Gene: ABL1 (c-abl oncogene 1, non-receptor tyrosine kinase)  Homo sapiens
Symbol: ABL1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Description: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Abelson tyrosine-protein kinase 1; ABL; bcr/abl; bcr/c-abl oncogene protein; c-ABL; c-abl oncogene 1, receptor tyrosine kinase; JTK7; OTTHUMP00000022375; OTTHUMP00000022376; p150; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine-protein kinase ABL1; v-abl; v-abl abelson murine leukemia viral oncogene homolog 1; v-abl Abelson murine leukemia viral oncogene homolog 1
Orthologs: Mus musculus : Abl1 (c-abl oncogene 1, non-receptor tyrosine kinase)  MGI
Rattus norvegicus : Abl1 (c-abl oncogene 1, non-receptor tyrosine kinase)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_19133,600,631 - 133,774,517+NCBI
Human Genome Assembly HuRef9103,075,969 - 103,249,725+NCBI
Human Genome Assembly GRCh379133,589,268 - 133,763,062+NCBI
Human Genome Assembly Build 369132,579,089 - 132,752,883+NCBI
Human Cytogenetic Map9q34.1 NCBI
Human Genome Assembly9130,619,260 - 130,792,614 NCBI
Model

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Sequence

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Nomenclature History
  
More on ABL1
Entrez Gene
Ensembl Gene
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Vista + UCSC

RGD Object Information
RGD ID: 1342972
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2013-05-28
Status: ACTIVE



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