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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrapyrrole metabolic process
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Accession:GO:0033013 term browser browse the term
Definition:The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Synonyms:exact_synonym: tetrapyrrole metabolism


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tetrapyrrole metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 involved_in ISO
ISS
(PMID:23792964)
GO_REF:0000024
RGD
UniProt
PMID:23792964 GO_REF:0000024 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
bilirubin conjugation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 TAS RGD PMID:11829457 RGD:70480 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
cobalamin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cubn cubilin IMP RGD PMID:14576052 RGD:8554807 NCBI chr17:80,584,921...80,807,181
Ensembl chr17:80,584,878...80,807,243
JBrowse link
cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd4 ATP binding cassette subfamily D member 4 involved_in ISO (PMID:22922874) RGD PMID:22922874 NCBI chr 6:108,315,026...108,329,550
Ensembl chr 6:108,315,035...108,329,464
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase TAS RGD PMID:3994693 RGD:5135263 NCBI chr 9:78,862,013...78,882,061
Ensembl chr 9:78,862,013...78,882,060
JBrowse link
G Cblif cobalamin binding intrinsic factor IDA RGD PMID:14166172 RGD:1624368 NCBI chr 1:228,118,048...228,132,296
Ensembl chr 1:228,118,048...228,132,404
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase TAS RGD PMID:3994693 RGD:5135263 NCBI chr11:31,780,477...31,805,728
Ensembl chr11:31,780,487...31,805,728
JBrowse link
G Mmachc metabolism of cobalamin associated C involved_in ISO
IBA
(PMID:19700356), (PMID:22642810), (PMID:23825108)
PMID:21873635
RGD PMID:19700356 PMID:22642810 PMID:23825108, PMID:21873635 RGD:13792537 NCBI chr 5:135,555,587...135,561,723
Ensembl chr 5:135,555,565...135,561,914
JBrowse link
G Mmadhc metabolism of cobalamin associated D involved_in IEA
ISS
ISO
GO_REF:0000002
GO_REF:0000024
(PMID:24722857)
InterPro
UniProt
RGD
PMID:24722857 GO_REF:0000002 GO_REF:0000024 NCBI chr 3:35,783,511...35,801,474
Ensembl chr 3:35,783,623...35,801,614
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in ISO
IEA
(PMID:23825108)
GO_REF:0000107
RGD
Ensembl
PMID:23825108 GO_REF:0000107 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
heme A biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in
acts_upstream_of_or_within
ISO (PMID:12928484)
(MGI:3604933|PMID:16103131), (MGI:3640032|PMID:16782876)
RGD PMID:12928484 PMID:16103131 PMID:16782876 MGI:3604933 MGI:3640032 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 involved_in ISO
IBA
UniProtKB:Q7KZN9-1 (PMID:12474143)
PMID:21873635
RGD PMID:12474143, PMID:21873635 RGD:13792537 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
heme B biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 NOT|involved_in ISO (PMID:22655043) RGD PMID:22655043 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in IEA
ISO
GO_REF:0000107
(MGI:5648801|PMID:24421385)
Ensembl
RGD
PMID:24421385 GO_REF:0000107 MGI:5648801 NCBI chr19:56,742,809...56,772,904
Ensembl chr19:56,742,835...56,772,904
JBrowse link
G Alad aminolevulinate dehydratase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
ISS
(MGI:53493|PMID:4959158), (MGI:53609|PMID:4981581), (MGI:63121|PMID:14050799)
(PMID:11032836)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:4959158 PMID:4981581 PMID:11032836 PMID:14050799, PMID:1764448, PMID:21873635 GO_REF:0000024 MGI:53493 MGI:53609 MGI:63121, RGD:1599020, RGD:13792537 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:3694153|PMID:9446639)
PMID:21873635
UniProt
RGD
PMID:9446639, PMID:21873635 GO_REF:0000024 MGI:3694153, RGD:13792537 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:5447588|PMID:23135403)
GO_REF:0000024
(PMID:23135403)
RGD
UniProt
PMID:23135403, PMID:21873635 GO_REF:0000024 MGI:5447588, RGD:13792537 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
G Cpox coproporphyrinogen oxidase acts_upstream_of_or_within IDA
ISO
(MGI:77569|PMID:8407975) RGD PMID:8407975, PMID:3955059 MGI:77569, RGD:1600961 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
MGI:1858114|MGI:2384729 (MGI:1327758|PMID:9989256), (MGI:3620268|PMID:16503645), (MGI:3696634|PMID:15496139), (MGI:3794459|PMID:16306232), (MGI:79136|PMID:8611576)
PMID:21873635
(PMID:27599036)
RGD PMID:8611576 PMID:9989256 PMID:15496139 PMID:16306232 PMID:16503645 PMID:27599036, PMID:3955059, PMID:21873635 MGI:1327758 MGI:3620268 MGI:3696634 MGI:3794459 MGI:79136, RGD:1600961, RGD:13792537 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fxn frataxin involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO MGI:2384429 (MGI:1352605|PMID:10617683) RGD PMID:10617683 MGI:1352605 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 involved_in ISO
ISS
IEA
(PMID:27599036)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:27599036 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Ppox protoporphyrinogen oxidase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:3687447|PMID:3346226)
(PMID:7713909)
PMID:21873635
RGD PMID:3346226 PMID:7713909, PMID:3955059, PMID:21873635 MGI:3687447, RGD:1600961, RGD:13792537 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Slc11a2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856400 (MGI:3691553|PMID:11739192)
Ensembl
RGD
PMID:11739192 GO_REF:0000107 MGI:3691553 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc25a39 solute carrier family 25, member 39 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:90,351,899...90,356,905
Ensembl chr10:90,351,900...90,356,242
JBrowse link
G Tmem14c transmembrane protein 14C involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:21,571,510...21,577,651
Ensembl chr17:21,571,518...21,577,631
JBrowse link
G Urod uroporphyrinogen decarboxylase acts_upstream_of_or_within
involved_in
NAS
ISO
IBA
IC
MGI:2687172 (MGI:3703836|PMID:17360334)
PMID:21873635
RGD PMID:17360334, PMID:3658690, PMID:21873635, PMID:15736160 MGI:3703836, RGD:70052, RGD:13792537, RGD:2301379 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO
IBA
(PMID:3805019)
PMID:21873635
RGD PMID:3805019, PMID:21873635 RGD:13792537 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link
heme catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blvra biliverdin reductase A involved_in ISO
IEA
(PMID:10858451)
GO_REF:0000104
GO_REF:0000002
RGD
UniProt
InterPro
PMID:10858451 GO_REF:0000002 GO_REF:0000104 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806
JBrowse link
G Blvrb biliverdin reductase B involved_in ISO (PMID:7929092) RGD PMID:7929092 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
JBrowse link
G Hmox1 heme oxygenase 1 involved_in IDA
IBA
ISO
PMID:21873635
(PMID:17915953)
RGD PMID:17915953, PMID:15226268, PMID:21873635 RGD:1547877, RGD:13792537 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hmox2 heme oxygenase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484
JBrowse link
G Hmox2-ps1 heme oxygenase (decycling) 2, pseudogene 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:215,370,196...215,372,406 JBrowse link
heme metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 involved_in ISO
ISS
(PMID:33007128)
GO_REF:0000024
RGD
UniProt
PMID:33007128 GO_REF:0000024 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 2:240,461,505...240,482,149
Ensembl chr 2:240,461,505...240,482,145
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 acts_upstream_of_or_within ISO (MGI:3607883|PMID:16183037) RGD PMID:16183037 MGI:3607883 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Fech ferrochelatase TAS RGD PMID:9113083 RGD:1598930 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Hmox1 heme oxygenase 1 acts_upstream_of_or_within ISO (MGI:3607883|PMID:16183037) RGD PMID:16183037 MGI:3607883 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpx hemopexin involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2447193 (MGI:3799398|PMID:18556779)
RGD PMID:18556779, PMID:21873635 MGI:3799398, RGD:13792537 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Slco1a6 solute carrier organic anion transporter family, member 1a6 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:176,345,671...176,390,729
Ensembl chr 4:176,345,671...176,381,477
JBrowse link
