Gene: Ccne1 (cyclin E1)  Mus musculus Symbol: Ccne1 Name: cyclin E1 Description: ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; protein kinase binding; INVOLVED IN DNA replication initiation; protein phosphorylation; regulation of cell cycle; PARTICIPATES IN mTOR signaling pathway; cell cycle pathway, mitotic; measles infection pathway; ASSOCIATED WITH abnormal aortic arch development; abnormal bone marrow morphology; abnormal cardiovascular system morphology; ASSOCIATED WITH Neoplasm Metastasis; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; FOUND IN cyclin-dependent protein kinase holoenzyme complex; nucleus; centrosome (ortholog); INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol Type: protein-coding RefSeq Status: PROVISIONAL Also known as: AW538188; CycE1; G1/S-specific cyclin-E1; OTTMUSP00000025179 Orthologs: Homo sapiens : CCNE1 (cyclin E1)  HGNC Rattus norvegicus : Ccne1 (cyclin E1) Latest Assembly: Mouse Genome Assembly Build 37 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 38,097,984 - 38,107,490 - NCBI Mouse cM Map 7 25.35   NCBI Mouse Celera Assembly 7 33,255,165 - 33,271,131 - NCBI Mouse Genome Assembly Build 37 7 38,883,003 - 38,892,509 - NCBI Mouse Genome Assembly Build 36.1 7 38,883,003 - 38,892,509 - NCBI Mouse Cytogenetic Map 7 B2   NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Bowen's Disease   ISS RGD:736488 2289255 associated with Vulvar Neoplasms;mRNA:increased expression:vulva RGD   Breast Neoplasms   ISS RGD:736488 2289225 DNA:amplification RGD   Breast Neoplasms Disease_progression ISS RGD:736488 2289231   RGD   Carcinoma, Endometrioid   ISS RGD:736488 2289230 protein:increased expression:endometrium RGD   Carcinoma, Hepatocellular   ISS RGD:2294 2289277   RGD   Carcinoma, Renal Cell   ISS RGD:736488 2289228 mRNA, protein:increased expression:kidney RGD   Cervical Intraepithelial Neoplasia   ISS RGD:736488 2293574 protein:increased expression:uterine cervix RGD   Colonic Neoplasms   ISS RGD:2294 2289293 mRNA, protein:increased expression:colon RGD   Diabetic Nephropathies   ISS RGD:2294 2289273 protein:increased expression:kidney RGD   Hypertension   ISS RGD:2294 2289296 protein:increased expression:vascular associated smooth muscle cell RGD   Lymphatic Metastasis   ISS RGD:736488 2289266 associated with Carcinoma, Transitional Cell;protein:decreased expression RGD   Mammary Neoplasms, Experimental   ISS RGD:2294 2289336 protein:decreased expression:mammary gland RGD   Mammary Neoplasms, Experimental   ISS RGD:2294 2289337   RGD   Neoplasm Metastasis Disease_progression IED   2289229 protein:altered processing RGD   Neoplasms, Germ Cell and Embryonal   ISS RGD:736488 2296041 mRNA, protein:decreased expression:testis RGD   Ovarian Neoplasms   ISS RGD:2294 2289335 protein:increased expression:ovary RGD   Ovarian Neoplasms Disease_progression ISS RGD:736488 2296042 protein:alternative forms, increased expression:ovary RGD   Ovarian Neoplasms Disease_progression ISS RGD:736488 2289287 protein:increased expression:ovary RGD   Prostatic Intraepithelial Neoplasia   IEP   2289283 mRNA, protein:increased expression:prostate gland RGD   Prostatic Neoplasms Disease_progression IEP   2289283 mRNA, protein:increased expression:prostate gland RGD   Spinal Cord Injuries   ISS RGD:2294 2289281 protein:increased expression:spinal cord RGD   Urinary Bladder Neoplasms Disease_progression ISS RGD:736488 2296035 protein:decreased expression:urinary bladder RGD   Urinary Bladder Neoplasms Severity ISS RGD:736488 2289267 protein:decreased expression:urinary bladder RGD   Uterine Cervical Neoplasms   IEP   2289265 protein:increased expression:cervix, epithelial cell RGD   Uterine Cervical Neoplasms Disease_progression ISS RGD:736488 2289268 protein:increased expression:cervix RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (S)-nicotine increases expression ISO RGD:736488 6480464 Nicotine results in increased expression of CCNE1 protein CTD PMID:20061081 (S)-nicotine multiple interactions ISO RGD:736488 6480464 L 663536 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] CTD PMID:20061081 17beta-estradiol multiple interactions ISO RGD:736488 6480464 Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA] CTD PMID:15897899 17beta-estradiol increases expression ISO RGD:736488 6480464 Estradiol results in increased expression of CCNE1 mRNA CTD PMID:15897899 PMID:19079715 17beta-estradiol increases expression ISO RGD:736488 6480464 Estradiol results in increased expression of CCNE1 mRNA CTD PMID:15897899 17beta-hydroxy-5alpha-androstan-3-one increases expression EXP   6480464 Dihydrotestosterone results in increased expression of CCNE1 mRNA CTD PMID:17023530 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [CCNE1 protein binds to CDK2 protein] CTD PMID:16636136 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of CCNE1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:2294 6480464 Tetrachlorodibenzodioxin affects the expression of CCNE1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein]]; more ... CTD PMID:20637255 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCNE1 promoter] CTD PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of CCNE1 mRNA CTD PMID:16120747 PMID:18372398 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of CCNE1 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of CCNE1 mRNA CTD PMID:18372398 PMID:16120747 2,6-di-tert-butyl-4-methylphenol increases expression EXP   6480464 Butylated Hydroxytoluene results in increased expression of CCNE1 mRNA; more ... CTD PMID:12867420 2,6-dinitrotoluene affects expression ISO RGD:2294 6480464 2,6-dinitrotoluene affects the expression of CCNE1 mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions ISO RGD:2294 6480464 2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein] CTD PMID:10708481 2-acetamidofluorene decreases activity ISO RGD:2294 6480464 2-Acetylaminofluorene results in decreased activity of CCNE1 protein CTD PMID:10708481 2-acetamidofluorene multiple interactions ISO RGD:2294 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA; more ... CTD PMID:14633663 2-butoxyethanol increases expression EXP   6480464 n-butoxyethanol results in increased expression of CCNE1 mRNA CTD PMID:19812364 3,3',4,4'-tetrachlorobiphenyl multiple interactions EXP   6480464 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CCNE1 mRNA] CTD PMID:19467301 3,3',5-triiodo-L-thyronine increases expression ISO RGD:736488 6480464 Triiodothyronine results in increased expression of CCNE1 protein CTD PMID:16021636 3,3',5-triiodo-L-thyronine increases expression ISO RGD:2294 6480464 Triiodothyronine results in increased expression of CCNE1 protein; more ... CTD PMID:16021636 5-fluorouracil decreases expression ISO RGD:736488 6480464 Fluorouracil results in decreased expression of CCNE1 mRNA CTD PMID:18930000 5-fluorouracil multiple interactions ISO RGD:736488 6480464 [Leucovorin co-treated with Fluorouracil] results in increased expression of CCNE1 mRNA CTD PMID:15342418 5-fluorouracil increases expression ISO RGD:736488 6480464 Fluorouracil results in increased expression of CCNE1 mRNA CTD PMID:16101138 5-fluorouracil increases expression ISO RGD:736488 6480464 Fluorouracil results in increased expression of CCNE1 protein CTD PMID:9930367 5-formyltetrahydrofolic acid multiple interactions ISO RGD:736488 6480464 [Leucovorin co-treated with Fluorouracil] results in increased expression of CCNE1 mRNA CTD PMID:15342418 acetylsalicylic acid affects expression ISO RGD:2294 6480464 Aspirin affects the expression of CCNE1 mRNA CTD PMID:12800193 acetylsalicylic acid decreases expression ISO RGD:736488 6480464 Aspirin results in decreased expression of CCNE1 mRNA CTD PMID:20457246 acrylamide decreases expression EXP   6480464 Acrylamide analog results in decreased expression of CCNE1 mRNA; more ... CTD PMID:17317719 afimoxifene multiple interactions ISO RGD:736488 6480464 4-hydroxytamoxifen promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; more ... CTD PMID:15665275 aflatoxin B1 increases expression ISO RGD:736488 6480464 Aflatoxin B1 results in increased expression of CCNE1 mRNA CTD PMID:22100608 all-trans-retinoic acid multiple interactions ISO RGD:736488 6480464 Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]] CTD PMID:12421932 all-trans-retinoic acid decreases degradation ISO RGD:736488 6480464 Tretinoin results in decreased degradation of CCNE1 protein CTD PMID:20935519 all-trans-retinoic acid multiple interactions EXP   6480464 [Tretinoin results in increased activity of RXRA protein] which results in increased expression of CCNE1 mRNA CTD PMID:20035057 all-trans-retinoic acid decreases expression EXP   6480464 Tretinoin results in decreased expression of CCNE1 mRNA CTD PMID:22498432 all-trans-retinoic acid decreases expression ISO RGD:736488 6480464 Tretinoin results in decreased expression of CCNE1 mRNA CTD PMID:15194426 more ... all-trans-retinoic acid decreases expression ISO RGD:736488 6480464 Tretinoin results in decreased expression of CCNE1 mRNA CTD PMID:16054129 more ... all-trans-retinoic acid decreases expression ISO RGD:736488 6480464 Tretinoin results in decreased expression of CCNE1 mRNA CTD PMID:15194426 more ... all-trans-retinoic acid decreases expression ISO RGD:736488 6480464 Tretinoin results in decreased expression of CCNE1 mRNA CTD PMID:16054129 more ... all-trans-retinoic acid decreases expression ISO RGD:736488 6480464 Tretinoin results in decreased expression of CCNE1 mRNA CTD PMID:17349212 more ... all-trans-retinoic acid decreases expression ISO RGD:2294 6480464 Tretinoin results in decreased expression of CCNE1 protein CTD PMID:11675954 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of CCNE1 protein CTD PMID:15231690 all-trans-retinoic acid multiple interactions ISO RGD:2294 6480464 Tretinoin inhibits the reaction [FGF2 protein results in increased expression of CCNE1 mRNA] CTD PMID:11675954 all-trans-retinoic acid decreases expression ISO RGD:736488 6480464 Tretinoin results in decreased expression of CCNE1 protein CTD PMID:15194426 all-trans-retinoic acid decreases expression ISO RGD:736488 6480464 Tretinoin results in decreased expression of CCNE1 mRNA CTD PMID:17349212 more ... all-trans-retinoic acid multiple interactions ISO RGD:736488 6480464 Tretinoin promotes the reaction [CDK2 protein binds to CCNE1 protein] CTD PMID:16765349 all-trans-retinoic acid multiple interactions ISO RGD:736488 6480464 Tretinoin inhibits the reaction [CDK2 protein binds to CCNE1 protein]; more ... CTD PMID:16766008 amlodipine decreases activity ISO RGD:736488 6480464 Amlodipine results in decreased activity of CCNE1 protein CTD PMID:17217918 ammonium chloride affects expression ISO RGD:2294 6480464 Ammonium Chloride affects the expression of CCNE1 mRNA CTD PMID:16483693 amsacrine increases expression ISO RGD:736488 6480464 Amsacrine results in increased expression of CCNE1 protein CTD PMID:11774253 aniline increases expression ISO RGD:2294 6480464 aniline results in increased expression of CCNE1 protein; more ... CTD PMID:21070798 arsenic atom increases expression ISO RGD:736488 6480464 Arsenic results in increased expression of CCNE1 mRNA CTD PMID:11134558 atropine increases expression ISO RGD:736488 6480464 Atropine results in increased expression of CCNE1 mRNA CTD PMID:17390078 atropine multiple interactions ISO RGD:736488 6480464 [Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA CTD PMID:17390078 benzo[a]pyrene decreases expression ISO RGD:736488 6480464 Benzo(a)pyrene results in decreased expression of CCNE1 mRNA; more ... CTD PMID:19027820 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of CCNE1 mRNA CTD PMID:19770486 benzo[a]pyrene increases expression EXP   6480464 Benzo(a)pyrene results in increased expression of CCNE1 mRNA CTD PMID:20713471 benzo[a]pyrene multiple interactions EXP   6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of CCNE1 mRNA CTD PMID:21715664 berberine decreases expression ISO RGD:736488 6480464 Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 bifenthrin multiple interactions ISO RGD:2294 6480464 bifenthrin inhibits the reaction [CGA protein results in increased expression of CCNE1 mRNA] CTD PMID:21251947 bis(2-chloroethyl) sulfide increases expression EXP   6480464 Mustard Gas results in increased expression of CCNE1 mRNA CTD PMID:15674843 brassinolide decreases expression ISO RGD:736488 6480464 brassinolide results in decreased expression of CCNE1 protein CTD PMID:20833159 budesonide decreases expression EXP   6480464 Budesonide results in decreased expression of CCNE1 mRNA CTD PMID:17163412 butyric acid decreases expression ISO RGD:2294 6480464 Butyric Acid results in decreased expression of CCNE1 mRNA CTD PMID:12800193 cadmium atom multiple interactions ISO RGD:736488 6480464 Cadmium promotes the reaction [CDKN1A protein binds to CDK2 protein binds to CCNE1 protein]; more ... CTD PMID:20839231 cadmium atom increases expression EXP   6480464 Cadmium results in increased expression of CCNE1 mRNA CTD PMID:22666406 calciol decreases expression ISO RGD:736488 6480464 Cholecalciferol results in decreased expression of CCNE1 protein CTD PMID:12907249 carmustine increases expression ISO RGD:2294 6480464 Carmustine results in increased expression of CCNE1 mRNA CTD PMID:16005536 cefaloridine increases expression ISO RGD:2294 6480464 Cephaloridine results in increased expression of CCNE1 mRNA CTD PMID:18500788 choline increases expression EXP   6480464 Choline results in increased expression of CCNE1 mRNA CTD PMID:16014740 choline increases expression ISO RGD:2294 6480464 Choline results in increased expression of CCNE1 mRNA CTD PMID:16014740 ciprofloxacin decreases expression ISO RGD:736488 6480464 Ciprofloxacin results in decreased expression of CCNE1 protein CTD PMID:10741713 cisplatin affects response to substance ISO RGD:736488 6480464 CCNE1 protein affects the susceptibility to Cisplatin CTD PMID:16217747 cisplatin multiple interactions ISO RGD:736488 6480464 Cisplatin results in decreased activity of [CCNE1 protein binds to CDK2 protein] CTD PMID:21592546 cisplatin increases response to substance ISO RGD:736488 6480464 CCNE1 results in increased susceptibility to Cisplatin CTD PMID:21103391 copper atom multiple interactions ISO RGD:736488 6480464 [Thiosemicarbazones binds to Copper] which results in decreased expression of CCNE1 protein CTD PMID:20931265 copper(0) multiple interactions ISO RGD:736488 6480464 [Thiosemicarbazones binds to Copper] which results in decreased expression of CCNE1 protein CTD PMID:20931265 copper(2+) sulfate decreases expression ISO RGD:736488 6480464 Copper Sulfate results in decreased expression of CCNE1 mRNA CTD PMID:19549813 