Ank1 (ankyrin 1) - Rat Genome Database

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Gene: Ank1 (ankyrin 1) Rattus norvegicus
Analyze
Symbol: Ank1
Name: ankyrin 1
RGD ID: 1309620
Description: Predicted to enable several functions, including enzyme binding activity; spectrin binding activity; and transmembrane transporter binding activity. Involved in positive regulation of organelle organization. Located in several cellular components, including axolemma; sarcolemma; and sarcomere. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in anemia; hereditary spherocytosis; and hereditary spherocytosis type 1. Orthologous to human ANK1 (ankyrin 1); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ankyrin 1, erythrocytic; ankyrin 1, erythroid; ankyrin-1; LOC306570
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21668,876,294 - 69,054,812 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1668,877,504 - 69,054,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,153,929 - 74,328,599 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01677,581,598 - 77,760,634 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01672,830,782 - 73,009,777 (-)NCBIRnor_WKY
Rnor_6.01673,681,422 - 73,912,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1673,681,422 - 73,827,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,397,821 - 73,459,822 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01673,314,002 - 73,331,197 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,333,564 - 73,437,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,333,832 - 73,438,435 (-)NCBI
Celera1666,776,909 - 66,863,441 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
valproic acid  (EXP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Integrity of the network sarcoplasmic reticulum in skeletal muscle requires small ankyrin 1. Ackermann MA, etal., J Cell Sci. 2011 Nov 1;124(Pt 21):3619-30. Epub 2011 Nov 1.
2. Normoblastosis, a murine model for ankyrin-deficient hemolytic anemia, is caused by a hypomorphic mutation in the erythroid ankyrin gene Ank1. Birkenmeier CS, etal., Hematol J. 2003;4(6):445-9.
3. Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis. Eber SW, etal., Nat Genet. 1996 Jun;13(2):214-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Distribution of ankyrin isoforms and their proteolysis after ischemia and reperfusion in rat brain. Harada K, etal., J Neurochem. 1997 Jul;69(1):371-6.
7. A deep intronic mutation in the ankyrin-1 gene causes diminished protein expression resulting in hemolytic anemia in mice. Huang H, etal., G3 (Bethesda). 2013 Oct 3;3(10):1687-95. doi: 10.1534/g3.113.007013.
8. A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. Hughes MR, etal., Exp Hematol. 2011 Mar;39(3):305-20, 320.e1-2. doi: 10.1016/j.exphem.2010.12.009. Epub 2010 Dec 28.
9. Obscurin modulates the assembly and organization of sarcomeres and the sarcoplasmic reticulum. Kontrogianni-Konstantopoulos A, etal., FASEB J. 2006 Oct;20(12):2102-11.
10. Obscurin is a ligand for small ankyrin 1 in skeletal muscle. Kontrogianni-Konstantopoulos A, etal., Mol Biol Cell 2003 Mar;14(3):1138-48.
11. An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves. Kordeli E, etal., J Cell Biol. 1990 Apr;110(4):1341-52.
12. AnkyrinG is associated with the postsynaptic membrane and the sarcoplasmic reticulum in the skeletal muscle fiber. Kordeli E, etal., J Cell Sci 1998 Aug;111 ( Pt 15):2197-207.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin. Morgans CW and Kopito RR, J Cell Sci. 1993 Aug;105 ( Pt 4):1137-42.
15. Ankyrin gene mutations in japanese patients with hereditary spherocytosis. Nakanishi H, etal., Int J Hematol. 2001 Jan;73(1):54-63.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Frequent de novo mutations of the ANK1 gene mimic a recessive mode of transmission in hereditary spherocytosis: three new ANK1 variants: ankyrins Bari, Napoli II and Anzio. Randon J, etal., Br J Haematol. 1997 Mar;96(3):500-6.
18. Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Rank G, etal., Blood. 2009 Apr 2;113(14):3352-62. doi: 10.1182/blood-2008-08-172841. Epub 2009 Jan 28.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. Proteolysis of erythrocyte-type and brain-type ankyrins in rat heart after postischemic reperfusion. Yoshida K and Harada K, J Biochem (Tokyo). 1997 Aug;122(2):279-85.
24. Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant. Yuki KE, etal., PLoS One. 2013;8(2):e55331. doi: 10.1371/journal.pone.0055331. Epub 2013 Feb 4.
25. Small, membrane-bound, alternatively spliced forms of ankyrin 1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle. Zhou D, etal., J Cell Biol. 1997 Feb 10;136(3):621-31.
Additional References at PubMed
PMID:379653   PMID:658175   PMID:2139228   PMID:6234993   PMID:7492791   PMID:8159688   PMID:8889548   PMID:12354383   PMID:18723693   PMID:18768923   PMID:19002483   PMID:21177872  
PMID:21700703   PMID:22416964   PMID:26405035  


Genomics

Comparative Map Data
Ank1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21668,876,294 - 69,054,812 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1668,877,504 - 69,054,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,153,929 - 74,328,599 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01677,581,598 - 77,760,634 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01672,830,782 - 73,009,777 (-)NCBIRnor_WKY
Rnor_6.01673,681,422 - 73,912,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1673,681,422 - 73,827,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,397,821 - 73,459,822 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01673,314,002 - 73,331,197 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,333,564 - 73,437,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,333,832 - 73,438,435 (-)NCBI
Celera1666,776,909 - 66,863,441 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
ANK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38841,653,225 - 41,896,741 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl841,653,220 - 41,896,741 (-)EnsemblGRCh38hg38GRCh38
GRCh37841,510,744 - 41,754,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36841,629,901 - 41,774,297 (-)NCBINCBI36Build 36hg18NCBI36
Build 34841,632,000 - 41,641,949NCBI
Celera840,459,268 - 40,702,528 (-)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,038,471 - 40,281,660 (-)NCBIHuRef
CHM1_1841,558,937 - 41,802,421 (-)NCBICHM1_1
T2T-CHM13v2.0841,926,848 - 42,170,259 (-)NCBIT2T-CHM13v2.0
Ank1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,464,852 - 23,640,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,464,860 - 23,640,513 (+)EnsemblGRCm39 Ensembl
GRCm38822,974,836 - 23,150,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,974,844 - 23,150,497 (+)EnsemblGRCm38mm10GRCm38
MGSCv37824,085,354 - 24,260,968 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,523,820 - 24,616,041 (+)NCBIMGSCv36mm8
Celera824,465,487 - 24,646,749 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Ank1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555361,049,407 - 1,237,943 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555361,049,325 - 1,237,943 (+)NCBIChiLan1.0ChiLan1.0
ANK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1838,346,503 - 38,588,620 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,346,503 - 38,588,549 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0840,897,879 - 41,140,290 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ANK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,858,299 - 23,966,181 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,766,193 - 23,964,226 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1624,254,185 - 24,469,762 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,498,990 - 25,712,885 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,499,092 - 25,712,882 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,869,170 - 24,084,432 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,430,879 - 24,646,688 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,481,503 - 24,697,954 (+)NCBIUU_Cfam_GSD_1.0
Ank1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,781,927 - 46,988,338 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785738,317 - 942,381 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936785738,323 - 944,734 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1710,779,055 - 10,985,191 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11710,752,258 - 10,985,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21712,184,513 - 12,419,119 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1839,627,766 - 39,871,329 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl839,626,981 - 39,871,151 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660521,919,618 - 2,190,241 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ank1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247801,429,403 - 1,617,743 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247801,429,415 - 1,619,010 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ank1
1352 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:55
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000064070
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat

Markers in Region
D16Rat56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21668,937,992 - 68,938,229 (+)MAPPERmRatBN7.2
Rnor_6.01673,796,479 - 73,796,715NCBIRnor6.0
Rnor_5.01673,428,945 - 73,429,181UniSTSRnor5.0
RGSC_v3.41673,406,840 - 73,407,077RGDRGSC3.4
RGSC_v3.41673,406,841 - 73,407,077UniSTSRGSC3.4
RGSC_v3.11673,407,019 - 73,407,477RGD
Celera1666,832,820 - 66,833,048UniSTS
SHRSP x BN Map1636.28RGD
SHRSP x BN Map1636.28UniSTS
Cytogenetic Map16q12.5UniSTS
RH141704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21668,877,869 - 68,878,069 (+)MAPPERmRatBN7.2
Rnor_6.01673,674,719 - 73,674,918NCBIRnor6.0
Rnor_5.01673,306,846 - 73,307,045UniSTSRnor5.0
RGSC_v3.41673,335,789 - 73,335,988UniSTSRGSC3.4
Celera1666,769,840 - 66,770,039UniSTS
RH 3.4 Map16635.2UniSTS
Cytogenetic Map16q12.5UniSTS
BI276346  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21668,930,087 - 68,930,245 (+)MAPPERmRatBN7.2
Rnor_6.01673,788,574 - 73,788,731NCBIRnor6.0
