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ONTOLOGY REPORT - ANNOTATIONS

Term:melanin biosynthetic process
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Accession:GO:0042438 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
Synonyms:exact_synonym: melanin anabolism;   melanin biosynthesis;   melanin formation;   melanin synthesis


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melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asip agouti signaling protein acts_upstream_of_or_within
involved_in		 ISO
ISS
IEA		 MGI:1855937 (MGI:76308|PMID:7665913)
(MGI:52685|PMID:8449404)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:7665913 PMID:8449404 GO_REF:0000024 GO_REF:0000107 MGI:52685 MGI:76308 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4412464|PMID:11434569)		 UniProt
RGD		 PMID:11434569 GO_REF:0000024 MGI:4412464 NCBI chr  X:67,350,376...67,355,072
Ensembl chr  X:67,350,373...67,355,162 		JBrowse link
G Dct dopachrome tautomerase acts_upstream_of_or_within ISO MGI:1856379 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Ddt D-dopachrome tautomerase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482 		JBrowse link
G Mc1r melanocortin 1 receptor acts_upstream_of_or_within ISO MGI:1856028 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:1856114 (MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913)
PMID:21873635		 RGD PMID:7665913 PMID:9548375 PMID:21873635 MGI:1202196 MGI:76308, RGD:13792537 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Pmel premelanosome protein acts_upstream_of_or_within ISO MGI:1857040 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of ISO (MGI:3775882|PMID:18166528) RGD PMID:18166528 MGI:3775882 NCBI chr 3:112,319,305...112,339,231
Ensembl chr 3:112,319,308...112,339,231 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:8126111)		 Ensembl
RGD		 PMID:8126111 GO_REF:0000107 NCBI chr 8:96,263,322...96,314,197
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Tyr tyrosinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1855976|MGI:1855978 (MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913)
(PMID:8126111)		 RGD PMID:7665913 PMID:8126111 PMID:9548375 PMID:21873635 MGI:1202196 MGI:76308, RGD:13792537 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase involved_in ISO (MGI:3690794|PMID:2169885), (MGI:6827472|PMID:33100333) RGD PMID:2169885 PMID:33100333 MGI:3690794 MGI:6827472 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein involved_in ISO (PMID:25513726), (PMID:32966160) RGD PMID:25513726 PMID:32966160 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 involved_in ISO (PMID:32966160)
(MGI:7338895|PMID:35469906)		 RGD PMID:32966160 PMID:35469906 MGI:7338895 NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317 		JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO (MGI:5912387|PMID:29025994) RGD PMID:29025994 MGI:5912387 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988 		JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:31097585) RGD PMID:31097585 NCBI chr13:87,589,330...87,619,847
Ensembl chr13:87,589,333...87,619,847 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5499726|PMID:16272156)		 UniProt
RGD		 PMID:16272156 GO_REF:0000024 MGI:5499726 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of_or_within ISO (MGI:3775882|PMID:18166528) RGD PMID:18166528 MGI:3775882 NCBI chr 3:112,319,305...112,339,231
Ensembl chr 3:112,319,308...112,339,231 		JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO
IEA		 (MGI:5619434|PMID:23569434)
GO_REF:0000107		 RGD
Ensembl		 PMID:23569434 GO_REF:0000107 MGI:5619434 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (PMID:21291857) RGD PMID:21291857 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692 		JBrowse link
G Asip agouti signaling protein involved_in IBA
ISO
IEA		 PMID:21873635
UniProtKB:P07147|UniProtKB:Q60696 (MGI:5294257|PMID:21949658)
GO_REF:0000107		 RGD
Ensembl		 PMID:21949658 PMID:21873635 GO_REF:0000107 MGI:5294257, RGD:13792537 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Atp7a ATPase copper transporting alpha involved_in ISS
ISO		 GO_REF:0000024
(PMID:11092760)		 UniProt
RGD		 PMID:11092760 GO_REF:0000024 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Cdh3 cadherin 3 involved_in ISO (PMID:23334344) RGD PMID:23334344 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:21291857)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21291857 GO_REF:0000024 GO_REF:0000107 NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997 		JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:28842328) RGD PMID:28842328 NCBI chr13:87,589,330...87,619,847
Ensembl chr13:87,589,333...87,619,847 		JBrowse link
G Pmel premelanosome protein involved_in ISO (MGI:5294257|PMID:21949658) RGD PMID:21949658 MGI:5294257 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
G Rab38 RAB38, member RAS oncogene family IMP RGD PMID:17043139 RGD:152025192 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in ISO (PMID:21996312)
UniProtKB:Q03288|UniProtKB:Q60696 (MGI:5294257|PMID:21949658)		 RGD PMID:21949658 PMID:21996312 MGI:5294257 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:22649030) RGD PMID:22649030 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO (PMID:33208952)
(MGI:6492453|PMID:33208952)
(PMID:31117290)		 RGD PMID:31117290 PMID:33208952 MGI:6492453 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (MGI:3588610|PMID:16037214) RGD PMID:16037214 MGI:3588610 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      secondary metabolic process 64
        secondary metabolite biosynthetic process 26
          melanin biosynthetic process 24
            1,8-dihydroxynaphthalene-melanin biosynthetic process 0
            melanin biosynthetic process from tyrosine 3
            negative regulation of melanin biosynthetic process 5
            positive regulation of melanin biosynthetic process 9
            regulation of melanin biosynthetic process + 15
Path 2
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      cellular metabolic process 7496
        cellular aromatic compound metabolic process 3078
          phenol-containing compound metabolic process 132
            melanin metabolic process 26
              melanin biosynthetic process 24
                1,8-dihydroxynaphthalene-melanin biosynthetic process 0
                melanin biosynthetic process from tyrosine 3
                negative regulation of melanin biosynthetic process 5
                positive regulation of melanin biosynthetic process 9
                regulation of melanin biosynthetic process + 15
paths to the root