| 14368817 | cno | | | | | | Fly | | symbol | gene, null |
| 1306037 | Bloc1s4 | biogenesis of lysosomal organelles complex 1 subunit 4 | INVOLVED IN anterograde axonal transport (ortholog); anterograde synaptic vesicle transport (ortholog); melanosome organization (ortholog); ASSOCIATED WITH Hermansky-Pudlak syndrome (ortholog); FOUND IN BLOC-1 complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; Cuprizon | 14 | 78267735 | 78269035 | Rat | 61 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332125 | Bloc1s4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | Involved in anterograde synaptic vesicle transport. Acts upstream of or within melanosome organization; neuromuscular process controlling balance; and platelet aggregation. Located in cytoplasm. Part of BLOC-1 complex. Used to study Hermansky-Pudlak syndrome. Orthologous to human BLOC1S4 (biogenesis of lysosomal organelles complex 1 subunit 4). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 36904718 | 36906023 | Mouse | 92 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1602324 | BLOC1S4 | biogenesis of lysosomal organelles complex 1 subunit 4 | This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky-Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking. [provided by RefSeq, Jul 2008] | 4 | 6716174 | 6717664 | Human | 62 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 11727861 | BLOC1S4 | biogenesis of lysosomal organelles complex 1 subunit 4 | INVOLVED IN melanosome organization (ortholog); neuromuscular process controlling balance (ortholog); platelet aggregation (ortholog); ASSOCIATED WITH Hermansky-Pudlak syndrome (ortholog); FOUND IN axon cytoplasm (inferred); BLOC-1 complex (inferred); cytoplasm (inferred) | | | | Bonobo | 13 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12366165 | BLOC1S4 | biogenesis of lysosomal organelles complex 1 subunit 4 | INVOLVED IN melanosome organization (ortholog); neuromuscular process controlling balance (ortholog); platelet aggregation (ortholog); ASSOCIATED WITH Hermansky-Pudlak syndrome (ortholog); FOUND IN axon cytoplasm (inferred); BLOC-1 complex (inferred); cytoplasm (inferred) | 3 | 58822405 | 58823770 | Dog | 13 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1308009 | Cnot1 | CCR4-NOT transcription complex, subunit 1 | ENCODES a protein that exhibits armadillo repeat domain binding (ortholog); molecular adaptor activity (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN miRNA-mediated post-transcriptional gene silencing (ortholog); negative regulation of intracellular estrogen receptor signaling pathway (ortholog); negative regulation of retinoic acid receptor signaling pathway (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN CCR4-NOT complex (ortholog); P-body (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 19 | 9261290 | 9352636 | Rat | 136 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1552621 | Cnot1 | CCR4-NOT transcription complex, subunit 1 | Predicted to enable armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Involved in regulation of stem cell population maintenance and trophectodermal cell differentiation. Loc ated in P-body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 96445559 | 96534741 | Mouse | 146 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602129 | CNOT1 | CCR4-NOT transcription complex subunit 1 | Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of intracellular signal transduction; positive regulation of cytopl asmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 58519951 | 58629826 | Human | 224 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 9066531 | Cnot1 | CCR4-NOT transcription complex subunit 1 | ENCODES a protein that exhibits armadillo repeat domain binding (ortholog); molecular adaptor activity (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN miRNA-mediated post-transcriptional gene silencing (ortholog); negative regulation of intracellular estrogen receptor signaling pathway (ortholog); negative regulation of retinoic acid receptor signaling pathway (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN CCR4-NOT complex (ortholog); P-body (ortholog) | NW_004955433 | 15938791 | 16027547 | Chinchilla | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11987927 | CNOT1 | CCR4-NOT transcription complex subunit 1 | ENCODES a protein that exhibits armadillo repeat domain binding (inferred); molecular adaptor activity (inferred); nuclear estrogen receptor binding (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated post-transcriptional gene silencing (inferred); negative regulation of i ntracellular estrogen receptor signaling pathway (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytoplasm (inferred) | 16 | 38793212 | 38902686 | Bonobo | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12186546 | CNOT1 | CCR4-NOT transcription complex subunit 1 | ENCODES a protein that exhibits armadillo repeat domain binding (inferred); molecular adaptor activity (inferred); nuclear estrogen receptor binding (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated post-transcriptional gene silencing (inferred); negative regulation of i ntracellular estrogen receptor signaling pathway (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytoplasm (inferred) | 2 | 58038456 | 58138364 | Dog | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12635089 | Cnot1 | CCR4-NOT transcription complex subunit 1 | ENCODES a protein that exhibits armadillo repeat domain binding (inferred); molecular adaptor activity (inferred); nuclear estrogen receptor binding (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated post-transcriptional gene silencing (inferred); negative regulation of i ntracellular estrogen receptor signaling pathway (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytoplasm (inferred) | NW_004936475 | 10302091 | 10384945 | Squirrel | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14128814 | CNOT1 | CCR4-NOT transcription complex subunit 1 | ENCODES a protein that exhibits armadillo repeat domain binding (inferred); molecular adaptor activity (inferred); nuclear estrogen receptor binding (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated post-transcriptional gene silencing (inferred); negative regulation of i ntracellular estrogen receptor signaling pathway (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytoplasm (inferred) | | | | Pig | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18407173 | CNOT1 | CCR4-NOT transcription complex subunit 1 | ENCODES a protein that exhibits armadillo repeat domain binding (inferred); molecular adaptor activity (inferred); nuclear estrogen receptor binding (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated post-transcriptional gene silencing (inferred); negative regulation of i ntracellular estrogen receptor signaling pathway (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytoplasm (inferred) | | | | Green Monkey | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922947 | Cnot1 | CCR4-NOT transcription complex subunit 1 | ENCODES a protein that exhibits