CNOT6L (CCR4-NOT transcription complex subunit 6 like) - Rat Genome Database

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Gene: CNOT6L (CCR4-NOT transcription complex subunit 6 like) Pan paniscus
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Symbol: CNOT6L
Name: CCR4-NOT transcription complex subunit 6 like
RGD ID: 11743640
Description: ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CCR4-NOT transcription complex subunit 6-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2352,244,754 - 52,353,101 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1452,431,326 - 52,539,612 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0446,374,255 - 46,482,552 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1452,220,159 - 52,327,311 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl452,263,010 - 52,320,307 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CNOT6LBonobomRNA destabilization acts_upstream_of_or_withinISORGD:15511669068941 PMID:17452450MGIPMID:17452450
CNOT6LBonobomRNA processing involved_inIEAUniProtKB-KW:KW-0507150520179 UniProtGO_REF:0000043
CNOT6LBonobonuclear-transcribed mRNA catabolic process, deadenylation-dependent decay acts_upstream_of_or_withinISORGD:15511669068941 PMID:17452450MGIPMID:17452450
CNOT6LBonobopositive regulation of cell population proliferation involved_inISORGD:13192969068941 PMID:21233283UniProtPMID:21233283
CNOT6LBonobopositive regulation of cell population proliferation acts_upstream_of_or_withinISORGD:15511669068941 PMID:17452450MGIPMID:17452450
CNOT6LBonobopositive regulation of cytoplasmic mRNA processing body assembly involved_inISORGD:13192969068941 PMID:21233283UniProtPMID:21233283
CNOT6LBonoboregulation of translation involved_inIEAUniProtKB-KW:KW-0810150520179 UniProtGO_REF:0000043
CNOT6LBonoboregulatory ncRNA-mediated gene silencing involved_inIEAUniProtKB-KW:KW-0943150520179 UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CNOT6LBonoboCCR4-NOT complex part_ofISORGD:13192969068941 PMID:19558367UniProtPMID:19558367
CNOT6LBonobocytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
CNOT6LBonobocytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
CNOT6LBonobocytosol located_inISORGD:13192969068941 HPAGO_REF:0000052
CNOT6LBonobonucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
CNOT6LBonobonucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043

Molecular Function
1 to 20 of 22 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CNOT6LBonobo3'-5'-RNA exonuclease activity enablesIEAPANTHER:PTN000251959150520179 TreeGrafterGO_REF:0000118
CNOT6LBonobocatalytic activity enablesIEAInterPro:IPR005135150520179 InterProGO_REF:0000002
CNOT6LBonoboexonuclease activity enablesIEAUniProtKB-KW:KW-0269150520179 UniProtGO_REF:0000043
CNOT6LBonobohydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
CNOT6LBonobometal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
CNOT6LBonobonuclease activity enablesIEAUniProtKB-KW:KW-0540150520179 UniProtGO_REF:0000043
CNOT6LBonobopoly(A)-specific ribonuclease activity enablesIEAEC:3.1.13.4150520179 UniProtGO_REF:0000003
CNOT6LBonobopoly(A)-specific ribonuclease activity enablesIEAInterPro:IPR034967150520179 InterProGO_REF:0000002
CNOT6LBonoboprotein binding enablesISOUniProtKB:P603229068941 PMID:20133598UniProtPMID:20133598
CNOT6LBonoboprotein binding enablesISOPR:Q6ZQ08|PR:Q8K0V4|PR:Q9D0N7|PR:Q9JKY09068941 PMID:17452450MGIPMID:17452450
CNOT6LBonoboprotein binding enablesISOUniProtKB:Q608099068941 PMID:17452450, PMID:21897366IntActPMID:17452450|PMID:21897366
CNOT6LBonoboprotein binding enablesISOUniProtKB:P479749068941 PMID:34611029UniProtPMID:34611029
CNOT6LBonoboprotein binding enablesISOUniProtKB:P506169068941 PMID:18377426IntActPMID:18377426
CNOT6LBonoboprotein binding enablesISOUniProtKB:A5YKK6|UniProtKB:Q9HCJ0|UniProtKB:Q9UIV19068941 PMID:21984185IntActPMID:21984185
CNOT6LBonoboprotein binding enablesISOUniProtKB:A5YKK69068941 PMID:22977175IntActPMID:22977175
CNOT6LBonoboprotein binding enablesISOUniProtKB:P50616|UniProtKB:Q9UIV19068941 PMID:28514442IntActPMID:28514442
CNOT6LBonoboprotein binding enablesISOUniProtKB:Q9UFF9|UniProtKB:Q9UIV19068941 PMID:32296183IntActPMID:32296183
CNOT6LBonoboprotein binding enablesISOUniProtKB:Q9HCJ09068941 PMID:21981923IntActPMID:21981923
CNOT6LBonoboprotein binding enablesISOUniProtKB:A5YKK6|UniProtKB:Q9NZN89068941 PMID:26496610IntActPMID:26496610
CNOT6LBonoboprotein binding enablesISOUniProtKB:A5YKK6|UniProtKB:O75175|UniProtKB:Q92600|UniProtKB:Q9C0C2|UniProtKB:Q9H9A5|UniProtKB:Q9NZN8|UniProtKB:Q9UFF9|UniProtKB:Q9UIV19068941 PMID:17452450IntActPMID:17452450
1 to 20 of 22 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CNOT6LBonobomicroRNA pathway   ISORGD:13192969068941 RGDPMID:23337855|REF_RGD_ID:9850101
PMID:22301074   PMID:30032202  



