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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apigenin
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Accession:CHEBI:18388 term browser browse the term
Definition:A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Synonyms:related_synonym: 2-(p-hydroxyphenyl)-5,7-dihydroxychromone;   4',5,7-Trihydroxyflavone;   5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;   5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone;   5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;   C.I. Natural Yellow 1;   Formula=C15H10O5;   InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H;   InChIKey=KZNIFHPLKGYRTM-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1;   chamomile;   spigenin;   versulin
 alt_id: CHEBI:12084;   CHEBI:22588;   CHEBI:2768
 xref: Beilstein:262620;   CAS:520-36-5;   HMDB:HMDB0002124;   KEGG:C01477;   KNApSAcK:C00003817;   LINCS:LSM-5206;   LIPID_MAPS_instance:LMPK12110005
 xref_mesh: MESH:D047310
 xref: MetaCyc:CPD-431;   PDBeChem:AGI;   PMID:23304222;   PMID:23344191;   PMID:23354402;   PMID:23359392;   PMID:28166217;   Reaxys:262620;   Wikipedia:Apigenin
 cyclic_relationship: is_conjugate_acid_of CHEBI:58470


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apigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin multiple interactions ISO Apigenin inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein] CTD PMID:15618353 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases activity
multiple interactions		 ISO Apigenin results in decreased activity of ABCC1 protein
[Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Apigenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]		 CTD PMID:11306701 PMID:12485947 PMID:15670588 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Apigenin inhibits the reaction [Rotenone results in increased activity of ACHE protein] CTD PMID:28389404 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions EXP Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACSL4 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACSL4 protein] CTD PMID:35500696 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531 		JBrowse link
G Afg3l2 AFG3-like AAA ATPase 2 increases expression EXP Apigenin results in increased expression of AFG3L2 mRNA CTD PMID:22359648 NCBI chr18:67,537,830...67,582,277
Ensembl chr18:67,537,834...67,582,242 		JBrowse link
G Afp alpha fetoprotein affects binding ISO Apigenin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions EXP
ISO		 Apigenin binds to and results in increased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
Apigenin binds to and results in decreased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]		 CTD PMID:14644660 PMID:17869316 PMID:20450880 PMID:29584932 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein multiple interactions EXP Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]] CTD PMID:20450880 NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases expression		 ISO [Apigenin co-treated with Fluorouracil] results in decreased expression of AKT1 protein
Apigenin results in decreased expression of AKT1 protein		 CTD PMID:15947208 PMID:19885610 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of APAF1 protein
Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 mRNA]		 CTD PMID:24070738 PMID:30107153 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Ar androgen receptor multiple interactions ISO Apigenin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 increases expression EXP Apigenin results in increased expression of ARHGAP29 mRNA CTD PMID:22359648 NCBI chr 3:121,746,752...121,810,326
Ensembl chr 3:121,746,190...121,810,402 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP
ISO		 Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]		 CTD PMID:20450880 NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of ATF6 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein] CTD PMID:20493918 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]; Glutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein] CTD PMID:29247770 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G B3galt5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 increases expression ISO Apigenin results in increased expression of B3GALT5 protein CTD PMID:22906706 NCBI chr16:96,037,001...96,121,059
Ensembl chr16:96,037,001...96,121,059 		JBrowse link
G Bax BCL2-associated X protein decreases expression
multiple interactions		 ISO Apigenin results in decreased expression of BAX protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of BAX protein; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of BAX protein]; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of BAX mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of BAX protein		 CTD PMID:24070738 PMID:24144774 PMID:25557508 PMID:30107153 PMID:30152906 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
decreases response to substance		 ISO Apigenin results in decreased expression of BCL2 protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of BCL2 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in decreased expression of BCL2 mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in decreased expression of BCL2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BCL2 protein
BCL2 protein results in decreased susceptibility to Apigenin		 CTD PMID:15486995 PMID:24070738 PMID:25557508 PMID:29247770 PMID:30107153 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions		 ISO Apigenin results in decreased expression of BCL2L1 protein
Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 protein]		 CTD PMID:24144774 PMID:30152906 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO Apigenin inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA] CTD PMID:28389404 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Becn1 beclin 1, autophagy related increases expression
multiple interactions		 EXP Apigenin results in increased expression of BECN1 protein
Apigenin promotes the reaction [Fluorouracil results in increased expression of BECN1 protein]; Fluorouracil promotes the reaction [Apigenin results in increased expression of BECN1 protein]		 CTD PMID:28025107 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO Apigenin results in increased expression of BID protein CTD PMID:24144774 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC2 protein CTD PMID:29247770 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases cleavage
multiple interactions		 ISO Apigenin results in increased cleavage of BIRC3 protein
[TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC3 protein		 CTD PMID:15486995 PMID:29247770 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like increases expression EXP Apigenin results in increased expression of BNIP3L mRNA CTD PMID:22359648 NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of CASP1 protein modified form] CTD PMID:29960001 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp12 caspase 12 multiple interactions EXP Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP12 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein] CTD PMID:20493918 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 ISO
EXP		 [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP3 protein; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]
Apigenin results in increased activity of CASP3 protein
Apigenin results in increased cleavage of CASP3 protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of CASP3 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of CASP3 protein]; Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP3 protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP3 protein]
Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP3 protein]		 CTD PMID:15486995 PMID:17132221 PMID:19397994 PMID:19647729 PMID:19885610 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 increases cleavage
increases activity		 ISO Apigenin results in increased cleavage of CASP7 protein
Apigenin results in increased activity of CASP7 protein		 CTD PMID:15486995 PMID:19647729 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
increases activity		 ISO Apigenin results in increased cleavage of CASP8 protein
[TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein
Apigenin results in increased activity of CASP8 protein
Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP8 protein]; Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP8 protein]; hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP8 protein]		 CTD PMID:15486995 PMID:24144774 PMID:29247770 PMID:30152906 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
multiple interactions		 ISO
EXP		 Apigenin results in increased cleavage of CASP9 protein
Apigenin results in increased activity of CASP9 protein
Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP9 protein]
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP9 protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of CASP9 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP9 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP9 mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP9 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP9 protein		 CTD PMID:15486995 PMID:19397994 PMID:24070738 PMID:25557508 PMID:28025107 More... NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase decreases expression
multiple interactions
increases activity
increases expression
decreases response to substance		 ISO
EXP		 Apigenin results in decreased expression of CAT mRNA
Apigenin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Apigenin inhibits the reaction [Rotenone results in decreased activity of CAT protein]
Apigenin results in increased activity of CAT protein
Apigenin results in increased expression of CAT mRNA
CAT protein results in decreased susceptibility to Apigenin		 CTD PMID:21756884 PMID:22359648 PMID:28389404 PMID:30152906 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Apigenin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions		 ISO Apigenin results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA]		 CTD PMID:23384675 NCBI chr 2:163,662,724...163,675,066
Ensembl chr 2:163,662,781...163,675,066 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Apigenin results in decreased expression of CCNB1 mRNA; Apigenin results in decreased expression of CCNB1 protein CTD PMID:19397994 PMID:26961604 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Cd40 CD40 antigen multiple interactions ISO Apigenin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO Apigenin results in decreased expression of CDC25C protein CTD PMID:26961604 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586 		JBrowse link
G Cdk1 cyclin dependent kinase 1 multiple interactions
decreases expression		 ISO Apigenin results in increased phosphorylation of and results in decreased activity of CDK1 protein
Apigenin results in decreased expression of CDK1 protein		 CTD PMID:11322924 PMID:26872304 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 increases expression EXP Apigenin results in increased expression of CDKAL1 mRNA CTD PMID:22359648 NCBI chr13:29,375,729...30,039,665
Ensembl chr13:29,375,729...30,039,657 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO Apigenin promotes the reaction [CDKN1A protein binds to PCNA protein]; TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein]
Apigenin results in increased expression of CDKN1A mRNA
Apigenin results in increased expression of CDKN1A mRNA; Apigenin results in increased expression of CDKN1A protein		 CTD PMID:11790449 PMID:16023288 PMID:19397994 PMID:26872304 PMID:31201582 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C increases expression ISO Apigenin results in increased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression EXP Apigenin results in decreased expression of CEBPB mRNA CTD PMID:18359623 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO Apigenin results in decreased activity of CES1 protein CTD PMID:37353134 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator increases activity
affects localization		 ISO Apigenin results in increased activity of CFTR protein; Apigenin results in increased activity of CFTR protein mutant form
Apigenin affects the localization of CFTR protein mutant form		 CTD PMID:15191910 PMID:15277574 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions ISO Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein] CTD PMID:25935278 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919 		JBrowse link
G Ckm creatine kinase, muscle multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of CKM protein] CTD PMID:25557508 NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766 		JBrowse link
G Clca1 chloride channel accessory 1 decreases expression EXP Apigenin results in decreased expression of CLCA1 mRNA CTD PMID:22359648 NCBI chr 3:144,710,298...144,738,537
Ensembl chr 3:144,709,578...144,738,537 		JBrowse link
G Cox17 cytochrome c oxidase assembly protein 17, copper chaperone multiple interactions ISO Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of COX17 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of COX17 protein] CTD PMID:30107153 NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions		 ISO Apigenin results in increased expression of CXCL12 mRNA
ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA]		 CTD PMID:23384675 PMID:28396216 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions		 ISO Apigenin affects the localization of CYCS protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CYCS protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] affects the localization of CYCS protein		 CTD PMID:15486995 PMID:24070738 PMID:30152906 PMID:31930969 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO Apigenin results in decreased expression of CYP11A1 mRNA CTD PMID:31201582 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] CTD PMID:23370353 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
decreases expression		 ISO Apigenin results in decreased activity of CYP19A1 protein
Apigenin results in decreased expression of CYP19A1 mRNA		 CTD PMID:10403137 PMID:15319488 PMID:16023337 PMID:16965912 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression		 ISO
EXP		 Apigenin binds to and results in decreased activity of CYP1A1 protein; Apigenin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Apigenin results in decreased activity of CYP1A1 protein
Apigenin results in increased expression of CYP1A1 mRNA
Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Apigenin promotes the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]		 CTD PMID:11454723 PMID:11752233 PMID:16271822 PMID:17012224 PMID:17090139 More... NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Apigenin results in decreased activity of CYP1A2 protein CTD PMID:20806393 PMID:21053930 PMID:29753067 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
increases expression
multiple interactions
increases chemical synthesis		 ISO
EXP		 Apigenin results in decreased activity of CYP1B1 protein
Apigenin results in increased expression of CYP1B1 mRNA
Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]
CYP1B1 protein results in increased chemical synthesis of Apigenin
[CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin; Apigenin binds to and results in decreased activity of CYP1B1 protein		 CTD PMID:16271822 PMID:19666078 PMID:20930378 PMID:21053930 PMID:21482471 More... NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 multiple interactions ISO Apigenin inhibits the reaction [Colforsin results in increased expression of CYP21A2 mRNA] CTD PMID:23370353 NCBI chr17:35,020,322...35,023,400
Ensembl chr17:35,020,322...35,023,535 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions
decreases activity		 ISO Apigenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]
Apigenin results in decreased activity of CYP2C9 protein		 CTD PMID:21053930 PMID:29753067 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 EXP
ISO		 Apigenin inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein]
Apigenin results in decreased activity of CYP2E1 protein		 CTD PMID:28803762 PMID:29753067 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Apigenin inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] CTD PMID:20493918 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions EXP Apigenin inhibits the reaction [Alcohols results in increased expression of DGAT1 protein] CTD PMID:28803762 NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Apigenin results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr11:84,711,547...84,719,880
Ensembl chr11:84,711,682...84,719,820 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Apigenin inhibits the reaction [Rotenone results in decreased expression of DRD2 protein] CTD PMID:28389404 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Duox1 dual oxidase 1 decreases expression EXP Apigenin results in decreased expression of DUOX1 mRNA CTD PMID:22359648 NCBI chr 2:122,143,525...122,178,454
Ensembl chr 2:122,146,153...122,178,453 		JBrowse link
G Ear1 eosinophil-associated, ribonuclease A family, member 1 multiple interactions EXP Apigenin inhibits the reaction [Ovalbumin results in increased secretion of RNASE3 protein] CTD PMID:36350155 NCBI chr14:44,056,222...44,057,096
Ensembl chr14:44,056,222...44,112,974 		JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression EXP Apigenin results in increased expression of EIF5B mRNA CTD PMID:22359648 NCBI chr 1:38,037,091...38,094,660
Ensembl chr 1:38,037,091...38,094,660 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Epo erythropoietin increases expression ISO Apigenin results in increased expression of EPO mRNA CTD PMID:37348668 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO [Apigenin co-treated with Fluorouracil] results in decreased expression of ERBB2 protein CTD PMID:19885610 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 multiple interactions EXP Apigenin inhibits the reaction [Brefeldin A results in increased phosphorylation of ERN1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein] CTD PMID:20493918 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression EXP Apigenin results in increased expression of ERP29 mRNA CTD PMID:22359648 NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
increases phosphorylation
increases activity
decreases expression
affects binding		 ISO Apigenin binds to and results in increased activity of ESR1 protein; Apigenin inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA]
Apigenin results in increased phosphorylation of ESR1 protein
Apigenin results in increased activity of ESR1 protein
Apigenin results in decreased expression of ESR1 protein
Apigenin binds to ESR1 protein		 CTD PMID:14579009 PMID:16118406 PMID:16541309 PMID:16860978 PMID:17323972 More... NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
affects binding
increases activity		 ISO Apigenin binds to and results in increased activity of ESR2 protein; Apigenin inhibits the reaction [Estradiol binds to ESR2 protein]
Apigenin binds to ESR2 protein
Apigenin results in increased activity of ESR2 protein		 CTD PMID:9751507 PMID:12224631 PMID:16118406 PMID:16860978 PMID:17132221 More... NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G F2 coagulation factor II multiple interactions ISO Apigenin inhibits the reaction [F2 protein results in increased localization of Calcium] CTD PMID:19814731 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Fas Fas cell surface death receptor decreases expression
multiple interactions		 EXP
ISO		 Apigenin results in decreased expression of FAS mRNA
Apigenin inhibits the reaction [Isoproterenol results in increased expression of FAS protein]		 CTD PMID:18359623 PMID:30152906 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Apigenin inhibits the reaction [Alcohols results in increased expression of FASN protein] CTD PMID:28803762 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fbp1 fructose bisphosphatase 1 decreases expression ISO Apigenin results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Apigenin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA] CTD PMID:26800359 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Apigenin results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of FOS protein]; Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA] CTD PMID:15322261 PMID:22634262 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Frmd4a FERM domain containing 4A increases expression EXP Apigenin results in increased expression of FRMD4A mRNA CTD PMID:22359648 NCBI chr 2:4,022,461...4,618,854
Ensembl chr 2:4,022,528...4,618,854 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions
increases expression		 EXP Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of FTH1 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of FTH1 protein]
Apigenin results in increased expression of FTH1 mRNA; Apigenin results in increased expression of FTH1 protein		 CTD PMID:35500696 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462 		JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions EXP Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of FTL mRNA] CTD PMID:35500696 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308 		JBrowse link