corticosterone decreases expression ISO RGD:2294 6480464 Corticosterone results in decreased expression of CCNE1 protein CTD PMID:12807724 coumarin increases expression ISO RGD:2294 6480464 coumarin results in increased expression of CCNE1 mRNA CTD PMID:18480146 crocidolite asbestos affects expression ISO RGD:736488 6480464 Asbestos, Crocidolite affects the expression of CCNE1 mRNA CTD PMID:17331233 curcumin decreases expression ISO RGD:736488 6480464 Curcumin results in decreased expression of CCNE1 protein CTD PMID:17148446 curcumin decreases expression ISO RGD:2294 6480464 Curcumin results in decreased expression of CCNE1 mRNA CTD PMID:18299980 curcumin multiple interactions ISO RGD:736488 6480464 lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein] CTD PMID:18156803 curcumin increases degradation ISO RGD:736488 6480464 Curcumin results in increased degradation of CCNE1 protein CTD PMID:18156803 daunorubicin affects expression ISO RGD:736488 6480464 Daunorubicin affects the expression of CCNE1 mRNA CTD PMID:12656675 desferrioxamine B increases expression ISO RGD:736488 6480464 Deferoxamine results in increased expression of CCNE1 protein CTD PMID:11468187 dexamethasone decreases expression EXP   6480464 Dexamethasone results in decreased expression of CCNE1 mRNA CTD PMID:21041162 diarsenic trioxide decreases expression ISO RGD:736488 6480464 arsenic trioxide results in decreased expression of CCNE1 mRNA CTD PMID:19236751 diarsenic trioxide decreases expression ISO RGD:736488 6480464 arsenic trioxide results in decreased expression of CCNE1 protein CTD PMID:12480548 diethanolamine increases expression EXP   6480464 diethanolamine results in increased expression of CCNE1 mRNA CTD PMID:16014740 diethanolamine increases expression ISO RGD:2294 6480464 diethanolamine results in increased expression of CCNE1 mRNA CTD PMID:16014740 diethylstilbestrol decreases expression EXP   6480464 Diethylstilbestrol results in decreased expression of CCNE1 mRNA CTD PMID:21041162 disodium selenite increases expression ISO RGD:736488 6480464 Sodium Selenite results in increased expression of CCNE1 mRNA CTD PMID:16705456 doxorubicin decreases expression ISO RGD:736488 6480464 Doxorubicin results in decreased expression of CCNE1 protein CTD PMID:16036217 doxorubicin multiple interactions ISO RGD:2294 6480464 Doxorubicin promotes the reaction [TAF1 protein results in increased expression of CCNE1 protein] CTD PMID:15124910 doxorubicin multiple interactions EXP   6480464 [zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCNE1 protein CTD PMID:19789217 ethidium multiple interactions ISO RGD:736488 6480464 Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA] CTD PMID:15897899 fluoxetine decreases expression EXP   6480464 Fluoxetine results in decreased expression of CCNE1 mRNA CTD PMID:21497159 fluoxetine affects expression ISO RGD:736488 6480464 Fluoxetine affects the expression of CCNE1 mRNA CTD PMID:18371935 fluoxetine multiple interactions ISO RGD:736488 6480464 [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CCNE1 protein CTD PMID:18371935 folic acid affects expression ISO RGD:736488 6480464 Folic Acid affects the expression of CCNE1 mRNA CTD PMID:16361273 fulvestrant decreases expression ISO RGD:736488 6480464 fulvestrant results in decreased expression of CCNE1 mRNA CTD PMID:20215421 furan increases expression ISO RGD:2294 6480464 furan results in increased expression of CCNE1 mRNA CTD PMID:22079235 furan increases expression ISO RGD:2294 6480464 furan results in increased expression of CCNE1 mRNA CTD PMID:20124500 PMID:22079235 gadolinium trichloride increases expression ISO RGD:736488 6480464 gadolinium chloride results in increased expression of CCNE1 CTD PMID:19184457 gallic acid decreases expression ISO RGD:736488 6480464 Gallic Acid results in decreased expression of CCNE1 protein CTD PMID:22245431 gamma-linolenic acid decreases expression ISO RGD:736488 6480464 gamma-Linolenic Acid results in decreased expression of CCNE1 protein CTD PMID:15318936 hydrogen chloride increases expression ISO RGD:736488 6480464 Hydrochloric Acid results in increased expression of CCNE1 mRNA CTD PMID:15046208 hydroxyurea increases expression ISO RGD:736488 6480464 Hydroxyurea results in increased expression of CCNE1 protein CTD PMID:11468187 indole-3-methanol affects localization ISO RGD:736488 6480464 indole-3-carbinol affects the localization of CCNE1 protein CTD PMID:15611077 indole-3-methanol decreases expression ISO RGD:736488 6480464 indole-3-carbinol results in decreased expression of CCNE1 CTD PMID:16082211 indole-3-methanol multiple interactions ISO RGD:736488 6480464 indole-3-carbinol promotes the reaction [CDK2 protein binds to CCNE1 protein alternative form]; more ... CTD PMID:15611077 indomethacin multiple interactions ISO RGD:2294 6480464 Indomethacin inhibits the reaction [FGF2 protein results in increased expression of CCNE1 protein] CTD PMID:11170841 kainic acid increases expression ISO RGD:2294 6480464 Kainic Acid results in increased expression of CCNE1 protein CTD PMID:12941380 lactacystin multiple interactions ISO RGD:736488 6480464 lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein] CTD PMID:18156803 lidocaine affects expression EXP   6480464 Lidocaine affects the expression of CCNE1 mRNA CTD PMID:18931217 LY294002 decreases expression ISO RGD:736488 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNE1 protein CTD PMID:14757120 LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of CCNE1 protein] CTD PMID:14971663 LY294002 decreases expression EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNE1 protein CTD PMID:15601625 lycopene decreases expression ISO RGD:736488 6480464 lycopene results in decreased expression of CCNE1 protein CTD PMID:17337101 lycopene increases expression ISO RGD:736488 6480464 lycopene results in increased expression of CCNE1 mRNA CTD PMID:16886892 malachite green cation multiple interactions ISO RGD:2294 6480464 malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein] CTD PMID:10906429 menadione affects expression ISO RGD:736488 6480464 Vitamin K 3 affects the expression of CCNE1 mRNA CTD PMID:20044591 mercaptopurine decreases expression ISO RGD:2294 6480464 6-Mercaptopurine results in decreased expression of CCNE1 mRNA CTD PMID:23358152 metformin multiple interactions ISO RGD:2294 6480464 Metformin inhibits the reaction [FSH protein results in increased expression of CCNE1 protein]; more ... CTD PMID:16760380 metformin decreases expression ISO RGD:2294 6480464 Metformin results in decreased expression of CCNE1 protein CTD PMID:16760380 methotrexate affects expression EXP   6480464 Methotrexate affects the expression of CCNE1 mRNA CTD PMID:18502557 methotrexate increases expression ISO RGD:2294 6480464 Methotrexate results in increased expression of CCNE1 mRNA CTD PMID:16005536 methyl isocyanate affects expression ISO RGD:736488 6480464 methyl isocyanate affects the expression of CCNE1 protein CTD PMID:19513903 methylarsonic acid increases expression ISO RGD:2294 6480464 monomethylarsonic acid results in increased expression of CCNE1 mRNA CTD PMID:17481689 methylmercury chloride increases cleavage ISO RGD:2294 6480464 methylmercuric chloride results in increased cleavage of CCNE1 protein CTD PMID:17760861 methylmercury chloride decreases expression ISO RGD:2294 