Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | cerebral infarction | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:10027711 more ... | cerebral palsy | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Cerebral palsy | ClinVar | PMID:10027711 more ... | congenital disorder of glycosylation type IIc | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Rambam Hasharon syndrome | ClinVar | PMID:16455955 more ... | Congenital Prothrombin Deficiency | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:10027711 more ... | genetic disease | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:25741868 more ... | Habitual Abortions | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Pregnancy loss more ... | ClinVar | PMID:10027711 more ... | intellectual disability | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Intellectual disability | ClinVar | | prostate cancer | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Malignant tumor of prostate | ClinVar | PMID:23265383 | prothrombin deficiency | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:10027711 more ... | Spontaneous Abortions | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Pregnancy loss more ... | ClinVar | PMID:10027711 more ... | Stroke | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT | ClinVar | PMID:10027711 more ... | thrombophilia due to thrombin defect | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Thrombophilia due to thrombin defect | ClinVar | PMID:10027711 more ... | Venous Thromboembolism | | ISO | F2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Venous thromboembolism | ClinVar | PMID:10027711 more ... | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
|
| You must be logged in to use this feature |
| {{ loginError }} |
|
|
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
|
||||||||||
Imported Disease Annotations - CTD
Imported Disease Annotations - OMIM
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations Click to see Annotation Detail View
RGD Manual Annotations
Imported Annotations - SMPDB
Imported Annotations - KEGG (archival)
Imported Annotations - PID (archival)
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
Click to see Annotation Detail View
Gene-Chemical Interaction Annotations
Click to see Annotation Detail View
|
|
|
Gene Ontology Annotations
Click to see Annotation Detail View
Biological Process
|
|
|
Cellular Component
|
|
Molecular Function
|
|
|
Molecular Pathway Annotations
Click to see Annotation Detail View
|
|
|
Phenotype Annotations
Click to see Annotation Detail View
Mammalian Phenotype
|
|
|
References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Identification and three-dimensional structural analysis of nine novel mutations in patients with prothrombin deficiency. | Akhavan S, etal., Thromb Haemost. 2000 Dec;84(6):989-97. |
| 2. | Hypercoagulability: interaction between inflammation and coagulation in familial Mediterranean fever. | Aksu G, etal., Clin Rheumatol. 2007 Mar;26(3):366-70. doi: 10.1007/s10067-006-0334-y. Epub 2006 May 24. |
| 3. | Continuous Active State of Coagulation System in Patients With Nonthrombotic Inflammatory Bowel Disease. | Alkim H, etal., Clin Appl Thromb Hemost. 2011 May 17. |
| 4. | The coagulation/fibrinolysis balance in systemic sclerosis: evidence for a haematological stress syndrome. | Ames PR, etal., Br J Rheumatol. 1997 Oct;36(10):1045-50. |
| 5. | Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice. | Arumugam PI, etal., Blood. 2015 Oct 8;126(15):1844-55. doi: 10.1182/blood-2015-01-625707. Epub 2015 Aug 18. |
| 6. | Markers of autoreactivity, coagulation and angiogenesis in patients with nonallergic asthma. | Asero R, etal., Allergy. 2011 Jun 10. doi: 10.1111/j.1398-9995.2011.02668.x. |
