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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrapyrrole biosynthetic process
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Accession:GO:0033014 term browser browse the term
Definition:The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Synonyms:exact_synonym: tetrapyrrole anabolism;   tetrapyrrole biosynthesis;   tetrapyrrole formation;   tetrapyrrole synthesis


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tetrapyrrole biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase IDA
IMP
RGD PMID:9344466, PMID:12127573, PMID:6712591, PMID:18760440 RGD:2301695, RGD:2301691, RGD:2301704, RGD:2301858 NCBI chr 8:44,673,554...44,680,950 JBrowse link
heme A biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in
acts_upstream_of_or_within
ISO (PMID:12928484)
(MGI:3604933|PMID:16103131), (MGI:3640032|PMID:16782876)
RGD PMID:12928484 PMID:16103131 PMID:16782876 MGI:3604933 MGI:3640032 NCBI chr10:48,630,993...48,742,835 JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 involved_in ISO
IBA
UniProtKB:Q7KZN9-1 (PMID:12474143)
PMID:21873635
RGD PMID:12474143, PMID:21873635 RGD:13792537 NCBI chr 1:242,605,588...242,622,279 JBrowse link
heme B biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 NOT|involved_in ISO (PMID:22655043) RGD PMID:22655043 NCBI chr 9:76,668,554...76,677,263 JBrowse link
heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO (MGI:5648801|PMID:24421385) RGD PMID:24421385 MGI:5648801 NCBI chr19:51,952,655...51,982,910 JBrowse link
G Alad aminolevulinate dehydratase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
ISS
(MGI:53493|PMID:4959158), (MGI:53609|PMID:4981581), (MGI:63121|PMID:14050799)
(PMID:11032836)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:4959158 PMID:4981581 PMID:11032836 PMID:14050799, PMID:1764448, PMID:21873635 GO_REF:0000024 MGI:53493 MGI:53609 MGI:63121, RGD:1599020, RGD:13792537 NCBI chr 5:75,961,993...75,972,334 JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:106,876,514...106,889,852 JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:3694153|PMID:9446639)
PMID:21873635
UniProt
RGD
PMID:9446639, PMID:21873635 GO_REF:0000024 MGI:3694153, RGD:13792537 NCBI chr  X:19,463,146...19,486,526 JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:5447588|PMID:23135403)
GO_REF:0000024
(PMID:23135403)
RGD
UniProt
PMID:23135403, PMID:21873635 GO_REF:0000024 MGI:5447588, RGD:13792537 NCBI chr 5:144,738,950...144,742,668 JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:48,630,993...48,742,835 JBrowse link
G Cpox coproporphyrinogen oxidase acts_upstream_of_or_within IDA
ISO
(MGI:77569|PMID:8407975) RGD PMID:8407975, PMID:3955059 MGI:77569, RGD:1600961 NCBI chr11:41,936,585...41,946,568 JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
MGI:1858114|MGI:2384729 (MGI:1327758|PMID:9989256), (MGI:3620268|PMID:16503645), (MGI:3696634|PMID:15496139), (MGI:3794459|PMID:16306232), (MGI:79136|PMID:8611576)
PMID:21873635
(PMID:27599036)
RGD PMID:8611576 PMID:9989256 PMID:15496139 PMID:16306232 PMID:16503645 PMID:27599036, PMID:3955059, PMID:21873635 MGI:1327758 MGI:3620268 MGI:3696634 MGI:3794459 MGI:79136, RGD:1600961, RGD:13792537 NCBI chr18:57,945,123...57,978,327 JBrowse link
G Fxn frataxin involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:221,874,007...221,897,841 JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IBA
ISO
PMID:21873635
(PMID:18936296)
RGD PMID:18936296, PMID:21873635 RGD:13792537 NCBI chr 8:44,673,554...44,680,950 JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO MGI:2384429 (MGI:1352605|PMID:10617683) RGD PMID:10617683 MGI:1352605 NCBI chr12:41,638,536...41,672,806 JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 involved_in ISO
ISS
IEA
(PMID:27599036)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:27599036 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:115,832,865...115,841,060 JBrowse link
G Ppox protoporphyrinogen oxidase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:3687447|PMID:3346226)
(PMID:7713909)
PMID:21873635
RGD PMID:3346226 PMID:7713909, PMID:3955059, PMID:21873635 MGI:3687447, RGD:1600961, RGD:13792537 NCBI chr13:83,697,661...83,701,998 JBrowse link
G Slc11a2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856400 (MGI:3691553|PMID:11739192)
Ensembl
RGD
PMID:11739192 GO_REF:0000107 MGI:3691553 NCBI chr 7:131,503,076...131,540,246 JBrowse link
G Slc25a39 solute carrier family 25, member 39 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:87,362,494...87,367,358 JBrowse link
G Tmem14c transmembrane protein 14C involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:23,733,769...23,739,906 JBrowse link
G Urod uroporphyrinogen decarboxylase acts_upstream_of_or_within
involved_in
NAS
ISO
IBA
IC
MGI:2687172 (MGI:3703836|PMID:17360334)
PMID:21873635
RGD PMID:17360334, PMID:3658690, PMID:21873635, PMID:15736160 MGI:3703836, RGD:70052, RGD:13792537, RGD:2301379 NCBI chr 5:130,464,695...130,468,783 JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO
IBA
(PMID:3805019)
PMID:21873635
RGD PMID:3805019, PMID:21873635 RGD:13792537 NCBI chr 1:188,490,832...188,513,659 JBrowse link
