GAST (gastrin) - Rat Genome Database

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Gene: GAST (gastrin) Homo sapiens
Analyze
Symbol: GAST
Name: gastrin
RGD ID: 735826
HGNC Page HGNC:4164
Description: Predicted to enable hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway and response to food. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GAS; preprogastrin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,712,331 - 41,715,969 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,712,331 - 41,715,969 (+)EnsemblGRCh38hg38GRCh38
GRCh371739,868,583 - 39,872,221 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,122,139 - 37,125,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,122,105 - 37,125,749NCBI
Celera1736,519,728 - 36,523,335 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,630,734 - 35,634,345 (+)NCBIHuRef
CHM1_11740,104,051 - 40,107,693 (+)NCBICHM1_1
T2T-CHM13v2.01742,568,780 - 42,572,417 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (EXP)
2',5'-Dideoxyadenosine  (ISO)
2-hydroxypropanoic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
alpha-methylhistamine  (ISO)
ammonium chloride  (ISO)
benzo[a]pyrene  (EXP)
bethanechol  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butanal  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (ISO)
carmustine  (EXP)
CGP 52608  (EXP)
chloral hydrate  (ISO)
ciglitazone  (EXP)
cimetidine  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
dioxygen  (EXP)
famotidine  (EXP,ISO)
fentanyl  (ISO)
fenvalerate  (ISO)
fluanisone  (ISO)
fucoidan  (ISO)
fulvestrant  (EXP)
Galanin  (ISO)
gamma-aminobutyric acid  (ISO)
gentamycin  (ISO)
glucose  (ISO)
histamine  (ISO)
lansoprazole  (EXP,ISO)
lead diacetate  (EXP)
luzindole  (ISO)
melatonin  (ISO)
methimazole  (ISO)
midazolam  (ISO)
misoprostol  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
nitrendipine  (EXP)
omeprazole  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentobarbital  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
progesterone  (EXP)
prostaglandin E2  (ISO)
rac-lactic acid  (EXP)
ranitidine  (EXP,ISO)
reserpine  (ISO)
resveratrol  (EXP)
sodium dodecyl sulfate  (EXP)
spermidine  (ISO)
sucralose  (ISO)
terbutaline  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
tryptamine  (ISO)
tyramine  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
valproic acid  (EXP)
wortmannin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
hormone activity  (IBA,IEA,ISO,TAS)
protein binding  (IPI)

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:463490   PMID:871064   PMID:2730647   PMID:2736261   PMID:3011648   PMID:3034736   PMID:5822140   PMID:5921183   PMID:6087340   PMID:6322186   PMID:6324077   PMID:6574456  
PMID:6689486   PMID:7488110   PMID:7530658   PMID:7681836   PMID:8055952   PMID:8240296   PMID:8244378   PMID:8244379   PMID:8504433   PMID:9369230   PMID:9645429   PMID:9797370  
PMID:9855703   PMID:10771309   PMID:11054648   PMID:11181948   PMID:11278902   PMID:11710799   PMID:12006703   PMID:12174892   PMID:12477932   PMID:12612900   PMID:14627349   PMID:14660571  
PMID:14719064   PMID:14729624   PMID:15040018   PMID:15489334   PMID:15533775   PMID:15655830   PMID:15682471   PMID:15949639   PMID:16174078   PMID:16228228   PMID:16341674   PMID:16547500  
PMID:16574647   PMID:16638693   PMID:16754659   PMID:17006979   PMID:17064691   PMID:17207965   PMID:17229384   PMID:17258885   PMID:17332476   PMID:17559360   PMID:17604853   PMID:17698249  
PMID:17889508   PMID:17922093   PMID:18057001   PMID:18234640   PMID:18438722   PMID:18473402   PMID:18577758   PMID:18609694   PMID:19031134   PMID:19166966   PMID:19664057   PMID:19674135  
PMID:19731026   PMID:19794299   PMID:20145424   PMID:20395538   PMID:20932834   PMID:21029692   PMID:21111741   PMID:21175799   PMID:21186400   PMID:21195058   PMID:21222340   PMID:21274374  
PMID:21509655   PMID:21873635   PMID:22037174   PMID:22066020   PMID:22110279   PMID:22112435   PMID:22366915   PMID:22532184   PMID:22593272   PMID:23121767   PMID:24086717   PMID:24210828  
PMID:24388886   PMID:25109333   PMID:25601282   PMID:25752269   PMID:25977510   PMID:25993755   PMID:26161647   PMID:26684862   PMID:27179776   PMID:27264047   PMID:27864307   PMID:28109268  
PMID:28408643   PMID:28498440   PMID:28514442   PMID:28609362   PMID:28980157   PMID:29268861   PMID:29620236   PMID:29729162   PMID:30005556   PMID:30115027   PMID:31268978   PMID:31414587  
PMID:32228342   PMID:32296183   PMID:32742135   PMID:33091962   PMID:33744371   PMID:33961781   PMID:34341100   PMID:36061351   PMID:37258205   PMID:38069171  


Genomics

Comparative Map Data
GAST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,712,331 - 41,715,969 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,712,331 - 41,715,969 (+)EnsemblGRCh38hg38GRCh38
GRCh371739,868,583 - 39,872,221 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,122,139 - 37,125,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,122,105 - 37,125,749NCBI
Celera1736,519,728 - 36,523,335 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,630,734 - 35,634,345 (+)NCBIHuRef
CHM1_11740,104,051 - 40,107,693 (+)NCBICHM1_1
T2T-CHM13v2.01742,568,780 - 42,572,417 (+)NCBIT2T-CHM13v2.0
Gast
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,225,233 - 100,227,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,225,233 - 100,227,822 (+)EnsemblGRCm39 Ensembl
GRCm3811100,334,407 - 100,336,997 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,334,407 - 100,336,996 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,195,726 - 100,198,310 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,150,497 - 100,153,086 (+)NCBIMGSCv36mm8
Celera11110,951,803 - 110,954,387 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.46NCBI
Gast
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,765,216 - 85,767,881 (+)NCBIGRCr8
mRatBN7.21085,264,832 - 85,269,393 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,264,832 - 85,267,496 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,304,617 - 90,307,386 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,782,921 - 89,785,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,173,120 - 85,175,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,245,532 - 88,248,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,245,532 - 88,248,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,038,779 - 88,041,731 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,273,628 - 89,276,192 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,287,997 - 89,290,562 (+)NCBI
Celera1083,982,177 - 83,985,941 (+)NCBICelera
Cytogenetic Map10q31NCBI
Gast
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545115,987,597 - 15,988,131 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545115,987,160 - 15,988,067 (+)NCBIChiLan1.0ChiLan1.0
GAST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,265,782 - 23,270,765 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11725,155,901 - 25,160,884 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,597,741 - 15,602,724 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,816,656 - 15,820,296 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,816,656 - 15,820,296 (-)Ensemblpanpan1.1panPan2
GAST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,081,638 - 21,084,122 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,081,639 - 21,083,932 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,543,614 - 20,545,919 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,802,583 - 21,804,888 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,802,584 - 21,804,877 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,588,491 - 20,590,796 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,854,461 - 20,856,766 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,958,434 - 20,960,739 (-)NCBIUU_Cfam_GSD_1.0
Gast
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,438,522 - 20,441,534 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,636,146 - 16,636,548 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,636,146 - 16,636,548 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,953,202 - 20,955,434 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,953,202 - 20,955,434 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,119,838 - 21,123,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GAST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,526,548 - 64,532,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,526,636 - 64,527,080 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607735,361,331 - 35,361,996 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gast
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,976,380 - 1,976,819 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,976,170 - 1,976,819 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GAST
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31		 pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_000805.5(GAST):c.116A>G (p.Asn39Ser) single nucleotide variant not provided [RCV000950261] Chr17:41715552 [GRCh38]
Chr17:39871804 [GRCh37]
Chr17:17q21.2		 benign
NM_000805.5(GAST):c.193C>T (p.Pro65Ser) single nucleotide variant not specified [RCV004282471] Chr17:41715629 [GRCh38]
Chr17:39871881 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_000805.5(GAST):c.180G>A (p.Leu60=) single nucleotide variant not provided [RCV000918398] Chr17:41715616 [GRCh38]
Chr17:39871868 [GRCh37]
Chr17:17q21.2		 likely benign
NM_000805.5(GAST):c.215C>T (p.Pro72Leu) single nucleotide variant not specified [RCV004270452] Chr17:41715781 [GRCh38]
Chr17:39872033 [GRCh37]
Chr17:17q21.2		 likely benign
NM_000805.5(GAST):c.155C>A (p.Pro52Gln) single nucleotide variant not specified [RCV004203042] Chr17:41715591 [GRCh38]
Chr17:39871843 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_000805.5(GAST):c.281G>A (p.Arg94His) single nucleotide variant not specified [RCV004128761] Chr17:41715847 [GRCh38]
Chr17:39872099 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_000805.5(GAST):c.174G>C (p.Arg58Ser) single nucleotide variant not specified [RCV004171094] Chr17:41715610 [GRCh38]
Chr17:39871862 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_000805.5(GAST):c.230G>A (p.Gly77Glu) single nucleotide variant not specified [RCV004325132] Chr17:41715796 [GRCh38]
Chr17:39872048 [GRCh37]
Chr17:17q21.2		 uncertain significance
GRCh37/hg19 17q21.2(chr17:39705863-40358580)x3 copy number gain not specified [RCV003987235] Chr17:39705863..40358580 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_000805.5(GAST):c.284G>T (p.Arg95Leu) single nucleotide variant not specified [RCV004395112] Chr17:41715850 [GRCh38]
Chr17:39872102 [GRCh37]
Chr17:17q21.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:268
Count of miRNA genes:240
Interacting mature miRNAs:243
Transcripts:ENST00000329402
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
GDB:178387  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371739,871,216 - 39,871,624UniSTSGRCh37
Build 361737,124,742 - 37,125,150RGDNCBI36
Celera1736,522,331 - 36,522,738RGD
Cytogenetic Map17q21UniSTS
HuRef1735,633,341 - 35,633,748UniSTS
GAS  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371739,871,736 - 39,872,098UniSTSGRCh37
Build 361737,125,262 - 37,125,624RGDNCBI36
Celera1736,522,850 - 36,523,212RGD
HuRef1735,633,860 - 35,634,222UniSTS
D17S2114  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371739,870,164 - 39,870,363UniSTSGRCh37
Build 361737,123,690 - 37,123,889RGDNCBI36
Celera1736,521,279 - 36,521,478RGD
Cytogenetic Map17q21UniSTS
HuRef1735,632,320 - 35,632,519UniSTS
Stanford-G3 RH Map171664.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 3 1
Medium 23 6 6 1 6 13 17 1
Low 76 8 96 27 46 29 130 7 499 13 217 61 10 78 2
Below cutoff 404 376 398 109 249 70 1272 250 1917 80 490 277 40 178 765 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000329402   ⟹   ENSP00000331358
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1741,712,331 - 41,715,969 (+)Ensembl
RefSeq Acc Id: NM_000805   ⟹   NP_000796
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381741,712,331 - 41,715,969 (+)NCBI
GRCh371739,868,578 - 39,872,221 (+)NCBI
Build 361737,122,139 - 37,125,747 (+)NCBI Archive
HuRef1735,630,734 - 35,634,345 (+)NCBI
CHM1_11740,104,051 - 40,107,693 (+)NCBI
T2T-CHM13v2.01742,568,780 - 42,572,417 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_000796   ⟸   NM_000805
- Peptide Label: preproprotein
- UniProtKB: P78463 (UniProtKB/Swiss-Prot),   P78464 (UniProtKB/Swiss-Prot),   P01350 (UniProtKB/Swiss-Prot),   A0A0E3VY36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000331358   ⟸   ENST00000329402
Protein Domains
Gastrin/cholecystokinin peptide hormone