| 7. | Prediction of venous thromboembolism in patients with cancer by measuring thrombin generation: results from the Vienna Cancer and Thrombosis Study. | Ay C, etal., J Clin Oncol. 2011 May 20;29(15):2099-103. Epub 2011 Apr 4. |
| 8. | Thrombin generation in type 2 diabetes with albuminuria and macrovascular disease. | Ay L, etal., Eur J Clin Invest. 2012 May;42(5):470-7. doi: 10.1111/j.1365-2362.2011.02602.x. Epub 2011 Sep 28. |
| 9. | Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species. | Banfield DK and MacGillivray RT, Proc Natl Acad Sci U S A 1992 Apr 1;89(7):2779-83. |
| 10. | Thrombin generation in pediatric patients with Crohn's disease. | Bernhard H, etal., Inflamm Bowel Dis. 2011 Feb 1. doi: 10.1002/ibd.21631. |
| 11. | Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke. | Berny-Lang MA, etal., Stroke. 2011 Jun;42(6):1736-41. Epub 2011 Apr 21. |
| 12. | Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease. | Bogatkevich GS, etal., Arthritis Rheum. 2011 May;63(5):1416-25. doi: 10.1002/art.30255. |
| 13. | Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. | Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247. |
| 14. | Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction. | Butt C, etal., Blood. 2003 Apr 15;101(8):3037-41. Epub 2002 Dec 12. |
| 15. | Increased blood coagulation and platelet activation in patients with infective endocarditis and embolic events. | Buyukasýk NS, etal., Clin Cardiol. 2004 Mar;27(3):154-8. doi: 10.1002/clc.4960270312. |
| 16. | Lack of association between inherited thrombophilic risk factors and idiopathic sudden sensorineural hearing loss in Italian patients. | Cadoni G, etal., Ann Otol Rhinol Laryngol. 2006 Mar;115(3):195-200. |
| 17. | Genetic and acquired prothrombotic risk factors and sudden hearing loss. | Capaccio P, etal., Laryngoscope. 2007 Mar;117(3):547-51. |
| 18. | A hypercoagulable and hypofibrinolytic state is detectable by global methods in patients with retinal vein occlusion. | Cellai AP, etal., Atherosclerosis. 2012 Sep;224(1):97-101. doi: 10.1016/j.atherosclerosis.2012.06.053. Epub 2012 Jul 3. |
| 19. | Thrombin mediates severe neurovascular injury during ischemia. | Chen B, etal., Stroke. 2010 Oct;41(10):2348-52. Epub 2010 Aug 12. |
| 20. | Multiplexed quantification of 63 proteins in human urine by multiple reaction monitoring-based mass spectrometry for discovery of potential bladder cancer biomarkers. | Chen YT, etal., J Proteomics. 2012 Jun 27;75(12):3529-45. Epub 2012 Jan 3. |
| 21. | Activation of the coagulation cascade in patients with leptospirosis. | Chierakul W, etal., Clin Infect Dis. 2008 Jan 15;46(2):254-60. doi: 10.1086/524664. |
| 22. | Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury. | Citron BA, etal., J Neurotrauma. 2000 Dec;17(12):1191-203. |
| 23. | Prevalence and association of the factor V Leiden and prothrombin G20210A in healthy subjects and patients with venous thromboembolism. | Coen D, etal., Croat Med J. 2001 Aug;42(4):488-92. |
| 24. | Nebulized anticoagulants limit coagulopathy but not inflammation in pseudomonas aeruginosa-induced pneumonia in rats. | Cornet AD, etal., Shock. 2011 Oct;36(4):417-23. |
| 25. | MTHFR C677T mutation, factor II G20210A mutation and factor V Leiden as risks factor for youth retinal vein occlusion. | Cruciani F, etal., Clin Ter. 2003 Sep-Oct;154(5):299-303. |
| 26. | Activation of the coagulation cascade in C1-inhibitor deficiencies. | Cugno M, etal., Blood. 1997 May 1;89(9):3213-8. |
| 27. | Acute coagulopathy of trauma in the rat. | Darlington DN, etal., Shock. 2013 May;39(5):440-6. doi: 10.1097/SHK.0b013e31829040e3. |
