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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDApigenin binds to ESR1 proteinPMID:14579009
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDApigenin results in decreased expression of ESR1 proteinPMID:16541309
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDApigenin results in increased activity of ESR1 proteinPMID:16118406 PMID:16860978 PMID:28396216
Esr1increases phosphorylationISOEsr1 (Rattus norvegicus)6480464CTDApigenin results in increased phosphorylation of ESR1 proteinPMID:17323972
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDApigenin binds to and results in increased activity of ESR1 protein; Apigenin inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA]PMID:14579009 PMID:16541309 PMID:23384675 PMID:29162470 PMID:33049310
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