Nkx3-1 (NK3 homeobox 1) - Rat Genome Database

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Gene: Nkx3-1 (NK3 homeobox 1) Mus musculus
Analyze
Symbol: Nkx3-1
Name: NK3 homeobox 1
RGD ID: 1313355
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and MADS box domain binding activity. Involved in several processes, including chordate embryonic development; circulatory system development; and reproductive structure development. Acts upstream of or within several processes, including epithelial cell proliferation involved in salivary gland morphogenesis; morphogenesis of a branching epithelium; and negative regulation of epithelial cell proliferation involved in prostate gland development. Located in nucleus. Is expressed in several structures, including arterial system; central nervous system; genitourinary system; paraxial mesenchyme; and tooth. Used to study prostate cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human NKX3-1 (NK3 homeobox 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ba; bag; bagpipe; Bax; Drosophila NK-3 transcription factor, locus 1; homeobox protein NK-3 homolog A; homeobox protein Nkx-3.1; NK-3 transcription factor, locus 1; NK-3 transcription factor, locus 1 (Drosophila); NKX; Nkx-3.; Nkx-3.1; NKX3.; NKX3.1; NKX3A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391469,428,141 - 69,432,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1469,428,087 - 69,432,111 (+)EnsemblGRCm39 Ensembl
GRCm381469,190,692 - 69,194,658 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,190,638 - 69,194,662 (+)EnsemblGRCm38mm10GRCm38
MGSCv371469,808,749 - 69,812,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361468,144,022 - 68,147,988 (+)NCBIMGSCv36mm8
Celera1466,971,062 - 66,975,028 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-Dihydroxybenzophenone  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
celastrol  (ISO)
chlordecone  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
daidzein  (ISO)
dapsone  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
enzalutamide  (ISO)
equol  (ISO)
fentin acetate  (ISO)
flufenamic acid  (ISO)
flutamide  (ISO)
fulvestrant  (EXP,ISO)
gedunin  (ISO)
genistein  (EXP,ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoflavones  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mibolerone  (ISO)
niclosamide  (ISO)
paracetamol  (ISO)
pioglitazone  (EXP)
piroxicam  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirtinol  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetramethrin  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
XL147  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (ISO)
branching involved in prostate gland morphogenesis  (IMP)
branching morphogenesis of an epithelial tube  (IMP)
cell differentiation  (IBA)
cellular response to hypoxia  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to xenobiotic stimulus  (ISO)
DNA damage response  (ISO)
dorsal aorta development  (IEP)
epithelial cell proliferation  (IMP)
epithelial cell proliferation involved in prostate gland development  (IMP)
epithelial cell proliferation involved in salivary gland morphogenesis  (IMP)
heart development  (IEP)
internal genitalia morphogenesis  (TAS)
male gonad development  (IEP)
metanephros development  (IEP)
negative regulation of cell population proliferation  (IGI,ISO)
negative regulation of DNA-templated transcription  (IMP,ISO)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of epithelial cell proliferation involved in prostate gland development  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of insulin-like growth factor receptor signaling pathway  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
pharyngeal system development  (IEP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP,ISO)
positive regulation of androgen secretion  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell division  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prostate gland development  (IEP,TAS)
regulation of DNA-templated transcription  (IEA)
regulation of protein localization  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to testosterone  (IMP)
salivary gland development  (IMP)
somitogenesis  (IEP)
urogenital system development  (IEP,TAS)

