RGD Reference Report - Consequences of CK2 signaling to the nuclear matrix. - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Consequences of CK2 signaling to the nuclear matrix.

Authors: Yu, S  Wang, H  Davis, A  Ahmed, K 
Citation: Yu S, etal., Mol Cell Biochem 2001 Nov;227(1-2):67-71.
RGD ID: 633399
Pubmed: PMID:11827176   (View Abstract at PubMed)

Protein kinase CK2 is recognized as one of the key cellular signals for cell growth and proliferation. Its nuclear targeting appears to be critical to its role in these functions. In the nucleus, nuclear matrix (NM) which plays a major role in growth-related activities is a primary locus for CK2 signaling. A variety of growth stimuli evoke a rapid translocation of the CK2 to the NM whereas removal of these factors has the opposite effect. These studies, employing various experimental models of cell growth (involving different growth-stimulatory factors), have suggested that rapid shuttling of CK2 to the NM is a key feature of early growth control. By contrast, removal of growth-stimulatory factors leading to the loss of cell viability is associated with early loss of CK2 from the NM (and chromatin). This indicates that absence of CK2 from the nuclear compartment is contributory to induction of cell death via apoptosis, implying a protective role for CK2 against cell death. Here, we review the evidence that suggests that CK2 signaling in the NM is not only involved in cell growth but also in cell survival.

Objects referenced in this article
Gene Csnk2b casein kinase 2 beta Rattus norvegicus
Gene Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 Rattus norvegicus

Additional Information