P2rx7 (purinergic receptor P2X, ligand-gated ion channel, 7) - Rat Genome Database

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Gene: P2rx7 (purinergic receptor P2X, ligand-gated ion channel, 7) Mus musculus
Analyze
Symbol: P2rx7
Name: purinergic receptor P2X, ligand-gated ion channel, 7
RGD ID: 730815
MGI Page MGI
Description: Enables several functions, including ATP binding activity; extracellularly ATP-gated monoatomic cation channel activity; and lipopolysaccharide binding activity. Involved in bleb assembly; negative regulation of cell volume; and sensory perception of pain. Acts upstream of or within several processes, including organophosphate ester transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is expressed in brain; cerebral cortex ventricular layer; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI467586; ATP receptor; P2X; P2X purinoceptor 7; P2X(7; P2X(7); P2X7 purinoceptor; P2X7 receptor; P2X7R; P2Z receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,781,990 - 122,830,399 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,781,974 - 122,829,495 (+)EnsemblGRCm39 Ensembl
GRCm385122,643,927 - 122,692,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,643,911 - 122,691,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv375123,093,920 - 123,141,441 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365122,904,528 - 122,952,049 (+)NCBIMGSCv36mm8
Celera5119,722,412 - 119,770,254 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(R)-adrenaline  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-O-(4-Benzoyl)benzoyl ATP  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (EXP,ISO)
adenosine 5'-[gamma-thio]triphosphate  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (EXP,ISO)
atrazine  (ISO)
avobenzone  (ISO)
azetidine  (EXP)
barium(0)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
berberine  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
calmidazolium  (ISO)
carbon nanotube  (EXP,ISO)
carrageenan  (ISO)
casticin  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
ethidium  (ISO)
etoposide  (EXP)
folic acid  (EXP)
FR900359  (ISO)
furan  (ISO)
gamma-aminobutyric acid  (ISO)
genistein  (EXP)
ginsenoside C-K  (EXP)
ginsenoside Rd  (EXP)
glucose  (ISO)
graphene oxide  (EXP)
hexadecanoic acid  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
melittin  (ISO)
metformin  (ISO)
methoxychlor  (ISO)
N(4)-hydroxycytidine  (EXP)
N-nitrosodiethylamine  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
oleic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pinostrobin  (ISO)
poly(I:C)  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
suramin  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (ISO)
ATP export  (ISO)
bleb assembly  (IMP,ISO)
calcium ion transmembrane transport  (IBA)
calcium ion transport  (IMP)
cell morphogenesis  (IMP)
cell surface receptor signaling pathway  (IBA,ISO)
cell volume homeostasis  (IDA)
cellular response to dsRNA  (IMP)
cellular response to organic cyclic compound  (IDA)
ceramide biosynthetic process  (IDA)
collagen metabolic process  (IMP)
defense response to Gram-positive bacterium  (IMP)
establishment of localization in cell  (IDA,IMP)
extrinsic apoptotic signaling pathway  (IMP,ISO)
gamma-aminobutyric acid secretion  (IMP)
gene expression  (IMP)
glutamate secretion  (IMP)
homeostasis of number of cells within a tissue  (IMP)
inflammatory response  (IMP)
lymphocyte apoptotic process  (IMP)
MAPK cascade  (IMP)
membrane depolarization  (ISO)
membrane protein ectodomain proteolysis  (IMP)
mitochondrial depolarization  (IMP)
mitochondrion organization  (IDA)
monoatomic cation transmembrane transport  (IEA)
monoatomic cation transport  (IMP)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
NAD transport  (IMP)
negative regulation of bone resorption  (IMP)
negative regulation of cell volume  (IMP,ISO)
negative regulation of MAPK cascade  (IDA)
neuronal action potential  (ISO)
phagolysosome assembly  (IMP)
phospholipid transfer to membrane  (IMP)
phospholipid translocation  (IDA)
plasma membrane organization  (IDA)
plasma membrane phospholipid scrambling  (ISO)
pore complex assembly  (IMP,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of bleb assembly  (ISO)
positive regulation of bone mineralization  (IMP)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of cytoskeleton organization  (ISO)
positive regulation of gamma-aminobutyric acid secretion  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of glutamate secretion  (IMP)
