Mgrn1 (mahogunin ring finger 1) - Rat Genome Database
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Gene: Mgrn1 (mahogunin ring finger 1) Rattus norvegicus
Analyze
Symbol: Mgrn1
Name: mahogunin ring finger 1
RGD ID: 1311862
Description: Predicted to have ubiquitin protein ligase activity. Predicted to be involved in endosome to lysosome transport; negative regulation of signal transduction; and protein ubiquitination. Predicted to localize to several cellular components, including early endosome; endoplasmic reticulum; and nucleus. Orthologous to human MGRN1 (mahogunin ring finger 1); PARTICIPATES IN melanocortin system pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH bisphenol A; furan; vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase MGRN1; LOC302938; mahoganoid; mahogunin ring finger 1, E3 ubiquitin protein ligase; mahogunin RING finger protein 1; mahogunin, ring finger 1; probable E3 ubiquitin-protein ligase MGRN1; RGD1311862; RING-type E3 ubiquitin transferase MGRN1; similar to mahogunin, ring finger 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21010,638,881 - 10,688,332 (-)NCBI
Rnor_6.0 Ensembl1010,833,519 - 10,881,977 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01010,832,573 - 10,881,999 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0109,599,503 - 9,648,909 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,756,804 - 10,805,883 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11010,756,804 - 10,805,883 (-)NCBI
Celera109,604,036 - 9,652,494 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12560552   PMID:15489334   PMID:17229889   PMID:19056867   PMID:19737927   PMID:19946888   PMID:22871113   PMID:23376485   PMID:28475871   PMID:29290584  


Genomics

Comparative Map Data
Mgrn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21010,638,881 - 10,688,332 (-)NCBI
Rnor_6.0 Ensembl1010,833,519 - 10,881,977 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01010,832,573 - 10,881,999 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0109,599,503 - 9,648,909 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,756,804 - 10,805,883 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11010,756,804 - 10,805,883 (-)NCBI
Celera109,604,036 - 9,652,494 (-)NCBICelera
Cytogenetic Map10q12NCBI
MGRN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl164,616,493 - 4,690,974 (+)EnsemblGRCh38hg38GRCh38
GRCh38164,624,826 - 4,690,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37164,674,827 - 4,740,973 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,614,854 - 4,680,974 (+)NCBINCBI36hg18NCBI36
Build 34164,614,853 - 4,680,972NCBI
Celera164,883,683 - 4,949,753 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef164,641,815 - 4,707,494 (+)NCBIHuRef
CHM1_1164,674,882 - 4,741,756 (+)NCBICHM1_1
Mgrn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,703,964 - 4,756,160 (+)NCBIGRCm39mm39
GRCm39 Ensembl164,704,113 - 4,756,160 (+)Ensembl
GRCm38164,886,100 - 4,938,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,886,249 - 4,938,296 (+)EnsemblGRCm38mm10GRCm38
MGSCv37164,886,252 - 4,938,296 (+)NCBIGRCm37mm9NCBIm37
MGSCv36164,801,480 - 4,853,524 (+)NCBImm8
Celera165,517,662 - 5,569,636 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.48NCBI
Mgrn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544212,781,539 - 12,824,222 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544212,780,795 - 12,823,716 (-)NCBIChiLan1.0ChiLan1.0
MGRN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1164,740,763 - 4,782,638 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl164,740,763 - 4,782,638 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0163,550,352 - 3,615,693 (+)NCBIMhudiblu_PPA_v0panPan3
MGRN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl636,716,343 - 36,769,417 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1636,716,071 - 36,775,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mgrn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365304,647,550 - 4,693,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGRN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl337,689,708 - 37,748,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1337,694,798 - 37,748,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2338,753,414 - 38,806,811 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MGRN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.154,310,924 - 4,372,896 (+)NCBI
ChlSab1.1 Ensembl54,310,970 - 4,375,423 (+)Ensembl
Mgrn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248242,419,973 - 2,473,580 (+)NCBI

