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positive regulation of extrinsic apoptotic signaling pathway - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of extrinsic apoptotic signaling pathway
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Accession:GO:2001238 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
Synonyms:exact_synonym: positive regulation of extrinsic apoptotic signalling pathway
 narrow_synonym: positive regulation of extrinsic apoptosis

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positive regulation of extrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G AGTR2 angiotensin II receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056 		JBrowse link
G BCL10 BCL10 immune signaling adaptor involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:130,645,427...130,653,317
Ensembl chr 4:130,645,216...130,657,995 		JBrowse link
G BCL2L14 BCL2 like 14 involved_in ISO (PMID:11054413) UniProt PMID:11054413 NCBI chr 5:60,334,813...60,357,935
Ensembl chr 5:60,332,451...60,357,897 		JBrowse link
G BID BH3 interacting domain death agonist involved_in IEA
IBA 		Ensembl
UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 5:69,849,007...69,874,647
Ensembl chr 5:69,849,002...69,875,853 		JBrowse link
G CASP8 caspase 8 acts_upstream_of_or_within ISO (PMID:16183742) MGI PMID:16183742 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468 		JBrowse link
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465 		JBrowse link
G CD40LG CD40 ligand involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:34,058,091...34,121,939
Ensembl chr 6:34,059,081...34,121,264 		JBrowse link
G DEDD2 death effector domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:49,710,948...49,730,457
Ensembl chr 6:49,710,933...49,727,192 		JBrowse link
G FADD Fas associated via death domain involved_in
acts_upstream_of_or_within 		IEA Ensembl GO_REF:0000107 NCBI chr 2:3,191,718...3,194,820
Ensembl chr 2:3,185,675...3,194,818 		JBrowse link
G FASLG Fas ligand involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464 		JBrowse link
G G0S2 G0/G1 switch 2 involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:133,287,065...133,288,066
Ensembl chr 9:133,287,325...133,287,742 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 involved_in ISO PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,980 		JBrowse link
G HYAL2 hyaluronidase 2 acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:19366691) Ensembl
BHF-UCL		 PMID:19366691 GO_REF:0000107 NCBI chr13:32,805,220...32,813,684
Ensembl chr13:32,805,227...32,815,333 		JBrowse link
G ITM2C integral membrane protein 2C involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:131,614,887...131,627,428
Ensembl chr15:131,614,743...131,628,619 		JBrowse link
G LTA lymphotoxin alpha involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:23,696,387...23,698,280
Ensembl chr 7:23,696,040...23,698,299 		JBrowse link
G LTB lymphotoxin beta involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:23,704,842...23,707,036
Ensembl chr 7:23,704,841...23,706,745 		JBrowse link
G LTBR lymphotoxin beta receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:64,271,372...64,278,422
Ensembl chr 5:64,270,310...64,287,523 		JBrowse link
G PAK2 p21 (RAC1) activated kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:133,276,122...133,383,506
Ensembl chr13:133,273,112...133,389,458 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:127,786,174...127,814,096
Ensembl chr 1:127,785,772...127,814,196 		JBrowse link
G PML PML nuclear body scaffold involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:59,405,044...59,450,155
Ensembl chr 7:59,405,053...59,450,105 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:18322138 RGD:8693423 NCBI chr 2:136,497,780...136,522,630
Ensembl chr 2:136,494,541...136,522,646 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786 		JBrowse link
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:34,784,018...34,801,228
Ensembl chr17:34,784,016...34,801,230 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within 		IEA Ensembl GO_REF:0000107 NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699 		JBrowse link
G RUNX3 RUNX family transcription factor 3 acts_upstream_of_or_within ISO (PMID:11955451) MGI PMID:11955451 NCBI chr 6:82,531,203...82,595,044
Ensembl chr 6:82,531,559...82,595,026 		JBrowse link
G SFRP1 secreted frizzled related protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748 		JBrowse link
G SIGLEC1 sialic acid binding Ig like lectin 1 acts_upstream_of_or_within ISO (PMID:23408841) MGI PMID:23408841 NCBI chr17:31,994,505...32,021,239
Ensembl chr17:31,994,632...32,021,239 		JBrowse link
G TLR4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR6 toll like receptor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:30,159,744...30,180,650
Ensembl chr 8:30,159,754...30,180,650 		JBrowse link
G TNF tumor necrosis factor involved_in ISO
IBA 		RGD
GO_Central		 PMID:12131680 GO_REF:0000033 RGD:14995454 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
G TNFRSF12A TNF receptor superfamily member 12A involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:39,166,288...39,168,294
Ensembl chr 3:39,166,298...39,168,302 		JBrowse link
G TNFSF10 TNF superfamily member 10 involved_in
acts_upstream_of_or_within 		ISO (PMID:20097879), (PMID:21525171), (PMID:22266862)
(PMID:15632112) 		UniProt
MGI		 PMID:15632112 PMID:20097879 PMID:21525171 PMID:22266862 NCBI chr13:111,021,952...111,103,060
Ensembl chr13:110,983,298...111,038,324 		JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:24,468,011...24,505,421
Ensembl chr11:24,468,110...24,505,477 		JBrowse link
G TNFSF12 TNF superfamily member 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,843,026...52,853,328
Ensembl chr12:52,843,026...52,853,325 		JBrowse link
G TNFSF14 TNF superfamily member 14 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:72,478,178...72,483,885
Ensembl chr 2:72,473,477...72,483,989 		JBrowse link
G TNFSF15 TNF superfamily member 15 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:255,328,731...255,349,508
Ensembl chr 1:255,328,719...255,349,539 		JBrowse link
G TRAF2 TNF receptor associated factor 2 involved_in IEA Ensembl GO_REF:0000107
G WDR35 WD repeat domain 35 ISO RGD PMID:20193664 RGD:11553917 NCBI chr 3:118,209,112...118,279,050
Ensembl chr 3:118,209,139...118,269,452 		JBrowse link
G WWOX WW domain containing oxidoreductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:8,910,209...9,871,048
Ensembl chr 6:8,910,138...9,871,053 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNA1 catenin alpha 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:140,682,776...140,869,828
Ensembl chr 2:140,682,371...140,871,334 		JBrowse link
G DAPK3 death associated protein kinase 3 involved_in ISO PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chr 2:74,758,962...74,776,355
Ensembl chr 2:74,759,004...74,775,330 		JBrowse link
G HTRA2 HtrA serine peptidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:68,516,666...68,520,025
Ensembl chr 3:68,516,500...68,519,886 		JBrowse link
G INHBA inhibin subunit beta A involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:53,115,379...53,117,128
NCBI chr18:52,889,684...52,909,260
Ensembl chr18:52,889,684...52,900,967 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (PMID:16020505) BHF-UCL PMID:16020505 NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495 		JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within ISO (PMID:15039234) MGI PMID:15039234 NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,813...43,753,969 		JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:5,120,202...5,123,168
Ensembl chr 2:5,119,939...5,123,617 		JBrowse link
G PPP2R1A protein phosphatase 2 scaffold subunit Aalpha acts_upstream_of_or_within ISO (PMID:12944463) MGI PMID:12944463 NCBI chr 6:57,929,520...57,964,948
Ensembl chr 6:57,921,329...57,964,961 		JBrowse link
G PPP2R1B protein phosphatase 2 scaffold subunit Abeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:39,479,040...39,518,773
Ensembl chr 9:39,480,331...39,517,629 		JBrowse link
G RET ret proto-oncogene involved_in ISO (PMID:10921886) UniProt PMID:10921886 NCBI chr14:61,305,818...61,361,416
Ensembl chr14:61,305,841...61,361,412 		JBrowse link
G SRPX sushi repeat containing protein X-linked acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:34,075,577...34,198,462
Ensembl chr  X:34,075,579...34,198,467 		JBrowse link
G TGFB2 transforming growth factor beta 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341 		JBrowse link
G UNC5B unc-5 netrin receptor B involved_in ISO PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chr14:74,120,055...74,208,055
Ensembl chr14:74,120,050...74,205,263 		JBrowse link
G WWOX WW domain containing oxidoreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:8,910,209...9,871,048
Ensembl chr 6:8,910,138...9,871,053 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1B bone morphogenetic protein receptor type 1B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:124,536,648...125,035,841
Ensembl chr 8:124,536,653...124,759,406 		JBrowse link
G FAF1 Fas associated factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:161,173,915...161,603,731
Ensembl chr 6:161,166,996...161,603,725 		JBrowse link
G MAL mal, T cell differentiation protein acts_upstream_of_or_within ISO (PMID:12776198) MGI PMID:12776198 NCBI chr 3:46,223,610...46,242,306
Ensembl chr 3:46,181,555...46,242,047 		JBrowse link
G PEA15 proliferation and apoptosis adaptor protein 15 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:90,263,600...90,276,142
Ensembl chr 4:90,263,604...90,276,147 		JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:15705586) BHF-UCL PMID:15705586 NCBI chr 1:161,184,458...161,188,138
Ensembl chr 1:161,182,887...161,188,164 		JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (PMID:8940094) MGI PMID:8940094 NCBI chr10:14,532,556...14,561,862
Ensembl chr10:14,532,767...14,577,251 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748 		JBrowse link
G SKIL SKI like proto-oncogene acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:109,029,831...109,059,176
Ensembl chr13:109,029,952...109,059,173 		JBrowse link
G STK3 serine/threonine kinase 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:38,011,802...38,306,777
Ensembl chr 4:38,011,814...38,306,773 		JBrowse link
G STK4 serine/threonine kinase 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:47,387,594...47,475,705
Ensembl chr17:47,387,600...47,475,718 		JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,784...131,746,115 		JBrowse link
G TRPS1 transcriptional repressor GATA binding 1 acts_upstream_of_or_within ISO (PMID:18363966) MGI PMID:18363966 NCBI chr 4:22,905,627...23,162,862
Ensembl chr 4:22,905,637...23,159,546 		JBrowse link
G ZSWIM2 zinc finger SWIM-type containing 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:91,840,694...91,865,227
Ensembl chr15:91,840,944...91,864,332 		JBrowse link
positive regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF3 activating transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:130,772,259...130,829,678
Ensembl chr 9:130,772,262...130,785,506 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18945
    cellular process 18488
      signal transduction 7030
        cell surface receptor signaling pathway 2811
          extrinsic apoptotic signaling pathway 248
            positive regulation of extrinsic apoptotic signaling pathway 69
              positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 14
              positive regulation of extrinsic apoptotic signaling pathway via death domain receptors + 14
Path 2
Term Annotations click to browse term
  biological_process 18945
    biological regulation 13007
      regulation of biological process 12626
        signaling 7571
          signal transduction 7030
            regulation of signal transduction 3191
              positive regulation of signal transduction 1731
                positive regulation of apoptotic signaling pathway 183
                  positive regulation of extrinsic apoptotic signaling pathway 69
                    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 14
                    positive regulation of extrinsic apoptotic signaling pathway via death domain receptors + 14
paths to the root