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)
site of DNA damage  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal bulbourethral gland development  (IAGP)
abnormal bulbourethral gland morphology  (IAGP)
abnormal bulbourethral gland physiology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cervical atlas morphology  (IAGP)
abnormal lumbar vertebrae morphology  (IAGP)
abnormal minor salivary gland morphology  (IAGP)
abnormal palatine gland morphology  (IAGP)
abnormal prostate gland anterior lobe morphology  (IAGP)
abnormal prostate gland branching morphogenesis  (IAGP)
abnormal prostate gland duct morphology  (IAGP)
abnormal prostate gland epithelium morphology  (IAGP)
abnormal prostate gland morphology  (IAGP)
abnormal prostate gland physiology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal salivary gland duct morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal sclerotome morphology  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebral body morphology  (IAGP)
bulbourethral gland hypoplasia  (IAGP)
decreased ductal branching in the coagulating gland  (IAGP)
decreased ductal branching in the palatine gland  (IAGP)
decreased prostate gland duct number  (IAGP)
decreased salivation  (IAGP)
increased cell proliferation  (IAGP)
increased metastatic potential  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate gland tumor incidence  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased salivary gland mucosal cell number  (IAGP)
kinked tail  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
narrow salivary ducts  (IAGP)
premature death  (IAGP)
preneoplasia  (IAGP)
prostate gland anterior lobe hyperplasia  (IAGP)
prostate gland dorsolateral lobe hyperplasia  (IAGP)
prostate gland epithelial hyperplasia  (IAGP)
prostate gland lateral lobe hypoplasia  (IAGP)
reduced male mating frequency  (IAGP)
salivary gland epithelial hyperplasia  (IAGP)
small bulbourethral gland  (IAGP)
small prostate gland anterior lobe  (IAGP)
small prostate gland ventral lobe  (IAGP)
small salivary gland  (IAGP)
small seminal vesicle  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. NK3 homeobox 1 (NKX3.1) up-regulates forkhead box O1 expression in hepatocellular carcinoma and thereby suppresses tumor proliferation and invasion. Jiang J, etal., J Biol Chem. 2017 Nov 24;292(47):19146-19159. doi: 10.1074/jbc.M117.793760. Epub 2017 Sep 27.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8943214   PMID:9142502   PMID:9344671   PMID:9510022   PMID:9620855   PMID:9621431   PMID:10215624   PMID:10349636   PMID:10415359   PMID:10588713   PMID:10729342   PMID:10906459  
PMID:10993896   PMID:11002344   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11739537   PMID:11839815   PMID:11854455   PMID:12036903   PMID:12204261   PMID:12466851   PMID:12477932  
PMID:12490554   PMID:12676585   PMID:12873978   PMID:14648854   PMID:15013801   PMID:15111307   PMID:15569926   PMID:15885713   PMID:15987773   PMID:16061659   PMID:16141072   PMID:16141073  
PMID:16201967   PMID:16245334   PMID:16581776   PMID:16697957   PMID:16814806   PMID:16912166   PMID:16973750   PMID:17078065   PMID:17215304   PMID:17477400   PMID:17909013   PMID:17917679  
PMID:18077445   PMID:18184727   PMID:18245377   PMID:18287559   PMID:18296735   PMID:18325490   PMID:18559517   PMID:18725989   PMID:18816836   PMID:18985768   PMID:18991257   PMID:19258508  
PMID:19494112   PMID:19597465   PMID:19741607   PMID:19797053   PMID:20059953   PMID:20103652   PMID:20195545   PMID:20363913   PMID:20412781   PMID:20932939   PMID:20969842   PMID:21267068  
PMID:21526719   PMID:21624358   PMID:21677750   PMID:21873635   PMID:21905163   PMID:22484818   PMID:22510988   PMID:22563073   PMID:22815528   PMID:22836754   PMID:22848398   PMID:22860005  
PMID:22898663   PMID:22960283   PMID:22988430   PMID:23060003   PMID:23077524   PMID:23087175   PMID:23300485   PMID:23396188   PMID:23434823   PMID:23538858   PMID:23610450   PMID:23674600  
PMID:23786676   PMID:23790631   PMID:23813564   PMID:23867798   PMID:23918374   PMID:24823640   PMID:24952961   PMID:25175604   PMID:25241035   PMID:25780911   PMID:26032417   PMID:26076167  
PMID:26387954   PMID:26660523   PMID:26883359   PMID:27226320   PMID:27339988   PMID:27341756   PMID:27536883   PMID:27703144   PMID:27986952   PMID:28112153   PMID:28385453   PMID:28400434  
PMID:28411207   PMID:28429718   PMID:28679531   PMID:28775169   PMID:29038439   PMID:29334357   PMID:29540470   PMID:29578405   PMID:30013107   PMID:30266798   PMID:30518758   PMID:30659795  
PMID:30720908   PMID:31213464   PMID:31719098   PMID:32325033   PMID:32450005   PMID:32497091   PMID:32943441   PMID:33025905   PMID:33094683   PMID:33176121   PMID:33318148   PMID:33323967  
PMID:33893149   PMID:34074765   PMID:35259458   PMID:36882525   PMID:36897957  


