AGTR2 (angiotensin II receptor type 2) - Rat Genome Database

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Gene: AGTR2 (angiotensin II receptor type 2) Sus scrofa
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Symbol: AGTR2
Name: angiotensin II receptor type 2
RGD ID: 13903652
Description: ENCODES a protein that exhibits transcription factor binding (ortholog); INVOLVED IN aldosterone secretion (ortholog); angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure (ortholog); brain renin-angiotensin system (ortholog); PARTICIPATES IN angiotensin II signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); asthma (ortholog); autistic disorder (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: angiotensin type II receptor; type-2 angiotensin II receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX95,269,300 - 95,270,388 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X95,267,709 - 95,272,237 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X109,822,530 - 109,826,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (IEA)
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
brain renin-angiotensin system  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell surface receptor signaling pathway  (IEA)
cellular response to dexamethasone stimulus  (ISO)
cellular sodium ion homeostasis  (ISO)
cerebellar cortex development  (ISO)
dopamine biosynthetic process  (ISO)
exploration behavior  (ISO)
G protein-coupled receptor signaling pathway  (IBA)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  (ISO)
inflammatory response  (IBA,ISO)
intracellular signal transduction  (ISO)
kidney development  (ISO)
kidney morphogenesis  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of heart rate  (ISO)
negative regulation of icosanoid secretion  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IEA)
negative regulation of norepinephrine secretion  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of metanephric glomerulus development  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (IEA)
positive regulation of renal sodium excretion  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of metanephros size  (ISO)
regulation of protein import into nucleus  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
renin-angiotensin regulation of aldosterone production  (ISO)
response to organonitrogen compound  (ISO)
vasodilation  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:17437130   PMID:21622819   PMID:22218590   PMID:28468964  


Genomics

Comparative Map Data
AGTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX95,269,300 - 95,270,388 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X95,267,709 - 95,272,237 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X109,822,530 - 109,826,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX116,170,744 - 116,174,974 (+)EnsemblGRCh38hg38GRCh38
GRCh38X116,170,744 - 116,174,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X115,301,997 - 115,306,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X115,215,986 - 115,220,253 (+)NCBINCBI36hg18NCBI36
Build 34X115,113,884 - 115,117,702NCBI
CeleraX115,832,555 - 115,836,822 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX104,838,955 - 104,843,260 (+)NCBIHuRef
CHM1_1X115,212,791 - 115,217,059 (+)NCBICHM1_1
Agtr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X21,350,863 - 21,355,072 (+)NCBIGRCm39mm39
GRCm39 EnsemblX21,350,783 - 21,355,403 (+)Ensembl
GRCm38X21,484,624 - 21,488,833 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX21,484,544 - 21,489,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X21,061,752 - 21,065,957 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X20,641,585 - 20,646,123 (+)NCBImm8
CeleraX19,607,387 - 19,611,593 (+)NCBICelera
Cytogenetic MapXA2NCBI
cM MapX16.71NCBI
Agtr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X112,119,673 - 112,124,060 (+)NCBImRatBN7.2
Rnor_6.0 EnsemblX119,390,013 - 119,393,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X119,389,480 - 119,393,845 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX111,375,374 - 111,376,465 (+)NCBICelera
Cytogenetic MapXq34NCBI
Agtr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555343,653,157 - 3,654,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555343,653,112 - 3,654,248 (-)NCBIChiLan1.0ChiLan1.0
AGTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X115,670,022 - 115,674,287 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX115,671,594 - 115,672,685 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X105,252,903 - 105,257,171 (+)NCBIMhudiblu_PPA_v0panPan3
AGTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X88,703,551 - 88,708,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX88,705,765 - 88,706,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX74,841,362 - 74,845,718 (+)NCBI
ROS_Cfam_1.0X90,431,596 - 90,435,944 (+)NCBI
UMICH_Zoey_3.1X87,892,846 - 87,897,203 (+)NCBI
UNSW_CanFamBas_1.0X89,651,006 - 89,655,363 (+)NCBI
UU_Cfam_GSD_1.0X89,385,692 - 89,390,050 (+)NCBI
Agtr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X87,731,904 - 87,736,189 (+)NCBI
SpeTri2.0NW_00493647913,252,678 - 13,255,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606528,955,602 - 28,958,335 (+)NCBI
Agtr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624967327,627 - 332,000 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system renal system reproductive system
High
Medium
Low 2 3 1
Below cutoff 1 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000013779   ⟹   ENSSSCP00000013398
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX95,269,300 - 95,270,388 (-)Ensembl
RefSeq Acc Id: XM_005673847   ⟹   XP_005673904
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X95,267,709 - 95,272,237 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005673904 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABB54489 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005673904   ⟸   XM_005673847
- UniProtKB: F1RWT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000013398   ⟸   ENSSSCT00000013779
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012600 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070029023 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000013398 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070049484 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013779 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070058205 UniProtKB/TrEMBL
InterPro ATII_AT2_rcpt UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report ssc:733586 UniProtKB/TrEMBL
NCBI Gene AGTR2 ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ANGIOTENSINR UniProtKB/TrEMBL
  ANGIOTENSN2R UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
UniProt A0A4X1W622_PIG UniProtKB/TrEMBL
  F1RWT0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85192 ENTREZGENE