armadillo repeat domain binding (ortholog); nuclear estrogen receptor binding (ortholog); nuclear retinoic acid receptor binding (ortholog); INVOLVED IN miRNA-mediated post-transcriptional gene silencing (ortholog); negative regulation of intracellular estrogen recept or signaling pathway (ortholog); negative regulation of retinoic acid receptor signaling pathway (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN CCR4-NOT complex (ortholog) | | | | Naked Mole-Rat | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241818 | cnot1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626150910 | Cnot1 | CCR4-NOT transcription complex subunit 1 | ENCODES a protein that exhibits armadillo repeat domain binding (ortholog); molecular adaptor activity (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN miRNA-mediated post-transcriptional gene silencing (ortholog); negative regulation of intracellular estrogen receptor signaling pathway (ortholog); negative regulation of retinoic acid receptor signaling pathway (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN CCR4-NOT complex (ortholog); P-body (ortholog) | | | | Black Rat | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1311672 | Cnot2 | CCR4-NOT transcription complex, subunit 2 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN negative regulation of intracellular estrogen receptor signaling pathway (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); posi tive regulation of cytoplasmic mRNA processing body assembly (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; ASSOCIATED WITH genetic disease (ortholog); Intellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; bisphenol A | 7 | 54016447 | 54117511 | Rat | 122 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323253 | CNOT2 | CCR4-NOT transcription complex subunit 2 | This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] | 12 | 70243018 | 70354993 | Human | 150 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323254 | Cnot2 | CCR4-NOT transcription complex, subunit 2 | Predicted to enable transcription corepressor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Involved in regulation of stem cell population maintenance and trophectodermal cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane . Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including 1st branchial arch; brain; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 116321065 | 116418891 | Mouse | 142 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9023820 | Cnot2 | CCR4-NOT transcription complex subunit 2 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN negative regulation of intracellular estrogen receptor signaling pathway (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); posi tive regulation of cytoplasmic mRNA processing body assembly (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH genetic disease (ortholog); Intellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog) | NW_004955405 | 10451414 | 10547229 | Chinchilla | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11742967 | CNOT2 | CCR4-NOT transcription complex subunit 2 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (inferred); transcription corepressor binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of intracellular estrogen receptor signaling pathway (inferred); negative regulation of transcripti on by RNA polymerase II (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH genetic disease (ortholog); Intellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytoplasm (inferred) | 12 | 67753703 | 67865375 | Bonobo | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12098136 | CNOT2 | CCR4-NOT transcription complex subunit 2 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN negative regulation of intracellular estrogen receptor signaling pathway (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); posi tive regulation of cytoplasmic mRNA processing body assembly (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH genetic disease (ortholog); Intellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (ortholog) | 10 | 12057269 | 12174405 | Dog | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12451590 | Cnot2 | CCR4-NOT transcription complex subunit 2 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (inferred); transcription corepressor binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of intracellular estrogen receptor signaling pathway (inferred); negative regulation of transcripti on by RNA polymerase II (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH genetic disease (ortholog); Intellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytoplasm (inferred) | NW_004936545 | 7938934 | 8040409 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14270794 | CNOT2 | CCR4-NOT transcription complex subunit 2 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (inferred); transcription corepressor binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of intracellular estrogen receptor signaling pathway (inferred); negative regulation of transcripti on by RNA polymerase II (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH genetic disease (ortholog); Intellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytoplasm (inferred) | | | | Pig | 39 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18520081 | CNOT2 | CCR4-NOT transcription complex subunit 2 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (inferred); transcription corepressor binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of intracellular estrogen receptor signaling pathway (inferred); negative regulation of transcripti on by RNA polymerase II (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH genetic disease (ortholog); Intellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytoplasm (inferred) | | | | Green Monkey | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919053 | Cnot2 | CCR4-NOT transcription complex subunit 2 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN negative regulation of intracellular estrogen receptor signaling pathway (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); posi tive regulation of cytoplasmic mRNA processing body assembly (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH genetic disease (ortholog); Intellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244886 | cnot2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625936872 | Cnot2 | CCR4-NOT transcription complex subunit 2 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN negative regulation of intracellular estrogen receptor signaling pathway (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); posi tive regulation of cytoplasmic mRNA processing body assembly (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH genetic disease (ortholog); Intellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog) | | | | Black Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1304771 | Cnot3 | CCR4-NOT transcription complex, subunit 3 | INVOLVED IN determination of left/right symmetry (ortholog); gene expression (ortholog); mRNA catabolic process (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); geneti c disease (ortholog); FOUND IN CCR4-NOT complex (ortholog); P-body (ortholog); INTERACTS WITH bisphenol A; nitrofen; vinclozolin | 1 | 74471284 | 74487527 | Rat | 106 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1312407 | CNOT3 | CCR4-NOT transcription complex subunit 3 | Involved in regulation of stem cell population maintenance. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 54137762 | 54155681 | Human | 179 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1312408 | Cnot3 | CCR4-NOT transcription complex, subunit 3 | Involved in positive regulation of cold-induced thermogenesis; regulation of stem cell population maintenance; and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and whi te fat. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 3646717 | 3664108 | Mouse | 168 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9058629 | Cnot3 | CCR4-NOT transcription complex subunit 3 | INVOLVED IN determination of left/right symmetry (ortholog); gene expression (ortholog); mRNA catabolic process (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); genetic disease (ortholog); FOU ND IN CCR4-NOT complex (ortholog); P-body (ortholog) | NW_004955604 | 109522 | 122001 | Chinchilla | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11979787 | CNOT3 | CCR4-NOT transcription complex subunit 3 | INVOLVED IN gene expression (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); genetic disease (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytosol (inferr ed) | 19 | 51071167 | 51089289 | Bonobo | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12339171 | CNOT3 | CCR4-NOT transcription complex subunit 3 | INVOLVED IN gene expression (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); genetic disease (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytosol (inferr ed) | 1 | 103057392 | 103070612 | Dog | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12611714 | Cnot3 | CCR4-NOT transcription complex subunit 3 | INVOLVED IN gene expression (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); genetic disease (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytosol (inferr ed) | NW_004936994 | 256022 | 271235 | Squirrel | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14181807 | CNOT3 | CCR4-NOT transcription complex subunit 3 | INVOLVED IN gene expression (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); genetic disease (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytosol (inferr ed) | | | | Pig | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18487839 | CNOT3 | CCR4-NOT transcription complex subunit 3 | INVOLVED IN gene expression (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); genetic disease (ortholog); FOUND IN CCR4-NOT complex (inferred); CCR4-NOT core complex (inferred); cytosol (inferr ed) | | | | Green Monkey | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929501 | Cnot3 | CCR4-NOT transcription complex subunit 3 | INVOLVED IN determination of left/right symmetry (ortholog); gene expression (ortholog); mRNA catabolic process (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); genetic disease (ortholog); FOU ND IN CCR4-NOT complex (ortholog) | | | | Naked Mole-Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254042 | cnot3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625973191 | Cnot3 | CCR4-NOT transcription complex subunit 3 | INVOLVED IN determination of left/right symmetry (ortholog); gene expression (ortholog); mRNA catabolic process (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); genetic disease (ortholog); FOU ND IN CCR4-NOT complex (ortholog); P-body (ortholog) | | | | Black Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1310318 | Cnot4 | CCR4-NOT transcription complex, subunit 4 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein autoubiquitination (ortholog); regulation of megakaryocyte differentiation (ortholog); ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN RNA degradation pathway; FOUND IN CC R4-NOT complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene | 4 | 64679903 | 64781432 | Rat | 107 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1321153 | CNOT4 | CCR4-NOT transcription complex subunit 4 | The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] | 7 | 135361795 | 135510102 | Human | 110 | symbol , old_gene_name , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1321154 | Cnot4 | CCR4-NOT transcription complex, subunit 4 | Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein autoubiquitination; regulation of megakaryocyte differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT complex. Is express ed in several structures, including central nervous system; genitourinary system; neural retina; and olfactory epithelium. Orthologous to human CNOT4 (CCR4-NOT transcription complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 34999000 | 35110646 | Mouse | 127 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8754010 | Cnot4 | CCR4-NOT transcription complex subunit 4 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein autoubiquitination (ortholog); regulation of megakaryocyte differentiation (ortholog); ubiquitin-dependent protein catabolic process (ortholog); FOUND IN CCR4-NOT complex (ortholog) | NW_004955494 | 7190361 | 7306298 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11753078 | CNOT4 | CCR4-NOT transcription complex subunit 4 | ENCODES a protein that exhibits metal ion binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN protein autoubiquitination (inferred); protein ubiquitination (inferred); regulation of megakaryocyte differentiation (inferred); FOUND IN CCR4-NOT complex (inferred); c ytoplasm (inferred); cytosol (inferred) | 7 | 127327092 | 127475213 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12174041 | CNOT4 | CCR4-NOT transcription complex subunit 4 | ENCODES a protein that exhibits metal ion binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN protein autoubiquitination (inferred); regulation of megakaryocyte differentiation (inferred); ubiquitin-dependent protein catabolic process (inferred); FOUND IN CCR4-NO T complex (inferred); cytoplasm (inferred); cytosol (inferred) | 16 | 12723243 | 12860851 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12709579 | Cnot4 | CCR4-NOT transcription complex subunit 4 | ENCODES a protein that exhibits metal ion binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN protein autoubiquitination (inferred); protein ubiquitination (inferred); regulation of megakaryocyte differentiation (inferred); FOUND IN CCR4-NOT complex (inferred); c ytoplasm (inferred); cytosol (inferred) | NW_004936592 | 195566 | 321131 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14155163 | CNOT4 | CCR4-NOT transcription complex subunit 4 | ENCODES a protein that exhibits metal ion binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN protein autoubiquitination (inferred); regulation of megakaryocyte differentiation (inferred); ubiquitin-dependent protein catabolic process (inferred); FOUND IN CCR4-NO T complex (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14371455 | Cnot4 | | | | | | Fly | | symbol | gene, null |
