RGD Reference Report - Morphological changes and expression of protein kinase CK2 beta subunit in the microglia after hypoglossal nerve transection. - Rat Genome Database

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Morphological changes and expression of protein kinase CK2 beta subunit in the microglia after hypoglossal nerve transection.

Authors: Gesase, AP  Kiyama, H 
Citation: Gesase AP and Kiyama H, J Neurocytol. 2000 Jan;29(1):61-6.
RGD ID: 11565824
Pubmed: PMID:11068334   (View Abstract at PubMed)

Following hypoglossal nerve transection, the microglia of the rat hypoglossal nucleus expressed protein kinase CK2 beta subunit immunoreactivity. CK2 beta immunostaining occurred on the operated side from postoperative day 3; on day 5 we observed strong immunoreactivity and the immunopositive microglial cell processes surrounded the injured neurones. Thereafter, the immunoreactivity decreased gradually and on day 10 the immunopositive cells surrounded only a few injured neurones. Electron microscopic observations on the hypoglossal nucleus revealed microglia-neuronal contact within 3 hours of nerve injury, and by day 3 all the injured neurones were in contact with microglial cells. These observations indicated that microglia-neuronal contact occurred earlier than the CK2 beta subunit immunoreactivity. CK2 may not be implicated during the initial migration of the microglia to the injured neurones; however, it may enhance the growth and elongation of the microglial cell processes around the injured neurones.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CSNK2BHumanHypoglossal Nerve Injuries  ISOCsnk2b (Rattus norvegicus) RGD 
Csnk2bRatHypoglossal Nerve Injuries  IEP  RGD 
Csnk2bMouseHypoglossal Nerve Injuries  ISOCsnk2b (Rattus norvegicus) RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Csnk2bRatcell projection  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Csnk2b  (casein kinase 2 beta)

Genes (Mus musculus)
Csnk2b  (casein kinase 2, beta polypeptide)

Genes (Homo sapiens)
CSNK2B  (casein kinase 2 beta)


Additional Information