G Gata3 GATA binding protein 3 multiple interactions EXP Apigenin inhibits the reaction [Ovalbumin results in increased expression of GATA3 mRNA]; Apigenin inhibits the reaction [Ovalbumin results in increased expression of GATA3 protein] CTD PMID:36350155 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO Apigenin results in increased expression of GCLC mRNA
[Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
Apigenin results in increased expression of GCLC mRNA; Apigenin results in increased expression of GCLC protein		 CTD PMID:11864778 PMID:22864849 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression
multiple interactions		 ISO Apigenin results in increased expression of GCLM mRNA; Apigenin results in increased expression of GCLM protein
[Apigenin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide		 CTD PMID:22864849 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor multiple interactions ISO Apigenin inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA] CTD PMID:28389404 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gli1 GLI-Kruppel family member GLI1 decreases expression EXP Apigenin results in decreased expression of GLI1 mRNA; Apigenin results in decreased expression of GLI1 protein CTD PMID:20395211 NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843 		JBrowse link
G Gm20348 predicted gene, 20348 increases expression ISO Apigenin results in increased expression of TP53I3 mRNA; Apigenin results in increased expression of TP53I3 protein CTD PMID:19397994 NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression EXP Apigenin results in increased expression of GPX1 mRNA CTD PMID:22359648 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
affects binding
increases expression		 EXP Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GPX4 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GPX4 protein]
Apigenin binds to GPX4 protein
Apigenin results in increased expression of GPX4 mRNA; Apigenin results in increased expression of GPX4 protein		 CTD PMID:35500696 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Greb1 gene regulated by estrogen in breast cancer protein increases expression
multiple interactions		 ISO Apigenin results in increased expression of GREB1 mRNA
Fulvestrant inhibits the reaction [Apigenin results in increased expression of GREB1 mRNA]		 CTD PMID:33405908 NCBI chr12:16,720,616...16,851,395
Ensembl chr12:16,720,616...16,850,887 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO
EXP		 Apigenin inhibits the reaction [Rotenone results in decreased activity of GSR protein]
Apigenin inhibits the reaction [Alcohols results in decreased expression of GSR protein]		 CTD PMID:28389404 PMID:28803762 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gypa glycophorin A increases expression ISO Apigenin results in increased expression of GYPA protein CTD PMID:25058688 NCBI chr 8:81,220,674...81,237,414
Ensembl chr 8:81,220,410...81,237,171 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Apigenin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858 		JBrowse link
G Hexa hexosaminidase A multiple interactions EXP
ISO		 Apigenin inhibits the reaction [Ovalbumin results in increased secretion of HEXA protein]
Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein]		 CTD PMID:36350155 NCBI chr 9:59,446,966...59,472,392
Ensembl chr 9:59,446,823...59,472,392 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit decreases expression
increases expression
multiple interactions
decreases activity		 ISO Apigenin results in decreased expression of HIF1A protein
Apigenin results in increased expression of HIF1A mRNA; Apigenin results in increased expression of HIF1A protein
Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]
[Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A mRNA; [Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein; Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; Apigenin inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; Apigenin results in decreased degradation of and results in increased expression of HIF1A protein modified form; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [[Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein]; Cycloheximide affects the reaction [[Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein]
Apigenin results in decreased activity of HIF1A protein		 CTD PMID:15947208 PMID:19958256 PMID:20153296 PMID:31930969 PMID:35513012 More... NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]] CTD PMID:36055550 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression		 EXP
ISO		 Apigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
[Apigenin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
Apigenin results in increased expression of HMOX1 mRNA; Apigenin results in increased expression of HMOX1 protein
Apigenin results in decreased expression of HMOX1 protein		 CTD PMID:16109301 PMID:22864849 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression ISO Apigenin results in decreased expression of HSD17B7 mRNA CTD PMID:31201582 NCBI chr 1:169,777,109...169,796,757
Ensembl chr 1:169,777,104...169,796,810 		JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 multiple interactions EXP Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSP90B1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSP90B1 protein] CTD PMID:20493918 NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373 		JBrowse link
G Hspa1a heat shock protein 1A decreases expression EXP Apigenin results in decreased expression of HSPA1A mRNA CTD PMID:22359648 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa1b heat shock protein 1B affects expression EXP Apigenin affects the expression of HSPA1B mRNA CTD PMID:22359648 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Hspa1l heat shock protein 1-like decreases expression EXP Apigenin results in decreased expression of HSPA1L mRNA CTD PMID:22359648 NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261 		JBrowse link
G Hspa2 heat shock protein 2 decreases expression EXP Apigenin results in decreased expression of HSPA2 mRNA CTD PMID:22359648 NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions
decreases expression		 EXP Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]
Apigenin results in decreased expression of HSPA5 mRNA		 CTD PMID:20493918 PMID:22359648 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Hspa8 heat shock protein 8 decreases expression EXP Apigenin results in decreased expression of HSPA8 mRNA; Apigenin results in decreased expression of HSPA8 protein CTD PMID:22359648 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15113938 PMID:15322261 PMID:16987811 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha decreases expression EXP Apigenin results in decreased expression of IDH3A mRNA CTD PMID:22359648 NCBI chr 9:54,493,795...54,511,946
Ensembl chr 9:54,493,618...54,511,945 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP		 Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
Apigenin inhibits the reaction [Ovalbumin results in decreased secretion of IFNG protein]		 CTD PMID:18090225 PMID:36350155 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO
EXP		 Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]; Apigenin results in decreased expression of and results in decreased activity of IKBKB protein; Apigenin results in decreased phosphorylation of and results in decreased activity of IKBKB protein; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]]
Apigenin inhibits the reaction [Ovalbumin results in increased phosphorylation of IKBKB protein]
Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]		 CTD PMID:24148603 PMID:25557508 PMID:25935278 PMID:36350155 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP
ISO		 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
Apigenin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]		 CTD PMID:16934226 PMID:30016632 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12b interleukin 12b multiple interactions ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B protein]] CTD PMID:28673093 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il13 interleukin 13 multiple interactions EXP Apigenin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:36350155 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 Apigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL1B mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Apigenin inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL1B mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Poly dA-dT results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin promotes the reaction [Antigens, Bacterial results in increased cleavage of and results in increased secretion of IL1B protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of IL1B protein]		 CTD PMID:15985724 PMID:18090225 PMID:24134915 PMID:25557508 PMID:25935278 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il33 interleukin 33 multiple interactions ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL33 mRNA]; Apigenin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA] CTD PMID:37545493 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions		 ISO
EXP		 Apigenin results in decreased expression of IL4 protein
Apigenin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein]
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL4 protein]		 CTD PMID:16343431 PMID:36350155 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP Apigenin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] CTD PMID:36350155 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]
Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL6 mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL6 mRNA]]; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]		 CTD PMID:24134915 PMID:25557508 PMID:25935278 PMID:28389404 PMID:30016632 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions EXP
ISO		 Apigenin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; Apigenin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]		 CTD PMID:18090225 PMID:18591783 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Jun jun proto-oncogene multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA] CTD PMID:15322261 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 multiple interactions ISO (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]] CTD PMID:31930969 NCBI chr 6:126,509,514...126,512,518
Ensembl chr 6:126,509,514...126,512,375 		JBrowse link