Rnor_5.01673,421,040 - 73,421,197UniSTSRnor5.0
RGSC_v3.41673,398,935 - 73,399,092UniSTSRGSC3.4
Celera1666,824,919 - 66,825,076UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 38 22 22 11 22 8 11 52 11 8
Low 5 15 4 7 4 22 26 25 11
Below cutoff 3 19 14 1 14 9 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005494624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000064070   ⟹   ENSRNOP00000062056
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1668,877,512 - 68,962,457 (-)Ensembl
Rnor_6.0 Ensembl1673,681,422 - 73,827,488 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094015   ⟹   ENSRNOP00000083447
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1668,877,512 - 68,969,283 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094734   ⟹   ENSRNOP00000081687
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1668,877,512 - 68,969,283 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094764   ⟹   ENSRNOP00000084044
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1668,877,504 - 68,994,211 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095662   ⟹   ENSRNOP00000091410
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1668,877,512 - 68,969,283 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102914   ⟹   ENSRNOP00000076708
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1668,877,512 - 69,054,759 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114184   ⟹   ENSRNOP00000080599
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1668,877,504 - 68,888,147 (-)Ensembl
RefSeq Acc Id: NM_001107322   ⟹   NP_001100792
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,885,524 - 68,969,002 (-)NCBI
Rnor_6.01673,681,422 - 73,827,488 (-)NCBI
Rnor_5.01673,314,002 - 73,331,197 (-)NCBI
Rnor_5.01673,397,821 - 73,459,822 (-)NCBI
RGSC_v3.41673,333,564 - 73,437,926 (-)RGD
Celera1666,776,909 - 66,863,441 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094562   ⟹   XP_038950490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094563   ⟹   XP_038950491
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094564   ⟹   XP_038950492
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094565   ⟹   XP_038950493
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094566   ⟹   XP_038950494
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094568   ⟹   XP_038950496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094569   ⟹   XP_038950497
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094570   ⟹   XP_038950498
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094571   ⟹   XP_038950499
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,296 - 69,054,812 (-)NCBI
RefSeq Acc Id: XM_039094572   ⟹   XP_038950500
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094573   ⟹   XP_038950501
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094574   ⟹   XP_038950502
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094575   ⟹   XP_038950503
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,296 - 69,054,812 (-)NCBI
RefSeq Acc Id: XM_039094576   ⟹   XP_038950504
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,969,145 (-)NCBI
RefSeq Acc Id: XM_039094577   ⟹   XP_038950505
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,296 - 69,054,812 (-)NCBI
RefSeq Acc Id: XM_039094578   ⟹   XP_038950506
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,969,140 (-)NCBI
RefSeq Acc Id: XM_039094579   ⟹   XP_038950507
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,969,142 (-)NCBI
RefSeq Acc Id: XM_039094580   ⟹   XP_038950508
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,969,142 (-)NCBI
RefSeq Acc Id: XM_039094581   ⟹   XP_038950509
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094582   ⟹   XP_038950510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,994,307 (-)NCBI
RefSeq Acc Id: XM_039094583   ⟹   XP_038950511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,296 - 69,054,812 (-)NCBI
RefSeq Acc Id: XM_039094584   ⟹   XP_038950512
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,888,455 (-)NCBI
RefSeq Acc Id: XM_039094585   ⟹   XP_038950513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,876,294 - 68,888,448 (-)NCBI
RefSeq Acc Id: XR_005494624
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21668,894,492 - 68,994,307 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100792 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382491 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382492 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382493 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382494 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382495 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382496 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382497 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950490 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950491 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950492 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950493 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950494 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950496 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950497 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950498 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950499 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950500 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950501 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950502 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950503 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950504 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950505 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950506 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950507 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950508 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950509 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950510 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950511 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950512 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950513 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09025 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100792   ⟸   NM_001107322
