Csnk2b (casein kinase 2 beta) - Rat Genome Database

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Gene: Csnk2b (casein kinase 2 beta) Rattus norvegicus
Analyze
Symbol: Csnk2b
Name: casein kinase 2 beta
RGD ID: 619978
Description: Enables ribonucleoprotein complex binding activity. Involved in liver regeneration and response to testosterone. Located in cell projection; chromatin; and nuclear matrix. Biomarker of myocardial infarction. Orthologous to human CSNK2B (casein kinase 2 beta); PARTICIPATES IN E-cadherin signaling pathway; mitochondrial autophagy pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: casein kinase 2, beta polypeptide; casein kinase 2, beta subunit; casein kinase II beta subunit; casein kinase II subunit beta; chimera Csnk2b-Ly6g5b splicing isoform 2050; chimera Csnk2b-Ly6g5b splicing isoform 2275; chimera Csnk2b-Ly6g5b splicing isoform 2531; chimera Csnk2b-Ly6g5b splicing isoform 901; CK II beta; Ck2; Csnk2b splicing isoform 280; Csnk2b splicing isoform 662; Csnk2b-Ly6g5b; phosvitin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,704,833 - 3,709,999 (+)NCBIGRCr8
mRatBN7.2203,700,363 - 3,705,331 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,698,733 - 3,707,133 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,399,893 - 4,404,317 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,761,951 - 3,766,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,299,839 - 4,304,262 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,108,692 - 5,113,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,106,890 - 5,113,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,181,951 - 7,186,861 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,764,565 - 3,768,985 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,764,954 - 3,769,209 (+)NCBI
Celera204,320,311 - 4,324,731 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
ATP  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
capsaicin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin 5,7-dimethyl ether  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
omeprazole  (EXP)
paracetamol  (ISO)
phenethyl isothiocyanate  (EXP)
pirinixic acid  (EXP)
Propiverine  (EXP)
pyrogallol  (ISO)
quercetin  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
silmitasertib  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (IDA)
chromatin  (IDA,IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
nuclear matrix  (IDA)
nucleus  (ISO)
PcG protein complex  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)
PML body  (IEA,ISO)
protein kinase CK2 complex  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of cDNAs encoding the alpha and beta subunits of rat casein kinase 2 (CK-2): investigation of molecular regulation of CK-2 by androgens in rat ventral prostate. Ahmed K, etal., Cell Mol Biol Res 1993;39(5):451-62.
2. Differential localization of alpha' and beta subunits of protein kinase CK2 during rat spermatogenesis. Alvarado-Diaz CP, etal., Cell Tissue Res. 2009 Oct;338(1):139-49. doi: 10.1007/s00441-009-0847-1. Epub 2009 Aug 27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Morphological changes and expression of protein kinase CK2 beta subunit in the microglia after hypoglossal nerve transection. Gesase AP and Kiyama H, J Neurocytol. 2000 Jan;29(1):61-6.
5. Protein kinase CK2 modulates synaptic plasticity by modification of synaptic NMDA receptors in the hippocampus. Kimura R and Matsuki N, J Physiol. 2008 Jul 1;586(13):3195-206. doi: 10.1113/jphysiol.2008.151894. Epub 2008 May 15.
6. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Kramerov AA, etal., Am J Pathol. 2006 May;168(5):1722-36.
7. Role of autophosphorylation in regulation of protein kinase CK2 from rat neuronal chromatin. Kulikova OG and Reikhardt BA, Biochemistry (Mosc). 1998 Dec;63(12):1400-6.
8. Protein kinase CK2: signaling and tumorigenesis in the mammary gland. Landesman-Bollag E, etal., Mol Cell Biochem 2001 Nov;227(1-2):153-65.
9. Quantitative proteome profiling of human myoma and myometrium tissue reveals kinase expression signatures with potential for therapeutic intervention. Lemeer S, etal., Proteomics. 2015 Jan;15(2-3):356-64. doi: 10.1002/pmic.201400213. Epub 2014 Dec 17.