G Kdm3a lysine (K)-specific demethylase 3A increases expression EXP Apigenin results in increased expression of KDM3A mRNA CTD PMID:22359648 NCBI chr 6:71,565,954...71,609,963
Ensembl chr 6:71,565,956...71,609,974 		JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions ISO [Apigenin co-treated with Oxygen deficiency] affects the phosphorylation of KDR protein CTD PMID:35513012 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Lamb2 laminin, beta 2 increases expression ISO Apigenin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 9:108,357,080...108,367,729
Ensembl chr 9:108,356,935...108,367,729 		JBrowse link
G Lep leptin increases expression EXP Apigenin results in increased expression of LEP mRNA; Apigenin results in increased expression of LEP protein CTD PMID:18359623 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lmbr1l limb region 1 like increases expression EXP Apigenin results in increased expression of LMBR1L mRNA CTD PMID:22359648 NCBI chr15:98,801,798...98,815,944
Ensembl chr15:98,801,798...98,816,112 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 multiple interactions EXP Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of LPCAT3 mRNA] CTD PMID:35500696 NCBI chr 6:124,639,887...124,681,142
Ensembl chr 6:124,639,990...124,681,381 		JBrowse link
G Lrrc26 leucine rich repeat containing 26 increases expression EXP Apigenin results in increased expression of LRRC26 mRNA CTD PMID:22359648 NCBI chr 2:25,179,923...25,181,205
Ensembl chr 2:25,179,927...25,181,192 		JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 decreases expression EXP Apigenin results in decreased expression of LTBP1 mRNA CTD PMID:22359648 NCBI chr17:75,312,475...75,699,507
Ensembl chr17:75,312,563...75,699,507 		JBrowse link
G Ltf lactotransferrin increases expression ISO Apigenin results in increased expression of LTF protein CTD PMID:24487097 NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form]; Glutathione inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form] CTD PMID:29247770 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
increases activity		 ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Apigenin results in increased phosphorylation of and results in increased activity of MAPK1 protein
Apigenin results in decreased phosphorylation of MAPK1 protein
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Apigenin results in increased activity of MAPK1 protein		 CTD PMID:15322261 PMID:19647729 PMID:22864849 PMID:25557508 PMID:27468969 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Apigenin results in increased phosphorylation of and results in increased activity of MAPK3 protein
Apigenin results in decreased phosphorylation of MAPK3 protein
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]		 CTD PMID:19647729 PMID:25557508 PMID:27468969 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of MAPK8 protein] CTD PMID:25557508 PMID:35373622 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:25557508 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression
multiple interactions		 EXP Apigenin results in decreased expression of MCL1 mRNA
Apigenin promotes the reaction [Fluorouracil results in decreased expression of MCL1 mRNA]; Fluorouracil promotes the reaction [Apigenin results in decreased expression of MCL1 mRNA]		 CTD PMID:28025107 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Met met proto-oncogene decreases phosphorylation ISO Apigenin results in decreased phosphorylation of MET protein CTD PMID:27468969 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979 		JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 increases expression EXP Apigenin results in increased expression of MIB1 mRNA CTD PMID:22359648 NCBI chr18:10,725,523...10,822,969
Ensembl chr18:10,725,548...10,818,704 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) decreases expression ISO Apigenin results in decreased expression of MMP1 mRNA; Apigenin results in decreased expression of MMP1 protein CTD PMID:21112745 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Apigenin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:26408079 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] CTD PMID:22634262 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase multiple interactions ISO Apigenin inhibits the reaction [Methylmercury Compounds results in decreased expression of MPG protein] CTD PMID:35373622 NCBI chr11:32,176,505...32,182,702
Ensembl chr11:32,176,505...32,182,700 		JBrowse link
G mt-Atp6 ATP synthase 6, mitochondrial multiple interactions ISO Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6 protein] CTD PMID:30107153 NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607 		JBrowse link
G mt-Atp8 ATP synthase 8, mitochondrial multiple interactions ISO Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP8 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP8 protein] CTD PMID:30107153 NCBI chr MT:7,766...7,969
Ensembl chr MT:7,766...7,969 		JBrowse link
G Mybl1 myeloblastosis oncogene-like 1 increases expression
multiple interactions		 ISO Apigenin results in increased expression of MYBL1 mRNA
Fulvestrant inhibits the reaction [Apigenin results in increased expression of MYBL1 mRNA]		 CTD PMID:33405908 NCBI chr 1:9,737,632...9,770,664
Ensembl chr 1:9,737,640...9,770,434 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO
EXP		 Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]
Apigenin inhibits the reaction [Ovalbumin results in increased expression of MYD88 protein]		 CTD PMID:36055550 PMID:36350155 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO Apigenin results in decreased expression of NANOG protein CTD PMID:27468969 NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592 		JBrowse link
G Ndufa4 Ndufa4, mitochondrial complex associated multiple interactions ISO Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of NDUFA4 mRNA] CTD PMID:30107153 NCBI chr 6:11,900,371...11,907,449
Ensembl chr 6:11,900,291...11,907,496 		JBrowse link
G Neo1 neogenin increases expression EXP Apigenin results in increased expression of NEO1 mRNA CTD PMID:22359648 NCBI chr 9:58,781,962...58,943,926
Ensembl chr 9:58,781,970...58,943,724 		JBrowse link
G Nfat5 nuclear factor of activated T cells 5 multiple interactions ISO Apigenin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA] CTD PMID:26800359 NCBI chr 8:108,020,072...108,106,149
Ensembl chr 8:108,020,102...108,106,149 		JBrowse link
G Nfe2 nuclear factor, erythroid derived 2 decreases expression ISO Apigenin results in decreased expression of NFE2 mRNA CTD PMID:31201582 NCBI chr15:103,156,640...103,166,809
Ensembl chr15:103,156,639...103,166,830 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Apigenin affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:22864849 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
affects localization		 ISO Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]
Apigenin affects the localization of NFKB1 protein
Apigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein]		 CTD PMID:18090225 PMID:24148603 PMID:28389404 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 protein] CTD PMID:25557508 NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
affects degradation		 ISO
EXP		 Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Apigenin affects the degradation of NFKBIA protein
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in decreased expression of NFKBIA protein]
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [Ovalbumin results in increased phosphorylation of NFKBIA protein]		 CTD PMID:15322261 PMID:16934226 PMID:18090225 PMID:24148603 PMID:25557508 More... NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] CTD PMID:15322261 NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of NLRP3 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of NLRP3 protein]] CTD PMID:36055550 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]		 CTD PMID:11343698 PMID:12512693 PMID:16934226 PMID:18090225 PMID:28389404 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Apigenin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO
EXP		 Apigenin results in increased activity of NR1I2 protein
Apigenin binds to and results in increased activity of NR1I2 protein		 CTD PMID:25455453 PMID:33049310 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like decreases expression ISO Apigenin results in decreased expression of NSDHL mRNA CTD PMID:31201582 NCBI chr  X:71,962,127...72,002,134
Ensembl chr  X:71,962,163...72,002,120 		JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 multiple interactions ISO Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein] CTD PMID:25935278 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495 		JBrowse link
G Pank2 pantothenate kinase 2 decreases expression EXP Apigenin results in decreased expression of PANK2 mRNA CTD PMID:22359648 NCBI chr 2:131,103,928...131,141,108
Ensembl chr 2:131,104,415...131,141,108 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage		 EXP
ISO		 Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of PARP1 protein]; Apigenin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of PARP1 protein]
Apigenin results in increased cleavage of PARP1 protein
[Apigenin co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile] results in increased cleavage of PARP1 protein; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased cleavage of PARP1 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of PARP1 protein		 CTD PMID:20493918 PMID:22155090 PMID:24070738 PMID:24148603 PMID:29247770 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Apigenin promotes the reaction [CDKN1A protein binds to PCNA protein] CTD PMID:26872304 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide multiple interactions ISO [Apigenin co-treated with Oxygen deficiency] affects the phosphorylation of PDGFRB protein CTD PMID:35513012 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Pgr progesterone receptor affects binding
multiple interactions		 ISO Apigenin binds to PGR protein
Apigenin inhibits the reaction [Progesterone binds to PGR protein]		 CTD PMID:14579009 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Pkm pyruvate kinase, muscle multiple interactions ISO Apigenin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658 		JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 decreases expression EXP Apigenin results in decreased expression of PKMYT1 mRNA CTD PMID:22359648 NCBI chr17:23,945,385...23,955,709
Ensembl chr17:23,945,310...23,955,709 		JBrowse link
G Polr2h polymerase (RNA) II (DNA directed) polypeptide H increases expression EXP Apigenin results in increased expression of POLR2H mRNA CTD PMID:22359648 NCBI chr16:20,536,552...20,541,015
