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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | cell cycle | | IEA | UniProtKB-KW:KW-0131 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 | cell division | | IEA | UniProtKB-KW:KW-0132 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 | cellular response to insulin stimulus | | ISO | UniProtKB:Q63699 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 | DNA repair | | IEA | UniProtKB-KW:KW-0234 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 | G1/S transition of mitotic cell cycle | | IDA | | 2290270 | MGI:MGI:2675510|PMID:12970171 | MGI | MGI:MGI:2675510 PMID:12970171 | histone phosphorylation | | ISO | UniProtKB:P24941 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 | meiosis | | IEA | UniProtKB-KW:KW-0469 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 | mitosis | | IEA | UniProtKB-KW:KW-0498 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 | phosphorylation | | IEA | UniProtKB-KW:KW-0418 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 | positive regulation of cell proliferation | | ISO | UniProtKB:P24941 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 | positive regulation of DNA-dependent DNA replication initiation | | IGI | MGI:MGI:1920234 | 2290270 | MGI:MGI:4439421|PMID:20215406 | MGI | MGI:MGI:4439421 PMID:20215406 | positive regulation of transcription, DNA-dependent | | IGI | MGI:MGI:108069 | 2290270 | MGI:MGI:3609508|PMID:16137671 | MGI | MGI:MGI:3609508 PMID:16137671 | potassium ion transport | | IGI | MGI:MGI:1929183 | 2290270 | MGI:MGI:3695173|PMID:16393152 | MGI | MGI:MGI:3695173 PMID:16393152 | protein phosphorylation | | IDA | | 2290270 | MGI:MGI:2384369|PMID:12124778 | MGI | MGI:MGI:2384369 PMID:12124778 | protein phosphorylation | | IEA | InterPro:IPR008271 | 2290270 | MGI:MGI:2152098 | GOC | MGI:MGI:2152098 | protein phosphorylation | | IEA | UniProtKB-KW:KW-0723 | 2290270 | MGI:MGI:1354194 | GOC | MGI:MGI:1354194 | regulation of gene silencing | | ISO | UniProtKB:P24941 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 | response to cAMP | | ISO | UniProtKB:Q63699 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 | response to DNA damage stimulus | | IEA | UniProtKB-KW:KW-0227 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 | response to electrical stimulus | | ISO | UniProtKB:Q63699 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations
Phenotype Annotations
Disease Annotations
Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Cell cycle |
| Epstein-Barr virus infection | |
| Hepatitis B | |
| Herpes simplex infection | |
| Measles | |
| Oocyte meiosis | |
| p53 signaling pathway | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Progesterone-mediated oocyte maturation | |
| Prostate cancer | |
| Small cell lung cancer | |
| Viral carcinogenesis | |
Phenotype Annotations
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References - curated| 1. |
Bokemeyer D, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3431-41. Epub 2007 Sep 24. |
| 2. |
Bonin S, etal., Virchows Arch. 2008 Jan 31;. |
| 3. |
Horree N, etal., J Clin Pathol. 2008 Jan;61(1):36-42. Epub 2007 May 4. |
| 4. |
Inamoto T, etal., Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3470-7. |
| 5. |
Ito K, etal., Anticancer Res. 1998 May-Jun;18(3A):1661-4. |
| 6. |
Marone M, etal., Int J Cancer. 1998 Jan 5;75(1):34-9. |
| 7. |
MGD data from the GO Consortium |
| 8. |
MGD IEA |
| 9. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 10. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 11. |
RGD automated import pipeline |
| 12. |
Shi SQ, etal., J Mol Med. 2006 Nov;84(11):933-41. Epub 2006 Aug 5. |
| 13. |
Shukla S and Gupta S, Mol Cancer Ther. 2006 Apr;5(4):843-52. |
| 14. |
Sui L, etal., Gynecol Oncol. 2001 Oct;83(1):56-63. |
| 15. |
Yang S, etal., World J Gastroenterol. 2006 Feb 21;12(7):1063-70. |
| 16. |
Zempolich K, etal., Gynecol Oncol. 2008 May;109(2):275-9. Epub 2008 Mar 4. |
References - uncurated| PubMed | 10068472 |
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RGD Disease Portals| Cdk2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Cdk2 (Mus musculus) |
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| Cdk2 (Rattus norvegicus) |
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Position Markers| UniSTS:236489 |
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| Cdk2 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_016756 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_183417 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHY01090100 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC117232 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ223732 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ223733 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK036589 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK042462 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK146845 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK148017 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK151979 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK152922 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK153983 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK154997 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK178832 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK179397 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK181235 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK183240 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK184593 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK186022 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK186779 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK187629 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK189612 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK200216 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK200296 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK208241 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK208316 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK209242 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK210959 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK214050 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK219393 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC005654 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC026145 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466578 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN705407 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U63337 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_016756 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_058036 | |||||||||||||||||||||||||
| Peptide Label: | isoform 2 | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_183417 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_904326 | |||||||||||||||||||||||||
| Peptide Label: | isoform 1 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058036 | (Get FASTA) |
| NP_904326 | (Get FASTA) | |
| GenBank Protein | AAB37128 | (Get FASTA) |
| AAH05654 | (Get FASTA) | |
| BAE27476 | (Get FASTA) | |
| BAE28290 | (Get FASTA) | |
| BAE30846 | (Get FASTA) | |
| BAE31597 | (Get FASTA) | |
| BAE32294 | (Get FASTA) | |
| BAE32983 | (Get FASTA) | |
| CAA11533 | (Get FASTA) | |
| CAA11534 | (Get FASTA) | |
| EDL24599 | (Get FASTA) | |
| EDL24600 | (Get FASTA) | |
| P97377 | (Get FASTA) |
Promoters| RGD ID: | 6819099 | ||||||||||
| Promoter ID: | MM_KWN:6018 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6 | ||||||||||
| Transcripts: | NM_016756, NM_183417, UC007HOA.1 | ||||||||||
| Position: |
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| RGD ID: | 6884778 | ||||||||||
| Promoter ID: | EPDNEW_M5840 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Cdk2_1 | ||||||||||
| Description: | cyclin-dependent kinase 2 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000025358 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000026415 | ENTREZGENE |
| ENSMUSP00000026416 | ENTREZGENE | |
| Ensembl Transcript | ENSMUST00000026415 | ENTREZGENE |
| ENSMUST00000026416 | ENTREZGENE | |
| Entrez Gene | 12566 | ENTREZGENE |
| Germonline | ENSMUSG00000025358 | |
| HomoloGene Group ID | 74409 | ENTREZGENE |
| InterPro | Kinase-like_dom | UniProtKB/Swiss-Prot |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_AS | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00124240 | UniProtKB/Swiss-Prot |
| IPI00225350 | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:12566 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:104772 | ENTREZGENE |
| Pfam | Pkinase | UniProtKB/Swiss-Prot |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| SMART | S_TKc | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Mm.111326 | ENTREZGENE |
| UniProt | CDK2_MOUSE | UniProtKB/Swiss-Prot |
| Q3U307_MOUSE | UniProtKB/TrEMBL | |
| Q3U6X7_MOUSE | UniProtKB/TrEMBL | |
| Q3UGB9_MOUSE | UniProtKB/TrEMBL |
| More on Cdk2 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 70501 |
| Created: | 2002-05-02 |
| Species: | Mus musculus |
| Last Modified: | 2013-02-27 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




