GAST (gastrin) - Rat Genome Database

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Gene: GAST (gastrin) Sus scrofa
Analyze
Symbol: GAST
Name: gastrin
RGD ID: 13901213
Description: ENCODES a protein that exhibits hormone activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Barrett's esophagus (ortholog); Colonic Neoplasms (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: preprogastrin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,953,202 - 20,955,434 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,953,202 - 20,955,434 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,119,838 - 21,123,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
hormone activity  (IBA,IEA,ISO)
protein binding  (ISO)

References
Additional References at PubMed
PMID:6930858   PMID:6951161   PMID:14248711   PMID:14248712   PMID:22301074   PMID:25491185   PMID:30032202  


Genomics

Comparative Map Data
GAST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,953,202 - 20,955,434 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,953,202 - 20,955,434 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,119,838 - 21,123,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GAST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,712,331 - 41,715,969 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,712,331 - 41,715,969 (+)EnsemblGRCh38hg38GRCh38
GRCh371739,868,583 - 39,872,221 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,122,139 - 37,125,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,122,105 - 37,125,749NCBI
Celera1736,519,728 - 36,523,335 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,630,734 - 35,634,345 (+)NCBIHuRef
CHM1_11740,104,051 - 40,107,693 (+)NCBICHM1_1
T2T-CHM13v2.01742,568,780 - 42,572,417 (+)NCBIT2T-CHM13v2.0
Gast
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,225,233 - 100,227,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,225,233 - 100,227,822 (+)EnsemblGRCm39 Ensembl
GRCm3811100,334,407 - 100,336,997 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,334,407 - 100,336,996 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,195,726 - 100,198,310 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,150,497 - 100,153,086 (+)NCBIMGSCv36mm8
Celera11110,951,803 - 110,954,387 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.46NCBI
Gast
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,765,216 - 85,767,881 (+)NCBIGRCr8
mRatBN7.21085,264,832 - 85,269,393 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,264,832 - 85,267,496 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,304,617 - 90,307,386 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,782,921 - 89,785,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,173,120 - 85,175,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,245,532 - 88,248,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,245,532 - 88,248,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,038,779 - 88,041,731 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,273,628 - 89,276,192 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,287,997 - 89,290,562 (+)NCBI
Celera1083,982,177 - 83,985,941 (+)NCBICelera
Cytogenetic Map10q31NCBI
Gast
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545115,987,597 - 15,988,131 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545115,987,160 - 15,988,067 (+)NCBIChiLan1.0ChiLan1.0
GAST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,265,782 - 23,270,765 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11725,155,901 - 25,160,884 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,597,741 - 15,602,724 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,816,656 - 15,820,296 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,816,656 - 15,820,296 (-)Ensemblpanpan1.1panPan2
GAST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,081,638 - 21,084,122 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,081,639 - 21,083,932 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,543,614 - 20,545,919 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,802,583 - 21,804,888 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,802,584 - 21,804,877 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,588,491 - 20,590,796 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,854,461 - 20,856,766 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,958,434 - 20,960,739 (-)NCBIUU_Cfam_GSD_1.0
Gast
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,438,522 - 20,441,534 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,636,146 - 16,636,548 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,636,146 - 16,636,548 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,526,548 - 64,532,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,526,636 - 64,527,080 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607735,361,331 - 35,361,996 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gast
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,976,380 - 1,976,819 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,976,170 - 1,976,819 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GAST
103 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system
High
Medium 1
Low 2 2 2
Below cutoff 1 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000025368   ⟹   ENSSSCP00000022312
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,953,202 - 20,955,434 (-)Ensembl
RefSeq Acc Id: NM_001004036   ⟹   NP_001004036
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,953,202 - 20,955,434 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001004036   ⟸   NM_001004036
- Peptide Label: precursor
- UniProtKB: P01351 (UniProtKB/Swiss-Prot),   A0A4X1U8N7 (UniProtKB/TrEMBL),   F1S0K9 (UniProtKB/TrEMBL),   A0A8D0JD88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000022312   ⟸   ENSSSCT00000025368
Protein Domains
Gastrin/cholecystokinin peptide hormone


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021910 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005023171 UniProtKB/TrEMBL
  ENSSSCG00015044155 UniProtKB/TrEMBL
  ENSSSCG00025029204 UniProtKB/TrEMBL
  ENSSSCG00030064482 UniProtKB/TrEMBL
  ENSSSCG00035024119 UniProtKB/TrEMBL
  ENSSSCG00040027451 UniProtKB/TrEMBL
  ENSSSCG00045037373 UniProtKB/TrEMBL
  ENSSSCG00050022964 UniProtKB/TrEMBL
  ENSSSCG00055012274 UniProtKB/TrEMBL
  ENSSSCG00060023601 UniProtKB/TrEMBL
  ENSSSCG00065010680 UniProtKB/TrEMBL
  ENSSSCG00070014978 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025368 ENTREZGENE
  ENSSSCT00000025368.2 UniProtKB/TrEMBL
  ENSSSCT00005036717.1 UniProtKB/TrEMBL
  ENSSSCT00005036743.1 UniProtKB/TrEMBL
  ENSSSCT00015058803.1 UniProtKB/TrEMBL
  ENSSSCT00015058836.1 UniProtKB/TrEMBL
  ENSSSCT00025039690.1 UniProtKB/TrEMBL
  ENSSSCT00030090135.1 UniProtKB/TrEMBL
  ENSSSCT00035031673.1 UniProtKB/TrEMBL
  ENSSSCT00035031676.1 UniProtKB/TrEMBL
  ENSSSCT00040036741.1 UniProtKB/TrEMBL
  ENSSSCT00045064489.1 UniProtKB/TrEMBL
  ENSSSCT00050031013.1 UniProtKB/TrEMBL
  ENSSSCT00055024111.1 UniProtKB/TrEMBL
  ENSSSCT00055024139.1 UniProtKB/TrEMBL
  ENSSSCT00060032012.1 UniProtKB/TrEMBL
  ENSSSCT00060032028.1 UniProtKB/TrEMBL
  ENSSSCT00065014177.1 UniProtKB/TrEMBL
  ENSSSCT00065014186.1 UniProtKB/TrEMBL
  ENSSSCT00070029395.1 UniProtKB/TrEMBL
  ENSSSCT00070029402.1 UniProtKB/TrEMBL
InterPro GAST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gastrin/CCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gastrin/cholecystokinin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:445524 UniProtKB/Swiss-Prot
NCBI Gene GAST ENTREZGENE
PANTHER GASTRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gastrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GASTRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
UniProt A0A4X1U8N7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U988_PIG UniProtKB/TrEMBL
  A0A8D0JD88 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0JEG3_PIG UniProtKB/TrEMBL
  A0A8D1USN0_PIG UniProtKB/TrEMBL
  F1S0K9 ENTREZGENE
  GAST_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1S0K9 UniProtKB/TrEMBL
VGNC ID VGNC:98994 ENTREZGENE