Genomics

Comparative Map Data
Nkx3-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391469,428,141 - 69,432,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1469,428,087 - 69,432,111 (+)EnsemblGRCm39 Ensembl
GRCm381469,190,692 - 69,194,658 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,190,638 - 69,194,662 (+)EnsemblGRCm38mm10GRCm38
MGSCv371469,808,749 - 69,812,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361468,144,022 - 68,147,988 (+)NCBIMGSCv36mm8
Celera1466,971,062 - 66,975,028 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.02NCBI
NKX3-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38823,678,693 - 23,682,938 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl823,678,697 - 23,682,938 (-)EnsemblGRCh38hg38GRCh38
GRCh37823,536,206 - 23,540,451 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,592,173 - 23,596,395 (-)NCBINCBI36Build 36hg18NCBI36
Build 34823,592,172 - 23,596,395NCBI
Celera822,499,634 - 22,503,878 (-)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef822,081,521 - 22,085,754 (-)NCBIHuRef
CHM1_1823,738,407 - 23,742,639 (-)NCBICHM1_1
T2T-CHM13v2.0823,953,650 - 23,957,884 (-)NCBIT2T-CHM13v2.0
Nkx3-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81550,883,661 - 50,886,253 (+)NCBIGRCr8
mRatBN7.21544,473,851 - 44,476,443 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,473,851 - 44,476,441 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1548,591,788 - 48,594,380 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01549,703,277 - 49,705,869 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01546,562,612 - 46,565,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,065,316 - 51,067,908 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,065,316 - 51,068,421 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01554,796,102 - 54,798,694 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41549,743,313 - 49,745,905 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11549,752,541 - 49,761,067 (+)NCBI
Celera1544,157,589 - 44,160,181 (+)NCBICelera
Cytogenetic Map15p11NCBI
Nkx3-1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540346,806,178 - 46,836,310 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540346,807,846 - 46,809,924 (-)NCBIChiLan1.0ChiLan1.0
NKX3-1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2742,181,366 - 42,185,602 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1817,908,475 - 17,912,736 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0822,926,145 - 22,930,396 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1819,860,748 - 19,864,968 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl819,863,275 - 19,864,942 (-)Ensemblpanpan1.1panPan2
NKX3-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12533,815,343 - 33,817,465 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2533,815,095 - 33,817,474 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2534,403,094 - 34,405,850 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02534,021,324 - 34,024,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2534,021,202 - 34,024,073 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12533,968,569 - 33,971,325 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02533,822,490 - 33,825,246 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02533,977,508 - 33,980,265 (+)NCBIUU_Cfam_GSD_1.0
Nkx3-1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494311,461,374 - 11,484,403 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365557,088,577 - 7,091,334 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365557,087,677 - 7,091,334 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX3-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl147,783,323 - 7,787,033 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1147,783,296 - 7,787,036 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2148,625,545 - 8,630,189 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NKX3-1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1821,792,069 - 21,797,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl821,791,422 - 21,796,319 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605220,424,660 - 20,428,943 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkx3-1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475818,875,475 - 18,876,971 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475818,874,399 - 18,876,982 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1702
Count of miRNA genes:702
Interacting mature miRNAs:920
Transcripts:ENSMUST00000022646
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse

Markers in Region
PMC134699P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381469,190,942 - 69,191,162UniSTSGRCm38
MGSCv371469,808,999 - 69,809,219UniSTSGRCm37
Celera1466,971,312 - 66,971,532UniSTS
Cytogenetic Map14D2UniSTS
cM Map1430.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022646   ⟹   ENSMUSP00000022646
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1469,428,087 - 69,432,111 (+)Ensembl
GRCm38.p6 Ensembl1469,190,638 - 69,194,662 (+)Ensembl
RefSeq Acc Id: NM_010921   ⟹   NP_035051
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391469,428,141 - 69,432,107 (+)NCBI
GRCm381469,190,692 - 69,194,658 (+)ENTREZGENE
MGSCv371469,808,749 - 69,812,715 (+)RGD
Celera1466,971,062 - 66,975,028 (+)RGD
cM Map14 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035051   ⟸   NM_010921
- UniProtKB: O09087 (UniProtKB/Swiss-Prot),   P97436 (UniProtKB/Swiss-Prot),   Q3UVH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022646   ⟸   ENSMUST00000022646
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97436-F1-model_v2 AlphaFold P97436 1-237 view protein structure

Promoters
RGD ID:8682846
Promoter ID:EPDNEW_M19454
Type:multiple initiation site
Name:Nkx3-1_1
Description:Mus musculus NK3 homeobox 1 (Nkx3-1), mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381469,190,683 - 69,190,743EPDNEW
RGD ID:6825225
Promoter ID:MM_KWN:17329
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000022646
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361469,808,551 - 69,809,051 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97352 AgrOrtholog
Ensembl Genes ENSMUSG00000022061 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022646 ENTREZGENE
  ENSMUST00000022646.9 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97352 ENTREZGENE
NCBI Gene 18095 ENTREZGENE
PANTHER HOMEOBOX PROTEIN NKX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NKX-3.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nkx3-1 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NKX31_MOUSE UniProtKB/Swiss-Prot
  O09087 ENTREZGENE
  P97436 ENTREZGENE
  Q3UVH8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O09087 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Nkx3-1  NK3 homeobox 1    NK-3 transcription factor, locus 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED