Ppox (protoporphyrinogen oxidase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ppox (protoporphyrinogen oxidase) Rattus norvegicus
Analyze
Symbol: Ppox
Name: protoporphyrinogen oxidase
RGD ID: 1310543
Description: Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme biosynthetic process; protoporphyrinogen IX metabolic process; and response to drug. Located in mitochondrion. Is integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase); PARTICIPATES IN heme biosynthetic pathway; acute intermittent porphyria pathway; erythropoietic porphyria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC289219
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21383,697,661 - 83,701,998 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1389,650,094 - 89,654,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01389,650,094 - 89,654,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01394,276,960 - 94,281,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,170,602 - 87,174,740 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11387,359,527 - 87,363,605 (-)NCBI
Celera1383,328,348 - 83,332,483 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:3346226   PMID:7713909   PMID:14651853   PMID:18614015   PMID:30361391  


Genomics

Comparative Map Data
Ppox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21383,697,661 - 83,701,998 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1389,650,094 - 89,654,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01389,650,094 - 89,654,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01394,276,960 - 94,281,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,170,602 - 87,174,740 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11387,359,527 - 87,363,605 (-)NCBI
Celera1383,328,348 - 83,332,483 (-)NCBICelera
Cytogenetic Map13q24NCBI
PPOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1161,166,056 - 161,178,013 (+)EnsemblGRCh38hg38GRCh38
GRCh381161,165,824 - 161,178,277 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371161,136,216 - 161,141,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,402,818 - 159,407,634 (+)NCBINCBI36hg18NCBI36
Build 341157,949,266 - 157,954,085NCBI
Celera1134,203,334 - 134,208,163 (+)NCBI
Cytogenetic Map1q23.3NCBI
HuRef1132,493,123 - 132,497,952 (+)NCBIHuRef
CHM1_11162,532,431 - 162,537,260 (+)NCBICHM1_1
Ppox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,104,564 - 171,108,955 (-)NCBIGRCm39mm39
GRCm39 Ensembl1171,103,563 - 171,108,760 (-)Ensembl
GRCm381171,276,991 - 171,281,193 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,275,990 - 171,281,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,207,123 - 173,211,317 (-)NCBIGRCm37mm9NCBIm37
MGSCv361173,113,667 - 173,117,835 (-)NCBImm8
Celera1173,733,013 - 173,737,208 (-)NCBICelera
Cytogenetic Map1H3NCBI
Ppox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,930,495 - 12,934,437 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,930,387 - 12,934,437 (+)NCBIChiLan1.0ChiLan1.0
PPOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11140,491,667 - 140,496,506 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,491,667 - 140,502,328 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01136,578,846 - 136,590,466 (+)NCBIMhudiblu_PPA_v0panPan3
PPOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,306,973 - 21,310,892 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,306,974 - 21,311,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,381,833 - 21,385,563 (-)NCBI
ROS_Cfam_1.03821,424,824 - 21,428,556 (-)NCBI
UMICH_Zoey_3.13821,312,659 - 21,316,388 (-)NCBI
UNSW_CanFamBas_1.03821,727,092 - 21,730,828 (-)NCBI
UU_Cfam_GSD_1.03822,136,240 - 22,139,973 (-)NCBI
Ppox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,261,120 - 7,266,047 (+)NCBI
SpeTri2.0NW_004936903470,317 - 474,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,277,117 - 89,288,902 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,277,984 - 89,288,946 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,134,711 - 97,145,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,814,571 - 2,819,384 (-)NCBI
ChlSab1.1 Ensembl202,814,571 - 2,818,936 (-)Ensembl
Vero_WHO_p1.0NW_0236660381,861,663 - 1,867,108 (-)NCBI
Ppox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624794212,220 - 215,891 (-)NCBI

Position Markers
W53272  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,703,257 - 83,703,366 (+)MAPPERmRatBN7.2
Rnor_6.01389,655,691 - 89,655,799NCBIRnor6.0
Rnor_5.01394,282,557 - 94,282,665UniSTSRnor5.0
RGSC_v3.41387,176,203 - 87,176,311UniSTSRGSC3.4
Celera1383,333,945 - 83,334,053UniSTS
Cytogenetic Map13q24UniSTS
RH129176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,701,048 - 83,701,242 (+)MAPPERmRatBN7.2
Rnor_6.01389,653,481 - 89,653,674NCBIRnor6.0
Rnor_5.01394,280,347 - 94,280,540UniSTSRnor5.0
RGSC_v3.41387,173,992 - 87,174,185UniSTSRGSC3.4
Celera1383,331,735 - 83,331,928UniSTS
RH 3.4 Map13561.3UniSTS
Cytogenetic Map13q24UniSTS
AA859700  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,697,746 - 83,698,136 (+)MAPPERmRatBN7.2
Rnor_6.01389,650,179 - 89,650,568NCBIRnor6.0
Rnor_5.01394,277,045 - 94,277,434UniSTSRnor5.0
RGSC_v3.41387,170,687 - 87,171,076UniSTSRGSC3.4
Celera1383,328,433 - 83,328,822UniSTS
RH 3.4 Map13552.3UniSTS
Cytogenetic Map13q24UniSTS
BF405831  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,702,405 - 83,702,559 (+)MAPPERmRatBN7.2
Rnor_6.01389,654,838 - 89,654,991NCBIRnor6.0
Rnor_5.01394,281,704 - 94,281,857UniSTSRnor5.0
RGSC_v3.41387,175,349 - 87,175,502UniSTSRGSC3.4
Celera1383,333,092 - 83,333,245UniSTS
RH 3.4 Map13568.4UniSTS
Cytogenetic Map13q24UniSTS
Ppox  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,697,781 - 83,698,111 (+)MAPPERmRatBN7.2
Rnor_6.01389,650,214 - 89,650,543NCBIRnor6.0
Rnor_5.01394,277,080 - 94,277,409UniSTSRnor5.0
RGSC_v3.41387,170,722 - 87,171,051UniSTSRGSC3.4
Celera1383,328,468 - 83,328,797UniSTS
Cytogenetic Map13q24UniSTS
G43283  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,702,692 - 83,702,832 (+)MAPPERmRatBN7.2
Rnor_6.01389,655,126 - 89,655,265NCBIRnor6.0
Rnor_5.01394,281,992 - 94,282,131UniSTSRnor5.0
RGSC_v3.41387,175,637 - 87,175,776UniSTSRGSC3.4
Celera1383,333,380 - 83,333,519UniSTS
Cytogenetic Map13q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135108098996080989Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)135157782490675199Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1357903612102903612Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136500824591629354Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137456837892916783Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137456837892916783Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137456837892916783Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)138040355991629354Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:68
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000004896
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 54 41 17 41 66 35 38 11
Low 15 3 2 8 11 8 3 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004896   ⟹   ENSRNOP00000004896
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1389,650,094 - 89,654,244 (-)Ensembl
RefSeq Acc Id: NM_001105968   ⟹   NP_001099438
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,697,662 - 83,701,797 (-)NCBI
Rnor_6.01389,650,094 - 89,654,229 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
RGSC_v3.41387,170,602 - 87,174,740 (-)RGD
Celera1383,328,348 - 83,332,483 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250240   ⟹   XP_006250302
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,697,661 - 83,701,998 (-)NCBI
Rnor_6.01389,650,094 - 89,654,998 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250241   ⟹   XP_006250303
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,697,661 - 83,701,822 (-)NCBI
Rnor_6.01389,650,094 - 89,654,262 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250243   ⟹   XP_006250305
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,697,661 - 83,701,392 (-)NCBI
Rnor_6.01389,650,094 - 89,653,824 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090506   ⟹   XP_038946434
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,697,661 - 83,701,998 (-)NCBI
RefSeq Acc Id: XM_039090507   ⟹   XP_038946435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,697,661 - 83,701,312 (-)NCBI
RefSeq Acc Id: XM_039090508   ⟹   XP_038946436
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,697,661 - 83,701,148 (-)NCBI
RefSeq Acc Id: XM_039090509   ⟹   XP_038946437
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,698,407 - 83,701,998 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001099438   ⟸   NM_001105968
- UniProtKB: D3ZVN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250302   ⟸   XM_006250240
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006250303   ⟸   XM_006250241
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006250305   ⟸   XM_006250243
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000004896   ⟸   ENSRNOT00000004896
RefSeq Acc Id: XP_038946434   ⟸   XM_039090506
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946435   ⟸   XM_039090507
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038946436   ⟸   XM_039090508
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038946437   ⟸   XM_039090509
- Peptide Label: isoform X5
Protein Domains
Amino_oxidase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699000
Promoter ID:EPDNEW_R9525
Type:initiation region
Name:Ppox_1
Description:protoporphyrinogen oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,654,237 - 89,654,297EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310543 AgrOrtholog
Ensembl Genes ENSRNOG00000003567 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004896 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004896 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro Amino_oxidase UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/TrEMBL
  Protoporphyrinogen_oxidase UniProtKB/TrEMBL
KEGG Report rno:289219 UniProtKB/TrEMBL
NCBI Gene 289219 ENTREZGENE
Pfam Amino_oxidase UniProtKB/TrEMBL
PhenoGen Ppox PhenoGen
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
TIGRFAMs proto_IX_ox UniProtKB/TrEMBL
UniProt D3ZVN7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ppox  protoporphyrinogen oxidase   Ppox_predicted  protoporphyrinogen oxidase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ppox_predicted  protoporphyrinogen oxidase (predicted)      Symbol and Name status set to approved 70820 APPROVED