Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Ontology Browser
Term:
granzyme-mediated programmed cell death signaling pathway (GO:0140507)
Annotations: Rat: (16) Mouse: (12) Human: (10) Chinchilla: (8) Bonobo: (10) Dog: (10) Squirrel: (9) Pig: (12) Naked Mole-rat: (9) Green Monkey: (11)
Parent Terms Term With Siblings Child Terms
programmed cell death +     
signal transduction +     
apoptotic process +   
apoptotic signaling pathway +   
autolysis 
autophagic cell death +   
bile acid signaling pathway +   
carbohydrate mediated signaling +   
cell surface receptor signaling pathway +   
cornification +   
cuproptosis 
extracellular ATP signaling 
ferroptosis +   
G protein-coupled receptor signaling pathway +   
granzyme-mediated programmed cell death signaling pathway +   
The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.
hormone-mediated signaling pathway +   
hydrogen peroxide mediated signaling pathway 
immune response-regulating signaling pathway +   
intracellular signal transduction +   
ligand-gated ion channel signaling pathway +   
lipoprotein particle mediated signaling +   
mitochondrial outer membrane permeabilization involved in programmed cell death +   
necroptotic signaling pathway  
negative regulation of programmed cell death +   
negative regulation of signal transduction +   
neuronal signal transduction +   
opioid growth factor receptor signaling pathway 
phototransduction +   
positive regulation of programmed cell death +   
positive regulation of signal transduction +   
postsynaptic signal transduction +   
presynaptic signal transduction +   
programmed cell death in response to reactive oxygen species +   
programmed cell death in response to retinoic acid 
programmed cell death involved in cell development +   
programmed necrotic cell death +   
pyroptotic cell death +   
red or far-red light signaling pathway +   
regulation of blood pressure by chemoreceptor signaling pathway 
regulation of floral organ abscission by signal transduction 
regulation of programmed cell death +   
regulation of signal transduction +   
salicylic acid mediated signaling pathway +  
serotonin receptor signaling pathway +   
signal transduction in absence of ligand +   
signal transduction involved in cellular response to ammonium ion 
signal transduction involved in filamentous growth 
signal transduction involved in positive regulation of conjugation with cellular fusion +  
signal transduction involved in regulation of gene expression  
sphingolipid mediated signaling pathway +   
symbiont-induced defense-related programmed cell death +   

Synonyms
Broad Synonyms: granzyme-mediated cell death signaling pathway
Definition Sources: PMID:32299851

paths to the root