6480464 methylmercuric chloride results in decreased expression of CCNE1 protein CTD PMID:17760861 mifepristone multiple interactions ISO RGD:736488 6480464 Mifepristone inhibits the reaction [CDK2 protein binds to CCNE1 protein]; more ... CTD PMID:17545545 N-acetyl-L-cysteine multiple interactions ISO RGD:2294 6480464 Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA] CTD PMID:15945272 N-nitrosodiethylamine multiple interactions ISO RGD:2294 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA; more ... CTD PMID:14633663 N-nitrosodiethylamine increases expression ISO RGD:2294 6480464 Diethylnitrosamine results in increased expression of CCNE1 protein CTD PMID:10906429 more ... N-nitrosodiethylamine increases expression ISO RGD:2294 6480464 Diethylnitrosamine results in increased expression of CCNE1 protein CTD PMID:10906429 more ... N-nitrosodiethylamine increases expression ISO RGD:2294 6480464 Diethylnitrosamine results in increased expression of CCNE1 protein CTD PMID:19254457 more ... N-nitrosodiethylamine increases expression ISO RGD:2294 6480464 Diethylnitrosamine results in increased expression of CCNE1 protein CTD PMID:11831363 more ... N-nitrosodiethylamine increases expression ISO RGD:2294 6480464 Diethylnitrosamine results in increased expression of CCNE1 protein CTD PMID:11831363 more ... N-nitrosodiethylamine multiple interactions ISO RGD:2294 6480464 malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]; more ... CTD PMID:10906429 N-nitrosodiethylamine increases expression ISO RGD:2294 6480464 Diethylnitrosamine results in increased expression of CCNE1 protein CTD PMID:19254457 more ... ochratoxin A increases expression ISO RGD:2294 6480464 ochratoxin A results in increased expression of CCNE1 mRNA CTD PMID:19237604 ochratoxin A increases expression ISO RGD:2294 6480464 ochratoxin A results in increased expression of CCNE1 mRNA CTD PMID:19237604 PMID:23358140 oxaliplatin increases expression ISO RGD:736488 6480464 oxaliplatin results in increased expression of CCNE1 protein CTD PMID:15204521 ozone increases expression ISO RGD:2294 6480464 Ozone results in increased expression of CCNE1 mRNA CTD PMID:16330353 paracetamol increases expression ISO RGD:736488 6480464 Acetaminophen results in increased expression of CCNE1 mRNA CTD PMID:22230336 parathion increases expression ISO RGD:736488 6480464 Parathion results in increased expression of CCNE1 mRNA CTD PMID:17390078 parathion multiple interactions ISO RGD:736488 6480464 [Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA CTD PMID:17390078 pentachlorophenol increases expression ISO RGD:2294 6480464 Pentachlorophenol results in increased expression of CCNE1 protein CTD PMID:19442831 phenobarbital multiple interactions ISO RGD:2294 6480464 Phenobarbital promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein] CTD PMID:10906429 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736488 6480464 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]; more ... CTD PMID:12421932 phorbol 13-acetate 12-myristate increases expression ISO RGD:736488 6480464 Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein CTD PMID:12421932 pioglitazone decreases expression ISO RGD:736488 6480464 pioglitazone results in decreased expression of CCNE1 protein CTD PMID:15729575 pirinixic acid multiple interactions EXP   6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCNE1 mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:2294 6480464 pirinixic acid results in increased expression of CCNE1 mRNA CTD PMID:19162173 progesterone decreases expression EXP   6480464 Progesterone results in decreased expression of CCNE1 mRNA CTD PMID:16966611 pterostilbene decreases expression ISO RGD:2294 6480464 pterostilbene results in decreased expression of CCNE1 protein CTD PMID:20398797 purine-6-thiol decreases expression ISO RGD:2294 6480464 6-Mercaptopurine results in decreased expression of CCNE1 mRNA CTD PMID:23358152 quercetin multiple interactions ISO RGD:736488 6480464 Quercetin inhibits the reaction [TNF protein results in increased expression of CCNE1 protein] CTD PMID:12589822 quercetin increases expression ISO RGD:736488 6480464 Quercetin results in increased expression of CCNE1 mRNA CTD PMID:21632981 quercetin multiple interactions ISO RGD:736488 6480464 Quercetin promotes the reaction [CDKN1A protein binds to CCNE1 protein] CTD PMID:12934110 resveratrol affects expression ISO RGD:736488 6480464 resveratrol affects the expression of CCNE1 protein CTD PMID:12392819 resveratrol increases expression ISO RGD:736488 6480464 resveratrol results in increased expression of CCNE1 protein CTD PMID:11481417 more ... resveratrol decreases expression ISO RGD:736488 6480464 resveratrol results in decreased expression of CCNE1 protein CTD PMID:17050787 PMID:18347188 resveratrol increases expression ISO RGD:736488 6480464 resveratrol results in increased expression of CCNE1 protein CTD PMID:15670636 resveratrol decreases expression ISO RGD:736488 6480464 resveratrol results in decreased expression of CCNE1 protein CTD PMID:17050787 resveratrol multiple interactions ISO RGD:736488 6480464 resveratrol inhibits the reaction [TNF protein results in increased expression of CCNE1 protein] CTD PMID:16317118 retinyl acetate increases expression EXP   6480464 retinol acetate results in increased expression of CCNE1 mRNA CTD PMID:16772331 rosiglitazone decreases expression ISO RGD:736488 6480464 rosiglitazone results in decreased expression of CCNE1 protein CTD PMID:15729575 silver atom increases expression ISO RGD:736488 6480464 Silver results in increased expression of CCNE1 protein CTD PMID:22546375 silver(0) increases expression ISO RGD:736488 6480464 Silver results in increased expression of CCNE1 protein CTD PMID:22546375 silver(1+) nitrate increases expression ISO RGD:736488 6480464 Silver Nitrate analog results in increased expression of CCNE1 mRNA; more ... CTD PMID:22831968 sodium dichromate affects expression ISO RGD:2294 6480464 sodium bichromate affects the expression of CCNE1 mRNA CTD PMID:22110744 sulindac decreases expression ISO RGD:736488 6480464 Sulindac results in decreased expression of CCNE1 protein CTD PMID:16488075 tamoxifen multiple interactions ISO RGD:736488 6480464 [Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1A protein binds to [CCNE1 protein binds to CDK2 protein]]; more ... CTD PMID:12866041 tamoxifen decreases expression ISO RGD:2294 6480464 Tamoxifen results in decreased expression of CCNE1 mRNA; more ... CTD PMID:12602925 tamoxifen increases expression EXP   6480464 Tamoxifen results in increased expression of CCNE1 protein CTD PMID:15642790 tamoxifen increases expression ISO RGD:736488 6480464 Tamoxifen results in increased expression of CCNE1 mRNA; more ... CTD PMID:20215421 tamoxifen affects response to substance ISO RGD:736488 6480464 CCNE1 protein affects the susceptibility to Tamoxifen CTD PMID:19148479 taurocholic acid multiple interactions ISO RGD:736488 6480464 sorafenib inhibits the reaction [Taurocholic Acid results in increased expression of CCNE1 protein]; more ... CTD PMID:18512153 taurocholic acid increases expression ISO RGD:736488 6480464 Taurocholic Acid results in increased expression of CCNE1 protein CTD PMID:18512153 tert-butyl hydroperoxide multiple interactions ISO RGD:736488 6480464 ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CCNE1 protein] CTD PMID:15606011 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of CCNE1 mRNA CTD PMID:17484886 thioacetamide increases expression ISO RGD:2294 6480464 Thioacetamide results in increased expression of CCNE1 mRNA CTD PMID:22659510 tioguanine increases expression ISO RGD:2294 6480464 Thioguanine results in increased expression of CCNE1 mRNA CTD PMID:16005536 tocopherol decreases expression ISO RGD:736488 6480464 Tocopherols results in decreased expression of CCNE1 mRNA; more ... CTD PMID:12504091 topotecan decreases expression ISO RGD:736488 6480464 Topotecan results in decreased expression of CCNE1 protein CTD PMID:15923621 trans-resveratrol affects expression ISO RGD:736488 6480464 resveratrol affects the expression of CCNE1 protein CTD PMID:12392819 trans-resveratrol increases expression ISO RGD:736488 6480464 resveratrol results in increased expression of CCNE1 protein CTD PMID:11481417 more ... trans-resveratrol decreases expression ISO RGD:736488 6480464 resveratrol results in decreased expression of CCNE1 protein CTD PMID:17050787 PMID:18347188 trans-resveratrol increases expression ISO RGD:736488 6480464 resveratrol results in increased expression of CCNE1 protein CTD PMID:15670636 trans-resveratrol decreases expression ISO RGD:736488 6480464 resveratrol results in decreased expression of CCNE1 protein CTD PMID:17050787 trans-resveratrol multiple interactions ISO RGD:736488 6480464 resveratrol inhibits the reaction [TNF protein results in increased expression of CCNE1 protein] CTD PMID:16317118 trichostatin A increases expression ISO RGD:736488 6480464 trichostatin A results in increased expression of CCNE1 protein CTD PMID:15179185 trimellitic anhydride increases expression EXP   6480464 trimellitic anhydride results in increased expression of CCNE1 mRNA CTD PMID:19042947 trimethylarsine oxide increases expression ISO RGD:2294 6480464 trimethylarsine oxide results in increased expression of CCNE1 mRNA CTD PMID:17481689 troglitazone decreases expression ISO RGD:736488 6480464 troglitazone results in decreased expression of CCNE1 protein CTD PMID:15729575 troglitazone decreases expression ISO RGD:736488 6480464 troglitazone results in decreased expression of CCNE1 protein CTD PMID:15729575 more ... troglitazone decreases expression ISO RGD:736488 6480464 troglitazone results in decreased expression of CCNE1 protein CTD PMID:20540935 more ... troglitazone decreases expression ISO RGD:736488 6480464 troglitazone results in decreased expression of CCNE1 protein CTD PMID:11834241 more ... troglitazone decreases expression ISO RGD:736488 6480464 troglitazone results in decreased expression of CCNE1 protein CTD PMID:20540935 more ... troglitazone multiple interactions ISO RGD:736488 6480464 [N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CCNE1 protein]; more ... CTD PMID:20540935 wortmannin multiple interactions EXP   6480464 wortmannin inhibits the reaction [Vanadates results in increased expression of CCNE1 protein] CTD PMID:14971663 zinc atom multiple interactions ISO RGD:736488 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of CCNE1 mRNA CTD PMID:18593933 zinc(0) multiple interactions ISO RGD:736488 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of CCNE1 mRNA CTD PMID:18593933 zoledronic acid multiple interactions EXP   6480464 [zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCNE1 protein CTD PMID:19789217 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell cycle   IEA UniProtKB-KW:KW-0131 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 cell division   IEA UniProtKB-KW:KW-0132 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 DNA replication initiation   IMP MGI:MGI:2675473 2290270 MGI:MGI:2673102|PMID:12941272 MGI MGI:MGI:2673102 PMID:12941272 positive regulation of cell differentiation   ISO UniProtKB:P39949 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein phosphorylation   IDA   2290270 MGI:MGI:2384369|PMID:12124778 MGI MGI:MGI:2384369 PMID:12124778 protein phosphorylation   ISS UniProtKB:P24864 2290270 MGI:MGI:1345775|PMID:10500095 MGI MGI:MGI:1345775 PMID:10500095 regulation of cell cycle   IDA   2290270 MGI:MGI:2675510|PMID:12970171 MGI MGI:MGI:2675510 PMID:12970171 regulation of cyclin-dependent protein serine/threonine kinase activity   IEA InterPro:IPR014400 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 Wnt receptor signaling pathway   IDA   2290270 MGI:MGI:3820325|PMID:19056892 MGI MGI:MGI:3820325 PMID:19056892 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) centrosome   ISO UniProtKB:P39949 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cyclin-dependent protein kinase holoenzyme complex   IPI UniProtKB:P97377 2290270 MGI:MGI:2677082|PMID:12970760 MGI MGI:MGI:2677082 PMID:12970760 cytoplasm   ISO UniProtKB:P39949 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 nucleus   ISO UniProtKB:P24864 2290270 MGI:MGI:3590381|PMID:16109376 MGI MGI:MGI:3590381 PMID:16109376 nucleus   ISO UniProtKB:C9J2U0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 nucleus   ISO UniProtKB:P39949 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 nucleus   IDA   2290270 MGI:MGI:1345775|PMID:10500095 MGI MGI:MGI:1345775 PMID:10500095 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) cyclin-dependent protein serine/threonine kinase regulator activity   IDA   2290270 MGI:MGI:2675510|PMID:12970171 MGI MGI:MGI:2675510 PMID:12970171 kinase activity   IDA   2290270 MGI:MGI:2384369|PMID:12124778 MGI MGI:MGI:2384369 PMID:12124778 protein binding   IPI UniProtKB:P97377 2290270 MGI:MGI:2677082|PMID:12970760 MGI MGI:MGI:2677082 PMID:12970760 protein binding   IPI UniProtKB:Q8VEH2 2290270 MGI:MGI:4439421|PMID:20215406 MGI MGI:MGI:4439421 PMID:20215406 protein binding   IPI UniProtKB:Q9JLV5 2290270 MGI:MGI:1345775|PMID:10500095 MGI MGI:MGI:1345775 PMID:10500095 protein binding   IPI UniProtKB:P11440|UniProtKB:P97377 2290270 MGI:MGI:4412428|PMID:19592082 IntAct MGI:MGI:4412428 PMID:19592082 protein complex binding   ISO UniProtKB:P39949 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein kinase binding   IPI UniProtKB:P97377 2290270 MGI:MGI:3617096|PMID:11981756 MGI MGI:MGI:3617096 PMID:11981756 protein kinase binding   ISO UniProtKB:P39949 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell cycle pathway, mitotic   IEA RGD:736489 6907045   KEGG mmu:04110 measles infection pathway   IEA RGD:736489 6907045   KEGG mmu:05162 mTOR signaling pathway   ISO RGD:736488 6484113   PID PID:200096 p53 signaling pathway   IEA RGD:736489 6907045   KEGG mmu:04115 prostate cancer pathway   IEA RGD:736489 6907045   KEGG mmu:05215 small cell lung cancer pathway   IEA RGD:736489 6907045   KEGG mmu:05222 External Database Links KEGG Pathway Cell cycle Hepatitis B Measles Oocyte meiosis p53 signaling pathway Pathways in cancer PI3K-Akt signaling pathway Prostate cancer Small cell lung cancer Viral carcinogenesis Pathway Interaction Database BARD1 signaling events (PID:200205) E2F transcription factor network (PID:200032) FOXM1 transcription factor network (PID:200141) mTOR signaling pathway (PID:200096) PLK3 signaling events (PID:200217) Regulation of retinoblastoma protein (PID:200223) Signaling events mediated by PRL (PID:200007) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal aortic arch development   IAGP   5509061   MGI PMID:12941272 