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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,3-dinitrobenzene | increases expression | ISO | RGD:1311217 | 6480464 | 3-dinitrobenzene results in increased expression of VCL mRNA | CTD | PMID:21983209 | 17beta-estradiol | affects expression | ISO | RGD:1322560 | 6480464 | Estradiol affects the expression of VCL mRNA | CTD | PMID:22574217 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | increases expression | ISO | RGD:1322560 | 6480464 | Metribolone results in increased expression of VCL protein | CTD | PMID:17152098 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of VCL mRNA | CTD | PMID:15667827 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of VCL mRNA | CTD | PMID:21570461 | 2,6-dinitrotoluene | affects expression | ISO | RGD:1311217 | 6480464 | 2,6-dinitrotoluene affects the expression of VCL mRNA | CTD | PMID:21346803 | 2-butoxyethanol | increases expression | EXP | | 6480464 | n-butoxyethanol results in increased expression of VCL mRNA | CTD | PMID:19812364 | 2-methoxyethanol | increases expression | ISO | RGD:1311217 | 6480464 | methyl cellosolve results in increased expression of VCL mRNA | CTD | PMID:21061450 | 2-methylcholine | affects expression | ISO | RGD:1322560 | 6480464 | beta-methylcholine affects the expression of VCL mRNA | CTD | PMID:21179406 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | affects localization | EXP | | 6480464 | Puromycin Aminonucleoside affects the localization of VCL protein | CTD | PMID:19617259 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | increases expression | ISO | RGD:1311217 | 6480464 | Puromycin Aminonucleoside results in increased expression of VCL protein; more ... | CTD | PMID:19617259 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of VCL mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of VCL mRNA | CTD | PMID:18648102 | 4-vinylcyclohexene dioxide | affects expression | EXP | | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of VCL mRNA | CTD | PMID:20829426 | 5-fluorouracil | affects response to substance | ISO | RGD:1322560 | 6480464 | VCL protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | acetylsalicylic acid | decreases expression | ISO | RGD:1322560 | 6480464 | Aspirin results in decreased expression of VCL mRNA | CTD | PMID:11906190 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of VCL mRNA | CTD | PMID:16236135 | ammonium chloride | decreases expression | ISO | RGD:1311217 | 6480464 | Ammonium Chloride results in decreased expression of VCL protein | CTD | PMID:16483693 | aniline | increases nitrosation | ISO | RGD:1311217 | 6480464 | aniline results in increased nitrosation of VCL protein | CTD | PMID:21708182 | arsenic atom | decreases expression | ISO | RGD:1322560 | 6480464 | Arsenic results in decreased expression of VCL protein | CTD | PMID:19818359 | arsenic atom | increases expression | EXP | | 6480464 | Arsenic results in increased expression of VCL protein | CTD | PMID:22552367 | atrazine | multiple interactions | ISO | RGD:1322560 | 6480464 | [Atrazine co-treated with Arsenates] results in increased expression of VCL mRNA | CTD | PMID:18585445 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of VCL mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of VCL mRNA | CTD | PMID:21715664 PMID:22228805 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of VCL mRNA | CTD | PMID:21715664 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1311217 | 6480464 | Diethylhexyl Phthalate results in decreased expression of VCL mRNA | CTD | PMID:20920545 | cadmium dichloride | decreases methylation | ISO | RGD:1311217 | 6480464 | Cadmium Chloride results in decreased methylation of VCL promoter | CTD | PMID:22457795 | chloroprene | increases expression | ISO | RGD:1311217 | 6480464 | Chloroprene results in increased expression of VCL mRNA | CTD | PMID:23125180 | chromium(6+) | increases expression | EXP | | 6480464 | chromium hexavalent ion results in increased expression of VCL protein | CTD | PMID:22552367 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of VCL mRNA | CTD | PMID:21151649 | cobalt dichloride | decreases expression | ISO | RGD:1322560 | 6480464 | cobaltous chloride results in decreased expression of VCL mRNA | CTD | PMID:19320972 | copper atom | multiple interactions | EXP | | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of VCL mRNA | CTD | PMID:15467011 | copper(0) | multiple interactions | EXP | | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of VCL mRNA | CTD | PMID:15467011 | copper(2+) sulfate | increases expression | ISO | RGD:1322560 | 6480464 | Copper Sulfate results in increased expression of VCL mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1322560 | 6480464 | Cyclosporine results in decreased expression of VCL mRNA | CTD | PMID:22147139 | cyclosporin A | increases secretion | EXP | | 6480464 | Cyclosporine results in increased secretion of VCL protein | CTD | PMID:21354196 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of VCL mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of VCL mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:1311217 | 6480464 | Dibutyl Phthalate results in increased expression of VCL mRNA | CTD | PMID:21266533 | dioxygen | increases expression | ISO | RGD:1322560 | 6480464 | Oxygen deficiency results in increased expression of VCL mRNA | CTD | PMID:17914565 | ethanol | decreases expression | ISO | RGD:1311217 | 6480464 | Ethanol results in decreased expression of VCL protein | CTD | PMID:20837132 | fumonisin B1 | increases expression | EXP | | 6480464 | fumonisin B1 results in increased expression of VCL mRNA | CTD | PMID:16221962 | genistein | decreases expression | ISO | RGD:1322560 | 6480464 | Genistein results in decreased expression of VCL protein | CTD | PMID:20884965 | genistein | multiple interactions | ISO | RGD:1322560 | 6480464 | ESR2 promotes the reaction [Genistein results in decreased expression of VCL protein] | CTD | PMID:20884965 | hydrogen peroxide | affects expression | ISO | RGD:1322560 | 6480464 | Hydrogen Peroxide affects the expression of VCL protein | CTD | PMID:21179406 | naphthalene | increases reduction | EXP | | 6480464 | naphthalene results in increased reduction of VCL protein | CTD | PMID:19843705 | nickel atom | decreases expression | EXP | | 6480464 | Nickel results in decreased expression of VCL mRNA | CTD | PMID:18922574 | paracetamol | increases expression | ISO | RGD:1322560 | 6480464 | Acetaminophen results in increased expression of VCL mRNA | CTD | PMID:22230336 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of VCL mRNA | CTD | PMID:18301758 PMID:16221962 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of VCL mRNA | CTD | PMID:16221962 PMID:18301758 | pirinixic acid | multiple interactions | ISO | RGD:1322560 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of VCL mRNA | CTD | PMID:19710929 | resveratrol | affects expression | ISO | RGD:1322560 | 6480464 | resveratrol affects the expression of VCL protein | CTD | PMID:22234583 | simvastatin | affects localization | ISO | RGD:1311217 | 6480464 | Simvastatin affects the localization of VCL protein | CTD | PMID:22306966 | trans-resveratrol | affects expression | ISO | RGD:1322560 | 6480464 | resveratrol affects the expression of VCL protein | CTD | PMID:22234583 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of VCL mRNA | CTD | PMID:21427059 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of VCL mRNA | CTD | PMID:15345369 | vancomycin | decreases expression | EXP | | 6480464 | Vancomycin results in decreased expression of VCL mRNA | CTD | PMID:18930951 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Adherens junction |
