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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619978
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csnk2b
Name: casein kinase 2 beta
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Csnk2bdecreases expressionISOCsnk2b (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of CSNK2B proteinPMID:37302538
Csnk2bincreases degradationISOCsnk2b (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased degradation of CSNK2B proteinPMID:37302538
Csnk2bincreases ubiquitinationISOCsnk2b (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased ubiquitination of CSNK2B proteinPMID:37302538
Csnk2bmultiple interactionsISOCsnk2b (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in increased degradation of CSNK2B protein]; CSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; CSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BDNF protein]; CSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of DLG4 protein]; CSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SYN1 protein]; CSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of AKT1 protein]; CSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of CREB1 protein]; CSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in increased cleavage of CASP3 protein]; Diethylhexyl Phthalate inhibits the reaction [Cycloheximide results in decreased degradation of CSNK2B protein]; MIR93 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CSNK2B protein]; TNFAIP1 protein affects the reaction [Diethylhexyl Phthalate results in increased ubiquitination of CSNK2B protein]PMID:37302538
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