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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionISOGclc (Rattus norvegicus)6480464CTDApigenin results in increased expression of GCLC mRNA; Apigenin results in increased expression of GCLC proteinPMID:22864849
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTDApigenin results in increased expression of GCLC mRNAPMID:11864778
Gclcmultiple interactionsISOGclc (Rattus norvegicus)6480464CTD[Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-ButylhydroperoxidePMID:22864849
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