- Sequence:
RefSeq Acc Id: ENSRNOP00000062056   ⟸   ENSRNOT00000064070
RefSeq Acc Id: XP_038950510   ⟸   XM_039094582
- Peptide Label: isoform X20
RefSeq Acc Id: XP_038950502   ⟸   XM_039094574
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038950498   ⟸   XM_039094570
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038950497   ⟸   XM_039094569
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038950491   ⟸   XM_039094563
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950509   ⟸   XM_039094581
- Peptide Label: isoform X19
RefSeq Acc Id: XP_038950501   ⟸   XM_039094573
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038950496   ⟸   XM_039094568
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038950494   ⟸   XM_039094566
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038950500   ⟸   XM_039094572
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038950493   ⟸   XM_039094565
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038950492   ⟸   XM_039094564
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038950490   ⟸   XM_039094562
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038950504   ⟸   XM_039094576
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038950508   ⟸   XM_039094580
- Peptide Label: isoform X18
RefSeq Acc Id: XP_038950507   ⟸   XM_039094579
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038950506   ⟸   XM_039094578
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038950512   ⟸   XM_039094584
- Peptide Label: isoform X22
RefSeq Acc Id: XP_038950513   ⟸   XM_039094585
- Peptide Label: isoform X23
RefSeq Acc Id: XP_038950511   ⟸   XM_039094583
- Peptide Label: isoform X21
RefSeq Acc Id: XP_038950505   ⟸   XM_039094577
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038950503   ⟸   XM_039094575
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038950499   ⟸   XM_039094571
- Peptide Label: isoform X9
RefSeq Acc Id: ENSRNOP00000076708   ⟸   ENSRNOT00000102914
RefSeq Acc Id: ENSRNOP00000083447   ⟸   ENSRNOT00000094015
RefSeq Acc Id: ENSRNOP00000080599   ⟸   ENSRNOT00000114184
RefSeq Acc Id: ENSRNOP00000091410   ⟸   ENSRNOT00000095662
RefSeq Acc Id: ENSRNOP00000084044   ⟸   ENSRNOT00000094764
RefSeq Acc Id: ENSRNOP00000081687   ⟸   ENSRNOT00000094734
Protein Domains
Death   ZU5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9Z0-F1-model_v2 AlphaFold D3Z9Z0 1-1707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309620 AgrOrtholog
BioCyc Gene G2FUF-10897 BioCyc
Ensembl Genes ENSRNOG00000018241 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062056.2 UniProtKB/TrEMBL
  ENSRNOP00000076708 ENTREZGENE
  ENSRNOP00000076708.1 UniProtKB/TrEMBL
  ENSRNOP00000080599 ENTREZGENE
  ENSRNOP00000080599.1 UniProtKB/TrEMBL
  ENSRNOP00000081687 ENTREZGENE
  ENSRNOP00000081687.1 UniProtKB/TrEMBL
  ENSRNOP00000083447.1 UniProtKB/TrEMBL
  ENSRNOP00000084044 ENTREZGENE
  ENSRNOP00000084044.1 UniProtKB/TrEMBL
  ENSRNOP00000091410 ENTREZGENE
  ENSRNOP00000091410.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064070.3 UniProtKB/TrEMBL
  ENSRNOT00000094015.1 UniProtKB/TrEMBL
  ENSRNOT00000094734 ENTREZGENE
  ENSRNOT00000094734.1 UniProtKB/TrEMBL
  ENSRNOT00000094764 ENTREZGENE
  ENSRNOT00000094764.1 UniProtKB/TrEMBL
  ENSRNOT00000095662 ENTREZGENE
  ENSRNOT00000095662.1 UniProtKB/TrEMBL
  ENSRNOT00000102914 ENTREZGENE
  ENSRNOT00000102914.1 UniProtKB/TrEMBL
  ENSRNOT00000114184 ENTREZGENE
  ENSRNOT00000114184.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ankyrin_UPA UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
KEGG Report rno:306570 UniProtKB/TrEMBL
NCBI Gene 306570 ENTREZGENE
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_3 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  UPA_2 UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
PhenoGen Ank1 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
  DEATH_DOMAIN UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  DEATH UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  SSF47986 UniProtKB/TrEMBL
UniProt A0A8I5ZJ94 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQ60_RAT UniProtKB/TrEMBL
  A0A8I5ZS64 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0H1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABK4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GAS7_RAT UniProtKB/TrEMBL
  D3Z9Z0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Ank1  ankyrin 1  Ank1  ankyrin 1, erythrocytic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Ank1  ankyrin 1, erythrocytic  Ank1  ankyrin 1, erythroid  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ank1  ankyrin 1, erythroid  Ank1_predicted  ankyrin 1, erythroid (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ank1_predicted  ankyrin 1, erythroid (predicted)      Symbol and Name status set to approved 70820 APPROVED