| Amoebiasis | |
| Bacterial invasion of epithelial cells | |
| Focal adhesion | |
| Leukocyte transendothelial migration | |
| Regulation of actin cytoskeleton | |
| Pathway Interaction Database | Integrins in angiogenesis (PID:200128) |
| RhoA signaling pathway (PID:200009) | |
| Signaling events mediated by focal adhesion kinase (PID:200224) | |
| Signaling events mediated by VEGFR1 and VEGFR2 (PID:200188) | |
| Stabilization and expansion of the E-cadherin adherens junction (PID:200182) | |
Phenotype Annotations
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References - curated| 1. |
MGD data from the GO Consortium |
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MGD IEA |
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Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 4. |
Pashmforoush M, etal., Nat Med 2001 May;7(5):591-7. |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
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RGD automated import pipeline |
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RGD automated import pipeline for gene-chemical interactions |
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RGD Automated Pipelines |
| 10. |
Vasile VC, etal., Mol Genet Metab. 2006 Feb;87(2):169-74. Epub 2005 Oct 19. |
References - uncurated| PubMed | 10085297 |
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RGD Disease Portals| Vcl has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Vcl (Mus musculus) |
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| VCL (Homo sapiens) |
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| Vcl (Rattus norvegicus) |
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Position Markers| AW545629 |
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| D14Mit50 |
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| AI462105 |
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| D15M14Mit50 |
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| VCL |
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| BARC0060 |
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| Vcl |
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| Vcl |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_009502 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01112097 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01112098 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01112099 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01112100 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01112101 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01112102 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01112103 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01112104 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB041262 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC154840 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC163681 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK035184 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK077850 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK135530 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC008520 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC008554 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466613 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L13299 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L13300 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L18880 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_009502 | |||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_033528 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_033528 | (Get FASTA) |
| GenBank Protein | AAA40557 | (Get FASTA) |
| AAB96843 | (Get FASTA) | |
| AAH08520 | (Get FASTA) | |
| AAH08554 | (Get FASTA) | |
| BAB16378 | (Get FASTA) | |
| BAC28973 | (Get FASTA) | |
| BAC37033 | (Get FASTA) | |
| EDL01481 | (Get FASTA) | |
| EDL01482 | (Get FASTA) | |
| Q64727 | (Get FASTA) |
Promoters| RGD ID: | 6825518 | ||||||||||
| Promoter ID: | MM_KWN:15821 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen | ||||||||||
| Transcripts: | NM_009502, UC007SKY.1 | ||||||||||
| Position: |
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| RGD ID: | 6887870 | ||||||||||
| Promoter ID: | EPDNEW_M7386 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Vcl_1 | ||||||||||
| Description: | vinculin | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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| RGD ID: | 6825519 | ||||||||||
| Promoter ID: | MM_KWN:15823 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen | ||||||||||
| Transcripts: | ENSMUST00000090432 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000021823 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000022369 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000022369 | ENTREZGENE |
| Entrez Gene | 22330 | ENTREZGENE |
| Germonline | ENSMUSG00000021823 | |
| HomoloGene Group ID | 7594 | ENTREZGENE |
| InterPro | Vinculin | UniProtKB/Swiss-Prot |
| Vinculin/catenin | UniProtKB/Swiss-Prot | |
| Vinculin_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00405227 | UniProtKB/Swiss-Prot |
| IPI00623058 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:22330 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:98927 | ENTREZGENE |
| Pfam | Vinculin | UniProtKB/Swiss-Prot |
| PRINTS | VINCULIN | UniProtKB/Swiss-Prot |
| PROSITE | VINCULIN_1 | UniProtKB/Swiss-Prot |
| VINCULIN_2 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Vinculin/catenin | UniProtKB/Swiss-Prot |
| UniGene | Mm.279361 | ENTREZGENE |
| UniProt | Q9ESQ3_MOUSE | UniProtKB/TrEMBL |
| VINC_MOUSE | UniProtKB/Swiss-Prot |
| More on Vcl | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1322561 |
| Created: | 2005-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




