ONTOLOGY REPORT - ANNOTATIONS
Term: tetrapyrrole biosynthetic process
Accession: GO:0033014
browse the term
Definition: The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Synonyms: exact_synonym: tetrapyrrole anabolism; tetrapyrrole biosynthesis; tetrapyrrole formation; tetrapyrrole synthesis
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Hmbs
hydroxymethylbilane synthase
IDA IMP
RGD
PMID:9344466 PMID:18760440 PMID:6712591 PMID:12127573
RGD:2301695 , RGD:2301858 , RGD:2301704 , RGD:2301691
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
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Alad
aminolevulinate dehydratase
involved_in
ISO
(PMID:14050799), (PMID:5393940)
RGD
PMID:5393940 PMID:14050799
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
G
Alas1
5'-aminolevulinate synthase 1
involved_in
IEA ISO
GO_REF:0000107 MGI:4440831 (PMID:33307066)
Ensembl RGD
PMID:33307066
GO_REF:0000107
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
G
Cox10
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
involved_in acts_upstream_of_or_within
ISO IBA
(PMID:12928484) GO_REF:0000033 UniProtKB:Q12887 (PMID:12928484) (PMID:16103131), (PMID:16782876)
RGD GO_Central
PMID:12928484 PMID:16103131 PMID:16782876
GO_REF:0000033
NCBI chr10:48,630,993...48,742,805
Ensembl chr10:48,630,676...48,746,667
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Cox15
cytochrome c oxidase assembly homolog COX15
involved_in
ISO IBA
UniProtKB:Q7KZN9-1 (PMID:12474143) GO_REF:0000033
RGD GO_Central
PMID:12474143
GO_REF:0000033
NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
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Cpox
coproporphyrinogen oxidase
involved_in
IEA ISO
GO_REF:0000107 (PMID:8407975)
Ensembl RGD
PMID:8407975
GO_REF:0000107
NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
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Fech
ferrochelatase
involved_in
ISO
MGI:1858114 (PMID:15677551)
RGD
PMID:15677551
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
G
Hmbs
hydroxymethylbilane synthase
involved_in
IEA ISO
GO_REF:0000107 MGI:2182340 (PMID:8563760)
Ensembl RGD
PMID:8563760
GO_REF:0000107
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
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Ppox
protoporphyrinogen oxidase
involved_in
ISO
(PMID:3346226)
RGD
PMID:3346226
NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
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Urod
uroporphyrinogen decarboxylase
involved_in
IEA ISO
GO_REF:0000107 MGI:2687172 (PMID:17360334)
Ensembl RGD
PMID:17360334
GO_REF:0000107
NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
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Uros
uroporphyrinogen III synthase
involved_in
ISO
MGI:3776884 (PMID:16532394)
RGD
PMID:16532394
NCBI chr 1:188,490,832...188,513,659
Ensembl chr 1:188,490,323...188,512,249
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Abcb6
ATP binding cassette subfamily B member 6
NOT|involved_in
ISO
(PMID:22655043)
RGD
PMID:22655043
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
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Alad
aminolevulinate dehydratase
involved_in
ISO
(PMID:14050799), (PMID:5393940)
RGD
PMID:5393940 PMID:14050799
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Alas1
5'-aminolevulinate synthase 1
involved_in
IEA ISO
GO_REF:0000107 MGI:4440831 (PMID:33307066)
Ensembl RGD
PMID:33307066
GO_REF:0000107
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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Cpox
coproporphyrinogen oxidase
involved_in
IEA ISO
GO_REF:0000107 (PMID:8407975)
Ensembl RGD
PMID:8407975
GO_REF:0000107
NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
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Fech
ferrochelatase
involved_in
ISO
MGI:1858114 (PMID:15677551)
RGD
PMID:15677551
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
G
Hmbs
hydroxymethylbilane synthase
involved_in
IEA ISO
GO_REF:0000107 MGI:2182340 (PMID:8563760)
Ensembl RGD
PMID:8563760
GO_REF:0000107
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
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Ppox
protoporphyrinogen oxidase
involved_in
ISO
(PMID:3346226)
RGD
PMID:3346226
NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
G
Urod
uroporphyrinogen decarboxylase
involved_in
IEA ISO
GO_REF:0000107 MGI:2687172 (PMID:17360334)
Ensembl RGD
PMID:17360334
GO_REF:0000107
NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
G
Uros
uroporphyrinogen III synthase
involved_in
ISO
MGI:3776884 (PMID:16532394)
RGD
PMID:16532394
NCBI chr 1:188,490,832...188,513,659
Ensembl chr 1:188,490,323...188,512,249
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Abcb10
ATP binding cassette subfamily B member 10
involved_in
ISO
(MGI:5648801|PMID:24421385)
RGD
PMID:24421385
MGI:5648801
NCBI chr19:51,952,655...51,982,910
Ensembl chr19:51,952,681...51,982,753
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Alad
aminolevulinate dehydratase
acts_upstream_of_or_within involved_in
IDA ISO ISS IBA
(PMID:14050799), (PMID:4959158), (PMID:4981581) GO_REF:0000024 (PMID:11032836) GO_REF:0000033
RGD UniProt GO_Central
PMID:4959158 PMID:4981581 PMID:11032836 PMID:14050799 PMID:1764448
GO_REF:0000024 GO_REF:0000033, RGD:1599020
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Alas1
5'-aminolevulinate synthase 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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Alas2
5'-aminolevulinate synthase 2
involved_in
ISO IBA ISS
(MGI:3694153|PMID:9446639) GO_REF:0000033 GO_REF:0000024
RGD GO_Central UniProt
PMID:9446639
GO_REF:0000024 GO_REF:0000033 MGI:3694153
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
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Atp5if1
ATP synthase inhibitory factor subunit 1
involved_in
ISS IBA ISO
GO_REF:0000024 GO_REF:0000033 (MGI:5447588|PMID:23135403)
UniProt GO_Central RGD
PMID:23135403
GO_REF:0000024 GO_REF:0000033 MGI:5447588
NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668
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Cpox
coproporphyrinogen oxidase
acts_upstream_of_or_within
IDA ISO
(PMID:8407975)
RGD
PMID:8407975 PMID:3955059
RGD:1600961
NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
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Fech
ferrochelatase
acts_upstream_of_or_within involved_in
IDA ISO IBA
MGI:1858114|MGI:2384729 (PMID:15496139), (PMID:16306232), (PMID:16503645), (PMID:8611576), (PMID:9989256) GO_REF:0000033 (PMID:27599036)
RGD GO_Central
PMID:8611576 PMID:9989256 PMID:15496139 PMID:16306232 PMID:16503645 PMID:27599036 PMID:3955059 More...
GO_REF:0000033, RGD:1600961
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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Fxn
frataxin
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540
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Hmbs
hydroxymethylbilane synthase
involved_in
ISO IBA
(PMID:18936296) GO_REF:0000033
RGD GO_Central
PMID:18936296
GO_REF:0000033
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
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Hnf1a
HNF1 homeobox A
acts_upstream_of_or_within
ISO
MGI:2384429 (PMID:10617683)
RGD
PMID:10617683
NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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Pgrmc1
progesterone receptor membrane component 1
involved_in
ISO ISS
(PMID:27599036) GO_REF:0000024
RGD UniProt
PMID:27599036
GO_REF:0000024
NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682
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Ppox
protoporphyrinogen oxidase
acts_upstream_of_or_within involved_in
IDA ISO IBA
(PMID:3346226) GO_REF:0000033 (PMID:7713909)
RGD GO_Central
PMID:3346226 PMID:7713909 PMID:3955059
GO_REF:0000033, RGD:1600961
NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
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Slc11a2
solute carrier family 11 member 2
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:1856400 (PMID:11739192)
Ensembl RGD
PMID:11739192
GO_REF:0000107
NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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Slc25a39
solute carrier family 25, member 39
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr10:87,362,494...87,367,358
Ensembl chr10:87,362,490...87,367,260
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Tmem14c
transmembrane protein 14C
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr17:23,733,769...23,739,906
Ensembl chr17:23,733,894...23,753,320
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Tmem14cl1
transmembrane protein 14C like 1
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr13:100,656,576...100,657,086
Ensembl chr13:100,656,593...100,657,445
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Urod
uroporphyrinogen decarboxylase
acts_upstream_of_or_within involved_in
NAS ISO IBA IC
MGI:2687172 (PMID:17360334) GO_REF:0000033
RGD GO_Central
PMID:17360334 PMID:3658690 PMID:15736160
GO_REF:0000033, RGD:70052 , RGD:2301379
NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
G
Uros
uroporphyrinogen III synthase
involved_in
ISO
(PMID:3805019)
RGD
PMID:3805019
NCBI chr 1:188,490,832...188,513,659
Ensembl chr 1:188,490,323...188,512,249
G
Alad
aminolevulinate dehydratase
involved_in
ISO
(PMID:14050799), (PMID:5393940)
RGD
PMID:5393940 PMID:14050799
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
G
Alas1
5'-aminolevulinate synthase 1
involved_in
IEA ISO
GO_REF:0000107 MGI:4440831 (PMID:33307066)
Ensembl RGD
PMID:33307066
GO_REF:0000107
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
G
Cox10
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
involved_in
ISO
UniProtKB:Q12887 (PMID:12928484)
RGD
PMID:12928484
NCBI chr10:48,630,993...48,742,805
Ensembl chr10:48,630,676...48,746,667
G
Cpox
coproporphyrinogen oxidase
involved_in
IEA ISO
GO_REF:0000107 (PMID:8407975)
Ensembl RGD
PMID:8407975
GO_REF:0000107
NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
G
Fech
ferrochelatase
involved_in
ISO
MGI:1858114 (PMID:15677551)
RGD
PMID:15677551
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
G
Hmbs
hydroxymethylbilane synthase
involved_in
IEA ISO
GO_REF:0000107 MGI:2182340 (PMID:8563760)
Ensembl RGD
PMID:8563760
GO_REF:0000107
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
G
Ppox
protoporphyrinogen oxidase
involved_in
ISO
(PMID:3346226)
RGD
PMID:3346226
NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
G
Urod
uroporphyrinogen decarboxylase
involved_in
IEA ISO
GO_REF:0000107 MGI:2687172 (PMID:17360334)
Ensembl RGD
PMID:17360334
GO_REF:0000107
NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
G
Uros
uroporphyrinogen III synthase
involved_in
ISO
MGI:3776884 (PMID:16532394)
RGD
PMID:16532394
NCBI chr 1:188,490,832...188,513,659
Ensembl chr 1:188,490,323...188,512,249
G
Abcb6
ATP binding cassette subfamily B member 6
involved_in
ISO
(PMID:17006453)
RGD
PMID:17006453
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
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Ank1
ankyrin 1
acts_upstream_of_or_within
ISO
MGI:1856298 (PMID:658175)
RGD
PMID:658175
NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759
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Fech
ferrochelatase
acts_upstream_of_or_within
ISO
MGI:2384729 (PMID:12149233)
RGD
PMID:12149233
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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Hmbs
hydroxymethylbilane synthase
IDA
uroporphyrin I Urophorphyrin I Uroporphyrinogen Uroporphyrin I
RGD
PMID:11786116 PMID:3963818 PMID:3702597 PMID:994723 PMID:6694518 PMID:1781034 PMID:6732900 PMID:971328 PMID:6893114 PMID:3179323 PMID:11202056 More...
