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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingolipid mediated signaling pathway
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Accession:GO:0090520 term browser browse the term
Definition:A series of molecular signals mediated by a sphingolipid.
Synonyms:exact_synonym: sphingolipid mediated signal transduction
 narrow_synonym: ceramide 1-phosphate signaling pathway;   ceramide signaling pathway;   sphingosine signaling pathway
 related_synonym: sphingolipid signaling pathway



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sphingolipid mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5518963|PMID:23651497)
Ensembl
RGD
PMID:23651497 GO_REF:0000107 MGI:5518963 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Sphk1 sphingosine kinase 1 acts_upstream_of_or_within ISO (MGI:5518963|PMID:23651497) RGD PMID:23651497 MGI:5518963 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
positive regulation of sphingolipid mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klf14 Kruppel-like factor 14 acts_upstream_of_or_within ISO MGI:3812953 (MGI:5588066|PMID:24759103) RGD PMID:24759103 MGI:5588066 NCBI chr 4:59,554,011...59,556,933
Ensembl chr 4:59,554,011...59,556,933
JBrowse link
regulation of sphingolipid mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plpp3 phospholipid phosphatase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2176173|MGI:3723633 (MGI:4939815|PMID:21319224)
Ensembl
RGD
PMID:21319224 GO_REF:0000107 MGI:4939815 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
JBrowse link
sphingosine-1-phosphate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:18558630) RGD PMID:18558630 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ezr ezrin involved_in ISO (PMID:23106337) RGD PMID:23106337 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Gpr6 G protein-coupled receptor 6 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in ISO
IEA
(PMID:18558630)
UniProtKB:O35904 (MGI:4461861|PMID:18558630)
GO_REF:0000107
RGD
Ensembl
PMID:18558630 GO_REF:0000107 MGI:4461861 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma involved_in ISO (PMID:18558630)
(MGI:4461861|PMID:18558630)
RGD PMID:18558630 MGI:4461861 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO
IEA
(PMID:18558630)
GO_REF:0000107
RGD
Ensembl
PMID:18558630 GO_REF:0000107 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:2151313|PMID:11032855)
(PMID:22344443)
PMID:21873635
UniProt
RGD
PMID:11032855 PMID:22344443 PMID:21873635 GO_REF:0000024 MGI:2151313, RGD:13792537 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 involved_in ISO
IBA
(PMID:23106337)
(MGI:5470025|PMID:23106337)
PMID:21873635
RGD PMID:23106337 PMID:21873635 MGI:5470025, RGD:13792537 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
JBrowse link
G S1pr4 sphingosine-1-phosphate receptor 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:8,207,767...8,210,043
Ensembl chr 7:8,208,098...8,211,893
JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
G Spns2 sphingolipid transporter 2 acts_upstream_of_or_within ISO MGI:4460276|MGI:5426395 (MGI:5424314|PMID:22406534), (MGI:5490425|PMID:23180825) RGD PMID:22406534 PMID:23180825 MGI:5424314 MGI:5490425 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    signaling 7490
      signal transduction 6908
        sphingolipid mediated signaling pathway 17
          negative regulation of sphingolipid mediated signaling pathway 0
          positive regulation of sphingolipid mediated signaling pathway 1
          regulation of sphingolipid mediated signaling pathway + 2
          sphingosine-1-phosphate receptor signaling pathway 14
Path 2
Term Annotations click to browse term
  biological_process 19497
    biological regulation 13606
      regulation of biological process 12866
        regulation of cellular process 12336
          signal transduction 6908
            sphingolipid mediated signaling pathway 17
              negative regulation of sphingolipid mediated signaling pathway 0
              positive regulation of sphingolipid mediated signaling pathway 1
              regulation of sphingolipid mediated signaling pathway + 2
              sphingosine-1-phosphate receptor signaling pathway 14
paths to the root