Ensembl chr16:20,536,415...20,541,017 		JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 decreases expression ISO Apigenin results in decreased expression of POU5F1 protein CTD PMID:22906706 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Apigenin inhibits the reaction [Alcohols results in decreased expression of PPARA protein] CTD PMID:28803762 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
decreases expression		 EXP
ISO		 Apigenin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
Apigenin results in decreased expression of PPARG mRNA		 CTD PMID:11343698 PMID:18359623 PMID:33049310 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit multiple interactions ISO Apigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein] CTD PMID:16873680 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Prom1 prominin 1 decreases expression ISO Apigenin results in decreased expression of PROM1 protein CTD PMID:27468969 NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374 		JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 increases expression EXP Apigenin results in increased expression of PRPSAP1 mRNA CTD PMID:22359648 NCBI chr11:116,361,641...116,385,739
Ensembl chr11:116,361,671...116,385,461 		JBrowse link
G Psca prostate stem cell antigen decreases expression ISO Apigenin results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr15:74,586,688...74,588,914
Ensembl chr15:74,586,688...74,588,918 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 EXP
ISO		 Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
Apigenin results in decreased expression of PTGS2 protein
Apigenin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein]
Apigenin affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:11343698 PMID:16552572 PMID:30152906 PMID:35500696 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta multiple interactions ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] CTD PMID:29960001 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Apigenin inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]] CTD PMID:29960001 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Ranbp10 RAN binding protein 10 increases expression EXP Apigenin results in increased expression of RANBP10 mRNA CTD PMID:22359648 NCBI chr 8:106,494,940...106,560,463
Ensembl chr 8:106,494,940...106,553,982 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases expression
multiple interactions
affects localization		 ISO
EXP		 Apigenin results in increased expression of RELA protein
Apigenin inhibits the reaction [Alcohols results in increased expression of RELA protein]
Apigenin affects the localization of RELA protein
Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of RELA protein]		 CTD PMID:15090468 PMID:15113938 PMID:18090225 PMID:22634262 PMID:24148603 More... NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 decreases expression ISO Apigenin results in decreased expression of RPS6KB1 protein CTD PMID:15947208 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR1 protein] CTD PMID:25557508 NCBI chr 3:115,504,082...115,508,704
Ensembl chr 3:115,504,082...115,508,721 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR2 protein] CTD PMID:25557508 NCBI chr 9:20,877,248...20,888,089
Ensembl chr 9:20,873,657...20,888,077 		JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR3 protein] CTD PMID:25557508 NCBI chr13:51,562,654...51,576,833
Ensembl chr13:51,562,675...51,576,833 		JBrowse link
G Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) multiple interactions ISO Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of SDHA mRNA] CTD PMID:30107153 NCBI chr13:74,470,374...74,498,359
Ensembl chr13:74,470,373...74,498,399 		JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:15113938 PMID:16987811 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Sf3b2 splicing factor 3b, subunit 2 increases expression EXP Apigenin results in increased expression of SF3B2 mRNA CTD PMID:22359648 NCBI chr19:5,323,949...5,345,485
Ensembl chr19:5,323,960...5,345,483 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Apigenin binds to SHBG protein CTD PMID:25349334 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731 		JBrowse link
G Slain2 SLAIN motif family, member 2 increases expression EXP Apigenin results in increased expression of SLAIN2 mRNA CTD PMID:22359648 NCBI chr 5:73,071,705...73,136,184
Ensembl chr 5:73,071,647...73,136,172 		JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO [Apigenin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 multiple interactions
decreases expression		 ISO Apigenin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]
Apigenin results in decreased expression of SLC2A1 mRNA; Apigenin results in decreased expression of SLC2A1 protein		 CTD PMID:36870413 PMID:37437745 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 multiple interactions
decreases expression		 ISO [Apigenin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA
Apigenin results in decreased expression of SLC2A3 mRNA; Apigenin results in decreased expression of SLC2A3 protein		 CTD PMID:20153296 PMID:37437745 NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions EXP Apigenin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 multiple interactions
decreases expression		 EXP Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC3A2 mRNA]
Apigenin results in decreased expression of SLC3A2 mRNA		 CTD PMID:35500696 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733 		JBrowse link
G Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 multiple interactions ISO Apigenin analog inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] CTD PMID:17495124 NCBI chr 5:33,261,563...33,320,043
Ensembl chr 5:33,261,563...33,320,214 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions EXP Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC7A11 mRNA] CTD PMID:35500696 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Slf2 SMC5-SMC6 complex localization factor 2 decreases expression EXP Apigenin results in decreased expression of SLF2 mRNA CTD PMID:22359648 NCBI chr19:44,906,948...44,972,225
Ensembl chr19:44,919,558...44,972,225 		JBrowse link
G Snca synuclein, alpha multiple interactions ISO Apigenin inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:28389404 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Apigenin results in increased expression of SOCS3 mRNA CTD PMID:23782265 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression EXP Apigenin results in decreased expression of SOD1 mRNA; Apigenin results in decreased expression of SOD1 protein CTD PMID:22359648 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 decreases expression ISO Apigenin results in decreased expression of SOX2 protein CTD PMID:27468969 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:25557508 NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501 		JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 increases expression EXP Apigenin results in increased expression of SPTBN1 mRNA CTD PMID:22359648 NCBI chr11:30,049,395...30,218,384
Ensembl chr11:30,049,395...30,218,175 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Apigenin inhibits the reaction [Alcohols results in increased expression of SREBF1 protein] CTD PMID:28803762 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions		 ISO Apigenin results in decreased phosphorylation of STAT3 protein
Apigenin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]		 CTD PMID:20153296 PMID:27468969 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 multiple interactions ISO Apigenin inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA] CTD PMID:22414680 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453 		JBrowse link
G Syk spleen tyrosine kinase multiple interactions ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein] CTD PMID:29960001 NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828 		JBrowse link
G Tbx21 T-box 21 multiple interactions EXP Apigenin inhibits the reaction [Ovalbumin results in decreased expression of TBX21 mRNA]; Apigenin inhibits the reaction [Ovalbumin results in decreased expression of TBX21 protein] CTD PMID:36350155 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
G Tecr trans-2,3-enoyl-CoA reductase increases expression EXP Apigenin results in increased expression of TECR mRNA CTD PMID:22359648 NCBI chr 8:84,298,327...84,321,120
Ensembl chr 8:84,298,327...84,334,600 		JBrowse link
G Tfpt TCF3 (E2A) fusion partner decreases expression EXP Apigenin results in decreased expression of TFPT mRNA CTD PMID:22359648 NCBI chr 7:3,623,323...3,632,911
Ensembl chr 7:3,623,323...3,632,928 		JBrowse link
G Tfrc transferrin receptor multiple interactions EXP Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TFRC protein] CTD PMID:35500696 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Apigenin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:28389404 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Apigenin binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Apigenin binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO
EXP		 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Apigenin inhibits the reaction [Ovalbumin results in increased expression of TLR4 protein]		 CTD PMID:36350155 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 decreases expression ISO Apigenin results in decreased expression of TM7SF2 mRNA CTD PMID:31201582 NCBI chr19:6,112,851...6,117,880
Ensembl chr19:6,112,851...6,118,403 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Apigenin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Apigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein]; Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of TNF protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Apigenin promotes the reaction [hydroxygenkwanin results in increased expression of TNF protein]; hydroxygenkwanin promotes the reaction [Apigenin results in increased expression of TNF protein]
Apigenin inhibits the reaction [Alcohols results in increased expression of TNF protein]; Apigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]		 CTD PMID:15113938 PMID:15322261 PMID:15985724 PMID:16987811 PMID:24144774 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 increases response to substance
multiple interactions		 ISO TNFSF10 protein results in increased susceptibility to Apigenin
[TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BCL2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP9 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of PARP1 protein		 CTD PMID:29247770 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions ISO
