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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:histamine
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Accession:CHEBI:18295 term browser browse the term
Definition:A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Synonyms:related_synonym: 1H-Imidazole-4-ethanamine;   2-(1H-Imidazol-4-yl)ethanamine;   2-(4-Imidazolyl)ethylamine;   Formula=C5H9N3;   InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8);   InChIKey=NTYJJOPFIAHURM-UHFFFAOYSA-N;   SMILES=NCCc1c[nH]cn1
 alt_id: CHEBI:14401;   CHEBI:24596;   CHEBI:43187;   CHEBI:817
 xref: Beilstein:2012;   CAS:51-45-6;   Drug_Central:1375;   Gmelin:2968;   HMDB:HMDB0000870;   KEGG:C00388;   KEGG:D08040;   KNApSAcK:C00001414
 xref_mesh: MESH:D006632
 xref: MetaCyc:HISTAMINE;   PDBeChem:HSM;   PMID:16399866;   PMID:19547708;   PMID:19843401;   PMID:22770225;   PMID:24101735;   Reaxys:2012;   Wikipedia:Histamine
 cyclic_relationship: is_conjugate_base_of CHEBI:58432


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histamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; [BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine; Imatinib Mesylate inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] CTD PMID:16849647 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675 		JBrowse link
G ADCYAP1 adenylate cyclase activating polypeptide 1 increases secretion
multiple interactions		 ISO ADCYAP1 protein results in increased secretion of Histamine
Dinoprostone inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; Galanin inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; IL1B protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; Misoprostol inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; SST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]		 CTD PMID:11164953 NCBI chr18:904,411...912,172
Ensembl chr18:904,871...912,172 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions
decreases response to substance
increases activity		 EXP
ISO		 Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]
Alprenolol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; carvedilol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; ICI 118551 inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]
[Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Isoproterenol results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Terbutaline results in increased activity of ADRB2 protein] which results in increased secretion of Histamine
Histamine results in increased activity of ADRB2 protein		 CTD PMID:11164953 PMID:12198331 PMID:17196553 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions EXP ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] CTD PMID:9609743 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein multiple interactions EXP ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] CTD PMID:9609743 NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426 		JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor decreases secretion ISO AMBP protein results in decreased secretion of Histamine CTD PMID:9579392 NCBI chr 9:114,060,127...114,078,300
Ensembl chr 9:114,060,127...114,078,328 		JBrowse link
G AOC1 amine oxidase copper containing 1 increases metabolic processing EXP AOC1 protein results in increased metabolism of Histamine CTD PMID:12072962 NCBI chr 7:150,852,120...150,861,504
Ensembl chr 7:150,824,627...150,861,504 		JBrowse link
G AQP5 aquaporin 5 affects localization
multiple interactions
decreases expression		 EXP Histamine affects the localization of AQP5 protein
Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased expression of AQP5 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in decreased expression of AQP5 protein]		 CTD PMID:19443731 PMID:29452068 NCBI chr12:49,961,872...49,965,682
Ensembl chr12:49,961,872...49,965,682 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression ISO Histamine results in increased expression of BAX mRNA CTD PMID:36565801 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression ISO Histamine results in decreased expression of BCL2 mRNA CTD PMID:36565801 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCR BCR activator of RhoGEF and GTPase multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; [BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine; Imatinib Mesylate inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] CTD PMID:16849647 NCBI chr22:23,180,509...23,318,037
Ensembl chr22:23,179,704...23,318,037 		JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions
increases secretion		 ISO [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein] CTD PMID:11166334 PMID:12791437 PMID:14991081 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354 		JBrowse link
G CASP3 caspase 3 increases expression ISO Histamine results in increased expression of CASP3 mRNA; Histamine results in increased expression of CASP3 protein CTD PMID:36565801 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase affects expression
decreases activity		 ISO Histamine affects the expression of CAT protein
Histamine results in decreased activity of CAT protein		 CTD PMID:17729160 PMID:36565801 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Lipopolysaccharides promotes the reaction [Histamine results in increased expression of CCL2 protein]; TNF protein promotes the reaction [Histamine results in increased expression of CCL2 protein] CTD PMID:11336536 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCND1 cyclin D1 multiple interactions EXP [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CCND1 protein CTD PMID:22363581 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CD14 CD14 molecule affects expression
