GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Apigenin binds to ESR1 protein | PMID:14579009 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Apigenin results in decreased expression of ESR1 protein | PMID:16541309 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Apigenin results in increased activity of ESR1 protein | PMID:16118406 PMID:16860978 PMID:28396216 | Esr1 | increases phosphorylation | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Apigenin results in increased phosphorylation of ESR1 protein | PMID:17323972 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Apigenin binds to and results in increased activity of ESR1 protein; Apigenin inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA] | PMID:14579009 PMID:16541309 PMID:23384675 PMID:29162470 PMID:33049310 | |
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