EXP		 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]]
Apigenin inhibits the reaction [Ovalbumin results in increased expression of TRAF6 protein]		 CTD PMID:36350155 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
affects activity
increases expression		 ISO TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein]
Apigenin affects the activity of TP53 protein
Apigenin results in increased expression of TP53 protein		 CTD PMID:11790449 PMID:16023288 PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trp63 transformation related protein 63 increases expression ISO Apigenin results in increased expression of TP63 protein CTD PMID:19397994 NCBI chr16:25,502,513...25,710,842
Ensembl chr16:25,502,513...25,710,852 		JBrowse link
G Trp73 transformation related protein 73 increases expression ISO Apigenin results in increased expression of TP73 protein CTD PMID:19397994 NCBI chr 4:154,140,706...154,224,332
Ensembl chr 4:154,140,706...154,224,665 		JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression EXP Apigenin results in increased expression of TUBB5 mRNA CTD PMID:22359648 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198 		JBrowse link
G Tyr tyrosinase increases expression EXP Apigenin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression
increases glucuronidation
multiple interactions		 ISO Apigenin results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of Apigenin
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Apigenin results in increased expression of UGT1A1 mRNA]; [sulforaphane co-treated with Apigenin] results in increased expression of UGT1A1 mRNA		 CTD PMID:14557274 PMID:15090468 PMID:29584932 PMID:31621310 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of Apigenin CTD PMID:14557274 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Apigenin CTD PMID:14557274 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII multiple interactions ISO Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of UQCRQ mRNA] CTD PMID:30107153 NCBI chr11:53,318,749...53,321,658
Ensembl chr11:53,318,749...53,321,658 		JBrowse link
G Usp48 ubiquitin specific peptidase 48 increases expression EXP Apigenin results in increased expression of USP48 mRNA CTD PMID:22359648 NCBI chr 4:137,321,079...137,385,842
Ensembl chr 4:137,321,066...137,385,848 		JBrowse link
G Utrn utrophin increases expression ISO Apigenin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr10:12,257,931...12,745,632
Ensembl chr10:12,257,932...12,745,109 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:15113938 PMID:16987811 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 ISO Apigenin results in decreased expression of VEGFA mRNA; Apigenin results in decreased expression of VEGFA protein
[Apigenin co-treated with Oxygen deficiency] affects the expression of VEGFA mRNA; [Apigenin co-treated with Oxygen deficiency] affects the expression of VEGFA protein; Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Apigenin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]		 CTD PMID:15947208 PMID:20153296 PMID:35513012 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Zcrb1 zinc finger CCHC-type and RNA binding motif 1 increases expression EXP Apigenin results in increased expression of ZCRB1 mRNA CTD PMID:22359648 NCBI chr15:93,283,987...93,296,218
Ensembl chr15:93,283,978...93,296,215 		JBrowse link
G Zfp110 zinc finger protein 110 increases expression EXP Apigenin results in increased expression of ZFP110 mRNA CTD PMID:22359648 NCBI chr 7:12,565,225...12,584,513
Ensembl chr 7:12,568,688...12,584,504 		JBrowse link
G Zfp809 zinc finger protein 809 increases expression EXP Apigenin results in increased expression of ZFP809 mRNA CTD PMID:22359648 NCBI chr 9:22,136,980...22,165,413
Ensembl chr 9:22,137,010...22,154,650 		JBrowse link
G Zfp941 zinc finger protein 941 decreases expression EXP Apigenin results in decreased expression of ZFP941 mRNA CTD PMID:22359648 NCBI chr 7:140,387,366...140,402,114
Ensembl chr 7:140,387,362...140,402,091 		JBrowse link
G Zfp957 zinc finger protein 957 decreases expression EXP Apigenin results in decreased expression of ZFP957 mRNA CTD PMID:22359648 NCBI chr14:79,449,795...79,484,807
Ensembl chr14:79,449,795...79,484,809 		JBrowse link
5,7-dihydroxy-4'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 decreases expression ISO acacetin results in decreased expression of CCNB1 protein CTD PMID:36740148 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO acacetin results in decreased expression of CCNE1 protein CTD PMID:36740148 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO acacetin results in decreased expression of CDC25C protein CTD PMID:36740148 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586 		JBrowse link
G Cdk1 cyclin dependent kinase 1 decreases expression ISO acacetin results in decreased expression of CDK1 protein CTD PMID:36740148 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO acacetin results in decreased expression of CDK2 protein CTD PMID:36740148 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO acacetin results in increased expression of CDKN1A protein CTD PMID:36740148 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO acacetin results in increased expression of CHK1 protein CTD PMID:36740148 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
decreases activity		 ISO CYP1A1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1A1 mRNA
acacetin results in decreased activity of CYP1A1 protein		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO acacetin results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:32738202 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
decreases activity
increases expression
multiple interactions		 ISO
EXP		 CYP1B1 protein results in increased metabolism of acacetin
acacetin results in decreased activity of CYP1B1 protein
acacetin results in increased expression of CYP1B1 mRNA
acacetin binds to and results in decreased activity of CYP1B1 protein		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene decreases activity ISO acacetin results in decreased activity of CYP2C11 protein CTD PMID:32738202 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO acacetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] CTD PMID:21053930 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO acacetin results in decreased activity of CYP2E1 protein CTD PMID:32738202 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Fadd Fas associated via death domain decreases expression ISO acacetin results in decreased expression of FADD protein CTD PMID:36740148 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK1 protein] CTD PMID:36740148 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO acacetin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:36740148 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression
multiple interactions		 ISO acacetin results in increased activity of NR1I2 protein
acacetin results in increased expression of NR1I2 mRNA
acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforaphane inhibits the reaction [acacetin results in increased activity of NR1I2 protein]		 CTD PMID:25455453 PMID:29933105 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases expression ISO acacetin results in increased expression of PARP1 protein CTD PMID:36740148 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 increases expression ISO acacetin results in increased expression of RIPK1 protein CTD PMID:36740148 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO acacetin results in increased expression of RIPK3 protein CTD PMID:36740148 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression EXP
ISO		 acacetin results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
apigenin 7-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gypa glycophorin A increases expression ISO apigetrin results in increased expression of GYPA protein CTD PMID:25058688 NCBI chr 8:81,220,674...81,237,414
Ensembl chr 8:81,220,410...81,237,171 		JBrowse link
genkwanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP1 protein] CTD PMID:34481870 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]] CTD PMID:34481870 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
decreases activity		 ISO CYP1A1 protein results in increased metabolism of genkwanin
genkwanin results in decreased activity of CYP1A1 protein		 CTD PMID:19666078 PMID:21482471 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of genkwanin CTD PMID:19666078 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions		 ISO CYP1B1 protein results in increased metabolism of genkwanin
[CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin		 CTD PMID:19666078 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]] CTD PMID:34481870 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]] CTD PMID:34481870 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]] CTD PMID:34481870 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]] CTD PMID:34481870 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]] CTD PMID:34481870 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TLR4 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]] CTD PMID:34481870 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]] CTD PMID:34481870 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
hinokiflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression EXP hinokiflavone results in increased expression of BAX protein CTD PMID:30575109 PMID:32252563 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression EXP hinokiflavone results in decreased expression of BCL2 protein CTD PMID:30575109 PMID:32252563 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage		 EXP hinokiflavone results in increased expression of CASP3 protein
hinokiflavone results in increased cleavage of CASP3 protein		 CTD PMID:30575109 PMID:32252563 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL15 protein] CTD PMID:29673161 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G F3 coagulation factor III multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:29673161 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:29673161 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:29673161 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO
EXP		 hinokiflavone results in decreased expression of MMP2 protein
hinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 protein		 CTD PMID:29635122 PMID:30575109 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP
ISO		 hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein CTD PMID:29635122 PMID:30575109 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:29673161 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Prpf40a pre-mRNA processing factor 40A increases sumoylation ISO hinokiflavone results in increased sumoylation of PRPF40A protein CTD PMID:28884683 NCBI chr 2:53,024,714...53,081,450
Ensembl chr 2:53,024,716...53,081,714 		JBrowse link
G Ptgds prostaglandin D2 synthase (brain) affects binding ISO hinokiflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 2:25,356,723...25,360,080
Ensembl chr 2:25,356,721...25,360,058 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:29673161 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:29673161 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 decreases activity ISO hinokiflavone results in decreased activity of SENP1 protein CTD PMID:28884683 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625 		JBrowse link
G Sf3a2 splicing factor 3a, subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3A2 protein CTD PMID:28884683 NCBI chr10:80,634,569...80,640,756
Ensembl chr10:80,634,032...80,640,758 		JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B1 protein CTD PMID:28884683 NCBI chr 1:55,024,328...55,066,660
Ensembl chr 1:55,024,328...55,066,640 		JBrowse link
G Sf3b2 splicing factor 3b, subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B2 protein CTD PMID:28884683 NCBI chr19:5,323,949...5,345,485
Ensembl chr19:5,323,960...5,345,483 		JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SNRPD2 protein CTD PMID:28884683 NCBI chr 7:18,883,370...18,886,659
Ensembl chr 7:18,883,647...18,887,467 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases localization ISO hinokiflavone results in increased localization of SUMO1 protein CTD PMID:28884683 NCBI chr 1:59,678,593...59,709,993
Ensembl chr 1:59,625,717...59,709,993 		JBrowse link
G Sumo2 small ubiquitin-like modifier 2 increases localization ISO hinokiflavone results in increased localization of SUMO2 protein CTD PMID:28884683 NCBI chr11:115,413,935...115,427,056
Ensembl chr11:115,413,928...115,427,102 		JBrowse link
G Sumo3 small ubiquitin-like modifier 3 increases localization ISO hinokiflavone results in increased localization of SUMO3 protein CTD PMID:28884683 NCBI chr10:77,441,931...77,454,165
Ensembl chr10:77,441,931...77,454,165 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 increases expression EXP hinokiflavone results in increased expression of TIMP2 mRNA; hinokiflavone results in increased expression of TIMP2 protein CTD PMID:30575109 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:29673161 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases sumoylation ISO hinokiflavone results in increased sumoylation of U2SURP protein CTD PMID:28884683 NCBI chr 9:95,338,947...95,394,049
Ensembl chr 9:95,338,951...95,394,049 		JBrowse link
hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Ins2 insulin II multiple interactions EXP hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO hispidulin decreases phoshphorylation of JAK2 protein in colon and colorectum RGD PMID:29575334 RGD:149735333 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] CTD PMID:22759588 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] CTD PMID:22759588 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 multiple interactions ISO hispidulin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose] CTD PMID:36870413 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases activity
multiple interactions		 ISO hispidulin results in decreased activity of SLCO1B1 protein
[hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate		 CTD PMID:32259555 NCBI chr 6:141,470,080...141,515,903
Ensembl chr 6:141,470,094...141,515,903 		JBrowse link
G Syn1 synapsin I affects response to substance EXP SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:20,726,750...20,787,157
Ensembl chr  X:20,726,750...20,787,243 		JBrowse link
isoscutellarein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP isoscutellarein results in increased expression of ADIPOQ protein CTD PMID:30445784 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Lep leptin decreases expression EXP isoscutellarein results in decreased expression of LEP protein CTD PMID:30445784 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Rbp4 retinol binding protein 4, plasma decreases expression EXP isoscutellarein results in decreased expression of RBP4 protein CTD PMID:30445784 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 increases expression EXP isoscutellarein results in increased expression of SLC2A4 protein CTD PMID:30445784 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Tnf tumor necrosis factor decreases expression EXP isoscutellarein results in decreased expression of TNF protein CTD PMID:30445784 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
isovitexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO isovitexin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; isovitexin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] CTD PMID:34217736 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO [isovitexin results in increased expression of and results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein; isovitexin inhibits the reaction [TNF protein results in decreased expression of AHR protein]; isovitexin results in increased expression of and results in increased activity of AHR protein CTD PMID:37263555 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO isovitexin results in decreased expression of CDK2 mRNA; isovitexin results in decreased expression of CDK2 protein CTD PMID:37939611 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO isovitexin results in increased expression of CDKN1A mRNA; isovitexin results in increased expression of CDKN1A protein CTD PMID:37939611 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin results in increased expression of CYP1A1 protein]; [isovitexin results in increased expression of and results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein CTD PMID:37263555 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]
isovitexin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]		 CTD PMID:37263555 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein] CTD PMID:37263555 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP isovitexin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:37263555 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of NFKBIA protein]]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:37263555 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Ocln occludin multiple interactions ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein] CTD PMID:37263555 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:37263555 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein] CTD PMID:37263555 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of NFKBIA protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; isovitexin inhibits the reaction [TNF protein results in decreased expression of AHR protein]; isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein]; isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
isovitexin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]		 CTD PMID:37263555 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO isovitexin results in increased expression of TP53 mRNA; isovitexin results in increased expression of TP53 protein CTD PMID:37939611 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
pectolinarigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ataxia telangiectasia mutated multiple interactions
increases phosphorylation		 ISO TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein] CTD PMID:37393350 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO pectolinarigenin results in increased expression of CDKN1A protein
TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein]		 CTD PMID:37393350 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO pectolinarigenin results in increased expression of H2AX protein
TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein]		 CTD PMID:37393350 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 ISO Chloroquine promotes the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein] CTD PMID:37393350 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression ISO pectolinarigenin results in decreased expression of MKI67 protein CTD PMID:37393350 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 ISO Chloroquine promotes the reaction [pectolinarigenin results in increased expression of SQSTM1 protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein] CTD PMID:37393350 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions ISO pectolinarigenin binds to and results in increased expression of TOP2A protein; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein] CTD PMID:37393350 NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression		 ISO TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein] CTD PMID:37393350 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trp53bp1 transformation related protein 53 binding protein 1 increases expression ISO pectolinarigenin results in increased expression of TP53BP1 protein CTD PMID:37393350 NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 affects binding
increases glucuronidation		 ISO pectolinarigenin binds to UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of pectolinarigenin		 CTD PMID:37797876 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of pectolinarigenin CTD PMID:37797876 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation
affects binding		 ISO UGT1A3 protein results in increased glucuronidation of pectolinarigenin
pectolinarigenin binds to UGT1A3 protein		 CTD PMID:37797876 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation
affects binding		 ISO UGT1A9 protein results in increased glucuronidation of pectolinarigenin
pectolinarigenin binds to UGT1A9 protein		 CTD PMID:37797876 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation ISO UGT2B17 protein results in increased glucuronidation of pectolinarigenin CTD PMID:37797876 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389 		JBrowse link
salvigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 decreases activity ISO salvigenin results in decreased activity of UGT1A10 protein CTD PMID:33440186 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
schaftoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO schaftoside inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin] CTD PMID:34217736 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