multiple interactions		 EXP Histamine affects the expression of CD14 protein
HRH2 protein affects the reaction [Histamine affects the expression of CD14 protein]		 CTD PMID:14499251 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700 		JBrowse link
G CD40 CD40 molecule multiple interactions EXP [alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of CD40 protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein CTD PMID:11306145 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863 		JBrowse link
G CD80 CD80 molecule multiple interactions EXP Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]] CTD PMID:12538815 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614 		JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions EXP [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CDK2 protein CTD PMID:22363581 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1A protein CTD PMID:22363581 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B multiple interactions EXP [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein CTD PMID:22363581 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 multiple interactions
affects response to substance		 ISO CHRM3 protein affects the reaction [Histamine results in increased secretion of Acids]
CHRM3 protein affects the susceptibility to Histamine		 CTD PMID:14724830 NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452 		JBrowse link
G CLCA1 chloride channel accessory 1 increases expression EXP Histamine results in increased expression of CLCA1 mRNA CTD PMID:17622767 NCBI chr 1:86,468,927...86,500,259
Ensembl chr 1:86,468,368...86,500,259 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation		 EXP Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein] CTD PMID:29452068 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CSF1 colony stimulating factor 1 decreases expression ISO Histamine results in decreased expression of CSF1 mRNA CTD PMID:9657254 NCBI chr 1:109,910,506...109,930,992
Ensembl chr 1:109,910,242...109,930,992 		JBrowse link
G CSF2 colony stimulating factor 2 increases expression
increases secretion
multiple interactions		 EXP
ISO		 Histamine results in increased expression of CSF2 protein
CSF2 results in increased secretion of Histamine
Histamine results in increased secretion of CSF2 protein
Particulate Matter analog promotes the reaction [Histamine results in increased secretion of CSF2 protein]; Vehicle Emissions analog promotes the reaction [Histamine results in increased secretion of CSF2 protein]		 CTD PMID:9606035 PMID:9685678 PMID:9856766 PMID:10051702 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
increases expression		 EXP [Histamine co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA; Cyclosporine inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Dexamethasone inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Dexamethasone inhibits the reaction [Histamine results in increased expression of CXCL8 protein]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of CXCL8 protein]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of CXCL8 protein]; Histamine results in increased activity of [CXCL8 protein binds to RELA protein]; L 655238 inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Leukotriene B4 inhibits the reaction [zileuton inhibits the reaction [Histamine results in increased expression of CXCL8 protein]]; Lipopolysaccharides promotes the reaction [Histamine results in increased expression of CXCL8 protein]; MK-886 inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; MK-886 inhibits the reaction [Histamine results in increased expression of CXCL8 protein]; Particulate Matter analog promotes the reaction [Histamine results in increased secretion of CXCL8 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased secretion of CXCL8 protein]; TNF protein promotes the reaction [Histamine results in increased expression of CXCL8 protein]; Vehicle Emissions analog promotes the reaction [Histamine results in increased secretion of CXCL8 protein]; zileuton inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; zileuton inhibits the reaction [Histamine results in increased expression of CXCL8 protein]
Histamine results in increased expression of CXCL8 mRNA; Histamine results in increased expression of CXCL8 protein		 CTD PMID:9609743 PMID:10051702 PMID:11336536 PMID:29452068 PMID:29594315 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G EDN1 endothelin 1 multiple interactions EXP EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP EGFR protein affects the reaction [Histamine results in increased secretion of MMP1 protein] CTD PMID:17656145 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression
increases activity		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of F3]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Histamine results in increased expression of F3]; [Histamine co-treated with splitomicin] results in increased expression of F3 protein; Chlorpheniramine inhibits the reaction [Histamine results in increased expression of F3]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]; pyrazolanthrone inhibits the reaction [Histamine results in increased expression of F3]; Pyrilamine inhibits the reaction [Histamine results in increased activity of F3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of F3]; SB 203580 inhibits the reaction [Histamine results in increased expression of F3]; wortmannin promotes the reaction [Histamine results in increased expression of F3]
Histamine results in increased expression of F3 mRNA; Histamine results in increased expression of F3 protein		 CTD PMID:16009787 PMID:20978007 PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G FCER1A Fc epsilon receptor Ia affects secretion EXP FCER1A polymorphism affects the secretion of Histamine CTD PMID:17125826 NCBI chr 1:159,283,575...159,308,202
Ensembl chr 1:159,289,714...159,308,224 		JBrowse link
G FGF1 fibroblast growth factor 1 increases expression ISO Histamine results in increased expression of FGF1 protein CTD PMID:15264218 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA] CTD PMID:9187264 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GAST gastrin affects abundance
increases secretion
affects activity
multiple interactions		 ISO GAST protein affects the abundance of Histamine
GAST protein modified form results in increased secretion of Histamine; GAST protein results in increased secretion of Histamine
Histamine affects the activity of GAST protein
[fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine]; alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine]; Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine]; CXCL8 protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; Dinoprostone inhibits the reaction [GAST protein results in increased secretion of Histamine]; Galanin inhibits the reaction [GAST protein results in increased secretion of Histamine]; Impromidine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine]; Misoprostol inhibits the reaction [GAST protein results in increased secretion of Histamine]; Pentobarbital inhibits the reaction [GAST protein results in increased secretion of Histamine]; SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; Urethane inhibits the reaction [GAST protein results in increased secretion of Histamine]		 CTD PMID:2470453 PMID:10864877 PMID:11164953 PMID:12190085 PMID:12893847 More... NCBI chr17:41,712,331...41,715,969
Ensembl chr17:41,712,331...41,715,969 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions ISO Histamine affects the reaction [GHRL protein results in increased secretion of Acids] CTD PMID:16838121 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947 		JBrowse link
G GUSB glucuronidase beta multiple interactions
increases expression		 EXP fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein]; fexofenadine inhibits the reaction [Histamine results in increased expression of GUSB protein]; HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein] CTD PMID:11238657 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215 		JBrowse link
G HDC histidine decarboxylase increases chemical synthesis
multiple interactions		 ISO
EXP		 HDC protein results in increased chemical synthesis of Histamine
[troglitazone results in decreased expression of HDC mRNA] which results in decreased secretion of Histamine		 CTD PMID:11834241 PMID:17075268 NCBI chr15:50,241,947...50,265,726
Ensembl chr15:50,241,947...50,265,965 		JBrowse link
G HNMT histamine N-methyltransferase increases methylation
multiple interactions		 EXP HNMT protein results in increased methylation of Histamine
SK&F 91488 inhibits the reaction [HNMT protein results in increased methylation of Histamine]		 CTD PMID:7943261 NCBI chr 2:137,964,473...138,016,364
Ensembl chr 2:137,964,020...138,016,364 		JBrowse link
G HRH1 histamine receptor H1 increases activity
affects binding
multiple interactions
increases expression
affects response to substance		 EXP
ISO		 Histamine results in increased activity of HRH1 protein
HRH1 protein binds to Histamine
1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]; [Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium; [HRH1 protein binds to Histamine] which results in increased import of Calcium; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein; Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]; fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein]; Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]; Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]; Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]; HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]]; HRH1 protein affects the reaction [Histamine results in increased transport of fluorescein isothiocyanate bovine serum albumin]; HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]; HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]; HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein]; HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein]; HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]; Quercetin inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]; Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]]
HRH1 protein affects the susceptibility to Histamine
[epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; [Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; [Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein; [Histamine results in increased activity of HRH1 protein] which affects the transport of Potassium; [Tripelennamine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; Histamine binds to and results in increased activity of HRH1 protein; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]; Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]; Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]		 CTD PMID:2419744 PMID:11238657 PMID:11306145 PMID:11527950 PMID:12095164 More... NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557 		JBrowse link
G HRH2 histamine receptor H2 multiple interactions
increases activity
affects localization
affects expression		 EXP
ISO		 [Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]]; [Histamine affects the localization of HRH2 protein] which affects the degradation of HRH2 protein; [Histamine binds to and results in increased activity of HRH2 protein] which results in decreased expression of IFNG mRNA; [Histamine binds to and results in increased activity of HRH2 protein] which results in increased abundance of Cyclic AMP; [Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA; [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein; [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC protein; Burimamide inhibits the reaction [[Cyclic AMP binds to and results in increased activity of HRH2 protein] which results in increased abundance of Histamine]; Burimamide inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]; Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Histamine binds to and results in increased activity of HRH2 protein; HRH2 protein affects the reaction [Histamine affects the expression of CD14 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12B protein]; HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]; tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]
[[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; [Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine; [roxatidine acetate binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine; [thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]; Histamine binds to and results in increased activity of HRH2 protein; Histamine inhibits the reaction [tiotidine binds to HRH2 protein]
HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]; HRH2 protein affects the reaction [Histamine results in increased expression of IL18 protein]
Histamine affects the expression of HRH2 protein		 CTD PMID:9187264 PMID:9681472 PMID:9819373 PMID:10569698 PMID:11306145 More... NCBI chr 5:175,658,071...175,710,756
Ensembl chr 5:175,658,030...175,710,756 		JBrowse link
G HRH3 histamine receptor H3 multiple interactions EXP
ISO		 Histamine binds to and results in increased activity of HRH3 protein
Histamine binds to Hrh3 protein; Histamine inhibits the reaction [N-methylhistamine binds to Hrh3 protein]
[Histamine binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium; Histamine binds to and results in increased activity of HRH3 protein		 CTD
RGD		 PMID:12706455 PMID:10869375 RGD:632981 NCBI chr20:62,214,960...62,220,278
Ensembl chr20:62,214,960...62,220,278 		JBrowse link
G HRH4 histamine receptor H4 multiple interactions
increases response to substance
increases activity		 EXP 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to Histamine]; [Histamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK1 protein; [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK3 protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein; [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CCND1 protein; [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CDK2 protein; [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1A protein; [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein; Histamine binds to and results in increased activity of HRH4 protein; Histamine promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein] CTD PMID:11181941 PMID:15843518 PMID:22363581 NCBI chr18:24,460,637...24,479,974
Ensembl chr18:24,460,637...24,479,961 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] CTD PMID:11752121 PMID:12364868 PMID:12538815 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions
affects expression		 EXP
ISO		 [Histamine binds to and results in increased activity of HRH2 protein] which results in decreased expression of IFNG mRNA; [Histamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA]; Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]
Histamine affects the expression of IFNG protein		 CTD PMID:10569698 PMID:11752121 PMID:12364868 PMID:17346280 PMID:19277450 More... NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 multiple interactions EXP [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Terfenadine inhibits the reaction [Histamine results in increased expression of IL10 protein] CTD PMID:11752121 PMID:12925206 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12A interleukin 12A multiple interactions
increases expression
decreases expression		 EXP [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]
Histamine results in increased expression of IL12A protein
Histamine results in decreased expression of IL12A mRNA; Histamine results in decreased expression of IL12A protein		 CTD PMID:9819373 PMID:11752121 PMID:12364868 PMID:15843518 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B decreases expression
increases expression
multiple interactions		 EXP Histamine results in decreased expression of IL12B mRNA; Histamine results in decreased expression of IL12B protein
Histamine results in increased expression of IL12B protein
[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12B protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12B protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein]		 CTD PMID:9819373 PMID:11752121 PMID:12364868 PMID:15843518 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL16 interleukin 16 multiple interactions
increases expression		 EXP Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]; HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]; thioperamide inhibits the reaction [Histamine results in increased expression of IL16 protein] CTD PMID:12235264 NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058 		JBrowse link
G IL18 interleukin 18 multiple interactions
increases expression		 EXP
ISO		 [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]
HRH2 protein affects the reaction [Histamine results in increased expression of IL18 protein]		 CTD PMID:11752121 PMID:12364868 PMID:16723495 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression		 ISO IL1B protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]
Histamine results in increased expression of IL1B mRNA		 CTD PMID:11164953 PMID:36565801 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2 interleukin 2 multiple interactions ISO
EXP		 Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]
[Histamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA		 CTD PMID:19277450 PMID:29594315 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL4 interleukin 4 multiple interactions
increases response to substance		 ISO Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]]
IL4 protein results in increased susceptibility to Histamine		 CTD PMID:12370375 PMID:19277450 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5 interleukin 5 multiple interactions EXP Terfenadine inhibits the reaction [Histamine results in increased expression of IL5 protein] CTD PMID:12925206 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases secretion
increases expression		 EXP
ISO		 Calcimycin inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]]; Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein]; Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]]; fexofenadine inhibits the reaction [Histamine results in increased expression of IL6 protein]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of IL6 protein]; HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein]; Lipopolysaccharides promotes the reaction [Histamine results in increased expression of IL6 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased secretion of IL6 protein]; TNF protein promotes the reaction [Histamine results in increased expression of IL6 protein]
Histamine results in increased expression of IL6 mRNA; Histamine results in increased expression of IL6 protein		 CTD PMID:9657254 PMID:9856766 PMID:11238657 PMID:11336536 PMID:29452068 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITGA2 integrin subunit alpha 2 multiple interactions ISO ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] CTD PMID:18234883 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779 		JBrowse link
G KCNQ2 potassium voltage-gated channel subfamily Q member 2 multiple interactions EXP Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]; Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] CTD PMID:12147327 NCBI chr20:63,400,208...63,472,655
Ensembl chr20:63,400,208...63,472,677 		JBrowse link
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 multiple interactions EXP Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]; Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] CTD PMID:12147327 NCBI chr 8:132,120,861...132,481,095
Ensembl chr 8:132,120,861...132,481,095 		JBrowse link
G KNG1 kininogen 1 multiple interactions ISO [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] CTD PMID:11166334 PMID:12791437 PMID:18234883 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410 		JBrowse link
G LTC4S leukotriene C4 synthase decreases response to substance EXP LTC4S polymorphism results in decreased susceptibility to Histamine CTD PMID:19862937 NCBI chr 5:179,793,986...179,796,647
Ensembl chr 5:179,793,980...179,796,647 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK1 protein; Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein]; Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Hydrogen Peroxide promotes the reaction [Histamine results in increased phosphorylation of MAPK1 protein]; Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein] CTD PMID:11181941 PMID:16009787 PMID:17656145 PMID:21179406 PMID:30310171 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK3 protein; Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein]; Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Hydrogen Peroxide promotes the reaction [Histamine results in increased phosphorylation of MAPK3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein] CTD PMID:11181941 PMID:16009787 PMID:17656145 PMID:21179406 PMID:30310171 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO Histamine inhibits the reaction [decamethrin results in decreased nitrosation of MAPK8 protein] CTD PMID:25299849 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MMP1 matrix metallopeptidase 1 multiple interactions
increases expression
increases secretion		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased secretion of MMP1 protein]; EGFR protein affects the reaction [Histamine results in increased secretion of MMP1 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; RTKI cpd inhibits the reaction [Histamine results in increased secretion of MMP1 protein] CTD PMID:9856766 PMID:17656145 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming multiple interactions
increases secretion
increases expression		 EXP Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of MUC5AC protein]; Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased secretion of MUC5AC protein]
Histamine results in increased expression of MUC5AC mRNA; Histamine results in increased expression of MUC5AC protein		 CTD PMID:17622767 PMID:29452068 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
affects localization		 EXP Histamine promotes the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Histamine promotes the reaction [TNF protein affects the localization of NFKB1 protein]
Histamine affects the localization of NFKB1 protein		 CTD PMID:11336536 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha increases phosphorylation
multiple interactions		 EXP Histamine results in increased phosphorylation of NFKBIA protein
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of NFKBIA protein]		 CTD PMID:29452068 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NGF nerve growth factor multiple interactions ISO [Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]; Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] CTD PMID:15167971 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression
increases phosphorylation		 EXP
ISO		 [PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein]; Deoxyglucose promotes the reaction [STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]]; STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein]; STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]
Histamine results in increased expression of NOS2 protein		 CTD PMID:21145922 PMID:36565801 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO Histamine inhibits the reaction [decamethrin results in decreased expression of NOS3 protein] CTD PMID:25299849 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NTF3 neurotrophin 3 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Cimetidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; ciproxifan inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; KN 62 inhibits the reaction [Histamine results in increased expression of NTF3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Pertussis Toxin inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Histamine results in increased expression of NTF3 protein]; thioperamide inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Triprolidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]
Histamine results in increased expression of NTF3 mRNA; Histamine results in increased expression of NTF3 protein		 CTD PMID:21276809 NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536 		JBrowse link
G PCNA proliferating cell nuclear antigen affects expression ISO Histamine affects the expression of PCNA protein CTD PMID:17729160 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PDE4B phosphodiesterase 4B multiple interactions
increases expression		 EXP Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA] CTD PMID:11131300 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579 		JBrowse link
G PLA2G4A phospholipase A2 group IVA multiple interactions
increases expression		 EXP Dexamethasone inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]; MK-886 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] CTD PMID:9609743 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981 		JBrowse link
G PPP3CA protein phosphatase 3 catalytic subunit alpha increases expression ISO Histamine results in increased expression of PPP3CA protein CTD PMID:30310171 NCBI chr 4:101,023,418...101,347,526
Ensembl chr 4:101,023,409...101,348,278 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein] CTD PMID:21145922 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein] CTD PMID:21145922 NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335 		JBrowse link
G PRKCD protein kinase C delta multiple interactions EXP epigallocatechin gallate inhibits the reaction [Histamine results in increased phosphorylation of PRKCD protein]; Histamine results in increased phosphorylation of and affects the localization of PRKCD protein; Quercetin inhibits the reaction [Histamine results in increased phosphorylation of and affects the localization of PRKCD protein] CTD PMID:23333628 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [SC 560 binds to and results in decreased activity of PTGS1 protein] promotes the reaction [Histamine results in increased secretion of Acids] CTD PMID:16299412 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP
ISO		 Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]; Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]; HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]]
Histamine results in increased expression of PTGS2 mRNA		 CTD PMID:20040740 PMID:36565801 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C multiple interactions EXP [alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of PTPRC protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein CTD PMID:11306145 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,757,476 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit affects localization
increases phosphorylation
multiple interactions		 EXP Histamine affects the localization of RELA protein
Histamine results in increased phosphorylation of RELA protein
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of RELA protein]; Histamine promotes the reaction [Lipopolysaccharides affects the localization of RELA protein]; Histamine promotes the reaction [TNF protein affects the localization of RELA protein]; Histamine results in increased activity of [CXCL8 protein binds to RELA protein]		 CTD PMID:9609743 PMID:11336536 PMID:29452068 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC18A1 solute carrier family 18 member A1 multiple interactions EXP Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr 8:20,144,855...20,183,136
Ensembl chr 8:20,144,855...20,183,206 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions
affects binding
increases secretion		 ISO
EXP		 Rabeprazole promotes the reaction [SLC18A2 protein results in increased secretion of Histamine]
Histamine binds to SLC18A2 protein		 CTD PMID:7912402 PMID:14642791 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions
increases uptake
increases transport
affects uptake		 ISO
EXP		 Corticosterone inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Estradiol inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; pseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Serotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]
SLC22A3 protein results in increased uptake of Histamine
SLC22A3 protein polymorphism affects the uptake of Histamine		 CTD PMID:12411423 PMID:16928864 PMID:20562519 PMID:20858707 NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577 		JBrowse link