| 28. | Fructose-1,6-bisphosphate inhibits in vitro and ex vivo platelet aggregation induced by ADP and ameliorates coagulation alterations in experimental sepsis in rats. | de Oliveira LM, etal., J Thromb Thrombolysis. 2010 May;29(4):387-94. doi: 10.1007/s11239-009-0387-2. Epub 2009 Aug 25. |
| 29. | Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus. | Demirci FY, etal., J Rheumatol. 2011 Apr;38(4):652-7. Epub 2011 Jan 15. |
| 30. | The 3'end prothrombin gene variants in patients with different thrombotic events. | Djordjevic V, etal., Lab Med. 2014 Fall;45(4):309-14. doi: 10.1309/LM8E84ZSLPDMWZCM. |
| 31. | Thrombin generation in trauma patients. | Dunbar NM and Chandler WL, Transfusion. 2009 Dec;49(12):2652-60. doi: 10.1111/j.1537-2995.2009.02335.x. Epub 2009 Aug 4. |
| 32. | Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II. | Ebbesen LS and Ingerslev J, J Nutr. 2005 Aug;135(8):1836-40. |
| 33. | Thrombophilia and avascular necrosis of femoral head in kidney allograft recipients. | Ekmekci Y, etal., Nephrol Dial Transplant. 2006 Dec;21(12):3555-8. Epub 2006 Sep 12. |
| 34. | Assessment of markers of thrombin generation in patients with acute myocardial infarction complicated by ventricular fibrillation. | Elmas E, etal., Clin Cardiol. 2006 Apr;29(4):165-9. |
| 35. | Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery. | Emiroglu O, etal., J Cardiothorac Surg. 2011 Sep 28;6:120. |
| 36. | The protein C pathway. | Esmon CT, Chest. 2003 Sep;124(3 Suppl):26S-32S. |
| 37. | The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. | Flick MJ, etal., Blood. 2011 Jun 9;117(23):6326-37. Epub 2011 Mar 24. |
| 38. | Cross Talk Pathways Between Coagulation and Inflammation. | Foley JH and Conway EM, Circ Res. 2016 Apr 29;118(9):1392-408. doi: 10.1161/CIRCRESAHA.116.306853. |
| 39. | The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation. | Franco RF, etal., Blood. 2000 Jul 15;96(2):554-9. |
| 40. | A specific thrombin inhibitor, argatroban, alleviates herpes zoster-associated pain. | Fujii K, etal., J Dermatol. 2001 Apr;28(4):200-7. doi: 10.1111/j.1346-8138.2001.tb00118.x. |
| 41. | Metabolic, inflammatory, endothelial and haemostatic markers in a group of Italian obese children and adolescents. | Giordano P, etal., Eur J Pediatr. 2011 Jul;170(7):845-50. Epub 2011 Jan 6. |
| 42. | Renal prothrombin mRNA is significantly decreased in a hyperoxaluric rat model of nephrolithiasis. | Grover PK, etal., J Pathol. 2006 Nov;210(3):273-81. |
| 43. | Factor V Leiden mutation and PAI-1 gene 4G/5G genotype in thrombotic patients with Behcet's disease. | Gurgey A, etal., Blood Coagul Fibrinolysis. 2003 Feb;14(2):121-4. |
| 44. | Recombinant human prothrombin (MEDI8111) prevents bleeding in haemophilia A and B mice. | Hansson KM, etal., Haemophilia. 2016 May;22(3):453-61. doi: 10.1111/hae.12861. Epub 2015 Dec 3. |
| 45. | The Acute Coagulopathy of Trauma is Due to Impaired Initial Thrombin Generation but Not Clot Formation or Clot Strength. | Harr JN, etal., J Surg Res. 2011 Apr 17. |
| 46. | Thrombin-cleaved osteopontin levels in synovial fluid correlate with disease severity of knee osteoarthritis. | Hasegawa M, etal., J Rheumatol. 2011 Jan;38(1):129-34. Epub 2010 Nov 1. |
| 47. | Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo. | Hassan S, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2959-65. Epub 2007 Feb 9. |
| 48. | Inflammatory and Prothrombotic Activation With Conserved Endothelial Function in Patients With Chronic, Asymptomatic Chagas Disease. | Herrera RN, etal., Clin Appl Thromb Hemost. 2010 Aug 10. |
| 49. | The role of thrombin in gliomas. | Hua Y, etal., J Thromb Haemost. 2005 Sep;3(9):1917-23. Epub 2005 Jun 24. |
| 50. | Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. | Huang YC, etal., PLoS One. 2011 Jan 31;6(1):e15809. |
