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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Trail mediated signaling pathway
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Accession:PW:0000682 term browser browse the term
Definition:Trail-mediated signaling leads to apoptosis via assembly of the DISC complex (Death-Inducing Signaling Complex) downstream of its receptors.
Synonyms:related_synonym: TRAIL signaling;   TRAIL-activated apoptotic signaling pathway
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Trail mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BID BH3 interacting domain death agonist TAS RGD PMID:17403612 PMID:19961901 RGD:4143170, RGD:4143171 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G CASP10 caspase 10 EXP PID PID:200068 NCBI chr 2:201,183,141...201,229,406
Ensembl chr 2:201,182,872...201,229,428 		JBrowse link
G CASP3 caspase 3 TAS RGD PMID:17403612 PMID:19961901 RGD:4143170, RGD:4143171 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP7 caspase 7 TAS RGD PMID:19961901 RGD:4143171 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 TAS
EXP		 PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator TAS
EXP		 PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex EXP PID PID:200068 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G DAP3 death associated protein 3 EXP PID PID:200068 NCBI chr 1:155,687,948...155,739,010
Ensembl chr 1:155,687,960...155,739,010 		JBrowse link
G FADD Fas associated via death domain TAS
EXP		 PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta EXP PID PID:200068 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma EXP PID PID:200068 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 EXP PID PID:200068 NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830 		JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 EXP PID PID:200068 NCBI chr 5:56,815,549...56,896,152
Ensembl chr 5:56,815,549...56,896,152 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 EXP PID PID:200068 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 EXP PID PID:200068 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 EXP PID PID:200068 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha EXP PID PID:200068 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta EXP PID PID:200068 NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,336...138,834,928 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta EXP PID PID:200068 NCBI chr 1:9,627,258...9,729,114
Ensembl chr 1:9,629,889...9,729,114 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 EXP PID PID:200068 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 EXP PID PID:200068 NCBI chr19:18,153,163...18,170,532
Ensembl chr19:18,153,163...18,170,540 		JBrowse link
G PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 EXP PID PID:200068 NCBI chr 1:46,040,140...46,174,901
Ensembl chr 1:46,040,140...46,133,036 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 EXP PID PID:200068 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187 		JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 EXP PID PID:200068 NCBI chr11:6,390,474...6,394,996
Ensembl chr11:6,390,440...6,394,998 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a TAS
EXP		 PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b ISO
TAS
EXP		 PID
RGD		 PMID:19934367 PMID:17403612 PMID:19961901 PID:200068, RGD:4142856, RGD:4143170, RGD:4143171 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031 		JBrowse link
G TNFRSF10C TNF receptor superfamily member 10c EXP PID PID:200068 NCBI chr 8:23,102,921...23,117,445
Ensembl chr 8:23,102,921...23,117,445 		JBrowse link
G TNFRSF10D TNF receptor superfamily member 10d EXP PID PID:200068 NCBI chr 8:23,135,588...23,164,027
Ensembl chr 8:23,135,588...23,164,027 		JBrowse link
G TNFSF10 TNF superfamily member 10 ISO
TAS
EXP		 PID
RGD		 PMID:19385008 PMID:17403612 PMID:19961901 PID:200068, RGD:2312745, RGD:4143170, RGD:4143171 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TRADD TNFRSF1A associated via death domain EXP PID PID:200068 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909 		JBrowse link
G TRAF2 TNF receptor associated factor 2 EXP PID PID:200068 NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    signaling pathway 2493
      cytokine and chemokine mediated signaling pathway 352
        cytokine mediated signaling pathway 351
          tumor necrosis factor superfamily mediated signaling pathway 91
            Trail mediated signaling pathway 31
              altered Trail mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 5957
    regulatory pathway 3600
      cell death pathway 250
        programmed cell death pathway 250
          apoptotic cell death pathway 161
            extrinsic apoptotic pathway 91
              Trail mediated signaling pathway 31
                altered Trail mediated signaling pathway 0
paths to the root