G Urod uroporphyrinogen decarboxylase acts_upstream_of_or_within ISO MGI:2687172 (MGI:1929011|PMID:11134514) RGD PMID:11134514 MGI:1929011 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
heme O biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
heme oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 involved_in IBA
ISO
PMID:21873635
(PMID:17915953)
RGD PMID:17915953, PMID:21873635 RGD:13792537 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hmox2 heme oxygenase 2 involved_in TAS
IBA
PMID:21873635 RGD
GO_Central
PMID:12114211, PMID:21873635 RGD:625638, RGD:13792537 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484
JBrowse link
G Hmox2-ps1 heme oxygenase (decycling) 2, pseudogene 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:215,370,196...215,372,406 JBrowse link
porphyrin-containing compound biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 involved_in ISO (PMID:17006453) RGD PMID:17006453 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Ank1 ankyrin 1 acts_upstream_of_or_within ISO MGI:1856298 (MGI:54462|PMID:658175) RGD PMID:658175 MGI:54462 NCBI chr16:73,681,422...73,912,605
Ensembl chr16:73,681,422...73,827,488
JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within ISO MGI:2384729 (MGI:2384247|PMID:12149233) RGD PMID:12149233 MGI:2384247 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Hmbs hydroxymethylbilane synthase IDA uroporphyrin I
Urophorphyrin I
Uroporphyrinogen
Uroporphyrin I
RGD PMID:11786116, PMID:3963818, PMID:3702597, PMID:994723, PMID:6694518, PMID:1781034, PMID:6732900, PMID:971328, PMID:6893114, PMID:3179323, PMID:11202056 RGD:26923962, RGD:4144803, RGD:4144820, RGD:25440497, RGD:25330343, RGD:25440495, RGD:25394584, RGD:25394583, RGD:26923963, RGD:2301707, RGD:4144783 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Ppox protoporphyrinogen oxidase involved_in IDA
ISO
(PMID:7713909) RGD PMID:7713909, PMID:3663105 RGD:1599180 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Slc11a2 solute carrier family 11 member 2 acts_upstream_of_or_within ISO MGI:1856400 (MGI:54462|PMID:658175) RGD PMID:658175 MGI:54462 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Spta1 spectrin, alpha, erythrocytic 1 acts_upstream_of_or_within ISO MGI:1856181|MGI:1856377 (MGI:54462|PMID:658175) RGD PMID:658175 MGI:54462 NCBI chr13:92,264,231...92,340,091
Ensembl chr13:92,264,231...92,340,083
JBrowse link
G Sptb spectrin, beta, erythrocytic acts_upstream_of_or_within ISO MGI:1856378 (MGI:54462|PMID:658175) RGD PMID:658175 MGI:54462 NCBI chr 6:99,657,144...99,783,189
Ensembl chr 6:99,659,651...99,783,047
JBrowse link
G Urod uroporphyrinogen decarboxylase IDA RGD PMID:12381387 RGD:4144825 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Uros uroporphyrinogen III synthase acts_upstream_of_or_within ISO MGI:3620007 (MGI:72967|PMID:7607680) RGD PMID:7607680 MGI:3620006 MGI:72967 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link
porphyrin-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 involved_in ISS
ISO
GO_REF:0000024
(MGI:5898211|PMID:27507172)
(PMID:27507172), (PMID:33007128)
UniProt
RGD
PMID:27507172 PMID:33007128 GO_REF:0000024 MGI:5898211 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA Uroporphyrinogen oxidation, generating hydrogen peroxide RGD PMID:12907239 RGD:2306674 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 acts_upstream_of_or_within ISO MGI:2182351 (MGI:1202011|PMID:9461503), (MGI:1934807|PMID:11274970) RGD PMID:9461503 PMID:11274970 MGI:1202011 MGI:1934807 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Hmbs hydroxymethylbilane synthase IDA Porphobilinogen
Uroporphyrinogen
RGD PMID:11786116, PMID:3963818, PMID:3702597, PMID:593266, PMID:994723, PMID:1781034, PMID:6732900, PMID:971328, PMID:6893114, PMID:3179323, PMID:11202056 RGD:26923962, RGD:4144803, RGD:4144820, RGD:26884337, RGD:25440497, RGD:25440495, RGD:25394584, RGD:25394583, RGD:26923963, RGD:2301707, RGD:4144783 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Slc11a2 solute carrier family 11 member 2 acts_upstream_of_or_within ISO MGI:1856400 (MGI:78347|PMID:4404581) RGD PMID:4404581 MGI:78347 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
positive regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase involved_in ISO (MGI:5926841|PMID:29056341) RGD PMID:29056341 MGI:5926841 NCBI chr15:108,608,203...108,838,222
Ensembl chr15:108,608,204...108,838,235
JBrowse link
positive regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
(PMID:30765471)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:30765471 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:75,150,511...75,291,950
Ensembl chr  X:75,150,608...75,291,938
JBrowse link
G Slc6a9 solute carrier family 6 member 9 involved_in ISO (MGI:6450351|PMID:28495915) RGD PMID:28495915 MGI:6450351 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Cpox coproporphyrinogen oxidase involved_in IDA
IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:3814086, PMID:21873635 GO_REF:0000041, RGD:4145128, RGD:13792537 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Ireb2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181660 (MGI:3695992|PMID:15831703)
Ensembl
RGD
PMID:15831703 GO_REF:0000107 MGI:3695992 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Ppox protoporphyrinogen oxidase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Uros uroporphyrinogen III synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link
protoporphyrinogen IX metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 acts_upstream_of_or_within ISO MGI:1353448|MGI:95513 (MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:3581470 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Fech ferrochelatase involved_in
acts_upstream_of_or_within
ISO (PMID:15123683)
MGI:1353448|MGI:95513 (MGI:3581470|PMID:15931390)
RGD PMID:15123683 PMID:15931390 MGI:3581470 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Ppox protoporphyrinogen oxidase IDA RGD PMID:3663105 RGD:1599180 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:29056341)
PMID:21873635
(MGI:5926841|PMID:29056341)
UniProt
RGD
PMID:29056341, PMID:21873635 GO_REF:0000024 MGI:5926841, RGD:13792537 NCBI chr15:108,608,203...108,838,222
Ensembl chr15:108,608,204...108,838,235
JBrowse link
regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srrd SRR1 domain containing involved_in ISO (MGI:6282940|PMID:28802827) RGD PMID:28802827 MGI:6282940 NCBI chr12:50,315,876...50,321,488
Ensembl chr12:50,315,933...50,321,144
JBrowse link
G Tmem14c transmembrane protein 14C acts_upstream_of_or_within ISO MGI:4351741 (MGI:5581691|PMID:25157825) RGD PMID:25157825 MGI:5581691 NCBI chr17:21,571,510...21,577,651
Ensembl chr17:21,571,518...21,577,631
JBrowse link
tetrapyrrole biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase IDA
IMP
RGD PMID:9344466, PMID:18760440, PMID:6712591, PMID:12127573 RGD:2301695, RGD:2301858, RGD:2301704, RGD:2301691 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
uroporphyrinogen III biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uros uroporphyrinogen III synthase involved_in IDA
IBA
ISO
PMID:21873635
(PMID:18004775), (PMID:3174619), (PMID:3805019)
RGD PMID:3174619 PMID:3805019 PMID:18004775, PMID:17763925, PMID:21873635 RGD:4144811, RGD:13792537 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link
uroporphyrinogen III metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Urod uroporphyrinogen decarboxylase IDA converts uroporphyrinogen to coproporphyrinogen via hepta-, hexa- and penta-carboxyporphyrinogen RGD PMID:15736160 RGD:2301379 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    metabolic process 11882
      cellular metabolic process 10839
        cellular aromatic compound metabolic process 5627
          tetrapyrrole metabolic process 49
            cobalamin metabolic process + 9
            corrin metabolic process + 0
            negative regulation of tetrapyrrole metabolic process + 0
            nickel-tetrapyrrole coenzyme metabolic process + 0
            phytochromobilin metabolic process + 0
            porphyrin-containing compound metabolic process + 40
            positive regulation of tetrapyrrole metabolic process + 3
            regulation of tetrapyrrole metabolic process + 5
            tetrapyrrole biosynthetic process + 27
            tetrapyrrole catabolic process + 7
paths to the root