| 51. | Detection of a single base substitution of the gene for prothrombin Tokushima. The application of PCR-SSCP for the genetic and molecular analysis of dysprothrombinemia. | Iwahana H, etal., Int J Hematol. 1992 Feb;55(1):93-100. |
| 52. | Shortened blood coagulation times in genetically obese rats and diet-induced obese mice. | Kaji N, etal., J Vet Med Sci. 2013 Oct 1;75(9):1245-8. Epub 2013 Apr 26. |
| 53. | Comparison of matrix proteins in different types of urinary stone by proteomic analysis using liquid chromatography-tandem mass spectrometry. | Kaneko K, etal., Int J Urol. 2012 Aug;19(8):765-72. doi: 10.1111/j.1442-2042.2012.03005.x. Epub 2012 Apr 11. |
| 54. | A prothrombin gene mutation is significantly associated with venous thrombosis. | Kapur RK, etal., Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2875-9. |
| 55. | [Evaluation of thrombin in urine as a real-time indicator of clotting activation in glomerulonephritis]. | Kitamoto Y, etal., Rinsho Byori. 2004 Apr;52(4):350-4. |
| 56. | Differential effects of TAK-442, a novel orally active direct factor Xa inhibitor, and ximelagatran, a thrombin inhibitor, on factor V-mediated feedback on coagulation cascade and bleeding. | Konishi N, etal., Thromb Haemost. 2010 Sep;104(3):504-13. doi: 10.1160/TH09-12-0817. Epub 2010 Jul 20. |
| 57. | Modification in the von Hippel-Lindau protein is involved in the progression of experimentally induced rat glomerulonephritis. | Kudo Y, etal., Nephron Exp Nephrol. 2007;106(3):e97-106. Epub 2007 May 22. |
| 58. | Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis. | Kukla M, etal., World J Gastroenterol. 2017 Apr 14;23(14):2613-2624. doi: 10.3748/wjg.v23.i14.2613. |
| 59. | In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats. | Kung CW, etal., Thromb Res. 2011 Jun;127(6):582-8. Epub 2011 Mar 10. |
| 60. | A common mutation, Arg457-->Gln, links prothrombin deficiencies in the Puerto Rican population. | Lefkowitz JB, etal., J Thromb Haemost. 2003 Nov;1(11):2381-8. |
| 61. | The thrombophilic network of autoantibodies in celiac disease. | Lerner A, etal., BMC Med. 2013 Apr 4;11:89. doi: 10.1186/1741-7015-11-89. |
| 62. | Alterations of the preoperative coagulation profile in patients with acute appendicitis. | Li J, etal., Clin Chem Lab Med. 2011 Aug;49(8):1333-9. Epub 2011 Jun 13. |
| 63. | Antithrombotic activity of HY023016, a novel Dabigatran prodrug evaluated in animal thrombosis models. | Li YZ, etal., Thromb Res. 2013 May;131(5):425-35. doi: 10.1016/j.thromres.2013.03.004. Epub 2013 Mar 25. |
| 64. | Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation. | Lin SW, etal., J Infect. 2012 Mar;64(3):325-34. doi: 10.1016/j.jinf.2011.11.023. Epub 2011 Nov 25. |
| 65. | In vitro efficacy of pro- and anticoagulant strategies in compensated and acutely ill patients with cirrhosis. | Lisman T, etal., Liver Int. 2018 Nov;38(11):1988-1996. doi: 10.1111/liv.13882. Epub 2018 May 30. |
| 66. | [Experimental anticoagulant therapy of acute lung injury induced by paraquat]. | Liu F, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Mar;30(3):190-3. |
| 67. | Thrombin activatable fibrinolysis inhibitor (TAFI) and markers of endothelial cell injury in dialyzed patients with diabetic nephropathy. | Malyszko J, etal., Thromb Haemost. 2004 Mar;91(3):480-6. |
| 68. | Thrombophilic risk factors in patients with severe carotid atherosclerosis. | Marcucci R, etal., J Thromb Haemost. 2005 Mar;3(3):502-7. |
| 69. | Activation of coagulation in bullous pemphigoid and other eosinophil-related inflammatory skin diseases. | Marzano AV, etal., Clin Exp Immunol. 2011 Jul;165(1):44-50. doi: 10.1111/j.1365-2249.2011.04391.x. Epub 2011 Apr 13. |
