MFHAS1 (multifunctional ROCO family signaling regulator 1) - Rat Genome Database

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Gene: MFHAS1 (multifunctional ROCO family signaling regulator 1) Sus scrofa
Analyze
Symbol: MFHAS1
Name: multifunctional ROCO family signaling regulator 1
RGD ID: 14082041
Description: ENCODES a protein that exhibits GTP binding (inferred); nucleotide binding (inferred); protein phosphatase 2A binding (inferred); INVOLVED IN defense response (ortholog); regulation of toll-like receptor signaling pathway (ortholog); ASSOCIATED WITH fibrous histiocytoma (ortholog); myoepithelioma (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoskeleton (ortholog); lysosome (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: malignant fibrous histiocytoma amplified sequence 1; malignant fibrous histiocytoma-amplified sequence 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1556,200,455 - 56,295,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11556,200,455 - 56,296,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MFHAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1556,200,455 - 56,295,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11556,200,455 - 56,296,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MFHAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3888,783,354 - 8,893,630 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl88,783,354 - 8,893,630 (-)EnsemblGRCh38hg38GRCh38
GRCh3788,640,864 - 8,751,140 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3688,679,409 - 8,788,541 (-)NCBINCBI36Build 36hg18NCBI36
Build 3488,680,941 - 8,787,978NCBI
Celera87,770,247 - 7,879,341 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef87,566,885 - 7,675,726 (-)NCBIHuRef
CHM1_188,707,354 - 8,816,498 (-)NCBICHM1_1
T2T-CHM13v2.0810,850,500 - 10,960,846 (+)NCBIT2T-CHM13v2.0
Mfhas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39836,054,922 - 36,146,603 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl836,054,952 - 36,146,603 (+)EnsemblGRCm39 Ensembl
GRCm38835,587,789 - 35,679,449 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl835,587,798 - 35,679,449 (+)EnsemblGRCm38mm10GRCm38
MGSCv37836,650,852 - 36,742,503 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36837,056,315 - 37,147,966 (+)NCBIMGSCv36mm8
Celera838,233,298 - 38,323,358 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map821.16NCBI
Mfhas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81663,248,833 - 63,336,441 (-)NCBIGRCr8
mRatBN7.21656,545,462 - 56,633,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1656,546,207 - 56,633,743 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1661,871,278 - 61,951,249 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01665,285,260 - 65,365,229 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01660,505,245 - 60,585,208 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01660,120,457 - 60,208,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1660,128,201 - 60,208,462 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01659,795,263 - 59,882,664 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41660,251,500 - 60,330,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11660,258,856 - 60,330,906 (-)NCBI
Celera1654,605,099 - 54,684,103 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
Mfhas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554634,900,060 - 4,993,793 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554634,900,115 - 4,993,793 (-)NCBIChiLan1.0ChiLan1.0
MFHAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2725,239,514 - 25,349,559 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan181,266,572 - 1,376,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0810,318,455 - 10,428,469 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MFHAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11635,579,531 - 35,676,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1635,579,585 - 35,674,063 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1636,043,903 - 36,140,864 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01637,611,966 - 37,715,247 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1637,611,037 - 37,724,094 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11635,717,994 - 35,814,591 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01636,280,244 - 36,377,395 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01636,399,273 - 36,496,290 (+)NCBIUU_Cfam_GSD_1.0
Mfhas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494343,482,035 - 43,574,638 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365731,567,798 - 1,662,442 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFHAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1810,158,951 - 10,268,286 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl810,159,421 - 10,268,323 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605232,127,152 - 32,236,483 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfhas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248394,908,639 - 5,000,677 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248394,908,861 - 5,000,218 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MFHAS1
1489 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000039578   ⟹   ENSSSCP00000044251
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1556,200,455 - 56,295,064 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000043858   ⟹   ENSSSCP00000032296
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1556,200,454 - 56,295,091 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000061461   ⟹   ENSSSCP00000035291
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1556,200,396 - 56,293,520 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000085870   ⟹   ENSSSCP00000066039
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1556,200,045 - 56,243,617 (+)Ensembl
RefSeq Acc Id: XM_021075967   ⟹   XP_020931626
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11556,200,455 - 56,296,151 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002339374
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11556,200,900 - 56,296,151 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002339375
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11556,200,900 - 56,282,457 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002339376
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11556,200,900 - 56,296,151 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020931626   ⟸   XM_021075967
- UniProtKB: A0A287AK26 (UniProtKB/TrEMBL),   A0A4X1VT11 (UniProtKB/TrEMBL),   A0A8D1MHN3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000044251   ⟸   ENSSSCT00000039578
Ensembl Acc Id: ENSSSCP00000035291   ⟸   ENSSSCT00000061461
Ensembl Acc Id: ENSSSCP00000066039   ⟸   ENSSSCT00000085870
Ensembl Acc Id: ENSSSCP00000032296   ⟸   ENSSSCT00000043858
Protein Domains
Roc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035366 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025007678 UniProtKB/TrEMBL
  ENSSSCG00045014061 UniProtKB/TrEMBL
  ENSSSCG00050040963 UniProtKB/TrEMBL
  ENSSSCG00055021647 UniProtKB/TrEMBL
  ENSSSCG00070026497 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000039578 ENTREZGENE
  ENSSSCT00000039578.3 UniProtKB/TrEMBL
  ENSSSCT00025010200.1 UniProtKB/TrEMBL
  ENSSSCT00025010203.1 UniProtKB/TrEMBL
  ENSSSCT00025010210.1 UniProtKB/TrEMBL
  ENSSSCT00045023939.1 UniProtKB/TrEMBL
  ENSSSCT00045023953.1 UniProtKB/TrEMBL
  ENSSSCT00045023968.1 UniProtKB/TrEMBL
  ENSSSCT00050055496.1 UniProtKB/TrEMBL
  ENSSSCT00055042525.1 UniProtKB/TrEMBL
  ENSSSCT00055042575.1 UniProtKB/TrEMBL
  ENSSSCT00055042642.1 UniProtKB/TrEMBL
  ENSSSCT00070053107.1 UniProtKB/TrEMBL
  ENSSSCT00070053108.1 UniProtKB/TrEMBL
  ENSSSCT00070053109.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRR_domain-containing UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  ROC_dom UniProtKB/TrEMBL
NCBI Gene MFHAS1 ENTREZGENE
PANTHER MALIGNANT FIBROUS HISTIOCYTOMA-AMPLIFIED SEQUENCE 1 HOMOLOG UniProtKB/TrEMBL
  PTHR48051 UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  Roc UniProtKB/TrEMBL
PRINTS LEURICHRPT UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  ROC UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  Polo-box domain UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A287AK26 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VSF9_PIG UniProtKB/TrEMBL
  A0A4X1VT11 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VUU9_PIG UniProtKB/TrEMBL
  A0A8D1MHN3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:107361 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-31 MFHAS1  multifunctional ROCO family signaling regulator 1  MFHAS1  malignant fibrous histiocytoma amplified sequence 1  Symbol and/or name change 19259463 PROVISIONAL