positive regulation of glycolytic process  (ISO)
positive regulation of interleukin-1 alpha production  (IMP)
positive regulation of interleukin-1 beta production  (IMP,ISO)
positive regulation of interleukin-6 production  (IMP)
positive regulation of lymphocyte apoptotic process  (IMP)
positive regulation of macrophage cytokine production  (IMP)
positive regulation of MAPK cascade  (IMP)
positive regulation of mitochondrial depolarization  (IMP)
positive regulation of monoatomic ion transmembrane transport  (ISO)
positive regulation of ossification  (IMP)
positive regulation of prostaglandin secretion  (IMP)
positive regulation of protein phosphorylation  (IMP,ISO)
positive regulation of protein secretion  (IDA)
positive regulation of T cell apoptotic process  (IMP)
positive regulation of T cell mediated cytotoxicity  (IMP)
programmed cell death  (IDA,IMP)
prostaglandin secretion  (IMP)
protein catabolic process  (IDA)
protein processing  (IMP)
protein secretion  (IDA)
purinergic nucleotide receptor signaling pathway  (ISO)
reactive oxygen species metabolic process  (IMP)
regulation of presynaptic dense core granule exocytosis  (ISO)
regulation of sodium ion transport  (ISO)
release of sequestered calcium ion into cytosol  (IMP)
response to ATP  (IDA,IMP,ISO)
response to bacterium  (IMP)
response to calcium ion  (IDA,IMP)
response to electrical stimulus  (IMP)
response to fluid shear stress  (IMP)
response to lipopolysaccharide  (IDA,IMP)
response to mechanical stimulus  (IMP)
response to organic cyclic compound  (IDA)
response to organic substance  (IMP)
response to xenobiotic stimulus  (IMP)
response to zinc ion  (IMP)
sensory perception of pain  (IMP)
skeletal system morphogenesis  (IMP)
synaptic vesicle exocytosis  (IMP)
T cell apoptotic process  (IMP)
T cell homeostasis  (IMP)
T cell mediated cytotoxicity  (IMP)
T cell proliferation  (IMP)
vesicle budding from membrane  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9849870   PMID:10349636   PMID:10395640   PMID:11016935   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11489964   PMID:11544199   PMID:11544318   PMID:11904160   PMID:12055263  
PMID:12370338   PMID:12466305   PMID:12466851   PMID:12477932   PMID:12598620   PMID:12621313   PMID:12677010   PMID:12759456   PMID:12796490   PMID:12814360   PMID:12968021   PMID:14511112  
PMID:14610273   PMID:14696971   PMID:14761980   PMID:14996828   PMID:15070812   PMID:15075209   PMID:15200422   PMID:15240711   PMID:15254086   PMID:15277380   PMID:15331634   PMID:15350640  
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PMID:16027239   PMID:16116196   PMID:16141072   PMID:16141073   PMID:16198349   PMID:16207496   PMID:16269410   PMID:16301672   PMID:16325464   PMID:16455971   PMID:16493071   PMID:16565512  
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PMID:21983632   PMID:22002608   PMID:22022466   PMID:22101787   PMID:22120528   PMID:22185840   PMID:22198387   PMID:22235111   PMID:22243662   PMID:22248690   PMID:22253851   PMID:22275804  
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PMID:24895290   PMID:24922070   PMID:24925032   PMID:24941004   PMID:24952961   PMID:24991816   PMID:25048544   PMID:25127469   PMID:25155463   PMID:25170954   PMID:25225402   PMID:25239372  
PMID:25281740   PMID:25310682   PMID:25318104   PMID:25343479   PMID:25451844   PMID:25464855   PMID:25486274   PMID:25502294   PMID:25542352   PMID:25542768   PMID:25542861   PMID:25564520  
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PMID:26358881   PMID:26384545   PMID:26461208   PMID:26474534   PMID:26483196   PMID:26522449   PMID:26529046   PMID:26553756   PMID:26556873   PMID:26572062   PMID:26592184   PMID:26631939  
PMID:26739809   PMID:26747786   PMID:26812038   PMID:26830892   PMID:26877061   PMID:26935289   PMID:27048203   PMID:27159053   PMID:27206526   PMID:27255725   PMID:27287410   PMID:27292635  
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PMID:31249344   PMID:31308092   PMID:31376190   PMID:31425346   PMID:31445901   PMID:31533918   PMID:31676289   PMID:31685912   PMID:31693933   PMID:31699796   PMID:31736956   PMID:31836429  
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PMID:32640257   PMID:32661361   PMID:32668623   PMID:32699136   PMID:32735377   PMID:32895896   PMID:32982684   PMID:33012061   PMID:33025427   PMID:33125712   PMID:33135636   PMID:33168313  