| 18458412 | CNOT4 | CCR4-NOT transcription complex subunit 4 | ENCODES a protein that exhibits metal ion binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN protein autoubiquitination (inferred); protein ubiquitination (inferred); regulation of megakaryocyte differentiation (inferred); FOUND IN CCR4-NOT complex (inferred); c ytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932617 | Cnot4 | CCR4-NOT transcription complex subunit 4 | ENCODES a protein that exhibits metal ion binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN protein autoubiquitination (ortholog); regulation of megakaryocyte differentiation (ortholog); ubiquitin-dependent protein catabolic process (ortholog); FOUND IN CCR4-NO T complex (ortholog) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238675 | cnot4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625964124 | Cnot4 | CCR4-NOT transcription complex subunit 4 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein autoubiquitination (ortholog); regulation of megakaryocyte differentiation (ortholog); ubiquitin-dependent protein catabolic process (ortholog); FOUND IN CCR4-NOT complex (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1310783 | Cnot6 | CCR4-NOT transcription complex, subunit 6 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); RNA exonuclease activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, no-go decay (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; FOUND IN CCR4-NOT complex (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 10 | 34479892 | 34532166 | Rat | 92 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1347023 | CNOT6 | CCR4-NOT transcription complex subunit 6 | This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation , and transcriptional regulation. [provided by RefSeq, Dec 2014] | 5 | 180494379 | 180578358 | Human | 92 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551782 | Cnot6 | CCR4-NOT transcription complex, subunit 6 | Predicted to enable poly(A)-specific ribonuclease activity and transcription coactivator activity. Predicted to be involved in negative regulation of gene expression; positive regulation of cell population proliferation; and positive regulation of cytoplasmic mRNA processing body assembly. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CNOT6 (CCR4-NOT transcription complex subunit 6). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 49562324 | 49604227 | Mouse | 103 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8999234 | Cnot6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); RNA exonuclease activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, no-go decay (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | NW_004955408 | 170399 | 239492 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11949517 | CNOT6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | 5 | 175695802 | 175780534 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12157674 | CNOT6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits catalytic activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | 11 | 1209732 | 1277435 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12694482 | Cnot6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936739 | 308117 | 384600 | Squirrel | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14039251 | CNOT6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits catalytic activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18405567 | CNOT6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929113 | Cnot6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits RNA exonuclease activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, no-go decay (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626024019 | Cnot6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); RNA exonuclease activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, no-go decay (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1305313 | Cnot7 | CCR4-NOT transcription complex, subunit 7 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); DNA-binding transcription factor binding (ortholog); piRNA binding (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); defense response to virus (ortholog); miRNA-mediated gene si lencing by mRNA destabilization (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; ASSOCIATED WITH male infertility; FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); nuclear body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium atom | 16 | 58478882 | 58498046 | Rat | 159 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313268 | CNOT7 | CCR4-NOT transcription complex subunit 7 | The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lea d to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016] | 8 | 17224966 | 17246857 | Human | 159 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313269 | Cnot7 | CCR4-NOT transcription complex, subunit 7 | Enables piRNA binding activity and poly(A)-specific ribonuclease activity. Involved in positive regulation of mRNA catabolic process and spermatogenesis. Acts upstream of or within P-body assembly and positive regulation of RNA metabolic process. Located in P-body and nucleus. Part of CCR4-NOT compl ex. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and skeleton. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 40945579 | 40968888 | Mouse | 207 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8905003 | Cnot7 | CCR4-NOT transcription complex subunit 7 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); DNA-binding transcription factor binding (ortholog); piRNA binding (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); defense response to virus (ortholog); miRNA-mediated gene si lencing by mRNA destabilization (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH male infertility (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); nuclear body (ortholog) | NW_004955463 | 285228 | 306077 | Chinchilla | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11897030 | CNOT7 | CCR4-NOT transcription complex subunit 7 | ENCODES a protein that exhibits piRNA binding (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); P-body assembly (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH male infertility (ortholog); FOUND IN P-body (ortholog) | 8 | 16439014 | 16459636 | Bonobo | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12162327 | CNOT7 | CCR4-NOT transcription complex subunit 7 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); DNA-binding transcription factor binding (inferred); exonuclease activity (inferred); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ort holog); P-body assembly (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH male infertility (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nuclear body (inferred) | 16 | 40554214 | 40571841 | Dog | 90 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12655890 | Cnot7 | CCR4-NOT transcription complex subunit 7 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); DNA-binding transcription factor binding (inferred); exonuclease activity (inferred); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ort holog); P-body assembly (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH male infertility (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nuclear body (inferred) | NW_004936573 | 6288397 | 6305984 | Squirrel | 86 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14048944 | CNOT7 | CCR4-NOT transcription complex subunit 7 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); DNA-binding transcription factor binding (inferred); exonuclease activity (inferred); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ort holog); P-body assembly (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH male infertility (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nuclear body (inferred) | | | | Pig | 90 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18353053 | CNOT7 | CCR4-NOT transcription complex subunit 7 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); DNA-binding transcription factor binding (inferred); exonuclease activity (inferred); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ort holog); P-body assembly (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH male infertility (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nuclear body (inferred) | | | | Green Monkey | 89 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909965 | Cnot7 | CCR4-NOT transcription complex subunit 7 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); DNA-binding transcription factor binding (ortholog); piRNA binding (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); defense response to virus (ortholog); miRNA-mediated gene si lencing by mRNA destabilization (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH male infertility (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nuclear speck (ortholog) | | | | Naked Mole-Rat | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237655 | cnot7 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625866790 | Cnot7 | CCR4-NOT transcription complex subunit 7 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); DNA-binding transcription factor binding (ortholog); piRNA binding (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); defense response to virus (ortholog); miRNA-mediated gene si lencing by mRNA destabilization (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH male infertility (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); nuclear body (ortholog) | | | | Black Rat | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1306401 | Cnot8 | CCR4-NOT transcription complex, subunit 8 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of mRNA cat abolic process (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; FOUND IN CCR4-NOT complex (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 10 | 42782042 | 42795207 | Rat | 83 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1314995 | CNOT8 | CCR4-NOT transcription complex subunit 8 | Enables poly(A)-specific ribonuclease activity. Involved in miRNA-mediated gene silencing by mRNA destabilization and positive regulation of cell population proliferation. Located in nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 154858249 | 154876792 | Human | 96 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1314996 | Cnot8 | CCR4-NOT transcription complex, subunit 8 | Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in miRNA-mediated gene silencing by mRNA destabilization; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of cell population proliferation. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human CNOT8 (CCR4-NOT transcription complex subunit 8). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 57983620 | 58009423 | Mouse | 91 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9036809 | Cnot8 | CCR4-NOT transcription complex subunit 8 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of mRNA cat abolic process (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog); nucleus (ortholog) | NW_004955408 | 9112208 | 9132650 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11783255 | CNOT8 | CCR4-NOT transcription complex subunit 8 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); positive regulation of cell population prol iferation (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | 5 | 150262907 | 150280215 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12079071 | CNOT8 | CCR4-NOT transcription complex subunit 8 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); positive regulation of cell population prol iferation (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | 4 | 54935476 | 54956000 | Dog | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12684936 | Cnot8 | CCR4-NOT transcription complex subunit 8 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of mRNA cat abolic process (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog); nucleus (ortholog) | NW_004936515 | 7971504 | 7988257 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14086463 | CNOT8 | CCR4-NOT transcription complex subunit 8 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); positive regulation of cell population prol iferation (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Pig | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18587094 | CNOT8 | CCR4-NOT transcription complex subunit 8 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); positive regulation of cell population prol iferation (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908463 | Cnot8 | CCR4-NOT transcription complex subunit 8 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of mRNA catabolic process (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235858 | cnot8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626060700 | Cnot8 | CCR4-NOT transcription complex subunit 8 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of mRNA cat abolic process (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog); nucleus (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1311495 | Cnot9 | CCR4-NOT transcription complex subunit 9 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); kinase binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of intracellular estrogen receptor signaling pathway (ortholog); positive regulation of epidermal growth factor receptor signaling pathway (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (ortholog); P-body (ortholog); protein-containing complex (ortholog); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; dibutyl phthalate | 9 | 83533369 | 83558207 | Rat | 116 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1322982 | CNOT9 | CCR4-NOT transcription complex subunit 9 | This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively splic ed transcript variants have been described for this gene. [provided by RefSeq, Oct 2012] | 2 | 218568839 | 218597080 | Human | 118 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322983 | Cnot9 | CCR4-NOT transcription complex, subunit 9 | Predicted to enable several functions, including epidermal growth factor receptor binding activity; protein homodimerization activity; and transcription coactivator activity. Acts upstream of or within cytokine-mediated signaling pathway. Located in P-body. Is expressed in several structures, includ ing alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Orthologous to human CNOT9 (CCR4-NOT transcription complex subunit 9). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 74545192 | 74570001 | Mouse | 113 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8743562 | Cnot9 | CCR4-NOT transcription complex subunit 9 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); kinase binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of intracellular estrogen receptor signaling pathway (ortholog); positive regulation of epidermal growth factor receptor signaling pathway (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (ortholog); P-body (ortholog); protein-containing complex (ortholog) | NW_004955453 | 14819007 | 14845879 | Chinchilla | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11821689 | CNOT9 | CCR4-NOT transcription complex subunit 9 | ENCODES a protein that exhibits epidermal growth factor receptor binding (inferred); kinase binding (inferred); protein domain specific binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN m icroRNA pathway; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (inferred); cytosol (inferred); nucleus (inferred) | 2B | 105826633 | 105854415 | Bonobo | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12129048 | CNOT9 | CCR4-NOT transcription complex subunit 9 | ENCODES a protein that exhibits epidermal growth factor receptor binding (inferred); kinase binding (inferred); protein domain specific binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN m icroRNA pathway; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (inferred); cytosol (inferred); nucleus (inferred) | 37 | 25186928 | 25213255 | Dog | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12637920 | Cnot9 | CCR4-NOT transcription complex subunit 9 | ENCODES a protein that exhibits epidermal growth factor receptor binding (inferred); kinase binding (inferred); protein domain specific binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN m icroRNA pathway; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (inferred); cytosol (inferred); nucleus (inferred) | NW_004936569 | 1023057 | 1048968 | Squirrel | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13950675 | CNOT9 | CCR4-NOT transcription complex subunit 9 | ENCODES a protein that exhibits epidermal growth factor receptor binding (inferred); kinase binding (inferred); protein domain specific binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN m icroRNA pathway; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (inferred); cytosol (inferred); nucleus (inferred) | | | | Pig | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18622273 | CNOT9 | CCR4-NOT transcription complex subunit 9 | ENCODES a protein that exhibits epidermal growth factor receptor binding (inferred); kinase binding (inferred); protein domain specific binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN m icroRNA pathway; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (inferred); cytosol (inferred); nucleus (inferred) | | | | Green Monkey | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902697 | Cnot9 | CCR4-NOT transcription complex subunit 9 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); kinase binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of intracellular estrogen receptor signaling pathway (ortholog); positive regulation of epidermal growth factor receptor signaling pathway (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH cerebrotendinous xanthomatosis (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234507 | cnot9 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625881019 | Cnot9 | CCR4-NOT transcription complex subunit 9 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); kinase binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of intracellular estrogen receptor signaling pathway (ortholog); positive regulation of epidermal growth factor receptor signaling pathway (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN CCR4-NOT complex (ortholog); P-body (ortholog); protein-containing complex (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1343563 | CNOT10 | CCR4-NOT transcription complex subunit 10 | Predicted to be involved in mRNA catabolic process and negative regulation of translation. Located in membrane. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 32685188 | 32773875 | Human | 60 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1359219 | Cnot10 | CCR4-NOT transcription complex, subunit 10 | INVOLVED IN DNA-templated transcription (inferred); regulation of translation (inferred); regulatory ncRNA-mediated gene silencing (inferred); PARTICIPATES IN microRNA pathway; RNA degradation pathway; FOUND IN CCR4-NOT complex (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3-chl oropropane-1,2-diol | 8 | 123158675 | 123208389 | Rat | 54 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1553028 | Cnot10 | CCR4-NOT transcription complex, subunit 10 | Predicted to be involved in mRNA catabolic process and negative regulation of translation. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and white fat. Orthologo us to human CNOT10 (CCR4-NOT transcription complex subunit 10). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 114414942 | 114469289 | Mouse | 60 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9046051 | Cnot10 | CCR4-NOT transcription complex subunit 10 | PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | NW_004955421 | 2807 | 69254 | Chinchilla | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11884650 | CNOT10 | CCR4-NOT transcription complex subunit 10 | INVOLVED IN DNA-templated transcription (inferred); mRNA catabolic process (inferred); negative regulation of translation (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | 3 | 32613213 | 32702062 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12162653 | CNOT10 | CCR4-NOT transcription complex subunit 10 | INVOLVED IN DNA-templated transcription (inferred); regulation of translation (inferred); regulatory ncRNA-mediated gene silencing (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | 23 | 3984505 | 4058649 | Dog | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12590452 | Cnot10 | CCR4-NOT transcription complex subunit 10 | INVOLVED IN DNA-templated transcription (inferred); mRNA catabolic process (inferred); negative regulation of translation (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936473 | 23121036 | 23192794 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13974586 | CNOT10 | CCR4-NOT transcription complex subunit 10 | INVOLVED IN DNA-templated transcription (inferred); regulation of translation (inferred); regulatory ncRNA-mediated gene silencing (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18677426 | CNOT10 | CCR4-NOT transcription complex subunit 10 | INVOLVED IN DNA-templated transcription (inferred); mRNA catabolic process (inferred); negative regulation of translation (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18933270 | Cnot10 | CCR4-NOT transcription complex subunit 10 | INVOLVED IN DNA-templated transcription (inferred); mRNA catabolic process (inferred); negative regulation of translation (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239999 | cnot10 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625923823 | Cnot10 | CCR4-NOT transcription complex subunit 10 | PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | | | | Black Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1348103 | CNOT11 | CCR4-NOT transcription complex subunit 11 | Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 101252886 | 101270316 | Human | 61 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1560909 | Cnot11 | CCR4-NOT transcription complex, subunit 11 | INVOLVED IN DNA-templated transcription (inferred); regulation of translation (inferred); regulatory ncRNA-mediated gene silencing (inferred); FOUND IN CCR4-NOT complex (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 9 | 49310624 | 49320325 | Rat | 55 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1617580 | Cnot11 | CCR4-NOT transcription complex, subunit 11 | Predicted to be involved in regulation of translation and regulatory ncRNA-mediated gene silencing. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT complex. Orthologous to human CNOT11 (CCR4-NOT transcription complex subunit 11). [provided b y Alliance of Genome Resources, Jul 2025] | 1 | 39574782 | 39585962 | Mouse | 62 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9003205 | Cnot11 | CCR4-NOT transcription complex subunit 11 | FOUND IN CCR4-NOT complex (ortholog) | NW_004955470 | 7036850 | 7050883 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11694656 | CNOT11 | CCR4-NOT transcription complex subunit 11 | INVOLVED IN DNA-templated transcription (inferred); regulatory ncRNA-mediated gene silencing (inferred); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Bonobo | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12160252 | CNOT11 | CCR4-NOT transcription complex subunit 11 | INVOLVED IN DNA-templated transcription (inferred); regulatory ncRNA-mediated gene silencing (inferred); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | 10 | 41652935 | 41667969 | Dog | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12600587 | Cnot11 | CCR4-NOT transcription complex subunit 11 | INVOLVED IN DNA-templated transcription (inferred); regulatory ncRNA-mediated gene silencing (inferred); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | NW_004936713 | 56853 | 69840 | Squirrel | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14067849 | CNOT11 | CCR4-NOT transcription complex subunit 11 | INVOLVED IN DNA-templated transcription (inferred); regulatory ncRNA-mediated gene silencing (inferred); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Pig | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18774298 | CNOT11 | CCR4-NOT transcription complex subunit 11 | INVOLVED IN DNA-templated transcription (inferred); regulatory ncRNA-mediated gene silencing (inferred); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926182 | Cnot11 | CCR4-NOT transcription complex subunit 11 | INVOLVED IN DNA-templated transcription (inferred); regulatory ncRNA-mediated gene silencing (inferred); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249356 | cnot11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625974897 | Cnot11 | CCR4-NOT transcription complex subunit 11 | FOUND IN CCR4-NOT complex (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1309128 | Cnot6l | CCR4-NOT transcription complex, subunit 6-like | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN micro RNA pathway; RNA degradation pathway; FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 14 | 13714475 | 13806481 | Rat | 115 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1319296 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | Predicted to enable 3'-5'-RNA exonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 77713387 | 77820269 | Human | 122 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1551166 | Cnot6l | CCR4-NOT transcription complex, subunit 6-like | Enables poly(A)-specific ribonuclease activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and positive regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary syst em; gut; hemolymphoid system gland; and musculature. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 96218192 | 96312044 | Mouse | 137 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8793346 | Cnot6l | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN micro RNA pathway; FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955433 | 2206462 | 2290773 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11743640 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell po pulation proliferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog); cytosol (ortholog) | 4 | 46374255 | 46482552 | Bonobo | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12426935 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits catalytic activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population pro liferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | 32 | 2192800 | 2305526 | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12496940 | Cnot6l | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell po pulation proliferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936676 | 1401428 | 1474167 | Squirrel | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13844228 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits catalytic activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population pro liferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18577679 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell po pulation proliferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919538 | Cnot6l | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell po pulation proliferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | | | | Naked Mole-Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237105 | cnot6l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625934660 | Cnot6l | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN micro RNA pathway; FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241817 | cnot1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259092 | cnot1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244885 | cnot2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245930 | cnot2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238391 | cnot3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256041 | cnot3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234808 | cnot4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245918 | cnot4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6480981 | CNOT4P1 | CCR4-NOT transcription complex subunit 4 pseudogene 1 | | 13 | 20921664 | 20923233 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11359066 | Cnot6l2 | CCR4-NOT transcription complex, subunit 6 like 2 | INTERACTS WITH glyphosate | 10 | 34520768 | 34531728 | Rat | 1 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 626180924 | cnot7.