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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:granzyme-mediated programmed cell death signaling pathway
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Accession:GO:0140507 term browser browse the term
Definition:The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.
Synonyms:broad_synonym: granzyme-mediated cell death signaling pathway

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granzyme-mediated programmed cell death signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:9396766) GO_Central PMID:9396766 NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:31953257), (PMID:32188940) UniProt PMID:31953257 PMID:32188940 NCBI chrNW_004955410:26,700,977...26,761,683
Ensembl chrNW_004955410:26,701,893...26,769,989 		JBrowse link
G Gzma granzyme A involved_in ISO (PMID:32299851), (PMID:34022140) UniProt PMID:32299851 PMID:34022140 NCBI chrNW_004955446:12,560,831...12,568,023
Ensembl chrNW_004955446:12,560,658...12,568,053 		JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in ISO (PMID:23632890) GO_Central PMID:23632890 NCBI chrNW_004955404:557,090...573,532
Ensembl chrNW_004955404:557,862...573,379 		JBrowse link
G Nkg7 natural killer cell granule protein 7 involved_in ISO (MGI:6810811|PMID:33911019) UniProt PMID:33911019 MGI:6810811 NCBI chrNW_004955558:1,027,682...1,029,338
Ensembl chrNW_004955558:1,028,425...1,029,161 		JBrowse link
G Prf1 perforin 1 involved_in ISO (PMID:35705808) UniProt PMID:35705808 NCBI chrNW_004955437:20,700,912...20,705,076
Ensembl chrNW_004955437:20,700,718...20,706,929 		JBrowse link
G Srgn serglycin involved_in ISO (PMID:11911826) GO_Central PMID:11911826 NCBI chrNW_004955437:21,954,837...21,966,552
Ensembl chrNW_004955437:21,951,732...21,965,581 		JBrowse link
granzyme-mediated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube4b ubiquitination factor E4B involved_in ISO (PMID:11802788) UniProt PMID:11802788 NCBI chrNW_004955486:3,518,873...3,626,036
Ensembl chrNW_004955486:3,518,740...3,626,121 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    cellular process 11480
      signal transduction 3950
        granzyme-mediated programmed cell death signaling pathway 8
          granzyme-mediated apoptotic signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 12346
    biological regulation 8880
      regulation of biological process 8618
        signaling 4445
          signal transduction 3950
            granzyme-mediated programmed cell death signaling pathway 8
              granzyme-mediated apoptotic signaling pathway 1
paths to the root