scutellarein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
affects metabolic processing
multiple interactions		 ISO scutellarein results in decreased activity of CYP1A1 protein
CYP1A1 protein affects the metabolism of scutellarein
[CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin		 CTD PMID:19666078 PMID:21482471 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of scutellarein CTD PMID:19666078 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
affects metabolic processing
multiple interactions		 ISO scutellarein results in decreased activity of CYP1B1 protein
CYP1B1 protein affects the metabolism of scutellarein
[CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin		 CTD PMID:19666078 PMID:21482471 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
scutellarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO scutellarin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO scutellarin inhibits the reaction [cobaltous chloride results in decreased expression of BCL2L1 mRNA] CTD PMID:18442013 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO scutellarin inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA] CTD PMID:37081038 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 scutellarin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]
scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]		 CTD PMID:18442013 PMID:36252740 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO scutellarin results in decreased expression of FGF2 protein CTD PMID:16297343 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO scutellarin inhibits the reaction [Streptozocin results in increased expression of GSDMD protein] CTD PMID:37081038 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; MG 262 inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]] CTD PMID:25192544 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO scutellarin inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:37081038 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP scutellarin inhibits the reaction [Zearalenone results in increased expression of JUN protein] CTD PMID:36252740 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 multiple interactions EXP scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] CTD PMID:36252740 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein] CTD PMID:25192544 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO scutellarin inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein] CTD PMID:37081038 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases expression ISO scutellarin results in decreased expression of NOS2 protein CTD PMID:16297343 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO scutellarin results in increased expression of NOS3 protein CTD PMID:16297343 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA protein] CTD PMID:25192544 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pkm pyruvate kinase, muscle increases activity ISO scutellarin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658 		JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) affects activity ISO scutellarin affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497 		JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 multiple interactions EXP scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 mRNA]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 protein] CTD PMID:36252740 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 ISO scutellarin results in decreased expression of VEGFA protein
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein]		 CTD PMID:16297343 PMID:25192544 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
vitexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 increases expression EXP vitexin results in increased expression of ABCA1 mRNA CTD PMID:29545167 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Apoe apolipoprotein E increases expression EXP vitexin results in increased expression of APOE mRNA CTD PMID:29545167 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases expression		 EXP
ISO		 vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Nitrogen Species]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species]; vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA]
vitexin results in decreased expression of APP mRNA; vitexin results in decreased expression of APP protein		 CTD PMID:29545167 PMID:32926499 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein] CTD PMID:29545167 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] CTD PMID:29545167 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein] CTD PMID:29545167 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA] CTD PMID:29545167 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression EXP vitexin results in increased expression of DHCR24 mRNA CTD PMID:29545167 NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions EXP vitexin inhibits the reaction [Streptozocin results in decreased expression of FSHB protein] CTD PMID:30365938 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA] CTD PMID:29545167 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions EXP vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA] CTD PMID:29545167 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Lhb luteinizing hormone beta multiple interactions EXP vitexin inhibits the reaction [Streptozocin results in decreased expression of LHB protein] CTD PMID:30365938 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA] CTD PMID:29545167 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP vitexin results in increased expression of NR1H3 mRNA CTD PMID:29545167 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Ppid peptidylprolyl isomerase D (cyclophilin D) multiple interactions EXP vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA] CTD PMID:29545167 NCBI chr 3:79,498,644...79,511,117
Ensembl chr 3:79,498,649...79,510,957 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22205
    role 22190
      biological role 22189
        biochemical role 21465
          metabolite 21413
            apigenin 293
              3-methoxyapigenin 0
              5,7-dihydroxy-4'-methoxyflavone + 21
              6,8-di-C-alpha-L-arabinosylapigenin 0
              6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)apigenin 0
              6-C-D-Xylopyranosyl-8-C-L-arabinopyranosylapigenin 0
              6-C-L-arabinopyranosyl-8-C-D-xylopyranosylapigenin 0
              7-O-[beta-D-arabinopyranosyl-(1->6)-beta-D-glucosyl]apigenin 0
              8-C-glucopyranosyl-6-C-xylopyranosylapigenin 0
              apigenin 7,4'-dimethyl ether 0
              apigenin 7-O-beta-D-glucoside 1
              apigenin 7-O-beta-L-glucoside 0
              apigenin 7-O-neohesperidoside 0
              apigenin C-pentoside 0
              apigenin-7-O-gentiobioside 0
              apiin + 0
              genkwanin 12
              hinokiflavone 27
              isoschaftoside 0
              isoscutellarein + 5
              isovitexin + 14
              neoschaftoside 0
              ochnaflavone 0
              schaftoside 1
              scutellarein + 46
              swertisin 0
              vitexin + 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 22205
    subatomic particle 22197
      composite particle 22197
        hadron 22197
          baryon 22197
            nucleon 22169
              atomic nucleus 22197
                atom 22197
                  main group element atom 22131
                    p-block element atom 22131
                      carbon group element atom 21928
                        carbon atom 21854
                          organic molecular entity 21854
                            organic molecule 21671
                              organic cyclic compound 21276
                                organic heterocyclic compound 20346
                                  oxacycle 18876
                                    benzopyran 12219
                                      1-benzopyran 11978
                                        flavonoid 7275
                                          anthoxanthin 4596
                                            flavones 4596
                                              hydroxyflavone 4567
                                                trihydroxyflavone 431
                                                  apigenin 293
                                                    3-methoxyapigenin 0
                                                    5,7-dihydroxy-4'-methoxyflavone + 21
                                                    6,8-di-C-alpha-L-arabinosylapigenin 0
                                                    6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)apigenin 0
                                                    6-C-D-Xylopyranosyl-8-C-L-arabinopyranosylapigenin 0
                                                    6-C-L-arabinopyranosyl-8-C-D-xylopyranosylapigenin 0
                                                    7-O-[beta-D-arabinopyranosyl-(1->6)-beta-D-glucosyl]apigenin 0
                                                    8-C-glucopyranosyl-6-C-xylopyranosylapigenin 0
                                                    apigenin 7,4'-dimethyl ether 0
                                                    apigenin 7-O-beta-D-glucoside 1
                                                    apigenin 7-O-beta-L-glucoside 0
                                                    apigenin 7-O-neohesperidoside 0
                                                    apigenin C-pentoside 0
                                                    apigenin-7-O-gentiobioside 0
                                                    apiin + 0
                                                    genkwanin 12
                                                    hinokiflavone 27
                                                    isoschaftoside 0
                                                    isoscutellarein + 5
                                                    isovitexin + 14
                                                    neoschaftoside 0
                                                    ochnaflavone 0
                                                    schaftoside 1
                                                    scutellarein + 46
                                                    swertisin 0
                                                    vitexin + 15
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