| 70. | Inverse correlation between activated protein C generation and carotid atherosclerosis in Type 2 diabetic patients. | Matsumoto K, etal., Diabet Med. 2007 Dec;24(12):1322-8. Epub 2007 Oct 29. |
| 71. | Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study. | Mello G, etal., Hypertension. 2005 Dec;46(6):1270-4. Epub 2005 Oct 24. |
| 72. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 73. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 74. | MGD IEA | MGD IEA |
| 75. | Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. | Mullins ES, etal., Blood. 2009 Jan 15;113(3):696-704. doi: 10.1182/blood-2008-07-169003. Epub 2008 Oct 16. |
| 76. | Thrombin-inhibiting perfluorocarbon nanoparticles provide a novel strategy for the treatment and magnetic resonance imaging of acute thrombosis. | Myerson J, etal., J Thromb Haemost. 2011 Jul;9(7):1292-300. doi: 10.1111/j.1538-7836.2011.04339.x. |
| 77. | Ellagic acid-induced hypercoagulable state in animals: a potentially useful animal hypercoagulable model for evaluation of anticoagulants. | Na L, etal., Chin Med Sci J. 2010 Dec;25(4):237-42. |
| 78. | Identification of thrombin-like activity in ovarian cancer associated ascites and modulation of multiple cytokine networks. | Naldini A, etal., Thromb Haemost. 2011 Aug 11;106(4). |
| 79. | Protease-activated receptor-1 and platelet-derived growth factor in spinal cord neurons are implicated in neuropathic pain after nerve injury. | Narita M, etal., J Neurosci. 2005 Oct 26;25(43):10000-9. |
| 80. | Activation of coagulation and fibrinolysis in childhood diarrhoea-associated haemolytic uraemic syndrome. | Nevard CH, etal., Thromb Haemost. 1997 Dec;78(6):1450-5. |
| 81. | Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats. | Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101. |
| 82. | Blood coagulation. | Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83. |
| 83. | Genetic analysis and functional characterization of prothrombins Corpus Christi (Arg382-Cys), Dhahran (Arg271-His), and hypoprothrombinemia. | O'Marcaigh AS, etal., Blood. 1996 Oct 1;88(7):2611-8. |
| 84. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 85. | Myocardial damage, coagulation activity and the response to thrombin inhibition in unstable coronary artery disease. | Oldgren J, etal., Thromb Haemost. 2004 Feb;91(2):381-7. |
| 86. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 87. | Early embryonic expression of murine coagulation system components. | Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30. |
| 88. | 5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy. | Ozcan A, etal., Am J Nephrol. 2012;35(4):356-64. doi: 10.1159/000337918. Epub 2012 Apr 2. |
| 89. | Heparin blunts endotoxin-induced coagulation activation. | Pernerstorfer T, etal., Circulation. 1999 Dec 21-28;100(25):2485-90. doi: 10.1161/01.cir.100.25.2485. |
| 90. | Enhanced thrombin generation in children with sickle cell disease. | Peters M, etal., Thromb Haemost. 1994 Feb;71(2):169-72. |
| 91. | Hypercoagulability biomarkers in Trypanosoma cruzi -infected patients. | Pinazo MJ, etal., Thromb Haemost. 2011 Oct;106(4):617-23. doi: 10.1160/TH11-04-0251. Epub 2011 Aug 25. |
| 92. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 93. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 94. | SMPDB Annotation Import Pipeline | Pipeline to import SMPDB annotations from SMPDB into RGD |
| 95. | Effect of acute exacerbations on circulating endothelial, clotting and fibrinolytic markers in COPD patients. | Polosa R, etal., Intern Emerg Med. 2011 Jun 10. |
| 96. | Risk factors of sensorineural hearing loss in patients with ischemic stroke. | Przewozny T, etal., Otol Neurotol. 2008 Sep;29(6):745-50. doi: 10.1097/MAO.0b013e318181336c. |
| 97. | Plasma markers of hypercoagulability in patients with serious infections and risk of septic shock. | Psuja P, etal., Clin Appl Thromb Hemost. 2002 Jul;8(3):225-30. |
| 98. | Bacillus anthracis cell wall peptidoglycan but not lethal or edema toxins produces changes consistent with disseminated intravascular coagulation in a rat model. | Qiu P, etal., J Infect Dis. 2013 Sep;208(6):978-89. doi: 10.1093/infdis/jit247. Epub 2013 Jun 3. |
| 99. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 100. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 101. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 102. | Hemodialysis vascular access thrombosis: The role of factor V Leiden, prothrombin gene mutation and ABO blood groups. | Rios DR, etal., Clin Chim Acta. 2011 Feb 20;412(5-6):425-9. Epub 2010 Nov 8. |
| 103. | Prothrombin haplotype associated with kidney stone disease in Northeastern Thai patients. | Rungroj N, etal., Urology. 2011 Jan;77(1):249.e17-23. Epub 2010 Nov 10. |
| 104. | Coagulation system activated in Duchenne muscular dystrophy patients with cardiac dysfunction. | Saito T, etal., Brain Dev. 2005 Sep;27(6):415-8. Epub 2004 Dec 15. |
| 105. | Enhanced expression of monocyte tissue factor in patients with liver cirrhosis. | Saliola M, etal., Gut. 1998 Sep;43(3):428-32. doi: 10.1136/gut.43.3.428. |
| 106. | Hematological and morphological investigation of thrombogenic mechanisms in the lungs of phenylhydrazine-treated rats. | Sato H, etal., Exp Toxicol Pathol. 2013 May;65(4):457-62. doi: 10.1016/j.etp.2012.01.004. Epub 2012 Mar 7. |
| 107. | Initial predictive factors of outcome in severe non-accidental head trauma in children. | Scavarda D, etal., Childs Nerv Syst. 2010 Nov;26(11):1555-61. Epub 2010 May 12. |
| 108. | The disturbance of hemostasis in septic shock: role of neutrophil elastase and thrombin, effects of antithrombin III and plasma substitution. | Seitz R, etal., Eur J Haematol. 1989 Jul;43(1):22-8. doi: 10.1111/j.1600-0609.1989.tb01246.x. |
| 109. | Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D. | Seven G, etal., Turk J Gastroenterol. 2011 Jun;22(3):305-14. |
| 110. | A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury. | Shim K, etal., Blood. 2004 Jul 15;104(2):415-9. Epub 2004 Mar 23. |
| 111. | Role of thrombin in chronic rhinosinusitis-associated tissue remodeling. | Shimizu S, etal., Am J Rhinol Allergy. 2011 Jan-Feb;25(1):7-11. |
| 112. | [Association of hemostatic disorders in diabetic patients with methylenetetrahydrofolate reductase (C677T) and coagulation factors II (G20210A) and V (G1691A) gene polymorphism]. | Sibireva OF, Klin Lab Diagn. 2011 Mar;(3):36-9. |
| 113. | Prevalence of Hereditary Thrombophilia in Patients Older Than 75 Years With Venous Thromboembolism Referred for Thrombophilia Screening. | Siguret V, etal., J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):977-81. doi: 10.1093/gerona/glu240. Epub 2015 Feb 9. |
| 114. | Factor V Leiden and prothrombin gene G20210A mutations in Italian patients with Behcet's disease and deep vein thrombosis. | Silingardi M, etal., Arthritis Rheum. 2004 Apr 15;51(2):177-83. |
| 115. | Is fibrin formation and thrombin generation increased during and after an acute coronary syndrome? | Skeppholm M, etal., Thromb Res. 2011 Apr 13. |
| 116. | How it all starts: Initiation of the clotting cascade. | Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28. |
| 117. | Renal tissue factor expression is increased in streptozotocin-induced diabetic mice. | Sommeijer DW, etal., Nephron Exp Nephrol. 2005;101(3):e86-94. Epub 2005 Jun 30. |
| 118. | Prothrombin deficiency results in embryonic and neonatal lethality in mice. | Sun WY, etal., Proc Natl Acad Sci U S A 1998 Jun 23;95(13):7597-602. |