abnormal bone marrow morphology   IAGP   5509061   MGI PMID:18559482 abnormal cardiovascular system morphology   IAGP   5509061   MGI PMID:12941272 abnormal cell morphology   IAGP   5509061   MGI PMID:16023597 abnormal cell physiology   IAGP   5509061   MGI PMID:16023597 abnormal dendritic spine morphology   IAGP   5509061   MGI PMID:21944720 abnormal embryonic growth/weight/body size   IAGP   5509061   MGI PMID:12970191 abnormal erythrocyte morphology   IAGP   5509061   MGI PMID:18559482 abnormal erythropoiesis   IAGP   5509061   MGI PMID:18559482 abnormal excitatory postsynaptic currents   IAGP   5509061   MGI PMID:21944720 abnormal excitatory postsynaptic potential   IAGP   5509061   MGI PMID:21944720 abnormal extraembryonic tissue morphology   IAGP   5509061   MGI PMID:12941272 abnormal extraembryonic tissue morphology   IAGP   5509061   MGI PMID:12970191 abnormal fertility/fecundity   IAGP   5509061   MGI PMID:12941272 abnormal hematopoiesis   IAGP   5509061   MGI PMID:12941272 abnormal intestinal epithelium morphology   IAGP   5509061   MGI PMID:18559482 abnormal involution of the mammary gland   IAGP   5509061   MGI PMID:18559482 abnormal mammary gland physiology   IAGP   5509061   MGI PMID:18559482 abnormal myeloid leukocyte morphology   IAGP   5509061   MGI PMID:18559482 abnormal placenta morphology   IAGP   5509061   MGI PMID:12941272 abnormal reproductive system morphology   IAGP   5509061   MGI PMID:12941272 abnormal spatial learning   IAGP   5509061   MGI PMID:21944720 abnormal spleen red pulp morphology   IAGP   5509061   MGI PMID:18559482 abnormal synapse morphology   IAGP   5509061   MGI PMID:21944720 abnormal thrombopoiesis   IAGP   5509061   MGI PMID:12941272 abnormal trophoblast giant cells   IAGP   5509061   MGI PMID:12941272 abnormal trophoblast layer morphology   IAGP   5509061   MGI PMID:12970191 abnormal vasculogenesis   IAGP   5509061   MGI PMID:12970191 abnormal vitelline vasculature morphology   IAGP   5509061   MGI PMID:12970191 anemia   IAGP   5509061   MGI PMID:18559482 anisopoikilocytosis   IAGP   5509061   MGI PMID:18559482 atrioventricular septal defect   IAGP   5509061   MGI PMID:12941272 chromosome breakage   IAGP   5509061   MGI PMID:16023597 complete embryonic lethality during organogenesis   IAGP   5509061   MGI PMID:12941272 decreased embryo size   IAGP   5509061   MGI PMID:12941272 decreased fibroblast proliferation   IAGP   5509061   MGI PMID:16023597 decreased tumor latency   IAGP   5509061   MGI PMID:16023597 double outlet right ventricle   IAGP   5509061   MGI PMID:12941272 embryonic growth retardation   IAGP   5509061   MGI PMID:12970191 enlarged spleen   IAGP   5509061   MGI PMID:18559482 extramedullary hematopoiesis   IAGP   5509061   MGI PMID:16023597 increased bone marrow cell number   IAGP   5509061   MGI PMID:18559482 increased cell proliferation   IAGP   5509061   MGI PMID:16023597 increased erythroid progenitor cell number   IAGP   5509061   MGI PMID:18559482 increased spleen weight   IAGP   5509061   MGI PMID:16023597 increased splenocyte proliferation   IAGP   5509061   MGI PMID:16023597 no abnormal phenotype detected   IAGP   5509061   MGI PMID:12941272 no abnormal phenotype detected   IAGP   5509061   MGI PMID:21944720 ostium primum atrial septal defect   IAGP   5509061   MGI PMID:12941272 partial embryonic lethality during organogenesis   IAGP   5509061   MGI PMID:12970191 premature death   IAGP   5509061   MGI PMID:16023597 reduced long term potentiation   IAGP   5509061   MGI PMID:21944720 reduced male fertility   IAGP   5509061   MGI PMID:12941272 reduced NMDA-mediated synaptic currents   IAGP   5509061   MGI PMID:21944720 spleen hyperplasia   IAGP   5509061   MGI PMID:18559482 testis hypoplasia   IAGP   5509061   MGI PMID:12941272 ventricular septal defect   IAGP   5509061   MGI PMID:12941272 Disease Annotations Bowen's Disease  (ISS) Breast Neoplasms  (ISS) Carcinoma, Endometrioid  (ISS) Carcinoma, Hepatocellular  (ISS) Carcinoma, Renal Cell  (ISS) Cervical Intraepithelial Neoplasia  (ISS) Colonic Neoplasms  (ISS) Diabetic Nephropathies  (ISS) Hypertension  (ISS) Lymphatic Metastasis  (ISS) Mammary Neoplasms, Experimental  (ISS) Neoplasm Metastasis  (IED) Neoplasms, Germ Cell and Embryonal  (ISS) Ovarian Neoplasms  (ISS) Prostatic Intraepithelial Neoplasia  (IEP) Prostatic Neoplasms  (IEP) Spinal Cord Injuries  (ISS) Urinary Bladder Neoplasms  (ISS) Uterine Cervical Neoplasms  (IEP,ISS) Gene-Chemical Interaction Annotations (S)-nicotine  (ISO) 17beta-estradiol  (ISO) 17beta-hydroxy-5alpha-androstan-3-one  (EXP) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,6-di-tert-butyl-4-methylphenol  (EXP) 2,6-dinitrotoluene  (ISO) 2-acetamidofluorene  (ISO) 2-butoxyethanol  (EXP) 3,3',4,4'-tetrachlorobiphenyl  (EXP) 3,3',5-triiodo-L-thyronine  (ISO) 5-fluorouracil  (ISO) 5-formyltetrahydrofolic acid  (ISO) acetylsalicylic acid  (ISO) acrylamide  (EXP) afimoxifene  (ISO) aflatoxin B1  (ISO) all-trans-retinoic acid  (EXP,ISO) amlodipine  (ISO) ammonium chloride  (ISO) amsacrine  (ISO) aniline  (ISO) arsenic atom  (ISO) atropine  (ISO) benzo[a]pyrene  (EXP,ISO) berberine  (ISO) bifenthrin  (ISO) bis(2-chloroethyl) sulfide  (EXP) brassinolide  (ISO) budesonide  (EXP) butyric acid  (ISO) cadmium atom  (EXP,ISO) calciol  (ISO) carmustine  (ISO) cefaloridine  (ISO) choline  (EXP,ISO) ciprofloxacin  (ISO) cisplatin  (ISO) copper atom  (ISO) copper(0)  (ISO) copper(2+) sulfate  (ISO) corticosterone  (ISO) coumarin  (ISO) crocidolite asbestos  (ISO) curcumin  (ISO) daunorubicin  (ISO) desferrioxamine B  (ISO) dexamethasone  (EXP) diarsenic trioxide  (ISO) diethanolamine  (EXP,ISO) diethylstilbestrol  (EXP) disodium selenite  (ISO) doxorubicin  (EXP,ISO) ethidium  (ISO) fluoxetine  (EXP,ISO) folic acid  (ISO) fulvestrant  (ISO) furan  (ISO) gadolinium trichloride  (ISO) gallic acid  (ISO) gamma-linolenic acid  (ISO) hydrogen chloride  (ISO) hydroxyurea  (ISO) indole-3-methanol  (ISO) indomethacin  (ISO) kainic acid  (ISO) lactacystin  (ISO) lidocaine  (EXP) LY294002  (EXP,ISO) lycopene  (ISO) malachite green cation  (ISO) menadione  (ISO) mercaptopurine  (ISO) metformin  (ISO) methotrexate  (EXP,ISO) methyl isocyanate  (ISO) methylarsonic acid  (ISO) methylmercury chloride  (ISO) mifepristone  (ISO) N-acetyl-L-cysteine  (ISO) N-nitrosodiethylamine  (ISO) ochratoxin A  (ISO) oxaliplatin  (ISO) ozone  (ISO) paracetamol  (ISO) parathion  (ISO) pentachlorophenol  (ISO) phenobarbital  (ISO) phorbol 13-acetate 12-myristate  (ISO) pioglitazone  (ISO) pirinixic acid  (EXP,ISO) progesterone  (EXP) pterostilbene  (ISO) purine-6-thiol  (ISO) quercetin  (ISO) resveratrol  (ISO) retinyl acetate  (EXP) rosiglitazone  (ISO) silver atom  (ISO) silver(0)  (ISO) silver(1+) nitrate  (ISO) sodium dichromate  (ISO) sulindac  (ISO) tamoxifen  (EXP,ISO) taurocholic acid  (ISO) tert-butyl hydroperoxide  (ISO) tetrachloromethane  (EXP) thioacetamide  (ISO) tioguanine  (ISO) tocopherol  (ISO) topotecan  (ISO) trans-resveratrol  (ISO) trichostatin A  (ISO) trimellitic anhydride  (EXP) trimethylarsine oxide  (ISO) troglitazone  (ISO) wortmannin  (EXP) zinc atom  (ISO) zinc(0)  (ISO) zoledronic acid  (EXP) Gene Ontology Annotations Biological Process cell cycle  (IEA) cell division  (IEA) DNA replication initiation  (IMP) positive regulation of cell differentiation  (ISO) protein phosphorylation  (IDA,ISS) regulation of cell cycle  (IDA) regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA) Wnt receptor signaling pathway  (IDA) Cellular Component centrosome  (ISO) cyclin-dependent protein kinase holoenzyme complex  (IPI) cytoplasm  (ISO) nucleus  (IDA,ISO) Molecular Function cyclin-dependent protein serine/threonine kinase regulator activity  (IDA) kinase activity  (IDA) protein binding  (IPI) protein complex binding  (ISO) protein kinase binding  (IPI,ISO) Molecular Pathway Annotations cell cycle pathway, mitotic  (IEA) measles infection pathway  (IEA) mTOR signaling pathway  (ISO) p53 signaling pathway  (IEA) prostate cancer pathway  (IEA) small cell lung cancer pathway  (IEA) External Database Links KEGG Pathway Cell cycle Hepatitis B Measles Oocyte meiosis p53 signaling pathway Pathways in cancer PI3K-Akt signaling pathway Prostate cancer Small cell lung cancer Viral carcinogenesis Pathway Interaction Database BARD1 signaling events (PID:200205) E2F transcription factor network (PID:200032) FOXM1 transcription factor network (PID:200141) mTOR signaling pathway (PID:200096) PLK3 signaling events (PID:200217) Regulation of retinoblastoma protein (PID:200223) Signaling events mediated by PRL (PID:200007) Phenotype Annotations abnormal aortic arch development  (IAGP) abnormal bone marrow morphology  (IAGP) abnormal cardiovascular system morphology  (IAGP) abnormal cell morphology  (IAGP) abnormal cell physiology  (IAGP) abnormal dendritic spine morphology  (IAGP) abnormal embryonic growth/weight/body size  (IAGP) abnormal erythrocyte morphology  (IAGP) abnormal erythropoiesis  (IAGP) abnormal excitatory postsynaptic currents  (IAGP) abnormal excitatory postsynaptic potential  (IAGP) abnormal extraembryonic tissue morphology  (IAGP) abnormal fertility/fecundity  (IAGP) abnormal hematopoiesis  (IAGP) abnormal intestinal epithelium morphology  (IAGP) abnormal involution of the mammary gland  (IAGP) abnormal mammary gland physiology  (IAGP) abnormal myeloid leukocyte morphology  (IAGP) abnormal placenta morphology  (IAGP) abnormal reproductive system morphology  (IAGP) abnormal spatial learning  (IAGP) abnormal spleen red pulp morphology  (IAGP) abnormal synapse morphology  (IAGP) abnormal thrombopoiesis  (IAGP) abnormal trophoblast giant cells  (IAGP) abnormal trophoblast layer morphology  (IAGP) abnormal vasculogenesis  (IAGP) abnormal vitelline vasculature morphology  (IAGP) anemia  (IAGP) anisopoikilocytosis  (IAGP) atrioventricular septal defect  (IAGP) chromosome breakage  (IAGP) complete embryonic lethality during organogenesis  (IAGP) decreased embryo size  (IAGP) decreased fibroblast proliferation  (IAGP) decreased tumor latency  (IAGP) double outlet right ventricle  (IAGP) embryonic growth retardation  (IAGP) enlarged spleen  (IAGP) extramedullary hematopoiesis  (IAGP) increased bone marrow cell number  (IAGP) increased cell proliferation  (IAGP) increased erythroid progenitor cell number  (IAGP) increased spleen weight  (IAGP) increased splenocyte proliferation  (IAGP) no abnormal phenotype detected  (IAGP) ostium primum atrial septal defect  (IAGP) partial embryonic lethality during organogenesis  (IAGP) premature death  (IAGP) reduced long term potentiation  (IAGP) reduced male fertility  (IAGP) reduced NMDA-mediated synaptic currents  (IAGP) spleen hyperplasia  (IAGP) testis hypoplasia  (IAGP) ventricular septal defect  (IAGP) References - curated 1. Adelaide J, etal., Cancer Res. 2007 Dec 15;67(24):11565-75. 2. Akli S, etal., Cancer Res. 2007 Aug 1;67(15):7212-22. 3. Bahnassy AA, etal., J Egypt Natl Canc Inst. 2006 Dec;18(4):292-302. 4. Berglund P, etal., J Clin Pathol. 2007 May 4;. 5. Christov K, etal., Breast Cancer Res Treat. 2003 Feb;77(3):253-64. 6. Davidson B, etal., Cancer. 2007 Sep 15;110(6):1264-71. 7. Eder AM, etal., Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12519-24. Epub 2005 Aug 22. 8. Erlandsson F, etal., Br J Cancer. 2006 Apr 10;94(7):1045-50. 9. Horree N, etal., J Clin Pathol. 2008 Jan;61(1):36-42. Epub 2007 May 4. 10. Hur K, etal., J Vet Sci. 2000 Dec;1(2):121-6. 11. Jiang W, etal., Cancer Res. 2003 Mar 15;63(6):1228-34. 12. Kaczmarek P, etal., Pol J Pathol. 2006;57(1):41-4. 13. Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. 14. Kim KK, etal., Pathol Int. 2003 May;53(5):291-6. 15. Maddison LA, etal., Prostate. 2004 Mar 1;58(4):335-44. 16. Mauriz JL, etal., Transl Res. 2007 Jan;149(1):46-53. 17. MGD and Homologene mouse data transfer 18. MGD data from the GO Consortium 19. MGD IEA 20. Nauman A, etal., Acta Biochim Pol. 2007;54(3):595-602. Epub 2007 Aug 28. 21. Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. 22. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 23. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 24. RGD automated import pipeline 25. RGD automated import pipeline for gene-chemical interactions 26. Santegoets LA, etal., Int J Cancer. 2007 Aug 15;121(4):759-66. 27. Schmidt BA, etal., Cancer Res. 2001 May 15;61(10):4214-21. 28. Shai A, etal., Cancer Res. 2007 Feb 15;67(4):1626-35. 29. Shariat SF, etal., Hum Pathol. 2006 Dec;37(12):1568-76. Epub 2006 Aug 10. 30. Shariat SF, etal., Urol Oncol. 2007 Nov-Dec;25(6):468-75. 31. Tanner FC, etal., Hypertension. 2003 Aug;42(2):184-8. Epub 2003 Jul 7. 32. Tian DS, etal., Zhonghua Yi Xue Za Zhi. 2006 Apr 4;86(13):901-5. 33. Zhang Y, etal., Biochem Biophys Res Commun. 2007 Nov 9;363(1):159-64. Epub 2007 Aug 31. References - uncurated PubMed 10349636   10380928   10457012   10500095   10508527   10531039   10618723   10790373   10913163   10922068   11042159   11076861   11095619   11397011   11463388   11585773   11687642   11850820   11919196   11981756   12124778   12429912   12477932   12729791   12884287   12941272   12970171   12970191   12970760   12972599   14561402   14610273   14627988   14672936   14742445   14766969   15028671   15124020   15136151   15155733   15214576   15299027   15315760   15327767   15459106   15707957   15722557   15730892   15749021   15782199   15799026   15800025   15838514   16007079   16023597   16102793   16109376   16141072   16141073   16602821   16919269   16954383   17000767   17151017   17218276   17274640   17276355   17360482   17362983   17369397   17392792   17475776   17517888   17581275   17699765   18206965   18340042   18356301   18443282   18462697   18559482   18635963   19056892   19129496   19139274   19217425   19228596   19265663   19287388   19325126   19433082   19449303   19474320   19574535   19590016   19592082   19644667   19706423   20215406   20392692   20450902   20530543   20660298   20737421   20808958   20863901   20877462   20962587   20978349   21108844   21109536   21185283   21267068   21349854   21372285   21503901   21518694   21519154   21536883   21636786   21677750   21690373   21731673   21746877   21944720   22154697   22234186   22360968   22405651   22411628   22560297   22737085   22957921   23223288   8003041   8033213   8226784   8552401   8640830   8668155   8674108   8812484   8822197   8833259   8947040   9110315   9166596   9171369   9615220   9664690   9856457 RGD Disease Portals Ccne1 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cardiovascular Diseases Cardiovascular Pathways Cardiovascular Phenotypes Diabetes Diseases Diabetes Pathways Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Neurological Diseases Neurological