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155237654 | cnot7.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6777190 | CNOT7P1 | CCR4-NOT transcription complex subunit 7 pseudogene 1 | | X | 69937288 | 69938257 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6777903 | CNOT7P2 | CCR4-NOT transcription complex subunit 7 pseudogene 2 | | 1 | 115564310 | 115565304 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 155235579 | cnot8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241731 | cnot8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247955 | cnot9.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241385 | cnot10.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240000 | cnot10.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257490 | cnot11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259170 | cnot11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155237104 | cnot6l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239402 | cnot6l.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2303314 | CNOT6LP1 | CNOT6L pseudogene 1 | INTERACTS WITH sodium arsenite | 15 | 56003305 | 56007179 | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 629021571 | CNOT6L-DT | CNOT6L divergent transcript | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 1590660 | Cnot8-ps1 | CCR4-NOT transcription complex, subunit 8, pseudogene 1 | | 2 | 104154943 | 104156006 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 6481313 | CNOT10-AS1 | CNOT10 antisense RNA 1 | | 3 | 32730635 | 32737457 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1352594 | BCAS4 | breast carcinoma amplified sequence 4 | Predicted to be located in cytoplasm. Predicted to be part of BLOC-1 complex. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 50794894 | 50882676 | Human | 42 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1314546 | Enox1 | ecto-NOX disulfide-thiol exchanger 1 | Predicted to enable NADH dehydrogenase activity and protein disulfide isomerase activity. Predicted to be involved in ultradian rhythm. Predicted to be located in external side of plasma membrane and extracellular region. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; eye; and genitourinary system. Orthologous to human ENOX1 (ecto-NOX disulfide-thiol exchanger 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 77393790 | 77959203 | Mouse | 95 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1605985 | ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at i ts peak when the other is at its lowest. [provided by RefSeq, Dec 2016] | 13 | 43213130 | 43786972 | Human | 90 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 3186 | Nos3 | nitric oxide synthase 3 | ENCODES a protein that exhibits actin binding; beta-catenin binding; cadherin binding; INVOLVED IN bone development; cellular response to cAMP; cellular response to growth factor stimulus; PARTICIPATES IN doxorubicin pharmacokinetics pathway; eicosanoid signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH acute kidney failure; Acute Liver Failure; Arteriovenous Fistula; FOUND IN apical part of cell; caveola; cytoplasm; INTERACTS WITH (R)-carnitine; 1,3-dinitrobenzene; 11-deoxycorticosterone | 4 | 11686088 | 11706604 | Rat | 1391 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10997 | Nos3 | nitric oxide synthase 3, endothelial cell | Enables nitric-oxide synthase activity and scaffold protein binding activity. Involved in several processes, including heart development; negative regulation of muscle hyperplasia; and smooth muscle hyperplasia. Acts upstream of with a positive effect on positive regulation of gene expression. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; nitric oxide biosynthetic process; and regulation of metal ion transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Used to study aortic valve disease; essential hypertension; persistent fetal circulation syndrome; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); leukemia (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 24569772 | 24589472 | Mouse | 1763 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735618 | NOS3 | nitric oxide synthase 3 | Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016] | 7 | 150991017 | 151014588 | Human | 1490 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 14180349 | NOS3 | nitric oxide synthase 3 | ENCODES a protein that exhibits actin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN vasodilation; angiogenesis (ortholog); bone development (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; eicosanoid signaling pathway; vascular endothe lial growth factor signaling pathway; ASSOCIATED WITH acute chest syndrome (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN apical part of cell (ortholog); caveola (ortholog); sarcolemma (ortholog); INTERACTS WITH 11-deoxyprostaglandin E1; 16,16-dimethylprostaglandin E2; 17beta-estradiol | | | | Pig | 508 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1323786 | TNKS1BP1 | tankyrase 1 binding protein 1 | Enables ankyrin repeat binding activity; enzyme binding activity; and protein serine/threonine kinase activator activity. Involved in cellular response to ionizing radiation and double-strand break repair. Located in several cellular components, including adherens junction; heterochromatin; and nucl eus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 57299642 | 57324952 | Human | 138 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8695502 | PRANCR | progenitor renewal associated non-coding RNA | INTERACTS WITH 17beta-estradiol; okadaic acid; propofol | 12 | 70222190 | 70243360 | Human | 3 | old_gene_name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 12243345 | NOS3 | nitric oxide synthase 3 | ENCODES a protein that exhibits actin binding (ortholog); actin monomer binding (ortholog); arginine binding (ortholog); INVOLVED IN angiogenesis (ortholog); aortic valve morphogenesis (ortholog); blood vessel diameter maintenance (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; eic osanoid signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH acute chest syndrome (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN apical part of cell (ortholog); caveola (ortholog); cytoplasm (ortholog); INTERACTS WITH all-trans-retinoic acid; enalapril; icariin | 16 | 15054196 | 15072454 | Dog | 466 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 16567821 | AC009118.3 | novel transcript, antisense to CNOT1 | | | | | Human | | name | gene, lncrna |
| 16558710 | AC104806.1 | CCR4-NOT transcription complex, subunit 7 (CNOT7) pseudogene | | | | | Human | | name | gene, processed_pseudogene |