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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrapyrrole metabolic process
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Accession:GO:0033013 term browser browse the term
Definition:The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Synonyms:exact_synonym: tetrapyrrole metabolism


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bilirubin conjugation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:70480
cobalamin catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cubn cubilin JBrowse link 17 80,584,921 80,807,181 RGD:8554807
cobalamin metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcd4 ATP binding cassette subfamily D member 4 JBrowse link 6 108,315,026 108,329,550 RGD:1624291
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase JBrowse link 9 78,862,013 78,882,061 RGD:5135263
G Cblif cobalamin binding intrinsic factor JBrowse link 1 228,118,048 228,132,296 RGD:1624368
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase JBrowse link 11 31,780,477 31,805,728 RGD:5135263
G Mmachc metabolism of cobalamin associated C JBrowse link 5 135,555,587 135,561,723 RGD:1624291
RGD:13792537
G Mmadhc metabolism of cobalamin associated D JBrowse link 3 35,783,511 35,801,474 RGD:1600115
RGD:1624291
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:1624291
RGD:1600115
heme A biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 JBrowse link 10 50,439,778 50,563,920 RGD:1624291
G Cox15 cytochrome c oxidase assembly homolog COX15 JBrowse link 1 263,494,850 263,511,510 RGD:1624291
RGD:13792537
heme biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:1599020
RGD:13792537
RGD:1624291
RGD:1600115
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:13792537
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:1624291
RGD:13792537
RGD:1600115
G Atp5if1 ATP synthase inhibitory factor subunit 1 JBrowse link 5 150,719,570 150,723,287 RGD:1624291
RGD:13792537
RGD:1600115
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 JBrowse link 10 50,439,778 50,563,920 RGD:13792537
G Cpox coproporphyrinogen oxidase JBrowse link 11 44,039,665 44,049,648 RGD:1600961
RGD:1624291
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1600961
RGD:13792537
RGD:1624291
G Fxn frataxin JBrowse link 1 242,123,975 242,152,834 RGD:1600115
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:13792537
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:1624291
G Pgrmc1 progesterone receptor membrane component 1 JBrowse link X 123,205,869 123,213,880 RGD:1600115
RGD:1624291
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1600961
RGD:13792537
RGD:1624291
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:1624291
RGD:1600115
G Slc25a39 solute carrier family 25, member 39 JBrowse link 10 90,351,899 90,356,905 RGD:1600115
G Tmem14c transmembrane protein 14C JBrowse link 17 21,571,510 21,577,651 RGD:1600115
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:70052
RGD:13792537
RGD:1624291
RGD:2301379
G Uros uroporphyrinogen III synthase JBrowse link 1 205,755,766 205,778,170 RGD:1624291
RGD:13792537
heme catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blvra biliverdin reductase A JBrowse link 3 119,552,550 119,577,796 RGD:1600115
G Blvrb biliverdin reductase B JBrowse link 1 84,256,063 84,273,726 RGD:1624291
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1547877
RGD:13792537
RGD:1624291
G Hmox2 heme oxygenase 2 JBrowse link 10 10,990,034 11,035,493 RGD:13792537
G Hmox2-ps1 heme oxygenase (decycling) 2, pseudogene 1 JBrowse link 2 215,370,196 215,372,406 RGD:13792537
heme metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdh2 3-hydroxybutyrate dehydrogenase 2 JBrowse link 2 240,461,505 240,482,149 RGD:1600115
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 JBrowse link 1 83,653,248 83,662,118 RGD:1624291
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1598930
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1624291
G Hpx hemopexin JBrowse link 1 170,423,558 170,431,066 RGD:1624291
RGD:13792537
G Slco1a6 solute carrier organic anion transporter family, member 1a6 JBrowse link 4 176,345,671 176,390,729 RGD:1600115
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:1624291
heme O biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 JBrowse link 10 50,439,778 50,563,920 RGD:1600115
heme oxidation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1624291
RGD:13792537
G Hmox2 heme oxygenase 2 JBrowse link 10 10,990,034 11,035,493 RGD:625638
RGD:13792537
G Hmox2-ps1 heme oxygenase (decycling) 2, pseudogene 1 JBrowse link 2 215,370,196 215,372,406 RGD:13792537
porphyrin-containing compound biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb6 ATP binding cassette subfamily B member 6 JBrowse link 9 82,373,950 82,382,228 RGD:1624291
G Ank1 ankyrin 1 JBrowse link 16 73,681,422 73,912,605 RGD:1624291
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1624291
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:26923962
RGD:4144803
RGD:4144820
RGD:25440497
RGD:25330343
RGD:25440495
RGD:25394584
RGD:25394583
RGD:26923963
RGD:2301707
RGD:4144783
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1599180
RGD:1624291
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:1624291
G Spta1 spectrin, alpha, erythrocytic 1 JBrowse link 13 92,264,231 92,340,091 RGD:1624291
G Sptb spectrin, beta, erythrocytic JBrowse link 6 99,657,144 99,783,189 RGD:1624291
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:4144825
G Uros uroporphyrinogen III synthase JBrowse link 1 205,755,766 205,778,170 RGD:1624291
porphyrin-containing compound metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:2306674
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:1624291
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:26923962
RGD:4144803
RGD:4144820
RGD:26884337
RGD:25440497
RGD:25440495
RGD:25394584
RGD:25394583
RGD:26923963
RGD:2301707
RGD:4144783
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:1624291
positive regulation of cobalamin metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clybl citramalyl-CoA lyase JBrowse link 15 108,608,203 108,838,222 RGD:1624291
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:1600115
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:1600115
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:1600115
G Cpox coproporphyrinogen oxidase JBrowse link 11 44,039,665 44,049,648 RGD:4145128
RGD:13792537
RGD:1600115
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:1600115
G Ireb2 iron responsive element binding protein 2 JBrowse link 8 59,450,974 59,503,634 RGD:1624291
RGD:1600115
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1600115
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:1600115
protoporphyrinogen IX metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 JBrowse link 12 12,749,026 12,782,078 RGD:1624291
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1624291
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1599180
regulation of cobalamin metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clybl citramalyl-CoA lyase JBrowse link 15 108,608,203 108,838,222 RGD:1624291
RGD:1600115
RGD:13792537
regulation of heme biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Srrd SRR1 domain containing JBrowse link 12 50,315,876 50,321,488 RGD:1624291
RGD:1600115
G Tmem14c transmembrane protein 14C JBrowse link 17 21,571,510 21,577,651 RGD:1624291
tetrapyrrole biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:2301695
RGD:1600115
RGD:2301858
RGD:2301704
RGD:2301691
uroporphyrinogen III biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Uros uroporphyrinogen III synthase JBrowse link 1 205,755,766 205,778,170 RGD:4144811
RGD:13792537
RGD:1624291
uroporphyrinogen III metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:2301379

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    metabolic process 11953
      cellular metabolic process 10781
        cellular aromatic compound metabolic process 5534
          tetrapyrrole metabolic process 46
            cobalamin metabolic process + 9
            corrin metabolic process + 0
            negative regulation of tetrapyrrole metabolic process + 0
            nickel-tetrapyrrole coenzyme metabolic process + 0
            phytochromobilin metabolic process + 0
            porphyrin-containing compound metabolic process + 37
            positive regulation of tetrapyrrole metabolic process + 1
            regulation of tetrapyrrole metabolic process + 3
            tetrapyrrole biosynthetic process + 24
            tetrapyrrole catabolic process + 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.