TRPV4 (transient receptor potential cation channel subfamily V member 4) - Rat Genome Database

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Gene: TRPV4 (transient receptor potential cation channel subfamily V member 4) Sus scrofa
Analyze
Symbol: TRPV4
Name: transient receptor potential cation channel subfamily V member 4
RGD ID: 13967072
Description: ENCODES a protein that exhibits calcium channel activity; actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN actin filament organization; ATP export; ATP transport; ASSOCIATED WITH 2-aminoadipic 2-oxoadipic aciduria (ortholog); amyotrophic lateral sclerosis type 5 (ortholog); Auditory Neuropathy (ortholog); FOUND IN apical plasma membrane; cilium; plasma membrane; INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,125,869 - 41,169,578 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,125,819 - 41,169,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,641,455 - 43,683,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
2-aminoadipic 2-oxoadipic aciduria  (ISO)
amyotrophic lateral sclerosis type 5  (ISO)
Auditory Neuropathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy 14  (ISO)
autosomal dominant distal hereditary motor neuronopathy 8  (ISO)
autosomal dominant nonsyndromic deafness 25  (ISO)
bone disease  (ISO)
brachyolmia  (ISO)
Brachyolmia Type 2  (ISO)
Brachyolmia Type 3  (ISO)
cerebral creatine deficiency syndrome 1  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease axonal type 2C  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
chronic obstructive pulmonary disease  (ISO)
clubfoot  (ISO)
connective tissue disease  (ISO)
Digital Arthropathy-Brachydactyly, Familial  (ISO)
Femur Head Necrosis  (ISO)
genetic disease  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
Hyponatremia  (ISO)
metatropic dysplasia  (ISO)
myoepithelioma  (ISO)
neuromuscular disease  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
parastremmatic dwarfism  (ISO)
pulmonary hypertension  (ISO)
scapuloperoneal spinal muscular atrophy  (ISO)
Skeletal Dysplasia And Progressive Central Nervous System Degeneration, Lethal  (ISO)
spinal muscular atrophy  (ISO)
spinocerebellar ataxia with axonal neuropathy 2  (ISO)
spondyloepimetaphyseal dysplasia, Strudwick type  (ISO)
spondyloepiphyseal dysplasia Maroteaux type  (ISO)
spondylometaphyseal dysplasia  (ISO)
spondylometaphyseal dysplasia Kozlowski type  (ISO)
Urination Disorders  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament organization  (IMP)
ATP export  (IMP)
ATP transport  (IMP)
blood vessel endothelial cell delamination  (IEA)
calcium ion import  (IEA)
calcium ion import across plasma membrane  (IMP)
calcium ion import into cytosol  (IEA)
calcium ion transmembrane transport  (IEA,IMP)
calcium ion transport  (IEA)
cartilage development involved in endochondral bone morphogenesis  (IEA)
cartilage homeostasis  (IMP)
cell-cell junction assembly  (IEA)
cellular hypotonic response  (IEA,IMP)
cellular hypotonic salinity response  (IEA)
cellular response to heat  (IEA)
cellular response to osmotic stress  (IEA)
cortical microtubule organization  (ISO)
diet induced thermogenesis  (IEA)
energy homeostasis  (IEA)
glucose homeostasis  (IEA)
hyperosmotic salinity response  (IEA,ISO)
hypotonic response  (ISO)
intracellular calcium ion homeostasis  (IEA)
microtubule polymerization  (ISO)
monoatomic ion transport  (IEA)
multicellular organismal-level water homeostasis  (IEA)
negative regulation of brown fat cell differentiation  (IEA)
negative regulation of cell volume  (IMP)
negative regulation of neuron projection development  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
osmosensory signaling pathway  (IEA,ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (IEA)
positive regulation of chemokine (C-X-C motif) ligand 1 production  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA,IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of intracellular protein transport  (IMP)
positive regulation of JNK cascade  (IEA)
positive regulation of macrophage chemotaxis  (IEA)
positive regulation of macrophage inflammatory protein 1 alpha production  (IEA)
positive regulation of membrane hyperpolarization  (IMP)
positive regulation of microtubule depolymerization  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA)
positive regulation of P-type sodium:potassium-exchanging transporter activity  (IMP)
positive regulation of prostaglandin secretion  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of protein tyrosine kinase activity  (IMP)
positive regulation of striated muscle contraction  (ISO)
positive regulation of vascular permeability  (IEA)
regulation of aerobic respiration  (IEA)
regulation of blood pressure  (ISO)
regulation of heart rate  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of response to osmotic stress  (IEA,ISO)
relaxation of vascular associated smooth muscle  (IMP)
response to fatty acid  (ISO)
response to hypoxia  (ISO)
response to insulin  (IEA)
response to lipopolysaccharide  (ISO)
response to osmotic stress  (IEA,ISO)
transmembrane transport  (IEA)
vasopressin secretion  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:17613724   PMID:19790068   PMID:22301074   PMID:22492652   PMID:25681460   PMID:28768667   PMID:30032202   PMID:35385164   PMID:38959010  


Genomics

Comparative Map Data
TRPV4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,125,869 - 41,169,578 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,125,819 - 41,169,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,641,455 - 43,683,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRPV4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812109,783,087 - 109,833,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12109,783,087 - 109,833,406 (-)EnsemblGRCh38hg38GRCh38
GRCh3712110,220,892 - 110,271,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,705,277 - 108,755,595 (-)NCBINCBI36Build 36hg18NCBI36
Celera12109,845,179 - 109,895,568 (-)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12107,237,035 - 107,287,147 (-)NCBIHuRef
CHM1_112110,188,702 - 110,239,020 (-)NCBICHM1_1
T2T-CHM13v2.012109,758,559 - 109,808,862 (-)NCBIT2T-CHM13v2.0
Trpv4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,760,213 - 114,796,497 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,760,213 - 114,796,482 (-)EnsemblGRCm39 Ensembl
GRCm385114,622,152 - 114,658,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,622,152 - 114,658,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,072,163 - 115,108,430 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,883,153 - 114,919,388 (-)NCBIMGSCv36mm8
Celera5111,719,696 - 111,755,858 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
Trpv4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,599,161 - 47,638,143 (+)NCBIGRCr8
mRatBN7.21241,938,533 - 41,977,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,938,560 - 41,977,517 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,106,237 - 43,144,888 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,719,815 - 43,758,467 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,780,312 - 42,818,968 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,698,915 - 47,737,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,698,947 - 47,737,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,492,064 - 49,529,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,226,933 - 43,265,889 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,090,320 - 43,129,277 (+)NCBI
Celera1243,552,408 - 43,590,250 (+)NCBICelera
Cytogenetic Map12q16NCBI
Trpv4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,744,176 - 8,783,741 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,744,865 - 8,781,644 (+)NCBIChiLan1.0ChiLan1.0
TRPV4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210117,849,960 - 117,900,314 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112117,846,362 - 117,896,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012107,359,005 - 107,409,359 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112110,754,238 - 110,786,182 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,754,238 - 110,786,182 (-)Ensemblpanpan1.1panPan2
TRPV4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,293,334 - 17,330,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,262,100 - 17,330,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,472,505 - 18,493,002 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02617,652,672 - 17,673,399 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2617,652,672 - 17,673,984 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12618,683,516 - 18,704,163 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02617,643,537 - 17,664,298 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02617,660,529 - 17,681,097 (+)NCBIUU_Cfam_GSD_1.0