| 119. | Validating the incidence of coagulopathy and disseminated intravascular coagulation in patients with traumatic brain injury--analysis of 242 cases. | Sun Y, etal., Br J Neurosurg. 2011 Jun;25(3):363-8. Epub 2011 Feb 28. |
| 120. | Comparison of prothrombin fragment 1 + 2 with thrombin-antithrombin III complex in plasma of patients with disseminated intravascular coagulation. | Takahashi H, etal., Blood Coagul Fibrinolysis. 1992 Dec;3(6):813-8. |
| 121. | Coagulation and fibrinolysis abnormalities in familial amyloid polyneuropathy. | Takahashi R, etal., Amyloid. 2012 Sep;19(3):129-32. doi: 10.3109/13506129.2012.691918. Epub 2012 May 25. |
| 122. | Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. | Tripodi A, etal., Hepatology. 2005 Mar;41(3):553-8. doi: 10.1002/hep.20569. |
| 123. | Evaluation of coagulation during treatment with directly acting antivirals in patients with hepatitis C virus related cirrhosis. | Tripodi A, etal., Liver Int. 2017 Sep;37(9):1295-1303. doi: 10.1111/liv.13374. Epub 2017 Feb 23. |
| 124. | Application of thrombelastography in liver injury induced by endotoxin in rat. | Tsai HJ, etal., Blood Coagul Fibrinolysis. 2012 Mar;23(2):118-26. doi: 10.1097/MBC.0b013e32834ee170. |
| 125. | Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis. | Tsai HJ, etal., Blood Coagul Fibrinolysis. 2015 Mar;26(2):175-84. doi: 10.1097/MBC.0000000000000214. |
| 126. | Beneficial effects of magnolol in a rodent model of endotoxin shock. | Tsai YC, etal., Eur J Pharmacol. 2010 Sep 1;641(1):67-73. Epub 2010 May 25. |
| 127. | Hyperglycemia is associated with enhanced thrombin formation, platelet activation, and fibrin clot resistance to lysis in patients with acute coronary syndrome. | Undas A, etal., Diabetes Care. 2008 Aug;31(8):1590-5. Epub 2008 May 16. |
| 128. | Association between low-grade disseminated intravascular coagulation and endotoxemia in patients with liver cirrhosis. | Violi F, etal., Gastroenterology. 1995 Aug;109(2):531-9. doi: 10.1016/0016-5085(95)90342-9. |
| 129. | Coagulation disorders in patients with severe leptospirosis are associated with severe bleeding and mortality. | Wagenaar JF, etal., Trop Med Int Health. 2010 Feb;15(2):152-9. doi: 10.1111/j.1365-3156.2009.02434.x. Epub 2009 Dec 9. |
| 130. | Expression of coagulation factors and their receptors in tumor tissue and coagulation factor upregulation in peripheral blood of patients with cerebral carcinoma metastases. | Walter J, etal., J Cancer Res Clin Oncol. 2012 Jan;138(1):141-51. Epub 2011 Nov 8. |
| 131. | Clinical features and treatment of COVID-19 patients in northeast Chongqing. | Wan S, etal., J Med Virol. 2020 Jul;92(7):797-806. doi: 10.1002/jmv.25783. Epub 2020 Apr 1. |
| 132. | [Effect of inhalation of aerosolized unfractioned heparin on peri alveolar coagulability and inflammatory response in endotoxin induced acute lung injury rat model]. | Wang ZY, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Apr;23(4):239-42. |
| 133. | Activated contact system and abnormal glycosaminoglycans in lupus and other auto- and non-autoimmune diseases. | Weiser P, etal., Prog Mol Biol Transl Sci. 2010;93:443-72. |
| 134. | Analysis of thrombin-antithrombin complex contents in plasma and hematoma fluid of hypertensive intracerebral hemorrhage patients after clot removal. | Wu CH, etal., Eur J Neurol. 2011 Aug;18(8):1060-6. doi: 10.1111/j.1468-1331.2010.03336.x. Epub 2011 Jan 18. |
| 135. | Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema. | Wu H, etal., Neurochem Int. 2010 Oct;57(3):248-53. Epub 2010 Jun 10. |
| 136. | cDNA microarray analysis of spinal cord injury and regeneration related genes in rat. | Xiao L, etal., Sheng Li Xue Bao. 2005 Dec 25;57(6):705-13. |