G SLC29A4 solute carrier family 29 member 4 increases uptake EXP SLC29A4 protein results in increased uptake of Histamine CTD PMID:20858707 NCBI chr 7:5,282,943...5,306,912
Ensembl chr 7:5,274,369...5,306,912 		JBrowse link
G SLC47A1 solute carrier family 47 member 1 multiple interactions EXP Histamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034 		JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Histamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,317...19,718,979
Ensembl chr17:19,678,288...19,718,979 		JBrowse link
G SOD1 superoxide dismutase 1 affects expression ISO Histamine affects the expression of SOD1 protein CTD PMID:17729160 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SST somatostatin multiple interactions ISO SST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:11164953 NCBI chr 3:187,668,912...187,670,394
Ensembl chr 3:187,668,912...187,670,394 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 increases expression EXP Histamine results in increased expression of STAT6 protein CTD PMID:12755381 NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139 		JBrowse link
G STK11 serine/threonine kinase 11 multiple interactions
increases phosphorylation		 EXP STK11 protein promotes the reaction [Histamine results in increased abundance of Cyclic GMP]; STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein]
Histamine results in increased phosphorylation of STK11 protein		 CTD PMID:21145922 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
G TAAR1 trace amine associated receptor 1 increases activity
multiple interactions		 ISO Histamine results in increased activity of TAAR1 protein
[Histamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 6:132,643,312...132,659,182
Ensembl chr 6:132,643,312...132,659,182 		JBrowse link
G TAC1 tachykinin precursor 1 multiple interactions
increases secretion		 EXP
ISO		 Nedocromil inhibits the reaction [TAC1 protein results in increased secretion of Histamine]; Theophylline inhibits the reaction [TAC1 protein results in increased secretion of Histamine]
Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]		 CTD PMID:1707400 PMID:9291295 PMID:11166334 PMID:18234883 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472 		JBrowse link
G TLR2 toll like receptor 2 multiple interactions EXP Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]; Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]; HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]] CTD PMID:20040740 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Histamine promotes the reaction [TNF protein affects the localization of NFKB1 protein]; Histamine promotes the reaction [TNF protein affects the localization of RELA protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; TNF protein promotes the reaction [Histamine results in increased expression of CCL2 protein]; TNF protein promotes the reaction [Histamine results in increased expression of CXCL8 protein]; TNF protein promotes the reaction [Histamine results in increased expression of IL6 protein]
Histamine results in increased expression of TNF mRNA; Histamine results in increased expression of TNF protein
TNF protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [GAST protein results in increased secretion of Histamine]
Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]		 CTD PMID:11164953 PMID:11336536 PMID:11752121 PMID:12538815 PMID:14499251 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UCP2 uncoupling protein 2 decreases secretion
affects secretion
affects abundance		 EXP
ISO		 UCP2 protein results in decreased secretion of Histamine
UCP2 protein affects the secretion of Histamine
UCP2 protein affects the abundance of Histamine		 CTD PMID:19846869 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843 		JBrowse link
G VIP vasoactive intestinal peptide increases secretion ISO VIP protein results in increased secretion of Histamine CTD PMID:11164953 NCBI chr 6:152,750,797...152,759,760
Ensembl chr 6:152,750,797...152,759,765 		JBrowse link
4-methylhistamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 decreases expression EXP 4-methylhistamine results in decreased expression of CCL2 protein CTD PMID:17507084 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CD14 CD14 molecule multiple interactions EXP [4-methylhistamine binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein CTD PMID:14499251 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700 		JBrowse link
G CD80 CD80 molecule multiple interactions EXP 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein] CTD PMID:12538815 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614 		JBrowse link
G HRH2 histamine receptor H2 multiple interactions EXP 4-methylhistamine binds to and results in increased activity of HRH2 protein; [4-methylhistamine binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein CTD PMID:14499251 NCBI chr 5:175,658,071...175,710,756
Ensembl chr 5:175,658,030...175,710,756 		JBrowse link
G HRH4 histamine receptor H4 multiple interactions EXP 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]; 4-methylhistamine binds to and results in increased activity of HRH4 protein; [4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium CTD PMID:17507084 NCBI chr18:24,460,637...24,479,974
Ensembl chr18:24,460,637...24,479,961 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] CTD PMID:11752121 PMID:12364868 PMID:12538815 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma affects expression
multiple interactions		 EXP 4-methylhistamine affects the expression of IFNG protein