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01350-F1-model_v2 AlphaFold P01350 1-101 view protein structure

Promoters
RGD ID:6850062
Promoter ID:EP25015
Type:single initiation site
Name:HS_GAS
Description:Gastrin, GAS gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:gastric antrum, pituitary(weak)
Experiment Methods:Nuclease protection with homologous sequence ladder; RNA sequencing by primer extension
Position:
Human AssemblyChrPosition (strand)Source
Build 361737,122,104 - 37,122,164EPD
RGD ID:7235007
Promoter ID:EPDNEW_H23249
Type:single initiation site
Name:GAST_1
Description:gastrin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381741,712,331 - 41,712,391EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4164 AgrOrtholog
COSMIC GAST COSMIC
Ensembl Genes ENSG00000184502 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000329402 ENTREZGENE
  ENST00000329402.4 UniProtKB/Swiss-Prot
GTEx ENSG00000184502 GTEx
HGNC ID HGNC:4164 ENTREZGENE
Human Proteome Map GAST Human Proteome Map
InterPro GAST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gastrin/CCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gastrin/cholecystokinin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2520 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2520 ENTREZGENE
OMIM 137250 OMIM
PANTHER GASTRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gastrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28577 PharmGKB
PROSITE GASTRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GASTRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0E3VY36 ENTREZGENE, UniProtKB/TrEMBL
  GAST_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  P78463 ENTREZGENE
  P78464 ENTREZGENE
UniProt Secondary P78463 UniProtKB/Swiss-Prot
  P78464 UniProtKB/Swiss-Prot