PMID:33187309   PMID:33199725   PMID:33243234   PMID:33301426   PMID:33336163   PMID:33402188   PMID:33504771   PMID:33510147   PMID:33558327   PMID:33563723   PMID:33603067   PMID:33734697  
PMID:33963520   PMID:34076906   PMID:34147620   PMID:34321999   PMID:34440697   PMID:34489954   PMID:34516970   PMID:34526512   PMID:34572093   PMID:34625535   PMID:34652813   PMID:34656546  
PMID:34884741   PMID:34936028   PMID:34950860   PMID:35065198   PMID:35119925   PMID:35126784   PMID:35163829   PMID:35203267   PMID:35254644   PMID:35256512   PMID:35264459   PMID:35266010  
PMID:35293345   PMID:35318854   PMID:35330818   PMID:35350380   PMID:35464490   PMID:35478453   PMID:35563010   PMID:35588154   PMID:35780081   PMID:35910348   PMID:35935830   PMID:36059446  
PMID:36072579   PMID:36098250   PMID:36115462   PMID:36248812   PMID:36435235   PMID:36499084   PMID:36507708   PMID:36634819   PMID:36637008   PMID:36732073   PMID:36993971   PMID:37101546  
PMID:37144844   PMID:37153798   PMID:37159387   PMID:37211083   PMID:37245531   PMID:37287063   PMID:37306742   PMID:37373111   PMID:37389242   PMID:37629116   PMID:37649698   PMID:37796207  
PMID:37955123   PMID:37967010   PMID:38164435   PMID:38239348   PMID:38331352   PMID:38395698   PMID:38426095  


Genomics

Comparative Map Data
P2rx7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,781,990 - 122,830,399 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,781,974 - 122,829,495 (+)EnsemblGRCm39 Ensembl
GRCm385122,643,927 - 122,692,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,643,911 - 122,691,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv375123,093,920 - 123,141,441 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365122,904,528 - 122,952,049 (+)NCBIMGSCv36mm8
Celera5119,722,412 - 119,770,254 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.5NCBI
P2RX7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812121,132,876 - 121,188,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12121,132,819 - 121,188,032 (+)EnsemblGRCh38hg38GRCh38
GRCh3712121,570,679 - 121,625,835 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,055,061 - 120,108,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412120,033,397 - 120,086,591NCBI
Celera12121,208,365 - 121,262,089 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,580,277 - 118,634,021 (+)NCBIHuRef
CHM1_112121,539,497 - 121,593,180 (+)NCBICHM1_1
T2T-CHM13v2.012121,123,629 - 121,178,800 (+)NCBIT2T-CHM13v2.0
P2rx7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81239,550,531 - 39,594,984 (-)NCBIGRCr8
mRatBN7.21233,889,709 - 33,934,168 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,879,745 - 33,934,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,064,139 - 35,106,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,675,576 - 35,717,824 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,727,868 - 34,770,118 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,353,613 - 39,396,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,353,613 - 39,396,042 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,804,060 - 41,808,755 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01241,242,368 - 41,284,797 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,074,025 - 35,117,152 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,937,412 - 34,980,540 (-)NCBI
Celera1235,564,374 - 35,607,476 (-)NCBICelera
Cytogenetic Map12q16NCBI
P2rx7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,048,776 - 7,086,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,048,674 - 7,087,525 (-)NCBIChiLan1.0ChiLan1.0
P2RX7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210129,218,528 - 129,272,802 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112129,214,900 - 129,269,176 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,731,761 - 118,786,039 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112122,102,888 - 122,154,068 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12122,102,888 - 122,154,068 (+)Ensemblpanpan1.1panPan2
P2RX7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1267,928,863 - 7,983,956 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl267,940,985 - 7,983,740 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,105,749 - 8,148,516 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,197,891 - 8,242,043 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,197,292 - 8,242,044 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,159,088 - 8,201,849 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,217,646 - 8,260,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,174,038 - 8,216,804 (-)NCBIUU_Cfam_GSD_1.0