4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]		 CTD PMID:11752121 PMID:12364868 PMID:17346280 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 multiple interactions EXP 4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein] CTD PMID:11752121 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12A interleukin 12A multiple interactions EXP 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:11752121 PMID:12364868 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B multiple interactions EXP 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:11752121 PMID:12364868 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL18 interleukin 18 multiple interactions EXP 4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein] CTD PMID:11752121 PMID:12364868 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:11752121 PMID:12538815 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
alpha-methylhistamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAL galanin and GMAP prepropeptide decreases expression ISO alpha-methylhistamine results in decreased expression of GAL mRNA CTD PMID:11956952 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175 		JBrowse link
G GAST gastrin multiple interactions ISO alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine] CTD PMID:2470453 NCBI chr17:41,712,331...41,715,969
Ensembl chr17:41,712,331...41,715,969 		JBrowse link
G HDC histidine decarboxylase decreases expression ISO alpha-methylhistamine results in decreased expression of HDC mRNA CTD PMID:11956952 NCBI chr15:50,241,947...50,265,726
Ensembl chr15:50,241,947...50,265,965 		JBrowse link
G HRH3 histamine receptor H3 multiple interactions
affects binding		 ISO
EXP		 6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]
alpha-methylhistamine binds to HRH3 protein
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]; Endocannabinoids inhibits the reaction [alpha-methylhistamine binds to and results in increased activity of HRH3 protein]; Histamine H3 Antagonists inhibits the reaction [alpha-methylhistamine binds to HRH3 protein]		 CTD PMID:11956952 PMID:21634396 PMID:30102254 PMID:31369746 NCBI chr20:62,214,960...62,220,278
Ensembl chr20:62,214,960...62,220,278 		JBrowse link
G HRH4 histamine receptor H4 multiple interactions EXP [alpha-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; alpha-methylhistamine binds to and results in increased activity of HRH4 protein; HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein] CTD PMID:11181941 PMID:12235264 NCBI chr18:24,460,637...24,479,974
Ensembl chr18:24,460,637...24,479,961 		JBrowse link
G IFNG interferon gamma affects expression EXP alpha-methylhistamine affects the expression of IFNG protein CTD PMID:17346280 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL16 interleukin 16 multiple interactions
increases expression		 EXP HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein] CTD PMID:12235264 NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL1B protein]] CTD PMID:31369746 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL6 protein]] CTD PMID:31369746 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]] CTD PMID:31369746 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of PTGS2 protein]] CTD PMID:31369746 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of RELA protein]] CTD PMID:31369746 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of TNF protein]] CTD PMID:31369746 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
histamine phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor increases expression EXP histamine phosphate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
N(tele)-methylhistamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 increases metabolic processing EXP AOC1 protein results in increased metabolism of tele-methylhistamine CTD PMID:12072962 NCBI chr 7:150,852,120...150,861,504
Ensembl chr 7:150,824,627...150,861,504 		JBrowse link
G HRH3 histamine receptor H3 affects binding ISO N(tele)-methylhistamine binds to Hrh3 protein RGD PMID:10869375 RGD:632981 NCBI chr20:62,214,960...62,220,278
Ensembl chr20:62,214,960...62,220,278 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        molecular messenger 20269
          neurotransmitter 11763
            histamine 99
              2-methylhistamine 0
              4-methylhistamine 12
              N(alpha)-gamma-L-glutamylhistamine + 0
              N(tele)-methylhistamine 2
              N-acetylhistamine 0
              N-guanylhistamine 0
              N-hydroxyhistamine 0
              alpha-methylhistamine 13
              carcinine 0
              histamine phosphate 1
              testosterone-3-CMO-Hist + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  heteroarene 18775
                                    monocyclic heteroarene 16136
                                      azole 15693
                                        diazole 11194
                                          imidazoles 10349
                                            histamine 99
                                              2-methylhistamine 0
                                              4-methylhistamine 12
                                              N(alpha)-gamma-L-glutamylhistamine + 0
                                              N(tele)-methylhistamine 2
                                              N-acetylhistamine 0
                                              N-guanylhistamine 0
                                              N-hydroxyhistamine 0
                                              alpha-methylhistamine 13
                                              carcinine 0
                                              histamine phosphate 1
                                              testosterone-3-CMO-Hist + 0
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