SPI1 (Spi-1 proto-oncogene) - Rat Genome Database

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Gene: SPI1 (Spi-1 proto-oncogene) Sus scrofa
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Symbol: SPI1
Name: Spi-1 proto-oncogene
RGD ID: 13869338
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN anatomical structure regression (ortholog); apoptotic process involved in blood vessel morphogenesis (ortholog); cellular response to ethanol (ortholog); PARTICIPATES IN DNA modification pathway; interleukin-4 signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); alcohol use disorder (ortholog); congenital disorder of glycosylation type IIc (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: PU.1; spleen focus forming virus (SFFV) proviral integration oncogene spi1; transcription factor PU.1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,227,829 - 15,245,667 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,227,850 - 15,245,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,434,712 - 16,452,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure regression  (IEA,ISO)
apoptotic process involved in blood vessel morphogenesis  (IEA,ISO)
cell differentiation  (IBA)
cellular response to ethanol  (ISO)
defense response to tumor cell  (IEA)
endothelial to hematopoietic transition  (IEA,ISO)
erythrocyte differentiation  (IEA,ISO)
follicular B cell differentiation  (IEA)
germinal center B cell differentiation  (IEA)
granulocyte differentiation  (IEA,ISO)
histone H3 acetylation  (IEA)
hypermethylation of CpG island  (IEA)
immature B cell differentiation  (IEA)
interleukin-6-mediated signaling pathway  (IEA)
lipopolysaccharide-mediated signaling pathway  (IEA)
lymphocyte differentiation  (ISO)
lymphoid progenitor cell differentiation  (ISO)
macrophage differentiation  (IEA,ISO)
myeloid dendritic cell differentiation  (IEA,ISO)
myeloid leukocyte differentiation  (ISO)
negative regulation of adipose tissue development  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of gene expression, epigenetic  (IEA)
negative regulation of histone H4 acetylation  (IEA)
negative regulation of MHC class II biosynthetic process  (IEA)
negative regulation of neutrophil degranulation  (IEA)
negative regulation of NF-kappaB transcription factor activity  (IEA)
negative regulation of NIK/NF-kappaB signaling  (IEA)
negative regulation of protein localization to chromatin  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription, DNA-templated  (ISO)
obsolete chromatin organization involved in regulation of transcription  (IEA)
oncogene-induced cell senescence  (IEA)
pericyte cell differentiation  (IEA)
positive regulation of antifungal innate immune response  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of microglial cell mediated cytotoxicity  (IEA)
positive regulation of myeloid dendritic cell chemotaxis  (IEA)
positive regulation of p38MAPK cascade  (IEA)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
pro-T cell differentiation  (IEA)
regulation of DNA-binding transcription factor activity  (ISO)
regulation of erythrocyte differentiation  (IEA)
regulation of histone H3-K27 acetylation  (IEA)
regulation of myeloid progenitor cell differentiation  (IEA)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of transcription, DNA-templated  (ISO)
somatic stem cell population maintenance  (IEA,ISO)
TRAIL-activated apoptotic signaling pathway  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IEA)
vasculature development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15922520   PMID:17145712   PMID:25691151  


Genomics

Comparative Map Data
SPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,227,829 - 15,245,667 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,227,850 - 15,245,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,434,712 - 16,452,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1147,354,860 - 47,378,547 (-)EnsemblGRCh38hg38GRCh38
GRCh381147,354,859 - 47,395,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371147,376,411 - 47,400,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,332,985 - 47,356,703 (-)NCBINCBI36hg18NCBI36
Build 341147,332,987 - 47,356,674NCBI
Celera1147,515,686 - 47,541,505 (-)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1147,075,532 - 47,099,721 (-)NCBIHuRef
CHM1_11147,375,652 - 47,399,367 (-)NCBICHM1_1
Spi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,912,750 - 90,946,104 (+)NCBIGRCm39mm39
GRCm39 Ensembl290,912,735 - 90,946,101 (+)Ensembl
GRCm38291,082,374 - 91,115,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,082,390 - 91,115,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,936,954 - 90,955,913 (+)NCBIGRCm37mm9NCBIm37
MGSCv36290,897,636 - 90,916,595 (+)NCBImm8
Celera292,481,297 - 92,500,928 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Spi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,059,744 - 77,093,730 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)Ensembl
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
Spi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422873,735 - 886,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422873,735 - 886,560 (+)NCBIChiLan1.0ChiLan1.0
SPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11147,853,991 - 47,880,259 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,853,991 - 47,880,259 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01147,301,245 - 47,326,891 (-)NCBIMhudiblu_PPA_v0panPan3
SPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,253,849 - 42,269,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,253,811 - 42,269,727 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,983,530 - 40,999,141 (+)NCBI
ROS_Cfam_1.01842,908,919 - 42,924,536 (+)NCBI
UMICH_Zoey_3.11842,395,271 - 42,410,877 (+)NCBI
UNSW_CanFamBas_1.01841,950,490 - 41,966,095 (+)NCBI
UU_Cfam_GSD_1.01842,679,725 - 42,695,395 (+)NCBI
Spi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBI
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,935,037 - 17,961,638 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl117,935,922 - 17,961,717 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038115,237,583 - 115,263,142 (+)NCBIVero_WHO_p1.0
Spi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 5 2 3
Low 7 2 3 2 21 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014457   ⟹   ENSSSCP00000014065
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,227,829 - 15,245,667 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000077556   ⟹   ENSSSCP00000073995
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,230,290 - 15,245,667 (+)Ensembl
RefSeq Acc Id: NM_001001865   ⟹   NP_001001865
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,227,931 - 15,245,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005660921   ⟹   XP_005660978
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,227,850 - 15,245,679 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001001865 (Get FASTA)   NCBI Sequence Viewer  
  XP_005660978 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT00590 (Get FASTA)   NCBI Sequence Viewer  
  Q6PKU1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005660978   ⟸   XM_005660921
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001001865   ⟸   NM_001001865
- UniProtKB: Q6PKU1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000073995   ⟸   ENSSSCT00000077556
RefSeq Acc Id: ENSSSCP00000014065   ⟸   ENSSSCT00000014457
Protein Domains
ETS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013237 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070026013 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014065 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000073995 UniProtKB/TrEMBL
  ENSSSCP00070044048 UniProtKB/TrEMBL
  ENSSSCP00070044059 UniProtKB/TrEMBL
  ENSSSCP00070044060 UniProtKB/TrEMBL
  ENSSSCP00070044064 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014457 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000077556 UniProtKB/TrEMBL
  ENSSSCT00070052058 UniProtKB/TrEMBL
  ENSSSCT00070052077 UniProtKB/TrEMBL
  ENSSSCT00070052078 UniProtKB/TrEMBL
  ENSSSCT00070052082 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ets_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:414912 UniProtKB/Swiss-Prot
NCBI Gene SPI1 ENTREZGENE
Pfam Ets UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ETSDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ETS_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETS_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ETS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1VKN7_PIG UniProtKB/TrEMBL
  A0A4X1VKP4_PIG UniProtKB/TrEMBL
  A0A4X1VPR8_PIG UniProtKB/TrEMBL
  A0A4X1VR90_PIG UniProtKB/TrEMBL
  A0A5G2RMU7_PIG UniProtKB/TrEMBL
  F1SID6_PIG UniProtKB/TrEMBL
  Q6PKU1 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:98335 ENTREZGENE