10. HIV-1 Rev transactivator: a beta-subunit directed substrate and effector of protein kinase CK2. Meggio F, etal., Mol Cell Biochem 2001 Nov;227(1-2):145-51.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Changes in the activity of nuclear protein kinase CK2 during rat liver regeneration. Pancetti F, etal., Biochem Biophys Res Commun. 1996 Jan 5;218(1):35-9.
13. Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2. Pancetti F, etal., Biochem Biophys Res Commun. 1999 Jun 24;260(1):17-22.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. The tight association of protein kinase CK2 with plasma membranes is mediated by a specific domain of its regulatory beta-subunit. Sarrouilhe D, etal., Biochim Biophys Acta. 1998 Jun 22;1403(2):199-210.
20. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
21. Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. Xu YJ, etal., J Cell Mol Med. 2004 Jan-Mar;8(1):85-92.
22. Consequences of CK2 signaling to the nuclear matrix. Yu S, etal., Mol Cell Biochem 2001 Nov;227(1-2):67-71.
23. Mechanism of protein kinase CK2 association with nuclear matrix: role of disulfide bond formation. Zhang P, etal., J Cell Biochem. 1998 May 1;69(2):211-20.
Additional References at PubMed
PMID:8083223   PMID:8206911   PMID:10094392   PMID:10398585   PMID:11744621   PMID:11984006   PMID:12477932   PMID:12511551   PMID:14645218   PMID:14667819   PMID:15060004   PMID:15297462  
PMID:15537897   PMID:15723517   PMID:15882073   PMID:15897466   PMID:16335525   PMID:17520485   PMID:17553997   PMID:18089804   PMID:18278803   PMID:19064667   PMID:19233263   PMID:19324893  
PMID:19460754   PMID:19542537   PMID:19592636   PMID:20458337   PMID:20493168   PMID:20869595   PMID:21187092   PMID:21282530   PMID:21431367   PMID:21630459   PMID:21988832   PMID:22206666  
PMID:22447044   PMID:23521802   PMID:23553788   PMID:23555304   PMID:25519132   PMID:25931508   PMID:25950943   PMID:26362340   PMID:27276705   PMID:27782092   PMID:27851782   PMID:29476059  
PMID:31904090   PMID:34884938   PMID:34948351   PMID:38381246  


Genomics

Comparative Map Data
Csnk2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,704,833 - 3,709,999 (+)NCBIGRCr8
mRatBN7.2203,700,363 - 3,705,331 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,698,733 - 3,707,133 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,399,893 - 4,404,317 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,761,951 - 3,766,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,299,839 - 4,304,262 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,108,692 - 5,113,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,106,890 - 5,113,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,181,951 - 7,186,861 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,764,565 - 3,768,985 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,764,954 - 3,769,209 (+)NCBI
Celera204,320,311 - 4,324,731 (-)NCBICelera
Cytogenetic Map20p12NCBI
CSNK2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,666,080 - 31,670,067 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,665,227 - 31,670,343 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,633,857 - 31,637,844 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,741,636 - 31,745,822 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,741,635 - 31,745,822NCBI
Celera633,231,878 - 33,236,064 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,419,882 - 31,424,068 (+)NCBIHuRef
CHM1_1631,635,793 - 31,639,979 (+)NCBICHM1_1
T2T-CHM13v2.0631,519,114 - 31,523,101 (+)NCBIT2T-CHM13v2.0
Csnk2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,335,171 - 35,341,029 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,335,172 - 35,341,029 (-)EnsemblGRCm39 Ensembl
GRCm381735,116,195 - 35,122,053 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,116,196 - 35,122,053 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,253,140 - 35,258,392 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,724,251 - 34,729,503 (-)NCBIMGSCv36mm8
Celera1738,213,147 - 38,218,397 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
Csnk2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437210,838 - 219,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437210,541 - 215,725 (+)NCBIChiLan1.0ChiLan1.0
CSNK2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,143,115 - 46,147,114 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,104,623 - 42,108,622 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,327,250 - 31,331,250 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,216,283 - 32,221,131 (+)NCBIpanpan1.1PanPan1.1panPan2