CNOT6L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2352,244,754 - 52,353,101 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1452,431,326 - 52,539,612 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0446,374,255 - 46,482,552 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1452,220,159 - 52,327,311 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl452,263,010 - 52,320,307 (+)Ensemblpanpan1.1panPan2
CNOT6L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38477,713,387 - 77,820,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl477,713,387 - 77,819,615 (-)EnsemblGRCh38hg38GRCh38
GRCh37478,634,541 - 78,741,423 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36478,853,565 - 78,959,568 (-)NCBINCBI36Build 36hg18NCBI36
Build 34479,004,337 - 79,097,701NCBI
Celera475,935,929 - 76,042,004 (-)NCBICelera
Cytogenetic Map4q21.1NCBI
HuRef474,386,458 - 74,492,461 (-)NCBIHuRef
CHM1_1478,611,478 - 78,717,345 (-)NCBICHM1_1
T2T-CHM13v2.0481,054,227 - 81,161,055 (-)NCBIT2T-CHM13v2.0
Cnot6l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39596,218,192 - 96,312,044 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl596,218,192 - 96,312,030 (-)EnsemblGRCm39 Ensembl
GRCm38596,070,333 - 96,164,198 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl596,070,333 - 96,164,171 (-)EnsemblGRCm38mm10GRCm38
MGSCv37596,504,756 - 96,591,009 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36596,315,891 - 96,402,292 (-)NCBIMGSCv36mm8
Celera593,419,034 - 93,505,443 (-)NCBICelera
Cytogenetic Map5E3NCBI
cM Map547.29NCBI
Cnot6l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81413,714,475 - 13,806,481 (+)NCBIGRCr8
mRatBN7.21413,410,499 - 13,502,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1413,411,281 - 13,498,203 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1413,379,451 - 13,466,326 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01414,679,308 - 14,766,183 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01413,395,794 - 13,482,664 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01415,059,101 - 15,148,255 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1415,059,387 - 15,146,586 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01415,000,591 - 15,089,212 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41414,924,620 - 15,011,984 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11414,877,885 - 15,010,870 (+)NCBI
Celera1413,458,539 - 13,545,193 (+)NCBICelera
Cytogenetic Map14p22NCBI
Cnot6l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554332,213,444 - 2,316,049 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554332,206,462 - 2,290,773 (-)NCBIChiLan1.0ChiLan1.0
CNOT6L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1322,192,800 - 2,305,526 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl322,145,813 - 2,306,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3239,584,726 - 39,698,628 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0322,218,607 - 2,332,531 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl322,171,626 - 2,332,326 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1322,217,455 - 2,331,474 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0322,165,687 - 2,279,692 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03237,893,391 - 38,007,445 (+)NCBIUU_Cfam_GSD_1.0
Cnot6l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528510,004,724 - 10,105,815 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366761,408,048 - 1,502,519 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366761,401,428 - 1,474,167 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNOT6L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl873,185,999 - 73,335,741 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1873,191,721 - 73,335,779 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2877,392,505 - 77,496,997 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNOT6L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1726,210,368 - 26,312,938 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl726,217,371 - 26,312,567 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660374,562,902 - 4,666,026 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnot6l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475713,219,267 - 13,340,955 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475713,218,464 - 13,346,404 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSPPAT00000036798   ⟹   ENSPPAP00000014122
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl452,263,010 - 52,320,307 (+)Ensembl
RefSeq Acc Id: XM_034958604   ⟹   XP_034814495
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2352,245,351 - 52,353,101 (+)NCBI
NHGRI_mPanPan1452,431,993 - 52,539,612 (+)NCBI
Mhudiblu_PPA_v0446,374,964 - 46,482,552 (+)NCBI
RefSeq Acc Id: XM_034958605   ⟹   XP_034814496
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2352,245,310 - 52,353,101 (+)NCBI
NHGRI_mPanPan1452,431,905 - 52,539,612 (+)NCBI
Mhudiblu_PPA_v0446,374,958 - 46,482,552 (+)NCBI
RefSeq Acc Id: XM_034958606   ⟹   XP_034814497
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2352,244,754 - 52,353,101 (+)NCBI
NHGRI_mPanPan1452,431,326 - 52,539,612 (+)NCBI
Mhudiblu_PPA_v0446,374,255 - 46,482,552 (+)NCBI
RefSeq Acc Id: XM_063603542   ⟹   XP_063459612
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2352,263,762 - 52,353,101 (+)NCBI
Protein RefSeqs XP_034814495 (Get FASTA)   NCBI Sequence Viewer  
  XP_034814496 (Get FASTA)   NCBI Sequence Viewer  
  XP_034814497 (Get FASTA)   NCBI Sequence Viewer  
  XP_063459612 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000014122.1
RefSeq Acc Id: XP_034814497   ⟸   XM_034958606
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AFH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034814496   ⟸   XM_034958605
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AFH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034814495   ⟸   XM_034958604
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AFH9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000014122   ⟸   ENSPPAT00000036798
RefSeq Acc Id: XP_063459612   ⟸   XM_063603542
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AFH9 (UniProtKB/TrEMBL)


1 to 21 of 21 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000030178 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036798.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.10.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro CCR4/nocturin_mRNA_transcr UniProtKB/TrEMBL
  Deadenylase_CCR4b UniProtKB/TrEMBL
  Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
NCBI Gene CNOT6L ENTREZGENE
PANTHER CARBON CATABOLITE REPRESSOR PROTEIN 4 UniProtKB/TrEMBL
  CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF56219 UniProtKB/TrEMBL
UniProt A0A2R9AFH9 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows