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ONTOLOGY REPORT - ANNOTATIONS


Term:extrinsic apoptotic signaling pathway
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Accession:GO:0097191 term browser browse the term
Definition:The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
Comment:Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
Synonyms:exact_synonym: extrinsic apoptotic pathway;   extrinsic apoptotic signalling pathway
 narrow_synonym: death receptor-mediated apoptosis;   extrinsic apoptosis;   extrinsic apoptotic signaling pathway in presence of ligand



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extrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor type 1B involved_in ISO (PMID:9884026) RGD PMID:9884026 NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673
JBrowse link
G Bad BCL2-associated agonist of cell death involved_in IBA
ISO
PMID:21873635
(PMID:18852119)
RGD PMID:18852119 PMID:21873635 RGD:13792537 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:15214043) RGD PMID:15214043 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within ISO MGI:2158671 (MGI:1343652|PMID:10476969) RGD PMID:10476969 MGI:1343652 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 involved_in ISO (MGI:4355273|PMID:19626005) RGD PMID:19626005 MGI:4355273 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:21785459)
MGI:104798|MGI:109324|MGI:1336166 (MGI:2386520|PMID:12065591), (MGI:3687663|PMID:10588860), (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168)
(MGI:6401035|PMID:31748744)
GO_REF:0000024
RGD
UniProt
PMID:10588860 PMID:12065591 PMID:21785459 PMID:22089168 PMID:22675671 More... GO_REF:0000024 MGI:2386520 MGI:3687663 MGI:5486419 MGI:5521568 MGI:6401035 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cd27 CD27 molecule involved_in ISO (PMID:9177220) RGD PMID:9177220 NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592
JBrowse link
G Cd70 Cd70 molecule involved_in ISO (PMID:9177220) RGD PMID:9177220 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715
JBrowse link
G Cttn cortactin acts_upstream_of
involved_in
ISO
IEA
MGI:1924375 (MGI:5437589|PMID:22660580)
GO_REF:0000107
RGD
Ensembl
PMID:22660580 GO_REF:0000107 MGI:5437589 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Dab2 DAB adaptor protein 2 acts_upstream_of ISO (MGI:5442513|PMID:15734730) RGD PMID:15734730 MGI:5442513 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
JBrowse link
G Fadd Fas associated via death domain involved_in
acts_upstream_of_or_within
ISO (PMID:16611992), (PMID:21785459)
MGI:1889507 (MGI:3603971|PMID:16183742), (MGI:3687663|PMID:10588860)
RGD PMID:10588860 PMID:16183742 PMID:16611992 PMID:21785459 MGI:3603971 MGI:3687663 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor involved_in
acts_upstream_of_or_within
ISO (PMID:22891283)
(MGI:2183141|PMID:12011074), (MGI:3818355|PMID:17980593)
RGD PMID:12011074 PMID:17980593 PMID:22891283 MGI:2183141 MGI:3818355 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand involved_in ISO (PMID:22891283) RGD PMID:22891283 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G G0s2 G0/G1switch 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19706769)
UniProt
RGD
PMID:19706769 GO_REF:0000024 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO UniProtKB:Q9WV60 (MGI:4818524|PMID:20371704) RGD PMID:20371704 MGI:4818524 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO UniProtKB:Q2NL51 (MGI:4818524|PMID:20371704) RGD PMID:20371704 MGI:4818524 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 involved_in ISO
IEA
(PMID:15701637)
GO_REF:0000107
RGD
Ensembl
PMID:15701637 GO_REF:0000107 NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 involved_in ISO (PMID:24970806) RGD PMID:24970806 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifng interferon gamma involved_in ISO (PMID:16942485) RGD PMID:16942485 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:16942485) RGD PMID:16942485 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il33 interleukin 33 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:99695 (MGI:5437589|PMID:22660580)
Ensembl
RGD
PMID:22660580 GO_REF:0000107 MGI:5437589 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (MGI:1340173|PMID:10429671) RGD PMID:10429671 MGI:1340173 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il7 interleukin 7 acts_upstream_of
involved_in
ISO
IEA
(MGI:1340173|PMID:10429671)
GO_REF:0000107
RGD
Ensembl
PMID:10429671 GO_REF:0000107 MGI:1340173 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Inhba inhibin subunit beta A involved_in ISO (PMID:9884026) RGD PMID:9884026 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Jak2 Janus kinase 2 acts_upstream_of_or_within ISO (MGI:5009182|PMID:12426001) RGD PMID:12426001 MGI:5009182 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Krt18 keratin 18 acts_upstream_of_or_within ISO MGI:2178045 (MGI:3711847|PMID:10747083) RGD PMID:10747083 MGI:3711847 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt8 keratin 8 acts_upstream_of_or_within ISO MGI:2178042 (MGI:3711847|PMID:10747083) RGD PMID:10747083 MGI:3711847 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor involved_in ISS
ISO
GO_REF:0000024
(PMID:18852119)
UniProt
RGD
PMID:18852119 GO_REF:0000024 NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 acts_upstream_of_or_within ISO (MGI:1930995|PMID:10924506) RGD PMID:10924506 MGI:1930995 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in
acts_upstream_of_or_within
IDA
ISO
PMID:8614837
MGI:2386080 (MGI:3700102|PMID:17286969)
PMID:12857854
RGD PMID:17286969 PMID:8614837 PMID:12857854 MGI:3700102, RGD:69918, RGD:8554350 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 acts_upstream_of_or_within ISO (MGI:2386520|PMID:12065591) RGD PMID:12065591 MGI:2386520 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 acts_upstream_of
involved_in
ISO
IEA
(MGI:3578073|PMID:15858817)
GO_REF:0000107
RGD
Ensembl
PMID:15858817 GO_REF:0000107 MGI:3578073 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 involved_in ISO (PMID:16207722) RGD PMID:16207722 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pidd1 p53-induced death domain protein 1 acts_upstream_of_or_within ISO MGI:1261423 (MGI:3603971|PMID:16183742) RGD PMID:16183742 MGI:3603971 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
JBrowse link
G Pml PML nuclear body scaffold acts_upstream_of_or_within ISO MGI:2429949 (MGI:1306978|PMID:9806545) RGD PMID:9806545 MGI:1306978 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of
involved_in
ISO
IEA
MGI:2668456 (MGI:3050700|PMID:15259009)
GO_REF:0000107
RGD
Ensembl
PMID:15259009 GO_REF:0000107 MGI:3050700 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of ISO MGI:1857277 (MGI:80946|PMID:8666928) RGD PMID:8666928 MGI:80946 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 acts_upstream_of ISO MGI:3690329 (MGI:3689241|PMID:17015619) RGD PMID:17015619 MGI:3689241 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:10521396), (PMID:7538908), (PMID:8612133) RGD PMID:7538908 PMID:8612133 PMID:10521396 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Rnf41 ring finger protein 41 involved_in ISO (PMID:14765125) RGD PMID:14765125 NCBI chr 7:838,160...876,869
Ensembl chr 7:838,203...865,511
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of
involved_in
ISO
IEA
MGI:3045799 (MGI:3040721|PMID:14976225)
GO_REF:0000107
RGD
Ensembl
PMID:14976225 GO_REF:0000107 MGI:3040721 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2386810|PMID:12235122)
GO_REF:0000107
RGD
Ensembl
PMID:12235122 GO_REF:0000107 MGI:2386810 NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor involved_in IBA
ISO
PMID:21873635
(PMID:9177220)
RGD PMID:9177220 PMID:21873635 RGD:13792537 NCBI chr 6:131,705,312...131,709,697
Ensembl chr 6:131,705,323...131,709,690
JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (PMID:15334054) RGD PMID:15334054 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:15334054)
UniProt
RGD
PMID:15334054 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:17217916)
AgBase
RGD
PMID:17217916 GO_REF:0000024 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tnf tumor necrosis factor involved_in
acts_upstream_of_or_within
ISO (PMID:11577081), (PMID:16611992)
MGI:104798|MGI:108212|MGI:1261423 (MGI:5510543|PMID:19498109), (MGI:5521568|PMID:22089168)
RGD PMID:11577081 PMID:16611992 PMID:19498109 PMID:22089168 MGI:5510543 MGI:5521568 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b involved_in ISO (PMID:21785459) RGD PMID:21785459 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A acts_upstream_of_or_within ISO (MGI:2667292|PMID:12821115) RGD PMID:12821115 MGI:2667292 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1857262 (MGI:69721|PMID:7990930)
RGD PMID:7990930 PMID:21873635 MGI:69721, RGD:13792537 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnfsf12 TNF superfamily member 12 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2667292|PMID:12821115)
RGD PMID:12821115 PMID:21873635 MGI:2667292, RGD:13792537 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
JBrowse link
G Tradd TNFRSF1A-associated via death domain involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:16611992)
MGI:104798|MGI:108212 (MGI:5521568|PMID:22089168)
PMID:21873635
RGD PMID:16611992 PMID:22089168 PMID:21873635 MGI:5521568, RGD:13792537 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Wwox WW domain-containing oxidoreductase acts_upstream_of_or_within ISO (MGI:3851310|PMID:19366691) RGD PMID:19366691 MGI:3851310 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
JBrowse link
G Yap1 Yes1 associated transcriptional regulator acts_upstream_of ISO MGI:95484 (MGI:3818355|PMID:17980593) RGD PMID:17980593 MGI:3818355 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link
G Zfp110 zinc finger protein 110 acts_upstream_of_or_within ISO MGI:2156881 (MGI:1929440|PMID:10545116) RGD PMID:10545116 MGI:1929440 NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086
JBrowse link
B cell receptor apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:15214043) RGD PMID:15214043 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
death-inducing signaling complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain involved_in ISO (PMID:24025841) RGD PMID:24025841 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO MGI:2388026 (MGI:3612236|PMID:16365167) RGD PMID:16365167 MGI:3612236 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC098008.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:157,043,792...157,044,304 JBrowse link
G Bad BCL2-associated agonist of cell death acts_upstream_of_or_within ISO MGI:1890081 (MGI:2183839|PMID:12115603), (MGI:2675215|PMID:12944463), (MGI:3029504|PMID:12431371), (MGI:3032484|PMID:14967141) RGD PMID:12115603 PMID:12431371 PMID:12944463 PMID:14967141 MGI:2183839 MGI:2675215 MGI:3029504 MGI:3032484 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bag3 BAG cochaperone 3 acts_upstream_of_or_within ISO (MGI:3513163|PMID:11527400) RGD PMID:11527400 MGI:3513163 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Bak1 BCL2-antagonist/killer 1 acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:1197519|MGI:99702 (MGI:3575206|PMID:15680329), (MGI:3581932|PMID:15967824)
PMID:21873635
RGD PMID:15680329 PMID:15967824 PMID:21873635 MGI:3575206 MGI:3581932, RGD:13792537 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1097161|MGI:1197519 (MGI:3575206|PMID:15680329), (MGI:3581932|PMID:15967824)
RGD PMID:15680329 PMID:15967824 PMID:21873635 MGI:3575206 MGI:3581932, RGD:13792537 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1309517 (MGI:2179928|PMID:12082633)
RGD PMID:12082633 PMID:21873635 MGI:2179928, RGD:13792537 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2183839|PMID:12115603)
RGD PMID:12115603 PMID:21873635 MGI:2183839, RGD:13792537 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l10 Bcl2-like 10 involved_in
acts_upstream_of
IBA
ISO
PMID:21873635
(MGI:1326939|PMID:9878060)
RGD PMID:9878060 PMID:21873635 MGI:1326939, RGD:13792537 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367
JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:1097161|MGI:2156498|MGI:99702 (MGI:3581932|PMID:15967824) RGD PMID:15967824 MGI:3581932 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl2l2 Bcl2-like 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2183839|PMID:12115603)
RGD PMID:12115603 PMID:21873635 MGI:2183839, RGD:13792537 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Casp2 caspase 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2159368 (MGI:3691999|PMID:11536012)
RGD PMID:11536012 PMID:21873635 MGI:3691999, RGD:13792537 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Col2a1 collagen type II alpha 1 chain acts_upstream_of ISO MGI:2152978 (MGI:1097047|PMID:9299161) RGD PMID:9299161 MGI:1097047 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Ctnna1 catenin alpha 1 acts_upstream_of ISO MGI:2677796 (MGI:5315030|PMID:22411810) RGD PMID:22411810 MGI:5315030 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 acts_upstream_of
involved_in
ISO
IEA
(MGI:3777228|PMID:18322241), (MGI:3833195|PMID:18971423)
GO_REF:0000107
RGD
Ensembl
PMID:18322241 PMID:18971423 GO_REF:0000107 MGI:3777228 MGI:3833195 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 involved_in ISO (PMID:17701904) RGD PMID:17701904 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 acts_upstream_of ISO MGI:1857803 (MGI:3577160|PMID:15817220) RGD PMID:15817220 MGI:3577160 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (MGI:2158099|PMID:11700312) RGD PMID:11700312 MGI:2158099 NCBI chr 3:154,335,558...154,519,006
Ensembl chr 3:154,335,400...154,518,793
JBrowse link
G Fadd Fas associated via death domain acts_upstream_of_or_within ISO (MGI:2675560|PMID:13679421) RGD PMID:13679421 MGI:2675560 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1856334|MGI:1861923 (MGI:2675560|PMID:13679421)
RGD PMID:13679421 PMID:21873635 MGI:2675560, RGD:13792537 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of ISO MGI:1859647 (MGI:3690587|PMID:16956603) RGD PMID:16956603 MGI:3690587 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Foxo3 forkhead box O3 acts_upstream_of_or_within ISO MGI:1096330 (MGI:3029504|PMID:12431371) RGD PMID:12431371 MGI:3029504 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:5514334|PMID:16543145)
PMID:21873635
UniProt
RGD
PMID:16543145 PMID:21873635 GO_REF:0000024 MGI:5514334, RGD:13792537 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:5514334|PMID:16543145)
PMID:21873635
UniProt
RGD
PMID:16543145 PMID:21873635 GO_REF:0000024 MGI:5514334, RGD:13792537 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO (MGI:3029504|PMID:12431371) RGD PMID:12431371 MGI:3029504 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il1a interleukin 1 alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2157371 (MGI:3691999|PMID:11536012)
Ensembl
RGD
PMID:11536012 GO_REF:0000107 MGI:3691999 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta acts_upstream_of_or_within ISO MGI:2157396 (MGI:3691999|PMID:11536012) RGD PMID:11536012 MGI:3691999 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO (MGI:2179928|PMID:12082633) RGD PMID:12082633 MGI:2179928 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 acts_upstream_of_or_within ISO (MGI:2387238|PMID:12124386), (MGI:2675215|PMID:12944463), (MGI:3032484|PMID:14967141), (MGI:3057092|PMID:15231831), (MGI:3513163|PMID:11527400), (MGI:3575206|PMID:15680329) RGD PMID:11527400 PMID:12124386 PMID:12944463 PMID:14967141 PMID:15231831 More... MGI:2387238 MGI:2675215 MGI:3032484 MGI:3057092 MGI:3513163 MGI:3575206 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2183839|PMID:12115603)
RGD PMID:12115603 PMID:21873635 MGI:2183839, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (MGI:3530680|PMID:15591537) RGD PMID:15591537 MGI:3530680 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itm2b integral membrane protein 2B acts_upstream_of_or_within ISO MGI:88138 (MGI:2179928|PMID:12082633) RGD PMID:12082633 MGI:2179928 NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
JBrowse link
G Kitlg KIT ligand acts_upstream_of_or_within ISO (MGI:3038547|PMID:15039234) RGD PMID:15039234 MGI:3038547 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Lcn2 lipocalin 2 acts_upstream_of_or_within ISO (MGI:4821076|PMID:16377569) RGD PMID:16377569 MGI:4821076 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(MGI:5514334|PMID:16543145)
(PMID:16543145)
UniProt
RGD
PMID:16543145 PMID:21873635 GO_REF:0000024 MGI:5514334, RGD:13792537 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 acts_upstream_of_or_within ISO MGI:3052673|MGI:894279 (MGI:3793518|PMID:17903173) RGD PMID:17903173 MGI:3793518 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 acts_upstream_of_or_within ISO MGI:3052675|MGI:894316 (MGI:3793518|PMID:17903173) RGD PMID:17903173 MGI:3793518 NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:121,882,565...121,884,500
Ensembl chr 6:121,882,366...121,898,643
JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of
involved_in
ISO
IEA
MGI:1857478 (MGI:3038547|PMID:15039234)
GO_REF:0000107
RGD
Ensembl
PMID:15039234 GO_REF:0000107 MGI:3038547 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Ngf nerve growth factor acts_upstream_of_or_within ISO (MGI:2681362|PMID:14623868) RGD PMID:14623868 MGI:2681362 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of ISO (MGI:67124|PMID:8206089) RGD PMID:8206089 MGI:67124 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death acts_upstream_of_or_within ISO MGI:3029528 (MGI:3029504|PMID:12431371) RGD PMID:12431371 MGI:3029504 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bag3 BAG cochaperone 3 acts_upstream_of_or_within ISO (PMID:10597216) RGD PMID:10597216 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO (MGI:1349210|PMID:10597216) RGD PMID:10597216 MGI:1349210 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO (PMID:10597216) RGD PMID:10597216 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bex3 brain expressed X-linked 3 acts_upstream_of_or_within ISO PR:Q9Z0W1 (MGI:1859527|PMID:10764727) RGD PMID:10764727 MGI:1859527 NCBI chr  X:99,273,238...99,274,799
Ensembl chr  X:99,273,161...99,274,800
JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 involved_in ISO
ISS
(PMID:18188704) RGD PMID:18188704 PMID:18188704 RGD:8553738 NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653
JBrowse link
G Casp8 caspase 8 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:11717445)
MGI:2177602|MGI:3054930 (MGI:3054336|PMID:15322156)
RGD PMID:11717445 PMID:15322156 PMID:21873635 MGI:3054336, RGD:13792537 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp8ap2 caspase 8 associated protein 2 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:17245429)
(MGI:1347587|PMID:10235259)
PMID:21873635
RGD PMID:10235259 PMID:17245429 PMID:21873635 MGI:1347587, RGD:13792537 NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO (PMID:19903888) RGD PMID:19903888 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Dapk1 death associated protein kinase 1 acts_upstream_of_or_within ISO MGI:3042776|MGI:3052030 (MGI:3051747|PMID:15010850), (MGI:4431305|PMID:20053891) RGD PMID:15010850 PMID:20053891 MGI:3051747 MGI:4431305 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Daxx death-domain associated protein involved_in ISO (PMID:9215629) RGD PMID:9215629 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:18846110) RGD PMID:18846110 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Ddx47 DEAD-box helicase 47 involved_in ISO (PMID:15977068) RGD PMID:15977068 NCBI chr 4:167,845,652...167,858,115
Ensembl chr 4:167,845,640...167,859,115
JBrowse link
G Dedd death effector domain-containing acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:1306907|PMID:9774341)
PMID:21873635
RGD PMID:9774341 PMID:21873635 MGI:1306907, RGD:13792537 NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332
JBrowse link
G Dedd2 death effector domain containing 2 involved_in IBA
ISO
PMID:21873635
(PMID:11741985)
RGD PMID:11741985 PMID:21873635 RGD:13792537 NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714
JBrowse link
G Dele1 DAP3 binding cell death enhancer 1 involved_in ISO
ISS
IBA
(PMID:20563667)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:20563667 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr18:30,085,093...30,098,105
Ensembl chr18:30,085,126...30,098,756
JBrowse link
G Fadd Fas associated via death domain involved_in ISO (PMID:24025841) RGD PMID:24025841 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor involved_in
acts_upstream_of_or_within
ISO (MGI:5009197|PMID:10950869)
MGI:1096330|MGI:1856334 (MGI:1340173|PMID:10429671), (MGI:2687085|PMID:12801066), (MGI:3029504|PMID:12431371), (MGI:3038547|PMID:15039234), (MGI:3576402|PMID:15632112), (MGI:3687663|PMID:10588860), (MGI:3819026|PMID:18363966), (MGI:77677|PMID:8524870)
RGD PMID:8524870 PMID:10429671 PMID:10588860 PMID:10950869 PMID:12431371 More... MGI:1340173 MGI:2687085 MGI:3029504 MGI:3038547 MGI:3576402 MGI:3687663 MGI:3819026 MGI:5009197 MGI:77677 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
(PMID:26582200)
(PMID:18835034)
(MGI:3038547|PMID:15039234), (MGI:3687663|PMID:10588860)
PMID:21873635
RGD PMID:10588860 PMID:15039234 PMID:18835034 PMID:26582200 PMID:16689665 More... MGI:3038547 MGI:3687663, RGD:1582444, RGD:13792537 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Gabarap GABA type A receptor-associated protein involved_in ISS
ISO
GO_REF:0000024
(PMID:15977068)
UniProt
RGD
PMID:15977068 GO_REF:0000024 NCBI chr10:54,714,834...54,717,769
Ensembl chr10:54,714,198...54,717,765
JBrowse link
G Hmgb2 high mobility group box 2 acts_upstream_of ISO MGI:2387671 (MGI:3831045|PMID:19139395) RGD PMID:19139395 MGI:3831045 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Il18 interleukin 18 involved_in ISO (PMID:11131641)
(PMID:11429161)
RGD PMID:11131641 PMID:11429161 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Itprip inositol 1,4,5-trisphosphate receptor interacting protein acts_upstream_of ISO MGI:1916885 (MGI:4431305|PMID:20053891) RGD PMID:20053891 MGI:4431305 NCBI chr 1:246,762,804...246,786,364
Ensembl chr 1:246,762,472...246,786,408
JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:121,882,565...121,884,500
Ensembl chr 6:121,882,366...121,898,643
JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857478|MGI:97583 (MGI:3038547|PMID:15039234)
Ensembl
RGD
PMID:15039234 GO_REF:0000107 MGI:3038547 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Ngf nerve growth factor involved_in ISO (PMID:14985763) RGD PMID:14985763 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Pidd1 p53-induced death domain protein 1 acts_upstream_of_or_within ISO MGI:109324 (MGI:3603971|PMID:16183742) RGD PMID:16183742 MGI:3603971 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97306 (MGI:3038547|PMID:15039234)
Ensembl
RGD
PMID:15039234 GO_REF:0000107 MGI:3038547 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase acts_upstream_of ISO MGI:2388026|MGI:95484|MGI:99255 (MGI:3612236|PMID:16365167) RGD PMID:16365167 MGI:3612236 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 acts_upstream_of_or_within ISO MGI:95484|MGI:97847 (MGI:3612236|PMID:16365167) RGD PMID:16365167 MGI:3612236 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Skil SKI-like proto-oncogene acts_upstream_of ISO MGI:2387096 (MGI:1858539|PMID:10811619) RGD PMID:10811619 MGI:1858539 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
JBrowse link
G Sort1 sortilin 1 involved_in ISO (PMID:14985763) RGD PMID:14985763 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
JBrowse link
G Stk3 serine/threonine kinase 3 acts_upstream_of
involved_in
ISO
IEA
MGI:104798|MGI:1928487|MGI:1929004 (MGI:4420852|PMID:20080598)
GO_REF:0000107
RGD
Ensembl
PMID:20080598 GO_REF:0000107 MGI:4420852 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
JBrowse link
G Stk4 serine/threonine kinase 4 acts_upstream_of ISO MGI:104798|MGI:1928487 (MGI:4420852|PMID:20080598) RGD PMID:20080598 MGI:4420852 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
JBrowse link
G Tnf tumor necrosis factor involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:10521396), (PMID:18202225), (PMID:18676776)
MGI:1096330|MGI:1928487|MGI:1929004 (MGI:3029504|PMID:12431371), (MGI:4420852|PMID:20080598)
PMID:21873635
RGD PMID:10521396 PMID:12431371 PMID:18202225 PMID:18676776 PMID:20080598 More... MGI:3029504 MGI:4420852, RGD:13792537 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b IMP RGD PMID:19934367 RGD:4142856 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467
JBrowse link
fibroblast growth factor receptor apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 involved_in ISO (PMID:17561467) RGD PMID:17561467 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
negative regulation of death-inducing signaling complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nol3 nucleolar protein 3 involved_in IDA PMID:12191471
PMID:15383280
UniProt PMID:12191471 PMID:15383280 RGD:631884, RGD:10047289 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250
JBrowse link
negative regulation of extrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (PMID:9884026) RGD PMID:9884026 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
G Ar androgen receptor involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:21310825)
Ensembl
UniProt
RGD
PMID:21310825 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 involved_in ISO (PMID:14765125) RGD PMID:14765125 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:3039210|PMID:15070745)
Ensembl
RGD
PMID:15070745 GO_REF:0000107 MGI:3039210 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator involved_in
acts_upstream_of_or_within
ISO (PMID:22266862), (PMID:9208847)
MGI:109324|MGI:2154952 (MGI:5486419|PMID:22675671)
RGD PMID:9208847 PMID:22266862 PMID:22675671 MGI:5486419 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Cttn cortactin acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:1924375 (MGI:5437589|PMID:22660580)
GO_REF:0000107
RGD
Ensembl
PMID:22660580 GO_REF:0000107 MGI:5437589 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Dab2 DAB adaptor protein 2 acts_upstream_of_or_within ISO (MGI:5442513|PMID:15734730) RGD PMID:15734730 MGI:5442513 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
JBrowse link
G Fcmr Fc mu receptor acts_upstream_of_or_within ISO (MGI:3576402|PMID:15632112) RGD PMID:15632112 MGI:3576402 NCBI chr13:42,337,363...42,351,706
Ensembl chr13:42,337,414...42,351,653
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO MGI:104995 (MGI:3047441|PMID:15288121) RGD PMID:15288121 MGI:3047441 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within ISO MGI:104990 (MGI:3047441|PMID:15288121) RGD PMID:15288121 MGI:3047441 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISO (PMID:16636664) RGD PMID:16636664 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Htt huntingtin involved_in ISO
IEA
(PMID:19240112)
GO_REF:0000107
RGD
Ensembl
PMID:19240112 GO_REF:0000107 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070
JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA
IDA
(PMID:16942485)
GO_REF:0000107
PMID:17023532
RGD
Ensembl
PMID:16942485 PMID:17023532 GO_REF:0000107, RGD:1600072 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il19 interleukin 19 acts_upstream_of_or_within ISO (MGI:5491082|PMID:23468852) RGD PMID:23468852 MGI:5491082 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:1340173|PMID:10429671)
RGD PMID:10429671 PMID:21873635 MGI:1340173, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il7 interleukin 7 acts_upstream_of_or_within ISO (MGI:1340173|PMID:10429671) RGD PMID:10429671 MGI:1340173 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Itga6 integrin subunit alpha 6 involved_in ISO (PMID:21310825) RGD PMID:21310825 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (PMID:10708943) RGD PMID:10708943 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Lgals3 galectin 3 involved_in ISO
IBA
(PMID:22761016)
PMID:21873635
RGD PMID:22761016 PMID:21873635 RGD:13792537 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lmna lamin A/C involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:4879057|PMID:21151901)
Ensembl
RGD
PMID:21151901 GO_REF:0000107 MGI:4879057 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Nol3 nucleolar protein 3 involved_in ISO
IEA
IBA
(PMID:9560245)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:9560245 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250
JBrowse link
G Nrp1 neuropilin 1 involved_in ISO (MGI:5287519|PMID:21828096) RGD PMID:21828096 MGI:5287519 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Pak5 p21 (RAC1) activated kinase 5 acts_upstream_of_or_within ISO (MGI:2673247|PMID:12897128) RGD PMID:12897128 MGI:2673247 NCBI chr 3:123,395,678...123,703,967
Ensembl chr 3:123,396,497...123,703,930
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO
ISS
(PMID:21785459)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:21785459 GO_REF:0000024 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO MGI:5441750 (MGI:5546581|PMID:23950925)
(PMID:24113711)
RGD PMID:23950925 PMID:24113711 MGI:5546581 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857
JBrowse link
G Phip pleckstrin homology domain interacting protein acts_upstream_of_or_within ISO (PMID:17636024) RGD PMID:17636024 NCBI chr 8:83,776,802...83,891,192
Ensembl chr 8:83,781,465...83,894,283
JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO MGI:2668456 (MGI:3050700|PMID:15259009) RGD PMID:15259009 MGI:3050700 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Psme3 proteasome activator subunit 3 involved_in ISO (PMID:18309296) RGD PMID:18309296 NCBI chr10:86,257,672...86,265,458
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 acts_upstream_of_or_within ISO MGI:3690329 (MGI:3689241|PMID:17015619) RGD PMID:17015619 MGI:3689241 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in
acts_upstream_of_or_within
ISO (PMID:21310825)
(MGI:5304595|PMID:22244329)
RGD PMID:21310825 PMID:22244329 MGI:5304595 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:21525013)
MGI:104798|MGI:109200 (MGI:5521568|PMID:22089168)
RGD PMID:21525013 PMID:22089168 MGI:5521568 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 acts_upstream_of_or_within ISO (MGI:4456959|PMID:11493700) RGD PMID:11493700 MGI:4456959 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Scg2 secretogranin II involved_in ISO (PMID:14970115) RGD PMID:14970115 NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097
JBrowse link
G Sgms1 sphingomyelin synthase 1 acts_upstream_of_or_within ISO (MGI:3609513|PMID:16226406) RGD PMID:16226406 MGI:3609513 NCBI chr 1:229,996,673...230,259,591
Ensembl chr 1:229,998,119...230,259,603
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 involved_in ISO (PMID:21586138) RGD PMID:21586138 NCBI chr16:28,735,522...28,901,690
Ensembl chr16:28,735,440...28,901,644
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 involved_in ISO (PMID:21586138) RGD PMID:21586138 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO
IBA
(PMID:19767770)
PMID:21873635
RGD PMID:19767770 PMID:21873635 RGD:13792537 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tcf7l2 transcription factor 7 like 2 involved_in IMP PMID:21965303 BHF-UCL PMID:21965303 RGD:14974246 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO (PMID:18625725) RGD PMID:18625725 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 involved_in ISO (MGI:2150820|PMID:11567634) RGD PMID:11567634 MGI:2150820 NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (MGI:5287519|PMID:21828096) RGD PMID:21828096 MGI:5287519 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Yap1 Yes1 associated transcriptional regulator acts_upstream_of_or_within ISO MGI:95484 (MGI:3818355|PMID:17980593) RGD PMID:17980593 MGI:3818355 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link
G Zmynd11 zinc finger, MYND-type containing 11 involved_in ISO (PMID:20732415) RGD PMID:20732415 NCBI chr17:60,542,669...60,631,913
Ensembl chr17:60,543,077...60,631,902
JBrowse link
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 involved_in IMP PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295
JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:99702 (PMID:8358790) RGD PMID:8358790 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l10 Bcl2-like 10 acts_upstream_of_or_within ISO (MGI:1326939|PMID:9878060) RGD PMID:9878060 MGI:1326939 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367
JBrowse link
G Col2a1 collagen type II alpha 1 chain acts_upstream_of_or_within ISO MGI:2152978 (MGI:1097047|PMID:9299161) RGD PMID:9299161 MGI:1097047 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Csf2 colony stimulating factor 2 involved_in ISO (PMID:10666185) RGD PMID:10666185 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctnna1 catenin alpha 1 acts_upstream_of_or_within ISO MGI:2677796 (MGI:5315030|PMID:22411810) RGD PMID:22411810 MGI:5315030 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3777228|PMID:18322241), (MGI:3833195|PMID:18971423)
Ensembl
RGD
PMID:18322241 PMID:18971423 GO_REF:0000107 MGI:3777228 MGI:3833195 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 acts_upstream_of_or_within ISO MGI:2670351 (MGI:3833195|PMID:18971423) RGD PMID:18971423 MGI:3833195 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1857803 (MGI:3577160|PMID:15817220)
RGD PMID:15817220 PMID:21873635 MGI:3577160, RGD:13792537 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:154,335,558...154,519,006
Ensembl chr 3:154,335,400...154,518,793
JBrowse link
G Eya3 EYA transcriptional coactivator and phosphatase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:144,806,523...144,934,522
Ensembl chr 5:144,806,577...144,934,518
JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976
JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647 (MGI:3690587|PMID:16956603) RGD PMID:16956603 MGI:3690587 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G Gas1 growth arrest-specific 1 acts_upstream_of_or_within ISO (MGI:5306314|PMID:15070677) RGD PMID:15070677 MGI:5306314 NCBI chr17:4,482,014...4,485,155 JBrowse link
G Gata1 GATA binding protein 1 involved_in ISO (PMID:17167422) RGD PMID:17167422 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Gdnf glial cell derived neurotrophic factor involved_in ISO
IEA
(PMID:10921886)
GO_REF:0000107
RGD
Ensembl
PMID:10921886 GO_REF:0000107 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gfral GDNF family receptor alpha like acts_upstream_of_or_within ISO (MGI:3610244|PMID:16086688) RGD PMID:16086688 MGI:3610244 NCBI chr 8:76,917,894...76,963,349
Ensembl chr 8:76,918,657...76,959,425
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:17167422) RGD PMID:17167422
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:17167422) RGD PMID:17167422 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:10748004) RGD PMID:10748004 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il7 interleukin 7 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:84869|PMID:8950980)
Ensembl
RGD
PMID:8950980 GO_REF:0000107 MGI:84869 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 involved_in IMP PMID:20551324 BHF-UCL PMID:20551324 RGD:8553940 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 involved_in ISO
IEA
UniProtKB:Q62862 (PMID:20551324)
GO_REF:0000107
RGD
Ensembl
PMID:20551324 GO_REF:0000107 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in ISO (PMID:20921992) RGD PMID:20921992 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Nrg1 neuregulin 1 involved_in ISO (PMID:9553078) RGD PMID:9553078 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Pf4 platelet factor 4 involved_in ISO (PMID:10666185) RGD PMID:10666185 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:86755|PMID:9115640)
Ensembl
RGD
PMID:9115640 GO_REF:0000107 MGI:86755 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:5306563|PMID:20125124) RGD PMID:20125124 MGI:5306563 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2178763|PMID:11050396)
Ensembl
RGD
PMID:11050396 GO_REF:0000107 MGI:2178763 NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476
JBrowse link