CSNK2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,149,467 - 1,154,417 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,149,548 - 1,154,418 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,285,676 - 1,290,594 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,294,469 - 1,299,387 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,294,519 - 1,301,941 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,153,768 - 1,158,617 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,221,041 - 1,225,991 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,288,118 - 1,293,071 (+)NCBIUU_Cfam_GSD_1.0
Csnk2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,698,801 - 35,703,748 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,857,596 - 1,862,002 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,857,596 - 1,862,551 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSNK2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,786,717 - 23,788,302 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1 Ensembl723,780,210 - 23,792,502 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,781,194 - 23,787,914 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,464,062 - 27,471,599 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSNK2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,354,520 - 40,359,136 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,352,367 - 40,358,401 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,577,195 - 31,581,146 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csnk2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,533,134 - 24,538,233 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Csnk2b
64 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:56
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000001123
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat

Markers in Region
D20Yum50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,702,594 - 3,702,749 (-)MAPPERmRatBN7.2
Rnor_6.0205,111,274 - 5,111,428NCBIRnor6.0
Rnor_5.0207,184,533 - 7,184,687UniSTSRnor5.0
RGSC_v3.4203,766,249 - 3,766,403UniSTSRGSC3.4
Celera204,322,893 - 4,323,047UniSTS
Cytogenetic Map20p12UniSTS
RH129972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,705,110 - 3,705,300 (-)MAPPERmRatBN7.2
Rnor_6.0205,108,723 - 5,108,912NCBIRnor6.0
Rnor_5.0207,181,982 - 7,182,171UniSTSRnor5.0
RGSC_v3.4203,768,765 - 3,768,954UniSTSRGSC3.4
Celera204,320,342 - 4,320,531UniSTS
Cytogenetic Map20p12UniSTS
RH137048  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,705,115 - 3,705,301 (-)MAPPERmRatBN7.2
Rnor_6.0205,108,722 - 5,108,907NCBIRnor6.0
Rnor_5.0207,181,981 - 7,182,166UniSTSRnor5.0
RGSC_v3.4203,768,770 - 3,768,955UniSTSRGSC3.4
Celera204,320,341 - 4,320,526UniSTS
RH 3.4 Map2052.22UniSTS
Cytogenetic Map20p12UniSTS
MARC_3347-3348:991937077:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,704,062 - 3,705,128 (-)MAPPERmRatBN7.2
Rnor_6.0205,108,895 - 5,109,960NCBIRnor6.0
Rnor_5.0207,182,154 - 7,183,219UniSTSRnor5.0
RGSC_v3.4203,767,717 - 3,768,782UniSTSRGSC3.4
Celera204,320,514 - 4,321,579UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001035238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB743000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB790784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV778558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE864425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE864426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE864431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE864432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE864433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE864434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001123   ⟹   ENSRNOP00000001123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,700,991 - 3,705,344 (+)Ensembl
Rnor_6.0 Ensembl205,108,695 - 5,112,984 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076528   ⟹   ENSRNOP00000068429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,698,733 - 3,707,133 (+)Ensembl
Rnor_6.0 Ensembl205,108,695 - 5,113,112 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076597   ⟹   ENSRNOP00000068454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,700,991 - 3,705,327 (+)Ensembl
Rnor_6.0 Ensembl205,109,462 - 5,110,191 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076983   ⟹   ENSRNOP00000068085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,108,692 - 5,112,872 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092222   ⟹   ENSRNOP00000075275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,700,991 - 3,705,016 (+)Ensembl
Rnor_6.0 Ensembl205,106,890 - 5,112,258 (-)Ensembl
RefSeq Acc Id: NM_001035238   ⟹   NP_001030315
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,705,579 - 3,709,999 (+)NCBI
mRatBN7.2203,700,911 - 3,705,331 (+)NCBI
Rnor_6.0205,108,692 - 5,113,112 (-)NCBI
Rnor_5.0207,181,951 - 7,186,861 (-)NCBI
RGSC_v3.4203,764,565 - 3,768,985 (+)RGD
Celera204,320,311 - 4,324,731 (-)RGD
Sequence:
RefSeq Acc Id: NM_031021   ⟹   NP_112283
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,705,723 - 3,709,999 (+)NCBI
mRatBN7.2203,701,055 - 3,705,331 (+)NCBI
Rnor_6.0205,108,692 - 5,112,968 (-)NCBI
Rnor_5.0207,181,951 - 7,186,861 (-)NCBI
RGSC_v3.4203,764,565 - 3,768,985 (+)RGD
Celera204,320,311 - 4,324,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256081   ⟹   XP_006256143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,704,833 - 3,709,996 (+)NCBI
mRatBN7.2203,700,363 - 3,705,331 (+)NCBI
Rnor_6.0205,108,692 - 5,113,675 (-)NCBI
Rnor_5.0207,181,951 - 7,186,861 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001030315   ⟸   NM_001035238
- UniProtKB: P67874 (UniProtKB/Swiss-Prot),   Q68G11 (UniProtKB/TrEMBL),   N0E459 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_112283   ⟸   NM_031021
- UniProtKB: P67874 (UniProtKB/Swiss-Prot),   Q68G11 (UniProtKB/TrEMBL),   N0E459 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256143   ⟸   XM_006256081
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UP98 (UniProtKB/TrEMBL),   A6KTU1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075275   ⟸   ENSRNOT00000092222
Ensembl Acc Id: ENSRNOP00000068085   ⟸   ENSRNOT00000076983
Ensembl Acc Id: ENSRNOP00000001123   ⟸   ENSRNOT00000001123
Ensembl Acc Id: ENSRNOP00000068454   ⟸   ENSRNOT00000076597
Ensembl Acc Id: ENSRNOP00000068429   ⟸   ENSRNOT00000076528

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P67874-F1-model_v2 AlphaFold P67874 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701391
Promoter ID:EPDNEW_R11915
Type:initiation region
Name:Csnk2b_1
Description:casein kinase 2 beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,112,981 - 5,113,041EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619978 AgrOrtholog
BioCyc Gene G2FUF-4646 BioCyc
Ensembl Genes ENSRNOG00000000847 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001123.8 UniProtKB/TrEMBL
  ENSRNOT00000076528.2 UniProtKB/TrEMBL
  ENSRNOT00000076597.2 UniProtKB/TrEMBL
  ENSRNOT00000092222.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1820.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.25.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133064 IMAGE-MGC_LOAD
InterPro Casein_kin_II_reg-sub_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Casein_kinase_II_beta-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Casein_kinase_II_reg-sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81650 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93390 IMAGE-MGC_LOAD
NCBI Gene 81650 ENTREZGENE
PANTHER CASEIN KINASE II SUBUNIT BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CK_II_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Csnk2b PhenoGen
PRINTS CASNKINASEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CK2_BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000847 RatGTEx
SMART CK_II_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57798 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MKB7_RAT UniProtKB/TrEMBL
  A0A0G2KA61_RAT UniProtKB/TrEMBL
  A0A8L2PYP5_RAT UniProtKB/TrEMBL
  A0A8L2UP98 ENTREZGENE, UniProtKB/TrEMBL
  A6KTU1 ENTREZGENE, UniProtKB/TrEMBL
  A6KTU4_RAT UniProtKB/TrEMBL
  CSK2B_RAT UniProtKB/Swiss-Prot
  N0E459 ENTREZGENE, UniProtKB/TrEMBL
  N0E631_RAT UniProtKB/TrEMBL
  P67874 ENTREZGENE
  Q68G11 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P07312 UniProtKB/Swiss-Prot
  P13862 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Csnk2b  casein kinase 2 beta  Csnk2b  casein kinase 2, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Csnk2b  casein kinase 2, beta polypeptide  Csnk2b  casein kinase 2, beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Csnk2b  casein kinase 2, beta subunit    casein kinase II beta subunit  Name updated 1299863 APPROVED
2002-08-07 Csnk2b  casein kinase II beta subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease increased expression is detected in carcinogen-induced breast tumors 727632
gene_regulation properties are modulated by Rev protein 727694