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ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction in absence of ligand
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Accession:GO:0038034 term browser browse the term
Definition:A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor.
Synonyms:exact_synonym: signal transduction in absence of agonist
 narrow_synonym: basal signaling
 broad_synonym: addiction receptor signaling pathway;   dependence receptor signaling pathway;   non-classical signal transduction
 related_synonym: negative signal transduction


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extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC098008.1 RGD:13792537
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1624291
G Bag3 BAG cochaperone 3 JBrowse link 1 199,941,258 199,965,191 RGD:1624291
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:1624291
RGD:13792537
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:13792537
RGD:1624291
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:13792537
RGD:1600115
G Bcl2a1 BCL2-related protein A1 JBrowse link 8 96,551,424 96,559,527 RGD:13792537
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:1624291
RGD:13792537
G Bcl2l10 BCL2 like 10 JBrowse link 8 82,288,705 82,294,750 RGD:13792537
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
G Bcl2l2 Bcl2-like 2 JBrowse link 15 33,543,774 33,549,165 RGD:1624291
RGD:13792537
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:13792537
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:1624291
RGD:13792537
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:1624291
RGD:1600115
G Eya2 EYA transcriptional coactivator and phosphatase 2 JBrowse link 3 162,285,275 162,470,642 RGD:1624291
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:1624291
RGD:13792537
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:1624291
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:1624291
RGD:13792537
RGD:1600115
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
RGD:13792537
RGD:1600115
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:1624291
RGD:1600115
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:1624291
G Il3 interleukin 3 JBrowse link 10 39,620,535 39,622,973 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
RGD:13792537
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:1624291
G Itm2b integral membrane protein 2B JBrowse link 15 55,254,703 55,277,713 RGD:1624291
G Kitlg KIT ligand JBrowse link 7 42,269,784 42,351,054 RGD:1624291
G Lcn2 lipocalin 2 JBrowse link 3 11,414,189 11,417,534 RGD:1624291
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:1624291
RGD:13792537
RGD:1600115
G Mknk1 MAPK interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:1624291
G Mknk2 MAPK interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:1624291
G Moap1 modulator of apoptosis 1 JBrowse link 6 126,620,597 126,622,532 RGD:1624291
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:1624291
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 JBrowse link 7 70,360,199 70,377,422 RGD:8553892
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:1600115
G Bcl2l10 BCL2 like 10 JBrowse link 8 82,288,705 82,294,750 RGD:1624291
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:1624291
RGD:1600115
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:1624291
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,229 28,055,972 RGD:1624291
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:1600115
RGD:1624291
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:1624291
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:1624291
RGD:13792537
G Eya2 EYA transcriptional coactivator and phosphatase 2 JBrowse link 3 162,285,275 162,470,642 RGD:13792537
G Eya3 EYA transcriptional coactivator and phosphatase 3 JBrowse link 5 150,833,754 150,915,390 RGD:13792537
G Eya4 EYA transcriptional coactivator and phosphatase 4 JBrowse link 1 23,237,617 23,611,580 RGD:13792537
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:1624291
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:8553892
G Gas1 growth arrest-specific 1 JBrowse link 17 4,846,116 4,849,350 RGD:1624291
G Gata1 GATA binding protein 1 JBrowse link X 15,273,937 15,281,759 RGD:1624291
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:1600115
RGD:1624291
G Gfral GDNF family receptor alpha like JBrowse link 8 83,235,647 83,282,635 RGD:1624291
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Il7 interleukin 7 JBrowse link 2 96,427,884 96,474,979 RGD:1624291
RGD:1600115
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:8553940
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:1624291
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:1624291
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:1624291
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:1624291
G Prdx2 peroxiredoxin 2 JBrowse link 19 26,084,816 26,090,095 RGD:1624291
RGD:1600115
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:1624291
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 JBrowse link 5 9,046,889 9,094,740 RGD:1624291
RGD:1600115
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:1624291
G Stradb STE20 related adaptor beta JBrowse link 9 65,763,437 65,782,513 RGD:1624291
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Unc5b unc-5 netrin receptor B JBrowse link 20 30,339,680 30,406,593 RGD:1600115
RGD:1624291
G Zc3hc1 zinc finger, C3HC-type containing 1 JBrowse link 4 57,684,678 57,706,613 RGD:1624291
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,229 28,055,972 RGD:1624291
G Dapk3 death-associated protein kinase 3 JBrowse link 7 11,392,436 11,400,855 RGD:8554227
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:1624291
G Inhba inhibin subunit beta A JBrowse link 17 51,894,869 51,919,998 RGD:1624291
RGD:1600115
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1624291
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1624291
RGD:1600115
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:1624291
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:1624291
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta JBrowse link 8 55,279,278 55,311,768 RGD:1624291
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:1624291
G Srpx sushi-repeat-containing protein, X-linked JBrowse link X 14,146,618 14,220,756 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Unc5b unc-5 netrin receptor B JBrowse link 20 30,339,680 30,406,593 RGD:8554227
G Wwox WW domain-containing oxidoreductase JBrowse link 19 46,761,353 47,695,247 RGD:1624291
regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    signaling 7553
      signal transduction 6968
        signal transduction in absence of ligand 79
          G protein-coupled receptor signaling in absence of ligand 0
          extrinsic apoptotic signaling pathway in absence of ligand + 79
          negative regulation of signal transduction in absence of ligand + 36
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            signal transduction in absence of ligand 79
              G protein-coupled receptor signaling in absence of ligand 0
              extrinsic apoptotic signaling pathway in absence of ligand + 79
              negative regulation of signal transduction in absence of ligand + 36
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.