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Term:granzyme-mediated apoptotic signaling pathway
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Accession:GO:0008626 term browser browse the term
Definition:The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
Synonyms:related_synonym: apoptotic signaling pathway in response to granzyme;   induction of apoptosis by granzyme

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granzyme-mediated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube4b ubiquitination factor E4B involved_in ISO (PMID:11802788) RGD PMID:11802788 NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509
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  biological_process 20094
    cellular process 18691
      signal transduction 7105
        apoptotic signaling pathway 638
          granzyme-mediated apoptotic signaling pathway 1
Path 2
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  biological_process 20094
    biological regulation 13926
      regulation of biological process 13157
        regulation of cellular process 12435
          signal transduction 7105
            granzyme-mediated programmed cell death signaling pathway 8
              granzyme-mediated apoptotic signaling pathway 1
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