Pathways Neurological Phenotypes Obesity Diseases Obesity Pathways Respiratory Pathways Genomics Comparative Map Data Ccne1   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 38,097,984 - 38,107,490 - NCBI Mouse cM Map 7 25.35   NCBI Mouse Celera Assembly 7 33,255,165 - 33,271,131 - NCBI Mouse Genome Assembly Build 37 7 38,883,003 - 38,892,509 - NCBI Mouse Genome Assembly Build 36.1 7 38,883,003 - 38,892,509 - NCBI Mouse Cytogenetic Map 7 B2   NCBI CCNE1   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 19 30,463,301 - 30,475,535 + NCBI Human Genome Assembly HuRef 19 26,814,506 - 26,826,846 + NCBI Human Genome Assembly GRCh37 19 30,302,901 - 30,315,215 + NCBI Human Genome Assembly Build 36 19 34,994,741 - 35,007,059 + NCBI Human Cytogenetic Map 19 q12   NCBI Human Genome Assembly 19 34,995,400 - 35,007,058   NCBI Ccne1   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 1 q22   NCBI RGSC Genome Assembly v5.0 1 95,575,136 - 95,584,373 - NCBI RGSC Genome Assembly v3.4 1 90,568,189 - 90,577,426 - NCBI Rat Celera Assembly 1 85,114,968 - 85,124,206 - NCBI Genome Assembly 3.1 1 90,646,304 - 90,655,502 - NCBI RH 3.4 1 885.7   RGD Position Markers AW538188   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 38,098,281 - 38,098,421   UniSTS Mouse cM Map 7 16.0   UniSTS Mouse Celera Assembly 7 33,255,462 - 33,255,602   UniSTS Mouse Genome Assembly Build 37 7 38,883,300 - 38,883,440   UniSTS Mouse Cytogenetic Map 7 B2   UniSTS UniSTS:235654   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 38,098,134 - 38,098,219   UniSTS Mouse cM Map 7 16.0   UniSTS Mouse Celera Assembly 7 33,255,315 - 33,255,400   UniSTS Mouse Genome Assembly Build 37 7 38,883,153 - 38,883,238   UniSTS Mouse Cytogenetic Map 7 B2   UniSTS Ccne1   Map Chr Position Strand Source Mouse cM Map 7 25.35   UniSTS Mouse Cytogenetic Map 7 B2   UniSTS Ccne1   Map Chr Position Strand Source Mouse Cytogenetic Map 7 B2   UniSTS QTLs in Region (Mouse Genome Assembly Build 37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 4142339 Spmd3_m spermatogenesis defect 3 (mouse) Not determined 7 10257545 44257688 Mouse 1300758 Bomd4_m bone mineral density 4 (mouse) Not determined 7 10523163 44523313 Mouse 1558951 mdlk1_m modifier of Dlk1 (mouse) Not determined 7 11074461 45074578 Mouse 1357699 Nhdlq6_m non-HDL QTL 6 (mouse) Not determined 7 11074461 45074578 Mouse 1558893 Spir1_m Streptococcus pneumoniae infection resistance 1 (mouse) Not determined 7 11391392 45391530 Mouse 1301627 Vmbic4_m ventral midbrain iron content 4 (mouse) Not determined 7 14118079 48118215 Mouse 1301041 Prnr2_m prion resistance 2 (mouse) Not determined 7 14118079 48118215 Mouse 1558790 Mmtp1_m modifier of mammary tumor progression 1 (mouse) Not determined 7 14118079 48118215 Mouse 4141790 Hfem1_m Hfe modifier 1 (mouse) Not determined 7 14118079 48118215 Mouse 1301352 Bis4_m beta-carboline induced seizures 4 (mouse) Not determined 7 17527929 51528044 Mouse 1301622 Eae12_m susceptibility to experimental allergic encephalomyelitis 12 (mouse) Not determined 7 20365609 54365698 Mouse 1357714 Hdl38_m HDL level 38 (mouse) Not determined 7 20365609 54365698 Mouse 1301052 Bhr6_m bronchial hyperresponsiveness 6 (mouse) Not determined 7 20927844 54927961 Mouse 4141960 Rosq1_m reactive oxygen species QTL 1 (mouse) Not determined 7 30279833 64279979 Mouse 1301711 Tbrs3_m tuberculosis resistance 3 (mouse) Not determined 7 30287212 64287356 Mouse 4141204 Wtlr4_m weight loss response 4 (mouse) Not determined 7 30287212 64287356 Mouse 1301709 Bdt4_m bone density traits 4 (mouse) Not determined 7 30494518 64494662 Mouse 1357445 Dyscalc1_m dystrophic cardiac calcinosis 1 (mouse) Not determined 7 35942350 69942472 Mouse Sequence Nucleotide Sequences Nucleotide RefSeqs NM_007633 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AAHY01060725 (Get FASTA) Search GEO for Microarray Profiles   AAHY01060726 (Get FASTA) Search GEO for Microarray Profiles   AAHY01060727 (Get FASTA) Search GEO for Microarray Profiles   AAHY01060728 (Get FASTA) Search GEO for Microarray Profiles   AAHY01060729 (Get FASTA) Search GEO for Microarray Profiles   AAHY01060730 (Get FASTA) Search GEO for Microarray Profiles   AC166334 (Get FASTA) Search GEO for Microarray Profiles   AK089950 (Get FASTA) Search GEO for Microarray Profiles   AK163046 (Get FASTA) Search GEO for Microarray Profiles   AK165658 (Get FASTA) Search GEO for Microarray Profiles   AK177216 (Get FASTA) Search GEO for Microarray Profiles   AK178079 (Get FASTA) Search GEO for Microarray Profiles   BC003499 (Get FASTA) Search GEO for Microarray Profiles   BC062152 (Get FASTA) Search GEO for Microarray Profiles   BC084588 (Get FASTA) Search GEO for Microarray Profiles   BC106191 (Get FASTA) Search GEO for Microarray Profiles   BC138660 (Get FASTA) Search GEO for Microarray Profiles   BC138662 (Get FASTA) Search GEO for Microarray Profiles   CH466618 (Get FASTA) Search GEO for Microarray Profiles   X75888 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_007633 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_031659 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 38,097,984 - 38,107,490 - ENTREZGENE Mouse cM Map 7   - ENTREZGENE Mouse Celera Assembly 7 33,255,165 - 33,271,131 - RGD Mouse Genome Assembly Build 37 7 38,883,003 - 38,892,509 - RGD Protein Sequences Protein RefSeqs NP_031659 (Get FASTA) GenBank Protein AAH03499 (Get FASTA)   AAH62152 (Get FASTA)   AAH84588 (Get FASTA)   AAI06192 (Get FASTA)   AAI38661 (Get FASTA)   AAI38663 (Get FASTA)   CAA53482 (Get FASTA)   EDL02991 (Get FASTA)   EDL02992 (Get FASTA)   Q61457 (Get FASTA) Promoters RGD ID: 6840800 Promoter ID: MM_KWN:50066 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: 3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   Spleen Transcripts: ENSMUST00000051596,   OTTMUST00000053001,   OTTMUST00000053002,   OTTMUST00000053003 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 7 38,892,161 - 38,893,272 - MPROMDB RGD ID: 6880898 Promoter ID: EPDNEW_M3900 Type: preliminary Name: Ccne1_1 Description: cyclin E1 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 7 38,892,500 - 38,892,560   EPDNEW Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSMUSG00000002068 ENTREZGENE Ensembl Protein ENSMUSP00000103658 ENTREZGENE Ensembl Transcript ENSMUST00000108023 ENTREZGENE Entrez Gene 12447 ENTREZGENE Gene3D-CATH Cyclin_related UniProtKB/Swiss-Prot Germonline ENSMUSG00000002068 HomoloGene Group ID 14452 ENTREZGENE InterPro Cyclin-like UniProtKB/Swiss-Prot   Cyclin_A/B/D/E UniProtKB/Swiss-Prot   Cyclin_C UniProtKB/Swiss-Prot   Cyclin_N UniProtKB/Swiss-Prot IPI IPI00121227 UniProtKB/Swiss-Prot   IPI00830366 UniProtKB/TrEMBL KEGG Report mmu:12447 ENTREZGENE, UniProtKB/Swiss-Prot MGD MGI:88316 ENTREZGENE Pfam Cyclin_C UniProtKB/Swiss-Prot   Cyclin_N UniProtKB/Swiss-Prot PIRSF Cyclin_A_B_D_E UniProtKB/Swiss-Prot PROSITE CYCLINS UniProtKB/Swiss-Prot SMART CYCLIN UniProtKB/Swiss-Prot Superfamily-SCOP Cyclin_like UniProtKB/Swiss-Prot UniGene Mm.16110 ENTREZGENE UniProt A0JLN2_MOUSE UniProtKB/TrEMBL   B2RS11_MOUSE UniProtKB/TrEMBL   CCNE1_MOUSE UniProtKB/Swiss-Prot   D3Z3N8_MOUSE UniProtKB/TrEMBL

More on Ccne1 Entrez Gene Ensembl Gene Genome Browser MGI Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 736489 Created: 2004-02-06 Species: Mus musculus Last Modified: 2013-04-09 Status: ACTIVE