ALOX5AP (arachidonate 5-lipoxygenase-activating protein)

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Keyword

Gene: ALOX5AP (arachidonate 5-lipoxygenase-activating protein) Homo sapiens

Symbol:

ALOX5AP

Name:

arachidonate 5-lipoxygenase-activating protein

Description:

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

arachidonate 5-lipoxygenase activating protein; arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein; OTTHUMP00000018204

Orthologs:

Mus musculus : Alox5ap (arachidonate 5-lipoxygenase activating protein) MGI
Rattus norvegicus : Alox5ap (arachidonate 5-lipoxygenase activating protein)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	13	12,236,269 - 12,287,155	+	NCBI
Human Genome Assembly HuRef	13	12,105,618 - 12,156,585	+	NCBI
Human Genome Assembly GRCh37	13	31,287,615 - 31,338,565	+	NCBI
Human Genome Assembly Build 36	13	30,207,669 - 30,236,556	+	NCBI
Human Cytogenetic Map	13	q12		NCBI
Human Genome Assembly	13	30,207,668 - 30,236,556		NCBI