS
Cytogenetic Map10D3UniSTS
Whitehead/MRC_RH101386.39UniSTS
AA986903  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38780,430,852 - 80,430,995UniSTSGRCm38
GRCm3810127,517,519 - 127,517,663UniSTSGRCm38
MGSCv3710126,954,575 - 126,954,719UniSTSGRCm37
MGSCv37787,575,738 - 87,575,881UniSTSGRCm37
Celera10129,909,273 - 129,909,417UniSTS
Celera777,830,746 - 77,830,889UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map10D3UniSTS
Whitehead/MRC_RH101383.53UniSTS
RH125781  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,517,322 - 127,517,421UniSTSGRCm38
MGSCv3710126,954,378 - 126,954,477UniSTSGRCm37
Celera10129,909,076 - 129,909,175UniSTS
Cytogenetic Map10D3UniSTS
Whitehead/MRC_RH101382.87UniSTS
PMC133987P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,521,925 - 127,522,266UniSTSGRCm38
MGSCv3710126,958,981 - 126,959,322UniSTSGRCm37
Celera10129,913,679 - 129,914,020UniSTS
Cytogenetic Map10D3UniSTS
Shmt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,519,406 - 127,519,475UniSTSGRCm38
MGSCv3710126,956,462 - 126,956,531UniSTSGRCm37
Celera10129,911,160 - 129,911,229UniSTS
Cytogenetic Map10D3UniSTS
cM Map10 UniSTS
Shmt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10D3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001252316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_028230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC167719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY760884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000026470   ⟹   ENSMUSP00000026470
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,353,008 - 127,358,313 (-)Ensembl
GRCm38.p6 Ensembl10127,517,139 - 127,522,444 (-)Ensembl
RefSeq Acc Id: ENSMUST00000217682
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,356,337 - 127,358,233 (-)Ensembl
GRCm38.p6 Ensembl10127,520,468 - 127,522,364 (-)Ensembl
RefSeq Acc Id: ENSMUST00000218035
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,353,728 - 127,354,649 (-)Ensembl
GRCm38.p6 Ensembl10127,517,859 - 127,518,780 (-)Ensembl
RefSeq Acc Id: ENSMUST00000218258
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,354,986 - 127,358,271 (-)Ensembl
GRCm38.p6 Ensembl10127,519,117 - 127,522,402 (-)Ensembl
RefSeq Acc Id: ENSMUST00000218313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,355,499 - 127,358,270 (-)Ensembl
GRCm38.p6 Ensembl10127,519,630 - 127,522,401 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219239   ⟹   ENSMUSP00000151616
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,352,992 - 127,358,255 (-)Ensembl
GRCm38.p6 Ensembl10127,517,123 - 127,522,386 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220356
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,353,602 - 127,354,645 (-)Ensembl
GRCm38.p6 Ensembl10127,517,733 - 127,518,776 (-)Ensembl
RefSeq Acc Id: NM_001252316   ⟹   NP_001239245
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,352,992 - 127,358,313 (-)NCBI
GRCm3810127,517,123 - 127,522,444 (-)ENTREZGENE
Celera10129,908,877 - 129,914,198 (-)ENTREZGENE
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_028230   ⟹   NP_082506
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,352,992 - 127,358,313 (-)NCBI
GRCm3810127,517,123 - 127,522,444 (-)ENTREZGENE
MGSCv3710126,954,195 - 126,959,491 (-)RGD
Celera10129,908,877 - 129,914,198 (-)ENTREZGENE
cM Map10 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_082506   ⟸   NM_028230
- Peptide Label: isoform 1
- UniProtKB: Q3TFD0 (UniProtKB/Swiss-Prot),   Q99K87 (UniProtKB/Swiss-Prot),   Q9CZN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239245   ⟸   NM_001252316
- Peptide Label: isoform 2
- UniProtKB: Q3TFD0 (UniProtKB/TrEMBL),   Q9CZN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026470   ⟸   ENSMUST00000026470
RefSeq Acc Id: ENSMUSP00000151616   ⟸   ENSMUST00000219239

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CZN7-F1-model_v2 AlphaFold Q9CZN7 1-504 view protein structure

Promoters
RGD ID:6848579
Promoter ID:MM_TRO:1262
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:MTR004063.10.2397.7
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,955,051 - 126,955,551 (-)MPROMDB
RGD ID:6846782
Promoter ID:MM_ACW:6341
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:SHMT2.ISEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,957,141 - 126,957,641 (-)MPROMDB
RGD ID:6846784
Promoter ID:MM_ACW:6342
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   MEF_B6
Transcripts:SHMT2.KSEP07,   SHMT2.LSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,958,171 - 126,958,927 (-)MPROMDB
RGD ID:6819909
Promoter ID:MM_KWN:5907
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_028230,   UC007HJV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,958,994 - 126,959,494 (-)MPROMDB
RGD ID:8673516
Promoter ID:EPDNEW_M14788
Type:initiation region
Name:Shmt2_1
Description:Mus musculus serine hydroxymethyltransferase 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810127,522,396 - 127,522,456EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277989 AgrOrtholog
Ensembl Genes ENSMUSG00000025403 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026470 ENTREZGENE
  ENSMUST00000026470.6 UniProtKB/Swiss-Prot
  ENSMUST00000219239 ENTREZGENE
  ENSMUST00000219239.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
InterPro PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
  Ser_HO-MeTrfase UniProtKB/Swiss-Prot
  Ser_HO-MeTrfase_PLP_BS UniProtKB/Swiss-Prot
  SHMT-like_dom UniProtKB/Swiss-Prot
KEGG Report mmu:108037 UniProtKB/Swiss-Prot
MGD MGI:1277989 ENTREZGENE
NCBI Gene 108037 ENTREZGENE
PANTHER PTHR11680 UniProtKB/Swiss-Prot
  SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam SHMT UniProtKB/Swiss-Prot
PhenoGen Shmt2 PhenoGen
PIRSF SHMT UniProtKB/Swiss-Prot
PROSITE SHMT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt GLYM_MOUSE UniProtKB/Swiss-Prot
  Q3TFD0 ENTREZGENE
  Q99K87 ENTREZGENE
  Q9CZN7 ENTREZGENE
UniProt Secondary Q3TFD0 UniProtKB/Swiss-Prot
  Q99K87 UniProtKB/Swiss-Prot