P2rx7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118156,329,671 - 156,378,094 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365583,108,283 - 3,149,765 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365583,106,819 - 3,149,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1431,415,193 - 31,476,472 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11431,415,188 - 31,476,502 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,281,108 - 33,340,508 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RX7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111116,505,975 - 116,560,151 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11116,529,346 - 116,563,059 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037128,519,187 - 128,586,099 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2rx7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,725,395 - 21,759,453 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474721,725,813 - 21,768,123 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2rx7
1633 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1625
Count of miRNA genes:656
Interacting mature miRNAs:815
Transcripts:ENSMUST00000031425, ENSMUST00000086247, ENSMUST00000100737, ENSMUST00000121489
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse

Markers in Region
AI467586  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
Whitehead/MRC_RH51493.68UniSTS
P2rx7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
cM Map562.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001038839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001038845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001038887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001284402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ009823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ489296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ489297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ554327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY752747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF912941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ436444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000031425   ⟹   ENSMUSP00000031425
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5122,782,002 - 122,829,495 (+)Ensembl
GRCm38.p6 Ensembl5122,643,939 - 122,691,432 (+)Ensembl
RefSeq Acc Id: ENSMUST00000086247   ⟹   ENSMUSP00000083425
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5122,782,072 - 122,793,325 (+)Ensembl
GRCm38.p6 Ensembl5122,644,009 - 122,655,262 (+)Ensembl
RefSeq Acc Id: ENSMUST00000100737   ⟹   ENSMUSP00000098303
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5122,781,974 - 122,822,352 (+)Ensembl
GRCm38.p6 Ensembl5122,643,911 - 122,684,289 (+)Ensembl
RefSeq Acc Id: ENSMUST00000121489   ⟹   ENSMUSP00000112440
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5122,781,974 - 122,822,360 (+)Ensembl
GRCm38.p6 Ensembl5122,643,911 - 122,684,297 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197042
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5122,820,245 - 122,822,347 (+)Ensembl
GRCm38.p6 Ensembl5122,682,182 - 122,684,284 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5122,820,005 - 122,821,587 (+)Ensembl
GRCm38.p6 Ensembl5122,681,942 - 122,683,524 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199281
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5122,782,228 - 122,785,857 (+)Ensembl
GRCm38.p6 Ensembl5122,644,165 - 122,647,794 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199371   ⟹   ENSMUSP00000158311
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5122,788,487 - 122,819,436 (+)Ensembl
GRCm38.p6 Ensembl5122,650,424 - 122,681,373 (+)Ensembl
RefSeq Acc Id: NM_001038839   ⟹   NP_001033928
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,781,990 - 122,822,352 (+)NCBI
GRCm385122,643,927 - 122,684,289 (+)NCBI
MGSCv375123,093,920 - 123,141,441 (+)RGD
Celera5119,722,412 - 119,770,254 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001038845   ⟹   NP_001033934
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,781,990 - 122,830,399 (+)NCBI
GRCm385122,643,927 - 122,692,336 (+)NCBI
MGSCv375123,093,920 - 123,141,441 (+)RGD
Celera5119,722,412 - 119,770,254 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001038887   ⟹   NP_001033976
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,781,990 - 122,793,329 (+)NCBI
