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ONTOLOGY REPORT - ANNOTATIONS


Term:secondary metabolite biosynthetic process
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Accession:GO:0044550 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
Synonyms:exact_synonym: secondary metabolite biosynthesis


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melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asip agouti signaling protein acts_upstream_of_or_within ISO MGI:1855937 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr 3:150,492,010...150,579,870
Ensembl chr 3:150,574,473...150,579,870
JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4412464|PMID:11434569)
UniProt
RGD
PMID:11434569 GO_REF:0000024 MGI:4412464 NCBI chr  X:72,128,996...72,133,692
Ensembl chr  X:72,128,994...72,133,692
JBrowse link
G Dct dopachrome tautomerase acts_upstream_of_or_within ISO MGI:1856379 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
G Ddt D-dopachrome tautomerase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:13,827,153...13,829,624
Ensembl chr20:13,827,132...13,831,588
JBrowse link
G Mc1r melanocortin 1 receptor acts_upstream_of_or_within ISO MGI:1856028 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr 8:82,038,966...82,156,507
Ensembl chr 8:82,037,977...82,156,617
JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within ISO MGI:1856114 (MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913) RGD PMID:7665913 PMID:9548375 MGI:1202196 MGI:76308 NCBI chr 1:114,661,970...114,987,433
Ensembl chr 1:114,679,537...114,987,433
JBrowse link
G Pmel premelanosome protein acts_upstream_of_or_within ISO MGI:1857040 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr 7:3,133,347...3,143,827
Ensembl chr 7:3,133,506...3,143,911
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:8126111)
Ensembl
RGD
PMID:8126111 GO_REF:0000107 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468
JBrowse link
G Tyr tyrosinase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1855976|MGI:1855978 (MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913)
(PMID:8126111)
RGD PMID:7665913 PMID:8126111 PMID:9548375, PMID:21873635 MGI:1202196 MGI:76308, RGD:13792537 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase involved_in ISO (MGI:3690794|PMID:2169885) RGD PMID:2169885 MGI:3690794 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO (MGI:5912387|PMID:29025994) RGD PMID:29025994 MGI:5912387 NCBI chr 7:11,214,832...11,223,713
Ensembl chr 7:11,216,975...11,223,649
JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:31097585) RGD PMID:31097585 NCBI chr13:93,716,481...93,746,994
Ensembl chr13:93,716,481...93,746,994
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5499726|PMID:16272156)
UniProt
RGD
PMID:16272156 GO_REF:0000024 MGI:5499726 NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157
JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of_or_within ISO (MGI:3775882|PMID:18166528) RGD PMID:18166528 MGI:3775882 NCBI chr 3:117,335,212...117,354,480
Ensembl chr 3:117,335,212...117,354,480
JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO
GO_REF:0000107
(MGI:5619434|PMID:23569434)
Ensembl
RGD
PMID:23569434 GO_REF:0000107 MGI:5619434 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (PMID:21291857) RGD PMID:21291857 NCBI chr16:2,560,103...2,602,035
Ensembl chr16:2,563,520...2,602,103
JBrowse link
G Asip agouti signaling protein involved_in IBA
ISO
PMID:21873635
UniProtKB:P07147|UniProtKB:Q60696 (MGI:5294257|PMID:21949658)
RGD PMID:21949658, PMID:21873635 MGI:5294257, RGD:13792537 NCBI chr 3:150,492,010...150,579,870
Ensembl chr 3:150,574,473...150,579,870
JBrowse link
G Atp7a ATPase copper transporting alpha involved_in ISS
ISO
GO_REF:0000024
(PMID:11092760)
UniProt
RGD
PMID:11092760 GO_REF:0000024 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Cdh3 cadherin 3 involved_in ISO (PMID:23334344) RGD PMID:23334344 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:21291857)
UniProt
RGD
PMID:21291857 GO_REF:0000024 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233
JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:28842328) RGD PMID:28842328 NCBI chr13:93,716,481...93,746,994
Ensembl chr13:93,716,481...93,746,994
JBrowse link
G Pmel premelanosome protein involved_in ISO (MGI:5294257|PMID:21949658) RGD PMID:21949658 MGI:5294257 NCBI chr 7:3,133,347...3,143,827
Ensembl chr 7:3,133,506...3,143,911
JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in ISO (PMID:21996312)
UniProtKB:Q03288|UniProtKB:Q60696 (MGI:5294257|PMID:21949658)
RGD PMID:21949658 PMID:21996312 MGI:5294257 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO
IEA
(PMID:22649030)
GO_REF:0000107
RGD
Ensembl
PMID:22649030 GO_REF:0000107 NCBI chr10:59,749,250...59,772,475
Ensembl chr10:59,749,256...59,764,868
JBrowse link
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO (PMID:33208952)
(MGI:6492453|PMID:33208952)
(PMID:31117290)
RGD PMID:31117290 PMID:33208952 MGI:6492453 NCBI chr 7:11,214,832...11,223,713
Ensembl chr 7:11,216,975...11,223,649
JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (MGI:3588610|PMID:16037214) RGD PMID:16037214 MGI:3588610 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
siderophore biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdh2 3-hydroxybutyrate dehydrogenase 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:4820913|PMID:20550936)
PMID:21873635
UniProt
RGD
PMID:20550936, PMID:21873635 GO_REF:0000024 MGI:4820913, RGD:13792537 NCBI chr 2:240,461,505...240,482,149
Ensembl chr 2:240,461,505...240,482,145
JBrowse link
toxin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 involved_in ISO (PMID:11511187) RGD PMID:11511187 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    metabolic process 11881
      secondary metabolic process 63
        secondary metabolite biosynthetic process 24
          (+)-kotanin biosynthetic process + 0
          (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process 0
          N',N'',N'''-triacetylfusarinine C biosynthetic process + 0
          arugosin biosynthetic process + 0
          asperthecin biosynthetic process + 0
          brevianamide F biosynthetic process + 0
          cichorine biosynthetic process 0
          cordyol C biosynthetic process + 0
          cspyrone B1 biosynthetic process 0
          cyanogenic glycoside biosynthetic process + 0
          dehydroaustinol biosynthetic process + 0
          demethylkotanin biosynthetic process + 0
          diorcinol biosynthetic process + 0
          emericellamide biosynthetic process + 0
          emericellin biosynthetic process + 0
          emodin biosynthetic process + 0
          endocrocin biosynthetic process + 0
          ergot alkaloid biosynthetic process + 0
          fumitremorgin B biosynthetic process + 0
          fumonisin biosynthetic process + 0
          gerfelin biosynthetic process + 0
          glycosinolate biosynthetic process + 0
          helvolic acid biosynthetic process + 0
          melanin biosynthetic process + 22
          monodictyphenone biosynthetic process + 0
          negative regulation of secondary metabolite biosynthetic process + 5
          o-orsellinic acid biosynthetic process + 0
          ocellus pigment biosynthetic process + 0
          ochratoxin A biosynthetic process 0
          orcinol biosynthetic process + 0
          orlandin biosynthetic process 0
          penicillin biosynthetic process + 0
          phenylpropanoid biosynthetic process + 0
          pheromone biosynthetic process 0
          phytochelatin biosynthetic process 0
          polyketide biosynthetic process + 0
          positive regulation of secondary metabolite biosynthetic process + 8
          regulation of secondary metabolite biosynthetic process + 14
          shamixanthone biosynthetic process 0
          siderophore biosynthetic process + 1
          tensidol A biosynthetic process + 0
          tensidol B biosynthetic process + 0
          terrequinone A biosynthetic process + 0
          toxin biosynthetic process + 1
          violaceol I biosynthetic process + 0
          violaceol II biosynthetic process + 0
paths to the root