RGD:26923962 , RGD:4144803 , RGD:4144820 , RGD:25440497 , RGD:25330343 , RGD:25440495 , RGD:25394584 , RGD:25394583 , RGD:26923963 , RGD:2301707 , RGD:4144783
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
G
Ppox
protoporphyrinogen oxidase
involved_in
IDA ISO
(PMID:7713909)
RGD
PMID:7713909 PMID:3663105
RGD:1599180
NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
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Rsad1
radical S-adenosyl methionine domain containing 1
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr10:79,485,253...79,499,616
Ensembl chr10:79,489,909...79,499,573
G
Slc11a2
solute carrier family 11 member 2
acts_upstream_of_or_within
ISO
MGI:1856400 (PMID:658175)
RGD
PMID:658175
NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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Spta1
spectrin, alpha, erythrocytic 1
acts_upstream_of_or_within
ISO
MGI:1856181|MGI:1856377 (PMID:658175)
RGD
PMID:658175
NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371
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Sptb
spectrin, beta, erythrocytic
acts_upstream_of_or_within
ISO
MGI:1856378 (PMID:658175)
RGD
PMID:658175
NCBI chr 6:95,310,342...95,437,221
Ensembl chr 6:95,310,326...95,437,118
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Urod
uroporphyrinogen decarboxylase
IDA
RGD
PMID:12381387
RGD:4144825
NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
G
Uros
uroporphyrinogen III synthase
acts_upstream_of_or_within
ISO
MGI:3620007 (PMID:7607680)
RGD
PMID:7607680
MGI:3620006
NCBI chr 1:188,490,832...188,513,659
Ensembl chr 1:188,490,323...188,512,249
G
Abcb7
ATP binding cassette subfamily B member 7
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:30765471) (MGI:6695684|PMID:30765471)
UniProt Ensembl RGD
PMID:30765471
GO_REF:0000024 GO_REF:0000107 MGI:6695684
NCBI chr X:69,295,598...69,436,775
Ensembl chr X:69,295,552...69,436,858
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Slc6a9
solute carrier family 6 member 9
involved_in
ISO
(MGI:6450351|PMID:28495915)
RGD
PMID:28495915
MGI:6450351
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
G
Alad
aminolevulinate dehydratase
involved_in
IEA
GO_REF:0000041
UniProt
GO_REF:0000041
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
G
Alas1
5'-aminolevulinate synthase 1
involved_in
IEA
GO_REF:0000041
UniProt
GO_REF:0000041
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
G
Alas2
5'-aminolevulinate synthase 2
involved_in
IEA
GO_REF:0000041
UniProt
GO_REF:0000041
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
G
Cpox
coproporphyrinogen oxidase
involved_in
IDA IBA IEA
GO_REF:0000033 GO_REF:0000041
GO_Central UniProt RGD
PMID:3814086
GO_REF:0000033 GO_REF:0000041, RGD:4145128
NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
G
Hmbs
hydroxymethylbilane synthase
involved_in
IEA
GO_REF:0000041
UniProt
GO_REF:0000041
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
G
Ireb2
iron responsive element binding protein 2
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:2181660 (PMID:15831703)
Ensembl RGD
PMID:15831703
GO_REF:0000107
NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
G
Ppox
protoporphyrinogen oxidase
involved_in
IEA
GO_REF:0000041
UniProt
GO_REF:0000041
NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
G
Urod
uroporphyrinogen decarboxylase
involved_in
IEA
GO_REF:0000041
UniProt
GO_REF:0000041
NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
G
Uros
uroporphyrinogen III synthase
involved_in
IEA
GO_REF:0000041
UniProt
GO_REF:0000041
NCBI chr 1:188,490,832...188,513,659
Ensembl chr 1:188,490,323...188,512,249
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Srrd
SRR1 domain containing
involved_in
ISO
(MGI:6282940|PMID:28802827)
RGD
PMID:28802827
MGI:6282940
NCBI chr12:44,294,675...44,300,287
Ensembl chr12:44,294,271...44,300,287
G
Tmem14a
transmembrane protein 14A
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 9:23,640,594...23,652,379
Ensembl chr 9:23,733,039...23,734,463 Ensembl chr 9:23,733,039...23,734,463
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Tmem14c
transmembrane protein 14C
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 MGI:4351741 (PMID:25157825)
GO_Central RGD
PMID:25157825
GO_REF:0000033
NCBI chr17:23,733,769...23,739,906
Ensembl chr17:23,733,894...23,753,320
G
Tmem14cl1
transmembrane protein 14C like 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr13:100,656,576...100,657,086
Ensembl chr13:100,656,593...100,657,445
G
Uros
uroporphyrinogen III synthase
involved_in
IDA IBA ISO
GO_REF:0000033 (PMID:18004775), (PMID:3174619), (PMID:3805019)
GO_Central RGD
PMID:3174619 PMID:3805019 PMID:18004775 PMID:17763925
GO_REF:0000033, RGD:4144811
NCBI chr 1:188,490,832...188,513,659
Ensembl chr 1:188,490,323...188,512,249
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all