Trpv4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,028,138 - 144,051,340 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367691,424,549 - 1,447,516 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367691,424,526 - 1,447,547 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPV4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,020,972 - 105,072,660 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037140,046,822 - 140,098,634 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpv4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474710,675,625 - 10,685,351 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TRPV4
1031 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 3 3 3 3 10 7 3 3 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000010881   ⟹   ENSSSCP00000010596
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1441,125,869 - 41,169,578 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000070051   ⟹   ENSSSCP00000069553
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1441,125,904 - 41,167,785 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000081350   ⟹   ENSSSCP00000062968
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1441,125,904 - 41,167,785 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000100739   ⟹   ENSSSCP00000080453
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1441,143,114 - 41,167,785 (+)Ensembl
RefSeq Acc Id: NM_001130729   ⟹   NP_001124201
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11441,143,114 - 41,167,251 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013982949   ⟹   XP_013838403
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11441,125,820 - 41,169,582 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071776   ⟹   XP_020927435
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11441,125,819 - 41,169,582 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020927435   ⟸   XM_021071776
- Peptide Label: isoform X2
- UniProtKB: A0A8D0M1P4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013838403   ⟸   XM_013982949
- Peptide Label: isoform X1
- UniProtKB: A0A4X1T2E0 (UniProtKB/TrEMBL),   A0A5G2QGN2 (UniProtKB/TrEMBL),   A0A480JHA1 (UniProtKB/TrEMBL),   A0A8D0M1P4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001124201   ⟸   NM_001130729
- UniProtKB: B3VP30 (UniProtKB/TrEMBL),   A0A8D0M1P4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000010596   ⟸   ENSSSCT00000010881
Ensembl Acc Id: ENSSSCP00000069553   ⟸   ENSSSCT00000070051
Ensembl Acc Id: ENSSSCP00000062968   ⟸   ENSSSCT00000081350
Ensembl Acc Id: ENSSSCP00000080453   ⟸   ENSSSCT00000100739
Protein Domains
Ion transport


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009929 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015055840 UniProtKB/TrEMBL
  ENSSSCG00025037309 UniProtKB/TrEMBL
  ENSSSCG00030010529 UniProtKB/TrEMBL
  ENSSSCG00035065916 UniProtKB/TrEMBL
  ENSSSCG00040003662 UniProtKB/TrEMBL
  ENSSSCG00050062256 UniProtKB/TrEMBL
  ENSSSCG00060028142 UniProtKB/TrEMBL
  ENSSSCG00065076602 UniProtKB/TrEMBL
  ENSSSCG00070005670 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010881 ENTREZGENE
  ENSSSCT00000010881.5 UniProtKB/TrEMBL
  ENSSSCT00000070051.2 UniProtKB/TrEMBL
  ENSSSCT00000081350 ENTREZGENE
  ENSSSCT00000081350.2 UniProtKB/TrEMBL
  ENSSSCT00000100739.1 UniProtKB/TrEMBL
  ENSSSCT00015075520.1 UniProtKB/TrEMBL
  ENSSSCT00025050937.1 UniProtKB/TrEMBL
  ENSSSCT00030014479.1 UniProtKB/TrEMBL
  ENSSSCT00035088927.1 UniProtKB/TrEMBL
  ENSSSCT00040004676.1 UniProtKB/TrEMBL
  ENSSSCT00050084833.1 UniProtKB/TrEMBL
  ENSSSCT00060038096.1 UniProtKB/TrEMBL
  ENSSSCT00065105880.1 UniProtKB/TrEMBL
  ENSSSCT00070010866.1 UniProtKB/TrEMBL
  ENSSSCT00070010883.1 UniProtKB/TrEMBL
  ENSSSCT00070010896.1 UniProtKB/TrEMBL
  ENSSSCT00070010901.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  TRPV UniProtKB/TrEMBL
  TRPV1-4_channel UniProtKB/TrEMBL
  TRPV4_channel UniProtKB/TrEMBL
KEGG Report ssc:100126845 UniProtKB/TrEMBL
NCBI Gene TRPV4 ENTREZGENE
PANTHER PTHR10582 UniProtKB/TrEMBL
  PTHR10582:SF4 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
PRINTS TRPVRECEPTOR UniProtKB/TrEMBL
  VRL2RECEPTOR UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A480JHA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T020_PIG UniProtKB/TrEMBL
  A0A4X1T150_PIG UniProtKB/TrEMBL
  A0A4X1T1Y5_PIG UniProtKB/TrEMBL
  A0A4X1T2E0 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QGN2 ENTREZGENE
  A0A5G2QZJ1_PIG UniProtKB/TrEMBL
  A0A8D0M1P4 ENTREZGENE
  A0A8W4FMN3_PIG UniProtKB/TrEMBL
  B3VP30 ENTREZGENE, UniProtKB/TrEMBL
  F1RIT1_PIG UniProtKB/TrEMBL
UniProt Secondary A0A5G2QGN2 UniProtKB/TrEMBL
VGNC ID VGNC:94476 ENTREZGENE