PPP2R1B (protein phosphatase 2 scaffold subunit Abeta) - Rat Genome Database

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Gene: PPP2R1B (protein phosphatase 2 scaffold subunit Abeta) Sus scrofa
Analyze
Symbol: PPP2R1B
Name: protein phosphatase 2 scaffold subunit Abeta
RGD ID: 14024199
Description: ENCODES a protein that exhibits protein phosphatase regulator activity (inferred); INVOLVED IN apoptotic process involved in morphogenesis (inferred); positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (inferred); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH ataxia telangiectasia (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); Carney-Stratakis syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; protein phosphatase 2A 65 kDa regulatory subunit, beta isoform; protein phosphatase 2A regulatory subunit A beta isoform; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,480,331 - 39,517,629 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,479,040 - 39,518,773 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,269,796 - 44,306,965 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2159327   PMID:2827745   PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PPP2R1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,480,331 - 39,517,629 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,479,040 - 39,518,773 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,269,796 - 44,306,965 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2R1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,688,000 - 111,766,389 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,726,908 - 111,766,389 (-)EnsemblGRCh38hg38GRCh38
GRCh3711111,597,637 - 111,637,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,102,842 - 111,142,379 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411111,102,845 - 111,142,379NCBI
Celera11108,750,797 - 108,790,353 (-)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,521,689 - 107,561,041 (-)NCBIHuRef
CHM1_111111,480,686 - 111,520,221 (-)NCBICHM1_1
T2T-CHM13v2.011111,698,152 - 111,776,539 (-)NCBIT2T-CHM13v2.0
Ppp2r1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,767,946 - 50,810,625 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,756,601 - 50,805,529 (+)EnsemblGRCm39 Ensembl
GRCm38950,856,896 - 50,899,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,845,301 - 50,894,229 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,665,040 - 50,702,334 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,609,165 - 50,646,459 (+)NCBIMGSCv36mm8
Celera948,143,459 - 48,180,581 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Ppp2r1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8860,092,540 - 60,125,512 (+)NCBIGRCr8
mRatBN7.2851,195,860 - 51,228,442 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,186,717 - 51,228,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,700,526 - 56,721,504 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,979,460 - 55,000,438 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,843,710 - 52,864,688 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,279,278 - 55,311,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,279,373 - 55,301,320 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,865,408 - 53,907,521 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,208,126 - 54,229,044 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1854,227,179 - 54,248,096 (+)NCBI
Celera850,743,113 - 50,764,139 (+)NCBICelera
Cytogenetic Map8q23NCBI
Ppp2r1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,458,136 - 13,494,585 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,458,078 - 13,494,583 (-)NCBIChiLan1.0ChiLan1.0
PPP2R1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,471,819 - 112,515,617 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,567,639 - 113,609,966 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,609,754 - 106,651,811 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,453,534 - 110,495,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,465,475 - 110,495,908 (-)Ensemblpanpan1.1panPan2
PPP2R1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,323,956 - 21,356,835 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,322,059 - 21,394,193 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha521,245,976 - 21,278,852 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,346,812 - 21,379,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,346,460 - 21,417,364 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,408,111 - 21,440,902 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,308,542 - 21,341,334 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,357,421 - 21,390,276 (+)NCBIUU_Cfam_GSD_1.0
Ppp2r1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,010,553 - 94,043,476 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,662,131 - 2,695,340 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,662,137 - 2,695,340 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2R1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,058,283 - 103,110,839 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,057,915 - 103,110,102 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,867,979 - 22,909,276 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2r1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247846,897,336 - 6,952,058 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247846,898,371 - 6,936,262 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPP2R1B
993 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000032388   ⟹   ENSSSCP00000020079
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,493,510 - 39,517,488 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000044791   ⟹   ENSSSCP00000045859
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,480,331 - 39,517,470 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053532   ⟹   ENSSSCP00000039100
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,493,510 - 39,517,488 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000078920   ⟹   ENSSSCP00000060949
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,480,393 - 39,517,451 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084671   ⟹   ENSSSCP00000063599
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,480,335 - 39,517,629 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000103343   ⟹   ENSSSCP00000079011
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,493,510 - 39,517,488 (-)Ensembl
RefSeq Acc Id: XM_003357285   ⟹   XP_003357333
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1939,491,077 - 39,517,516 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005667316   ⟹   XP_005667373
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1939,479,040 - 39,517,505 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013979368   ⟹   XP_013834822
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1939,480,336 - 39,518,773 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021062773   ⟹   XP_020918432
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1939,484,346 - 39,517,505 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002335629
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1939,491,077 - 39,518,751 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005667373   ⟸   XM_005667316
- Peptide Label: isoform X1
- UniProtKB: A0A8D1LXD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013834822   ⟸   XM_013979368
- Peptide Label: isoform X4
- UniProtKB: A0A4X1TCQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918432   ⟸   XM_021062773
- Peptide Label: isoform X2
- UniProtKB: A0A287APB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003357333   ⟸   XM_003357285
- Peptide Label: isoform X3
- UniProtKB: A0A287A5F7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000060949   ⟸   ENSSSCT00000078920
RefSeq Acc Id: ENSSSCP00000045859   ⟸   ENSSSCT00000044791
RefSeq Acc Id: ENSSSCP00000063599   ⟸   ENSSSCT00000084671
RefSeq Acc Id: ENSSSCP00000020079   ⟸   ENSSSCT00000032388
RefSeq Acc Id: ENSSSCP00000039100   ⟸   ENSSSCT00000053532
RefSeq Acc Id: ENSSSCP00000079011   ⟸   ENSSSCT00000103343


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029538 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00030071372 UniProtKB/TrEMBL
  ENSSSCG00050025257 UniProtKB/TrEMBL
  ENSSSCG00055014447 UniProtKB/TrEMBL
  ENSSSCG00065077285 UniProtKB/TrEMBL
  ENSSSCG00070008762 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000032388.4 UniProtKB/TrEMBL
  ENSSSCT00000044791 ENTREZGENE
  ENSSSCT00000044791.3 UniProtKB/TrEMBL
  ENSSSCT00000053532 ENTREZGENE
  ENSSSCT00000053532.3 UniProtKB/TrEMBL
  ENSSSCT00000078920.1 UniProtKB/TrEMBL
  ENSSSCT00000084671.1 UniProtKB/TrEMBL
  ENSSSCT00000103343.1 UniProtKB/TrEMBL
  ENSSSCT00030100168.1 UniProtKB/TrEMBL
  ENSSSCT00050034083.1 UniProtKB/TrEMBL
  ENSSSCT00055029018.1 UniProtKB/TrEMBL
  ENSSSCT00065107779.1 UniProtKB/TrEMBL
  ENSSSCT00070017012.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEAT_type_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397470 UniProtKB/TrEMBL
NCBI Gene PPP2R1B ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HEAT_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 2AAB_PIG UniProtKB/Swiss-Prot
  A0A287A5F7 ENTREZGENE, UniProtKB/TrEMBL
  A0A287APB4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TCQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2Q9H1_PIG UniProtKB/TrEMBL
  A0A5G2QH01_PIG UniProtKB/TrEMBL
  A0A8D1LXD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FI60_PIG UniProtKB/TrEMBL
  I3L7S2_PIG UniProtKB/TrEMBL
  P54613 ENTREZGENE
  Q2VLK0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91747 ENTREZGENE