Position Markers
D10Mco27  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01010,862,771 - 10,862,887NCBIRnor6.0
Rnor_5.0109,629,701 - 9,629,817UniSTSRnor5.0
RGSC_v3.41010,786,056 - 10,786,173RGDRGSC3.4
RGSC_v3.41010,786,057 - 10,786,173UniSTSRGSC3.4
RGSC_v3.11010,786,056 - 10,786,173RGD
Celera109,633,304 - 9,633,420UniSTS
Cytogenetic Map10q12UniSTS
RH144481  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01010,839,752 - 10,839,872NCBIRnor6.0
Rnor_5.0109,606,682 - 9,606,802UniSTSRnor5.0
RGSC_v3.41010,763,038 - 10,763,158UniSTSRGSC3.4
Celera109,610,270 - 9,610,390UniSTS
RH 3.4 Map1099.53UniSTS
Cytogenetic Map10q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129592136Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10483563820170031Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719917555534Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719919591669Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10546011921524070Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10546011921524070Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10546011921524070Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10622928936185929Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:95
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000004416
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 40 19 40 8 11 74 35 41 11 8
Low 1 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE574489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE574490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000004416   ⟹   ENSRNOP00000004416
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1010,833,519 - 10,881,977 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087118   ⟹   ENSRNOP00000071642
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1010,835,904 - 10,881,844 (-)Ensembl
RefSeq Acc Id: NM_001013964   ⟹   NP_001013986
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,639,826 - 10,688,296 (-)NCBI
Rnor_6.01010,833,518 - 10,881,977 (-)NCBI
Rnor_5.0109,599,503 - 9,648,909 (-)NCBI
RGSC_v3.41010,756,804 - 10,805,883 (-)RGD
Celera109,604,036 - 9,652,494 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245792   ⟹   XP_006245854
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,638,881 - 10,688,332 (-)NCBI
Rnor_6.01010,832,573 - 10,881,999 (-)NCBI
Rnor_5.0109,599,503 - 9,648,909 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245793   ⟹   XP_006245855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,638,881 - 10,688,317 (-)NCBI
Rnor_6.01010,832,573 - 10,881,999 (-)NCBI
Rnor_5.0109,599,503 - 9,648,909 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245794   ⟹   XP_006245856
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,638,881 - 10,688,291 (-)NCBI
Rnor_6.01010,832,573 - 10,881,998 (-)NCBI
Rnor_5.0109,599,503 - 9,648,909 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245795   ⟹   XP_006245857
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,638,881 - 10,688,317 (-)NCBI
Rnor_6.01010,832,573 - 10,881,998 (-)NCBI
Rnor_5.0109,599,503 - 9,648,909 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245796   ⟹   XP_006245858
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,638,881 - 10,688,291 (-)NCBI
Rnor_6.01010,832,573 - 10,881,999 (-)NCBI
Rnor_5.0109,599,503 - 9,648,909 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767485   ⟹   XP_008765707
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,638,881 - 10,688,317 (-)NCBI
Rnor_6.01010,832,573 - 10,881,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767486   ⟹   XP_008765708
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,638,881 - 10,688,317 (-)NCBI
Rnor_6.01010,832,573 - 10,881,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597213   ⟹   XP_017452702
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,638,881 - 10,688,329 (-)NCBI
Rnor_6.01010,832,573 - 10,881,842 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085844   ⟹   XP_038941772
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,648,248 - 10,688,291 (-)NCBI
RefSeq Acc Id: XM_039085845   ⟹   XP_038941773
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21010,638,881 - 10,658,366 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001013986   ⟸   NM_001013964
- UniProtKB: Q5XIQ4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245857   ⟸   XM_006245795
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006245855   ⟸   XM_006245793
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006245854   ⟸   XM_006245792
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006245858   ⟸   XM_006245796
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006245856   ⟸   XM_006245794
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008765708   ⟸   XM_008767486
- Peptide Label: isoform X8
- UniProtKB: G3C8Z1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765707   ⟸   XM_008767485
- Peptide Label: isoform X6
- UniProtKB: D3ZEH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452702   ⟸   XM_017597213
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: ENSRNOP00000004416   ⟸   ENSRNOT00000004416
RefSeq Acc Id: ENSRNOP00000071642   ⟸   ENSRNOT00000087118
RefSeq Acc Id: XP_038941773   ⟸   XM_039085845
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038941772   ⟸   XM_039085844
- Peptide Label: isoform X9
Protein Domains
RING-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696970
Promoter ID:EPDNEW_R7495
Type:multiple initiation site
Name:Mgrn1_1
Description:mahogunin ring finger 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01010,881,987 - 10,882,047EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311862 AgrOrtholog
Ensembl Genes ENSRNOG00000003234 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004416 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071642 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004416 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000087118 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134018 IMAGE-MGC_LOAD
InterPro Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302938 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94393 IMAGE-MGC_LOAD
NCBI Gene 302938 ENTREZGENE
PhenoGen Mgrn1 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3ZEH9 ENTREZGENE, UniProtKB/TrEMBL
  G3C8Z1 ENTREZGENE, UniProtKB/TrEMBL
  MGRN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Mgrn1  mahogunin ring finger 1  Mgrn1  mahogunin ring finger 1, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Mgrn1  mahogunin ring finger 1, E3 ubiquitin protein ligase  Mgrn1  mahogunin, ring finger 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-10-02 Mgrn1  mahogunin, ring finger 1  RGD1311862  similar to mahogunin, ring finger 1; mahoganoid  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 PENDING
2005-12-06 RGD1311862  similar to mahogunin, ring finger 1; mahoganoid  RGD1311862_predicted  similar to mahogunin, ring finger 1; mahoganoid (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311862_predicted  similar to mahogunin, ring finger 1; mahoganoid (predicted)  LOC302938_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC302938_predicted  similar to mahogunin, ring finger 1; mahoganoid (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL