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ONTOLOGY REPORT - ANNOTATIONS

Term:p38MAPK cascade
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Accession:GO:0038066 term browser browse the term
Definition:A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
Synonyms:exact_synonym: p38 MAPK cascade;   p38 cascade
 narrow_synonym: osmosensory signaling MAPK cascade
 related_synonym: MAPK14 cascade


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p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:80,984,969...81,076,573
Ensembl chr15:80,985,126...81,081,014 		JBrowse link
G ATF7 activating transcription factor 7 involved_in ISO (PMID:17699753) MGI PMID:17699753 NCBI chr 5:18,726,329...18,838,670
Ensembl chr 5:18,728,694...18,838,542 		JBrowse link
G BECN1 beclin 1 ISO RGD PMID:27769861 RGD:329853763 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (PMID:20053668) MGI PMID:20053668 NCBI chr 8:879,151...894,968
Ensembl chr 8:879,159...894,964 		JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29540778) Ensembl
MGI		 PMID:29540778 GO_REF:0000107 NCBI chr 5:51,695,927...51,704,402
Ensembl chr 5:51,696,188...51,703,813 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr12:44,155,079...44,173,634 JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha ISO RGD PMID:27769861 RGD:329853763 NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505 		JBrowse link
G MAP2K3 mitogen-activated protein kinase kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:61,396,337...61,417,333
Ensembl chr12:61,396,369...61,417,321 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:10,891,445...11,018,617
Ensembl chr12:10,894,966...11,018,641 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:79,174,444...79,378,520
Ensembl chr15:79,173,033...79,380,993 		JBrowse link
G MAP3K4 mitogen-activated protein kinase kinase kinase 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:6,891,255...7,049,784
Ensembl chr 1:6,891,265...7,049,775 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:27,380,143...27,600,500
Ensembl chr 1:27,380,142...27,600,493 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057 		JBrowse link
G MAPK11 mitogen-activated protein kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:420,848...428,103
Ensembl chr 5:421,798...428,101 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031 		JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24020373) Ensembl
MGI		 PMID:24020373 GO_REF:0000107 NCBI chr 9:67,314,651...67,365,060
Ensembl chr 9:67,314,484...67,365,059 		JBrowse link
G NR2C2 nuclear receptor subfamily 2 group C member 2 involved_in ISO (MGI:5320687|PMID:22337877) CACAO PMID:22337877 MGI:5320687 NCBI chr13:69,464,798...69,577,638
Ensembl chr13:69,464,795...69,576,946 		JBrowse link
G ZFP36 ZFP36 ring finger protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:48,063,732...48,066,235
Ensembl chr 6:48,063,677...48,066,250 		JBrowse link
G ZFP36L1 ZFP36 ring finger protein like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:92,490,069...92,495,864
Ensembl chr 7:92,490,017...92,495,554 		JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:34,058,091...34,121,939
Ensembl chr 6:34,059,081...34,121,264 		JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:132,819,931...133,084,880
Ensembl chr13:132,820,870...133,086,841 		JBrowse link
G DUSP1 dual specificity phosphatase 1 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086 		JBrowse link
G DUSP10 dual specificity phosphatase 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857 		JBrowse link
G EZR ezrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,403,362...8,452,750
Ensembl chr 1:8,403,453...8,452,742 		JBrowse link
G MIR20A microRNA mir-20a involved_in ISO (PMID:22696064) BHF-UCL PMID:22696064 NCBI chr11:60,735,109...60,735,179
Ensembl chr11:60,735,099...60,735,196 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6695687|PMID:31900229) ARUK-UCL PMID:31900229 MGI:6695687 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
positive regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 involved_in IMP (PMID:23389627) AgBase PMID:23389627 NCBI chr 4:94,026,391...94,082,206
Ensembl chr 4:94,026,386...94,080,420 		JBrowse link
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,195 		JBrowse link
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:18584881 RGD:2303073 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,285,012...29,376,343 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:144,940,702...144,944,089
Ensembl chr 6:144,940,697...144,944,089 		JBrowse link
G GADD45B growth arrest and DNA damage inducible beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:76,107,928...76,111,458
Ensembl chr 2:76,107,929...76,111,479 		JBrowse link
G GADD45G growth arrest and DNA damage inducible gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:1,166,000...1,167,538
Ensembl chr14:1,165,982...1,167,529 		JBrowse link
G GDF6 growth differentiation factor 6 involved_in ISO (MGI:5751611|PMID:26774823) UniProt PMID:26774823 MGI:5751611 NCBI chr 4:40,473,015...40,491,142
Ensembl chr 4:40,472,935...40,490,033 		JBrowse link
G GSN gelsolin ISO RGD PMID:24505034 RGD:329333013 NCBI chr 1:261,295,711...261,372,848
Ensembl chr 1:261,307,008...261,372,848 		JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:16,460,089...16,462,979
Ensembl chr14:16,459,971...16,462,207 		JBrowse link
G KCNN4 potassium calcium-activated channel subfamily N member 4 ISO RGD PMID:28679649 RGD:329955564 NCBI chr 6:50,580,016...50,593,518
Ensembl chr 6:50,580,022...50,593,544 		JBrowse link
G LEP leptin involved_in ISS
IEA
IBA		 UniProt
Ensembl
TreeGrafter
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323 		JBrowse link
G LOC110258578 interleukin-1 beta-like involved_in ISO (MGI:5902681|PMID:20739563) ARUK-UCL PMID:20739563 MGI:5902681
G MAP3K3 mitogen-activated protein kinase kinase kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10700190) Ensembl
MGI		 PMID:10700190 GO_REF:0000107 NCBI chr12:15,228,979...15,298,784
Ensembl chr12:15,230,182...15,298,784 		JBrowse link
G MAP3K4 mitogen-activated protein kinase kinase kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:6,891,255...7,049,784
Ensembl chr 1:6,891,265...7,049,775 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 ISO RGD PMID:20716917 RGD:10412640 NCBI chr 1:27,380,143...27,600,500
Ensembl chr 1:27,380,142...27,600,493 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:23994610) MGI PMID:23994610 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:56,200,455...56,296,151
Ensembl chr15:56,200,455...56,295,064 		JBrowse link
G MINK1 misshapen like kinase 1 involved_in ISO (MGI:1354211|PMID:10708748) UniProt PMID:10708748 MGI:1354211 NCBI chr12:52,016,297...52,066,687
Ensembl chr12:52,016,299...52,066,693 		JBrowse link
G MIR181A-1 microRNA mir-181a-1 involved_in ISO (PMID:23993976) BHF-UCL PMID:23993976 NCBI chr10:21,696,653...21,696,756
Ensembl chr10:21,696,653...21,696,756 		JBrowse link
G MIR181A-2 microRNA mir-181a-2 involved_in ISO (PMID:23993976) BHF-UCL PMID:23993976 NCBI chr 1:265,497,249...265,497,328
Ensembl chr 1:265,497,249...265,497,328 		JBrowse link
G MIR181B-1 microRNA mir-181b-1 involved_in ISO (PMID:23993976) BHF-UCL PMID:23993976 NCBI chr10:21,696,492...21,696,571
Ensembl chr10:21,696,492...21,696,571 		JBrowse link
G MIR181B-2 microRNA mir-181b-2 involved_in ISO (PMID:23993976) BHF-UCL PMID:23993976 NCBI chr 1:265,499,111...265,499,196
Ensembl chr 1:265,499,108...265,499,196 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:11,820,367...11,834,394
Ensembl chr 3:11,820,266...11,839,354 		JBrowse link
G OPRK1 opioid receptor kappa 1 ISO RGD PMID:16648139 RGD:9831415 NCBI chr 4:77,399,298...77,429,025
Ensembl chr 4:77,399,183...77,426,879 		JBrowse link
G PJA2 praja ring finger ubiquitin ligase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:114,319,972...114,675,761
Ensembl chr 2:114,319,991...114,558,272 		JBrowse link
G PRMT1 protein arginine methyltransferase 1 involved_in ISO PMID:23483889 BHF-UCL PMID:23483889 RGD:10047341 NCBI chr 6:54,718,845...54,730,411
Ensembl chr 6:54,714,157...54,732,574 		JBrowse link
G RELL1 RELT like 1 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:29,118,511...29,190,591
Ensembl chr 8:29,118,514...29,190,565 		JBrowse link
G RELL2 RELT like 2 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:143,287,507...143,291,683
Ensembl chr 2:143,288,004...143,293,031 		JBrowse link
G SASH1 SAM and SH3 domain containing 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23776175) MGI
Ensembl		 PMID:23776175 GO_REF:0000107 NCBI chr 1:17,306,364...17,663,117
Ensembl chr 1:17,306,373...17,511,672 		JBrowse link
G SPHK1 sphingosine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:5,114,946...5,122,580
Ensembl chr12:5,114,947...5,120,083 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in ISO (MGI:6478061|PMID:28912174) ARUK-UCL PMID:28912174 MGI:6478061 NCBI chr 2:15,227,850...15,245,679
Ensembl chr 2:15,227,881...15,245,677 		JBrowse link
G STK39 serine/threonine kinase 39 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:74,441,019...74,757,851
Ensembl chr15:74,447,787...74,758,122 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
G XDH xanthine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:93,541,334...93,551,200
Ensembl chr 6:93,541,334...93,551,193 		JBrowse link
regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162 		JBrowse link
G CAV3 caveolin 3 acts_upstream_of_or_within ISO (PMID:21182936) MGI PMID:21182936 NCBI chr13:65,117,868...65,130,886
Ensembl chr13:65,117,795...65,131,273 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,660...261,859,022 		JBrowse link
G HGF hepatocyte growth factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23994610) Ensembl
MGI		 PMID:23994610 GO_REF:0000107 NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564 		JBrowse link
G LGALS9 galectin 9 NOT|involved_in ISO (PMID:24465902) UniProt PMID:24465902 NCBI chr12:44,155,079...44,173,634 JBrowse link
G PER1 period circadian regulator 1 involved_in ISO PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chr12:53,361,863...53,376,723
Ensembl chr12:53,361,889...53,374,248 		JBrowse link
G PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:158,642,810...158,863,643
Ensembl chr 1:158,642,818...158,862,106 		JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 NOT|involved_in ISO (PMID:19933860) UniProt PMID:19933860 NCBI chr 1:132,702,495...132,786,536
Ensembl chr 1:132,702,541...132,786,532 		JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 NOT|involved_in ISO (MGI:5440106|PMID:23021218) UniProt PMID:23021218 MGI:5440106 NCBI chr14:41,125,819...41,169,582
Ensembl chr14:41,125,869...41,169,578 		JBrowse link
G ULK4 unc-51 like kinase 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24284070) MGI
Ensembl		 PMID:24284070 GO_REF:0000107 NCBI chr13:25,207,890...25,751,465
Ensembl chr13:25,209,368...25,751,500 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17806
    cellular process 16838
      signal transduction 6976
        intracellular signal transduction 2737
          intracellular signaling cassette 1933
            MAPK cascade 794
              p38MAPK cascade 70
                negative regulation of p38MAPK cascade 8
                positive regulation of p38MAPK cascade 37
                regulation of p38MAPK cascade + 54
Path 2
Term Annotations click to browse term
  biological_process 17806
    biological regulation 12907
      regulation of biological process 12540
        signaling 7520
          signal transduction 6976
            intracellular signal transduction 2737
              intracellular signaling cassette 1933
                MAPK cascade 794
                  p38MAPK cascade 70
                    negative regulation of p38MAPK cascade 8
                    positive regulation of p38MAPK cascade 37
                    regulation of p38MAPK cascade + 54
paths to the root