heme O biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:48,630,993...48,742,835 JBrowse link
porphyrin-containing compound biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 involved_in ISO (PMID:17006453) RGD PMID:17006453 NCBI chr 9:76,668,554...76,677,263 JBrowse link
G Ank1 ankyrin 1 acts_upstream_of_or_within ISO MGI:1856298 (MGI:54462|PMID:658175) RGD PMID:658175 MGI:54462 NCBI chr16:68,876,294...69,054,812 JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within ISO MGI:2384729 (MGI:2384247|PMID:12149233) RGD PMID:12149233 MGI:2384247 NCBI chr18:57,945,123...57,978,327 JBrowse link
G Hmbs hydroxymethylbilane synthase IDA uroporphyrin I
Urophorphyrin I
Uroporphyrinogen
Uroporphyrin I
RGD PMID:11786116, PMID:3963818, PMID:3702597, PMID:994723, PMID:6694518, PMID:1781034, PMID:6732900, PMID:971328, PMID:6893114, PMID:3179323, PMID:11202056 RGD:26923962, RGD:4144803, RGD:4144820, RGD:25440497, RGD:25330343, RGD:25440495, RGD:25394584, RGD:25394583, RGD:26923963, RGD:2301707, RGD:4144783 NCBI chr 8:44,673,554...44,680,950 JBrowse link
G Ppox protoporphyrinogen oxidase involved_in IDA
ISO
(PMID:7713909) RGD PMID:7713909, PMID:3663105 RGD:1599180 NCBI chr13:83,697,661...83,701,998 JBrowse link
G Slc11a2 solute carrier family 11 member 2 acts_upstream_of_or_within ISO MGI:1856400 (MGI:54462|PMID:658175) RGD PMID:658175 MGI:54462 NCBI chr 7:131,503,076...131,540,246 JBrowse link
G Spta1 spectrin, alpha, erythrocytic 1 acts_upstream_of_or_within ISO MGI:1856181|MGI:1856377 (MGI:54462|PMID:658175) RGD PMID:658175 MGI:54462 NCBI chr13:86,203,504...86,279,371 JBrowse link
G Sptb spectrin, beta, erythrocytic acts_upstream_of_or_within ISO MGI:1856378 (MGI:54462|PMID:658175) RGD PMID:658175 MGI:54462 NCBI chr 6:95,310,342...95,437,221 JBrowse link
G Urod uroporphyrinogen decarboxylase IDA RGD PMID:12381387 RGD:4144825 NCBI chr 5:130,464,695...130,468,783 JBrowse link
G Uros uroporphyrinogen III synthase acts_upstream_of_or_within ISO MGI:3620007 (MGI:72967|PMID:7607680) RGD PMID:7607680 MGI:3620006 MGI:72967 NCBI chr 1:188,490,832...188,513,659 JBrowse link
positive regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:30765471)
(MGI:6695684|PMID:30765471)
UniProt
Ensembl
RGD
PMID:30765471 GO_REF:0000024 GO_REF:0000107 MGI:6695684 NCBI chr  X:69,295,598...69,436,775 JBrowse link
G Slc6a9 solute carrier family 6 member 9 involved_in ISO (MGI:6450351|PMID:28495915) RGD PMID:28495915 MGI:6450351 NCBI chr 5:131,374,562...131,408,733 JBrowse link
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:75,961,993...75,972,334 JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:106,876,514...106,889,852 JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr  X:19,463,146...19,486,526 JBrowse link
G Cpox coproporphyrinogen oxidase involved_in IDA
IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:3814086, PMID:21873635 GO_REF:0000041, RGD:4145128, RGD:13792537 NCBI chr11:41,936,585...41,946,568 JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:44,673,554...44,680,950 JBrowse link
G Ireb2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181660 (MGI:3695992|PMID:15831703)
Ensembl
RGD
PMID:15831703 GO_REF:0000107 MGI:3695992 NCBI chr 8:55,228,080...55,311,613 JBrowse link
G Ppox protoporphyrinogen oxidase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr13:83,697,661...83,701,998 JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:130,464,695...130,468,783 JBrowse link
G Uros uroporphyrinogen III synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:188,490,832...188,513,659 JBrowse link
regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srrd SRR1 domain containing involved_in ISO (MGI:6282940|PMID:28802827) RGD PMID:28802827 MGI:6282940 NCBI chr12:44,294,675...44,300,287 JBrowse link
G Tmem14c transmembrane protein 14C acts_upstream_of_or_within ISO MGI:4351741 (MGI:5581691|PMID:25157825) RGD PMID:25157825 MGI:5581691 NCBI chr17:23,733,769...23,739,906 JBrowse link
uroporphyrinogen III biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uros uroporphyrinogen III synthase involved_in IDA
IBA
ISO
PMID:21873635
(PMID:18004775), (PMID:3174619), (PMID:3805019)
RGD PMID:3174619 PMID:3805019 PMID:18004775, PMID:17763925, PMID:21873635 RGD:4144811, RGD:13792537 NCBI chr 1:188,490,832...188,513,659 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      biosynthetic process 6127
        cellular biosynthetic process 5969
          heterocycle biosynthetic process 3864
            tetrapyrrole biosynthetic process 27
              cobalamin biosynthetic process + 0
              corrin biosynthetic process 0
              negative regulation of tetrapyrrole biosynthetic process + 0
              phycocyanobilin biosynthetic process 0
              phytochromobilin biosynthetic process 0
              porphyrin-containing compound biosynthetic process + 27
              positive regulation of tetrapyrrole biosynthetic process + 2
              regulation of tetrapyrrole biosynthetic process + 4
              tetrapyrrole biosynthetic process from glutamate + 0
              tetrapyrrole biosynthetic process from glycine and succinyl-CoA + 0
paths to the root