| 137. | Levels of vitamin K, immunoreactive prothrombin, des-gamma-carboxy prothrombin and gamma-glutamyl carboxylase activity in hepatocellular carcinoma tissue. | Yamagata H, etal., J Gastroenterol Hepatol. 1995 Jan-Feb;10(1):8-13. doi: 10.1111/j.1440-1746.1995.tb01040.x. |
| 138. | Protective effects of antithrombin on puromycin aminonucleoside nephrosis in rats. | Yamashita J, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):239-44. Epub 2008 May 14. |
| 139. | Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. | Yan Y, etal., BMJ Open Diabetes Res Care. 2020 Apr;8(1). pii: 8/1/e001343. doi: 10.1136/bmjdrc-2020-001343. |
| 140. | [Effects of n-3 polyunsaturated fatty acids on hemorheology and coagulation in atherosclerotic rats]. | Yang YB, etal., Zhonghua Yi Xue Za Zhi. 2010 Jul 27;90(28):2004-7. |
| 141. | Clinicopathological features of severe and fulminant forms of autoimmune hepatitis. | Yasui S, etal., J Gastroenterol. 2011 Mar;46(3):378-90. Epub 2010 Sep 7. |
| 142. | Risk factors associated with relapse of type 1 autoimmune hepatitis in Japan. | Yokokawa J, etal., Hepatol Res. 2011 Jul;41(7):641-6. doi: 10.1111/j.1872-034X.2011.00812.x. |
| 143. | Exogenous normal lymph alleviating kidney injury by improving coagulation function in disseminated intravascular coagulation rats. | Zhao ZG, etal., Ren Fail. 2012;34(2):221-6. Epub 2012 Jan 9. |
| 144. | Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu. | Zheng Y, etal., J Clin Virol. 2020 Jun;127:104366. doi: 10.1016/j.jcv.2020.104366. Epub 2020 Apr 10. |
| 145. | Analysis of coagulation parameters in patients with COVID-19 in Shanghai, China. | Zou Y, etal., Biosci Trends. 2020 Apr 30. doi: 10.5582/bst.2020.03086. |
Additional References at PubMed
| PMID:2222810 | PMID:7608171 | PMID:8291612 | PMID:8707309 | PMID:8903359 | PMID:9263397 | PMID:9565620 | PMID:9636196 | PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 |
| PMID:11776313 | PMID:12477932 | PMID:14610273 | PMID:15265791 | PMID:15452111 | PMID:15489334 | PMID:16141072 | PMID:16141073 | PMID:16428384 | PMID:16602821 | PMID:16720835 | PMID:16824188 |
| PMID:17021183 | PMID:17330941 | PMID:17380206 | PMID:17428793 | PMID:17606903 | PMID:18224415 | PMID:18305483 | PMID:18398001 | PMID:18772359 | PMID:18990707 | PMID:19351827 | PMID:19592578 |
| PMID:19794141 | PMID:20519511 | PMID:21191574 | PMID:21267068 | PMID:21339289 | PMID:21531712 | PMID:21724997 | PMID:21840881 | PMID:21873635 | PMID:22235124 | PMID:23239877 | PMID:23299312 |
| PMID:23409043 | PMID:23982175 | PMID:24194600 | PMID:24311376 | PMID:24652285 | PMID:24665136 | PMID:24710407 | PMID:24740693 | PMID:24790104 | PMID:25112870 | PMID:25604482 | PMID:25967238 |
| PMID:26045608 | PMID:26238780 | PMID:26350460 | PMID:26370502 | PMID:26457757 | PMID:26475502 | PMID:26742564 | PMID:26748875 | PMID:26769047 | PMID:27034473 | PMID:27252233 | PMID:27626380 |
| PMID:28071719 | PMID:28409836 | PMID:28489922 | PMID:29321368 | PMID:29438518 | PMID:30066835 | PMID:30606478 | PMID:30870413 | PMID:31040226 | PMID:31461896 | PMID:31910739 | PMID:32000579 |
| PMID:32325033 | PMID:33458764 | PMID:33720950 | PMID:36724509 | PMID:37309666 | PMID:37511175 |
Genomics
Comparative Map Data
| F2 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| F2 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| F2 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| F2 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| F2 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| F2 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| F2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| F2 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| F2 (Heterocephalus glaber - naked mole-rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Variants
.
Variants in F2
566 total Variants 
|
