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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:melanocortin system pathway
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Accession:PW:0000365 term browser browse the term
Definition:The melanocortin dependent system is involved in a diverse number of pathways such as pigmentation, steroidogenesis, sexual function, energy homeostasis. Its implication in energy homeostasis is of particular interest as alterations of this system have been associated with obesity.
Synonyms:related_synonym: SMP:00310
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melanocortin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy2 adenylate cyclase 2 ISO SMPDB SMP:00310 NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:36,204,054...36,650,645 		JBrowse link
G Agrp agouti related neuropeptide TAS
ISO 		RGD PMID:10875247 PMID:15189116 RGD:632165, RGD:1357925 NCBI chr19:50,357,899...50,396,758
Ensembl chr19:50,357,905...50,358,698 		JBrowse link
G Asip agouti signaling protein ISO RGD PMID:15189116 RGD:1357925 NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:164,015,903...164,021,378 		JBrowse link
G Atrn attractin ISO RGD PMID:20654690 RGD:5144214 NCBI chr 3:138,563,271...138,697,360
Ensembl chr 3:138,563,312...138,697,360 		JBrowse link
G Atrnl1 attractin like 1 ISO RGD PMID:20654690 RGD:5144214 NCBI chr 1:266,676,051...267,216,847
Ensembl chr 1:266,675,852...267,216,842 		JBrowse link
G Cpe carboxypeptidase E ISS RGD PMID:11874690 RGD:1357926 NCBI chr16:29,796,707...29,908,647
Ensembl chr16:29,796,689...29,909,524 		JBrowse link
G Gnas GNAS complex locus ISO SMPDB
RGD		 PMID:20852827 SMP:00310, RGD:5144213 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536 		JBrowse link
G Gnb1 G protein subunit beta 1 ISO SMPDB SMP:00310 NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:171,357,797...171,424,488 		JBrowse link
G Gng12 G protein subunit gamma 12 ISO SMPDB SMP:00310 NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:97,340,472...97,464,476 		JBrowse link
G Mc1r melanocortin 1 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr19:68,360,950...68,363,877
Ensembl chr19:68,360,950...68,363,877 		JBrowse link
G Mc2r melanocortin 2 receptor ISO SMPDB
RGD		 PMID:20852827 SMP:00310, RGD:5144213 NCBI chr18:64,279,878...64,291,775
Ensembl chr18:64,277,360...64,291,881 		JBrowse link
G Mc3r melanocortin 3 receptor IDA
ISO 		RGD PMID:8415620 PMID:20852827 RGD:69884, RGD:5144213 NCBI chr 3:181,434,776...181,435,873
Ensembl chr 3:181,434,776...181,435,873 		JBrowse link
G Mc4r melanocortin 4 receptor TAS
ISO 		RGD PMID:11963824 PMID:20852827 RGD:729360, RGD:5144213 NCBI chr18:62,689,798...62,691,685 JBrowse link
G Mc5r melanocortin 5 receptor ISO RGD PMID:9512481 PMID:20852827 RGD:1626223, RGD:5144213 NCBI chr18:64,185,013...64,190,054
Ensembl chr18:64,185,013...64,190,054 		JBrowse link
G Mgrn1 mahogunin ring finger 1 ISO RGD PMID:20654690 RGD:5144214 NCBI chr10:11,142,626...11,194,773
Ensembl chr10:11,145,690...11,194,805 		JBrowse link
G Mrap melanocortin 2 receptor accessory protein ISO RGD PMID:20654690 RGD:5144214 NCBI chr11:43,477,382...43,489,118
Ensembl chr11:43,478,001...43,489,118 		JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 ISO RGD PMID:20654690 RGD:5144214 NCBI chr 8:96,968,239...97,024,581
Ensembl chr 8:96,988,079...97,024,579 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase ISO RGD PMID:11874690 RGD:1357926 NCBI chr 9:105,445,812...105,719,287
Ensembl chr 9:105,445,929...105,719,285 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 ISS
ISO 		RGD PMID:11874690 PMID:15189116 RGD:1357926, RGD:1357925 NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:6,129,592...6,176,974 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO RGD PMID:11874690 RGD:1357926 NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:151,333,234...151,638,849 		JBrowse link
G Pomc proopiomelanocortin ISS
ISO 		SMPDB
RGD		 PMID:11874690 PMID:15189116 SMP:00310, RGD:1357926, RGD:1357925 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta ISO SMPDB SMP:00310 NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315 		JBrowse link
G Sdc1 syndecan 1 ISO RGD PMID:15189116 RGD:1357925 NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:37,297,010...37,304,500 		JBrowse link
G Sdc3 syndecan 3 ISO RGD PMID:15189116 RGD:1357925 NCBI chr 5:148,249,792...148,282,524
Ensembl chr 5:148,271,842...148,280,614 		JBrowse link
altered melanocortin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide ISO RGD PMID:15189116 RGD:1357925 NCBI chr19:50,357,899...50,396,758
Ensembl chr19:50,357,905...50,358,698 		JBrowse link
G Mc4r melanocortin 4 receptor ISS RGD PMID:15189116 RGD:1357925 NCBI chr18:62,689,798...62,691,685 JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 ISS
ISO 		RGD PMID:11874690 PMID:15189116 RGD:1357926, RGD:1357925 NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:6,129,592...6,176,974 		JBrowse link
G Pomc proopiomelanocortin ISS
ISO 		RGD PMID:15189116 PMID:11874690 RGD:1357925, RGD:1357926 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Sdc1 syndecan 1 ISO RGD PMID:15189116 RGD:1357925 NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:37,297,010...37,304,500 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      hormone signaling pathway 623
        peptide and protein hormone signaling pathway 438
          melanocortin system pathway 24
            altered melanocortin system pathway 5
paths to the root