TRPV4 (transient receptor potential cation channel subfamily V member 4) - Rat Genome Database

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Gene: TRPV4 (transient receptor potential cation channel subfamily V member 4) Sus scrofa
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Symbol: TRPV4
Name: transient receptor potential cation channel subfamily V member 4
RGD ID: 13967072
Description: ENCODES a protein that exhibits calcium channel activity; actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN actin filament organization; ATP export; ATP transport; ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy (ortholog); bone development disease (ortholog); bone disease (ortholog); FOUND IN apical plasma membrane; cilium; plasma membrane
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,125,869 - 41,169,582 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,125,819 - 41,169,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,641,455 - 43,683,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
actin filament organization  (IBA,IMP)
ATP export  (IMP)
ATP transport  (IMP)
blood vessel endothelial cell delamination  (IEA)
calcium ion import  (ISO)
calcium ion import across plasma membrane  (IBA,IMP)
calcium ion import into cytosol  (IEA)
calcium ion transmembrane transport  (IEA,IMP)
calcium ion transport  (ISO)
cartilage development involved in endochondral bone morphogenesis  (IEA)
cartilage homeostasis  (IMP)
cell-cell junction assembly  (IEA)
cellular calcium ion homeostasis  (ISO)
cellular hypotonic response  (IMP)
cellular hypotonic salinity response  (IEA)
cellular response to heat  (IEA)
cellular response to osmotic stress  (ISO)
cortical microtubule organization  (ISO)
diet induced thermogenesis  (IEA)
energy homeostasis  (IEA)
glucose homeostasis  (IEA)
hyperosmotic salinity response  (IEA,ISO)
hypotonic response  (ISO)
ion transmembrane transport  (IEA)
microtubule polymerization  (ISO)
multicellular organismal water homeostasis  (IEA)
negative regulation of brown fat cell differentiation  (IEA)
negative regulation of cell volume  (IMP)
negative regulation of neuron projection development  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
osmosensory signaling pathway  (IBA,IEA,ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (IEA)
positive regulation of chemokine (C-X-C motif) ligand 1 production  (IEA)
positive regulation of cytosolic calcium ion concentration  (IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of intracellular protein transport  (IMP)
positive regulation of JNK cascade  (IEA)
positive regulation of macrophage chemotaxis  (IEA)
positive regulation of macrophage inflammatory protein 1 alpha production  (IEA)
positive regulation of membrane hyperpolarization  (IMP)
positive regulation of microtubule depolymerization  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA)
positive regulation of P-type sodium:potassium-exchanging transporter activity  (IMP)
positive regulation of prostaglandin secretion  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of protein tyrosine kinase activity  (IMP)
positive regulation of striated muscle contraction  (ISO)
positive regulation of vascular permeability  (IEA)
regulation of aerobic respiration  (IEA)
regulation of blood pressure  (ISO)
regulation of heart rate  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of response to osmotic stress  (IEA,ISO)
relaxation of vascular associated smooth muscle  (IMP)
response to fatty acid  (ISO)
response to insulin  (IEA)
response to lipopolysaccharide  (ISO)
response to osmotic stress  (ISO)
vasopressin secretion  (IEA,ISO)

References
Additional References at PubMed
PMID:17613724   PMID:19790068   PMID:22492652   PMID:25681460   PMID:28768667  


Genomics

Comparative Map Data
TRPV4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,125,869 - 41,169,582 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,125,819 - 41,169,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,641,455 - 43,683,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRPV4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12109,783,087 - 109,833,406 (-)EnsemblGRCh38hg38GRCh38
GRCh3812109,783,087 - 109,833,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712110,220,892 - 110,271,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,705,277 - 108,755,595 (-)NCBINCBI36hg18NCBI36
Celera12109,845,179 - 109,895,568 (-)NCBI
Cytogenetic Map12q24.11NCBI
HuRef12107,237,035 - 107,287,147 (-)NCBIHuRef
CHM1_112110,188,702 - 110,239,020 (-)NCBICHM1_1
Trpv4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,760,213 - 114,796,497 (-)NCBIGRCm39mm39
GRCm39 Ensembl5114,760,213 - 114,796,482 (-)Ensembl
GRCm385114,622,152 - 114,658,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,622,152 - 114,658,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,072,163 - 115,108,430 (-)NCBIGRCm37mm9NCBIm37
MGSCv365114,883,153 - 114,919,388 (-)NCBImm8
Celera5111,719,696 - 111,755,858 (-)NCBICelera
Cytogenetic Map5FNCBI
Trpv4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21241,938,533 - 41,977,517 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1247,698,947 - 47,737,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01247,698,915 - 47,737,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01249,492,064 - 49,529,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,226,933 - 43,265,889 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11243,090,320 - 43,129,277 (+)NCBI
Celera1243,552,408 - 43,590,250 (+)NCBICelera
Cytogenetic Map12q16NCBI
Trpv4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,744,176 - 8,783,741 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,744,865 - 8,781,644 (+)NCBIChiLan1.0ChiLan1.0
TRPV4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112110,754,238 - 110,786,182 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,754,238 - 110,786,182 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012107,359,005 - 107,409,359 (-)NCBIMhudiblu_PPA_v0panPan3
TRPV4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,293,334 - 17,330,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,262,100 - 17,330,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,472,505 - 18,493,002 (-)NCBI
ROS_Cfam_1.02617,652,672 - 17,673,399 (+)NCBI
UMICH_Zoey_3.12618,683,516 - 18,704,163 (-)NCBI
UNSW_CanFamBas_1.02617,643,537 - 17,664,298 (+)NCBI
UU_Cfam_GSD_1.02617,660,529 - 17,681,097 (+)NCBI
Trpv4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,028,138 - 144,051,340 (+)NCBI
SpeTri2.0NW_0049367691,424,526 - 1,447,547 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPV4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,020,972 - 105,072,660 (-)NCBI
Vero_WHO_p1.0NW_023666037140,046,822 - 140,098,634 (+)NCBI
Trpv4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474710,675,625 - 10,685,351 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1
Low 3 1 1 1 1 1
Below cutoff 6 3 2 2 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010881   ⟹   ENSSSCP00000010596
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1441,125,869 - 41,169,582 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000070051   ⟹   ENSSSCP00000069553
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1441,125,869 - 41,169,582 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081350   ⟹   ENSSSCP00000062968
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1441,125,873 - 41,169,476 (+)Ensembl
RefSeq Acc Id: NM_001130729   ⟹   NP_001124201
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11441,143,114 - 41,167,251 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013982949   ⟹   XP_013838403
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11441,125,820 - 41,169,582 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071776   ⟹   XP_020927435
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11441,125,819 - 41,169,582 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001124201 (Get FASTA)   NCBI Sequence Viewer  
  XP_013838403 (Get FASTA)   NCBI Sequence Viewer  
  XP_020927435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACF05802 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020927435   ⟸   XM_021071776
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013838403   ⟸   XM_013982949
- Peptide Label: isoform X1
- UniProtKB: F1RIT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001124201   ⟸   NM_001130729
- UniProtKB: B3VP30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000010596   ⟸   ENSSSCT00000010881
RefSeq Acc Id: ENSSSCP00000069553   ⟸   ENSSSCT00000070051
RefSeq Acc Id: ENSSSCP00000062968   ⟸   ENSSSCT00000081350
Protein Domains
ANK_REP_REGION   Ion_trans


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009929 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070005670 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010596 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000062968 UniProtKB/TrEMBL
  ENSSSCP00000069553 UniProtKB/TrEMBL
  ENSSSCP00070008949 UniProtKB/TrEMBL
  ENSSSCP00070008964 UniProtKB/TrEMBL
  ENSSSCP00070008976 UniProtKB/TrEMBL
  ENSSSCP00070008980 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010881 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000070051 UniProtKB/TrEMBL
  ENSSSCT00000081350 UniProtKB/TrEMBL
  ENSSSCT00070010866 UniProtKB/TrEMBL
  ENSSSCT00070010883 UniProtKB/TrEMBL
  ENSSSCT00070010896 UniProtKB/TrEMBL
  ENSSSCT00070010901 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  TRPV UniProtKB/TrEMBL
  TRPV1-4_channel UniProtKB/TrEMBL
  TRPV4_channel UniProtKB/TrEMBL
KEGG Report ssc:100126845 UniProtKB/TrEMBL
NCBI Gene TRPV4 ENTREZGENE
PANTHER PTHR10582 UniProtKB/TrEMBL
  PTHR10582:SF4 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
PRINTS TRPVRECEPTOR UniProtKB/TrEMBL
  VRL2RECEPTOR UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A480JHA1_PIG UniProtKB/TrEMBL
  A0A4X1T020_PIG UniProtKB/TrEMBL
  A0A4X1T150_PIG UniProtKB/TrEMBL
  A0A4X1T1Y5_PIG UniProtKB/TrEMBL
  A0A4X1T2E0_PIG UniProtKB/TrEMBL
  A0A5G2QGN2_PIG UniProtKB/TrEMBL
  A0A5G2QZJ1_PIG UniProtKB/TrEMBL
  B3VP30 ENTREZGENE, UniProtKB/TrEMBL
  F1RIT1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:94476 ENTREZGENE