GRCm385122,643,927 - 122,655,266 (+)NCBI
MGSCv375123,093,920 - 123,141,441 (+)RGD
Celera5119,722,412 - 119,770,254 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001284402   ⟹   NP_001271331
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,788,446 - 122,822,352 (+)NCBI
GRCm385122,650,383 - 122,684,289 (+)NCBI
Celera5119,722,412 - 119,770,254 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011027   ⟹   NP_035157
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,781,990 - 122,822,352 (+)NCBI
GRCm385122,643,927 - 122,684,289 (+)NCBI
MGSCv375123,093,920 - 123,141,441 (+)RGD
Celera5119,722,412 - 119,770,254 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001033976   ⟸   NM_001038887
- Peptide Label: isoform d
- UniProtKB: Q6P5P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001033934   ⟸   NM_001038845
- Peptide Label: isoform b
- UniProtKB: F8WI93 (UniProtKB/TrEMBL),   Q3TBP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_035157   ⟸   NM_011027
- Peptide Label: isoform a
- UniProtKB: Q9Z1M0 (UniProtKB/Swiss-Prot),   Q8CHP4 (UniProtKB/TrEMBL),   Q8CHP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001033928   ⟸   NM_001038839
- Peptide Label: isoform c
- UniProtKB: Q3UN00 (UniProtKB/TrEMBL),   Q3TBP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001271331   ⟸   NM_001284402
- Peptide Label: isoform e
- UniProtKB: C8YIX4 (UniProtKB/TrEMBL),   Q8CHP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000083425   ⟸   ENSMUST00000086247
RefSeq Acc Id: ENSMUSP00000031425   ⟸   ENSMUST00000031425
RefSeq Acc Id: ENSMUSP00000158311   ⟸   ENSMUST00000199371
RefSeq Acc Id: ENSMUSP00000112440   ⟸   ENSMUST00000121489
RefSeq Acc Id: ENSMUSP00000098303   ⟸   ENSMUST00000100737
Protein Domains
P2X purinoreceptor 7 intracellular

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1M0-F1-model_v2 AlphaFold Q9Z1M0 1-595 view protein structure

Promoters
RGD ID:6887986
Promoter ID:EPDNEW_M7444
Type:initiation region
Name:P2rx7_1
Description:Mus musculus purinergic receptor P2X, ligand-gated ion channel,7 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7445  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385122,643,976 - 122,644,036EPDNEW
RGD ID:6887988
Promoter ID:EPDNEW_M7445
Type:multiple initiation site
Name:P2rx7_2
Description:Mus musculus purinergic receptor P2X, ligand-gated ion channel,7 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7444  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385122,650,383 - 122,650,443EPDNEW
RGD ID:6837991
Promoter ID:MM_KWN:43967
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung
Transcripts:ENSMUST00000121489,   NM_001038845,   OTTMUST00000066137,   OTTMUST00000066140
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365123,093,926 - 123,094,426 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339957 AgrOrtholog
Ensembl Genes ENSMUSG00000029468 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031425 ENTREZGENE
  ENSMUST00000031425.15 UniProtKB/TrEMBL
  ENSMUST00000086247 ENTREZGENE
  ENSMUST00000086247.6 UniProtKB/TrEMBL
  ENSMUST00000100737 ENTREZGENE
  ENSMUST00000100737.10 UniProtKB/Swiss-Prot
  ENSMUST00000121489 ENTREZGENE
  ENSMUST00000121489.8 UniProtKB/TrEMBL
  ENSMUST00000199371 ENTREZGENE
  ENSMUST00000199371.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  atp-gated p2x4 ion channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P2RX7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X7_purinoceptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18439 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1339957 ENTREZGENE
NCBI Gene 18439 ENTREZGENE
PANTHER P2X PURINOCEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10125:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P2RX7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2rx7 PhenoGen
PRINTS P2X7RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2XRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P2X_RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2VCP3_MOUSE UniProtKB/TrEMBL
  C8YIX4 ENTREZGENE, UniProtKB/TrEMBL
  F8WI93 ENTREZGENE, UniProtKB/TrEMBL
  P2RX7_MOUSE UniProtKB/Swiss-Prot
  Q3TBP1 ENTREZGENE, UniProtKB/TrEMBL
  Q3ULZ7_MOUSE UniProtKB/TrEMBL
  Q3UM93_MOUSE UniProtKB/TrEMBL
  Q3UN00 ENTREZGENE, UniProtKB/TrEMBL
  Q6P5P0 ENTREZGENE, UniProtKB/TrEMBL
  Q8CHP3 ENTREZGENE, UniProtKB/TrEMBL
  Q8CHP4 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1M0 ENTREZGENE