G Snai2 snail family transcriptional repressor 2 acts_upstream_of_or_within ISO (MGI:5142392|PMID:10518215) RGD PMID:10518215 MGI:5142392 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Stradb STE20 related adaptor beta acts_upstream_of_or_within ISO (MGI:2656105|PMID:12574163) RGD PMID:12574163 MGI:2656105 NCBI chr 9:60,414,182...60,433,084
Ensembl chr 9:60,414,182...60,433,084
JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO (PMID:10449030) RGD PMID:10449030 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:10666185), (PMID:10748004) RGD PMID:10666185 PMID:10748004 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Unc5b unc-5 netrin receptor B involved_in ISO
IEA
(PMID:18469807)
GO_REF:0000107
RGD
Ensembl
PMID:18469807 GO_REF:0000107 NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537
JBrowse link
G Zc3hc1 zinc finger, C3HC-type containing 1 acts_upstream_of_or_within ISO (MGI:2670822|PMID:12748172) RGD PMID:12748172 MGI:2670822 NCBI chr 4:58,989,989...59,011,925
Ensembl chr 4:58,989,987...59,011,933
JBrowse link
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) RGD PMID:22711822 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
JBrowse link
G Bcl2l1 Bcl2-like 1 acts_upstream_of_or_within ISO (PMID:26582200) RGD PMID:26582200 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Brca1 BRCA1, DNA repair associated involved_in ISO
IEA
(PMID:23415688)
GO_REF:0000107
RGD
Ensembl
PMID:23415688 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Caps calcyphosine acts_upstream_of_or_within ISO (MGI:2450205|PMID:12466268) RGD PMID:12466268 MGI:2450205 NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:26582200)
(PMID:18202225)
RGD PMID:18202225 PMID:26582200 PMID:21873635 RGD:13792537 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Dapk1 death associated protein kinase 1 acts_upstream_of_or_within ISO (MGI:2152512|PMID:11485996) RGD PMID:11485996 MGI:2152512 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:18846110) RGD PMID:18846110 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Faim Fas apoptotic inhibitory molecule involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:1332875|PMID:10075978)
RGD PMID:10075978 PMID:21873635 MGI:1332875, RGD:13792537 NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:26582200)
GO_REF:0000107
RGD
Ensembl
PMID:26582200 GO_REF:0000107 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168
JBrowse link
G Fga fibrinogen alpha chain involved_in IBA
ISO
PMID:21873635
(PMID:10903502)
RGD PMID:10903502 PMID:21873635 RGD:13792537 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain involved_in ISO (PMID:10903502) RGD PMID:10903502 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain involved_in ISO (PMID:10903502) RGD PMID:10903502 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:12221075)
Ensembl
RGD
PMID:12221075 GO_REF:0000107 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:18846110)
UniProt
Ensembl
RGD
PMID:18846110 GO_REF:0000024 GO_REF:0000107 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hgf hepatocyte growth factor acts_upstream_of_or_within ISO (MGI:3054501|PMID:15314156) RGD PMID:15314156 MGI:3054501 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hmgb2 high mobility group box 2 acts_upstream_of_or_within ISO MGI:2387671 (MGI:3831045|PMID:19139395) RGD PMID:19139395 MGI:3831045 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmox1 heme oxygenase 1 involved_in ISO (PMID:18202225) RGD PMID:18202225 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in ISO (PMID:10903502) RGD PMID:10903502 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Itprip inositol 1,4,5-trisphosphate receptor interacting protein acts_upstream_of_or_within ISO MGI:1916885 (MGI:4431305|PMID:20053891) RGD PMID:20053891 MGI:4431305 NCBI chr 1:246,762,804...246,786,364
Ensembl chr 1:246,762,472...246,786,408
JBrowse link
G LOC684466 similar to Fas apoptotic inhibitory molecule 1 (rFAIM) involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:99,791,849...99,810,206
Ensembl chr 8:99,791,981...99,810,228
JBrowse link
G Nol3 nucleolar protein 3 involved_in IMP PMID:12191471
PMID:15383280
UniProt PMID:12191471 PMID:15383280 RGD:631884, RGD:10047289 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:10442631)
(MGI:3687663|PMID:10588860)
PMID:21873635
RGD PMID:10442631 PMID:10588860 PMID:21873635 MGI:3687663, RGD:13792537 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499
JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO (MGI:1099227|PMID:9353287) RGD PMID:9353287 MGI:1099227 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO MGI:2388026|MGI:95484|MGI:99255 (MGI:3612236|PMID:16365167) RGD PMID:16365167 MGI:3612236 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:15069192)
UniProt
RGD
PMID:15069192 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:67,740,711...67,803,694
Ensembl chr10:67,740,712...67,824,434
JBrowse link
G Rnf34 ring finger protein 34 involved_in IBA
ISO
ISS
PMID:21873635
(PMID:15069192)
GO_REF:0000024
RGD
UniProt
PMID:15069192 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr12:33,703,655...33,724,606
Ensembl chr12:33,703,673...33,724,586
JBrowse link
G Serpine1 serpin family E member 1 involved_in ISO
IEA
(PMID:18835034)
GO_REF:0000107
RGD
Ensembl
PMID:18835034 GO_REF:0000107 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 involved_in ISO (MGI:4835156|PMID:9391078) RGD PMID:9391078 MGI:4835156 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063
JBrowse link
G Tmbim1 transmembrane BAX inhibitor motif containing 1 involved_in ISO
ISS
(PMID:21107705)
GO_REF:0000024
RGD
UniProt
PMID:21107705 GO_REF:0000024 NCBI chr 9:75,871,835...75,889,366
Ensembl chr 9:75,871,835...75,889,069
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:12167698) RGD PMID:12167698 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
negative regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir221 microRNA 221 involved_in ISO (PMID:18246122), (PMID:19962668) RGD PMID:18246122 PMID:19962668 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Mir222 microRNA 222 involved_in ISO (PMID:18246122), (PMID:19962668) RGD PMID:18246122 PMID:19962668 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISS
ISO
GO_REF:0000024
(PMID:21785459)
ParkinsonsUK-UCL
RGD
PMID:21785459 GO_REF:0000024 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
positive regulation of extrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:10406457) RGD PMID:10406457 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in ISO (PMID:10406457) RGD PMID:10406457 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Bcl10 BCL10, immune signaling adaptor involved_in
acts_upstream_of_or_within
IBA
ISO
ISS
PMID:21873635
(MGI:1355482|PMID:10753917)
GO_REF:0000024
(PMID:11466612)
RGD
UniProt
PMID:10753917 PMID:11466612 PMID:21873635 GO_REF:0000024 MGI:1355482, RGD:13792537 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Bcl2l14 Bcl2-like 14 involved_in ISO (PMID:11054413) RGD PMID:11054413 NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
JBrowse link
G Bid BH3 interacting domain death agonist involved_in IBA
ISO
PMID:21873635
(PMID:21459798)
RGD PMID:21459798 PMID:21873635 RGD:13792537 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp8 caspase 8 acts_upstream_of_or_within ISO MGI:1889507 (MGI:3603971|PMID:16183742) RGD PMID:16183742 MGI:3603971 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cav1 caveolin 1 involved_in ISO (PMID:21382479) RGD PMID:21382479 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in IBA
ISO
PMID:21873635
(PMID:21525013)
RGD PMID:21525013 PMID:21873635 RGD:13792537 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Dedd2 death effector domain containing 2 involved_in ISO (PMID:11741985) RGD PMID:11741985 NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714
JBrowse link
G Fadd Fas associated via death domain involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1336166|MGI:2154952 (MGI:5486419|PMID:22675671)
(PMID:21525013)
RGD PMID:21525013 PMID:22675671 PMID:21873635 MGI:5486419, RGD:13792537 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G G0s2 G0/G1switch 2 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:19706769)
UniProt
RGD
PMID:19706769 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in IDA PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Hyal2 hyaluronidase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3851310|PMID:19366691)
Ensembl
RGD
PMID:19366691 GO_REF:0000107 MGI:3851310 NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850
JBrowse link
G Itm2c integral membrane protein 2C involved_in ISO (MGI:4821078|PMID:14592447) RGD PMID:14592447 MGI:4821078 NCBI chr 9:86,545,927...86,559,745
Ensembl chr 9:86,545,921...86,559,742
JBrowse link
G Ltbr lymphotoxin beta receptor involved_in ISO (PMID:20732415) RGD PMID:20732415 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 involved_in ISO (PMID:19240112) RGD PMID:19240112 NCBI chr11:68,708,070...68,766,622
Ensembl chr11:68,707,969...68,768,816
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3578073|PMID:15858817)
Ensembl
RGD
PMID:15858817 GO_REF:0000107 MGI:3578073 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:21803845) RGD PMID:21803845 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:1857277 (MGI:80946|PMID:8666928) RGD PMID:8666928 MGI:80946 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:16964285) RGD PMID:16964285 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5000222 (MGI:4437982|PMID:19136968)
Ensembl
RGD
PMID:19136968 GO_REF:0000107 MGI:4437982 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:21525013), (PMID:22274400)
MGI:104798 (MGI:5510543|PMID:19498109)
RGD PMID:19498109 PMID:21525013 PMID:22274400 MGI:5510543 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Runx3 RUNX family transcription factor 3 acts_upstream_of_or_within ISO MGI:2179229 (MGI:2177980|PMID:11955451) RGD PMID:11955451 MGI:2177980 NCBI chr 5:147,393,926...147,419,161
Ensembl chr 5:147,360,994...147,419,156
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of_or_within ISO MGI:3045799 (MGI:3040721|PMID:14976225) RGD PMID:14976225 MGI:3040721 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 acts_upstream_of_or_within ISO MGI:3617694 (MGI:5469747|PMID:23408841) RGD PMID:23408841 MGI:5469747 NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850
JBrowse link
G Tnf tumor necrosis factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A involved_in IBA
ISO
PMID:21873635
(PMID:21525013)
RGD PMID:21525013 PMID:21873635 RGD:13792537 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tnfsf10 TNF superfamily member 10 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:20097879), (PMID:21525171), (PMID:22266862)
PMID:21873635
(MGI:3576402|PMID:15632112)
RGD PMID:15632112 PMID:20097879 PMID:21525171 PMID:22266862 PMID:21873635 MGI:3576402, RGD:13792537 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf12 TNF superfamily member 12 involved_in ISO (PMID:21525013) RGD PMID:21525013 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
JBrowse link
G Traf2 Tnf receptor-associated factor 2 involved_in ISO (PMID:21525013) RGD PMID:21525013 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Wwox WW domain-containing oxidoreductase involved_in ISO (MGI:3851310|PMID:19366691) RGD PMID:19366691 MGI:3851310 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
JBrowse link
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO (MGI:67275|PMID:8358790) RGD PMID:8358790 MGI:67275 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Ctnna1 catenin alpha 1 acts_upstream_of_or_within ISO MGI:2677796 (MGI:5315030|PMID:22411810) RGD PMID:22411810 MGI:5315030 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910
JBrowse link
G Dapk3 death-associated protein kinase 3 involved_in IMP PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558
JBrowse link
G Htra2 HtrA serine peptidase 2 involved_in ISO (PMID:20125124) RGD PMID:20125124 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
JBrowse link
G Inhba inhibin subunit beta A involved_in ISO
ISS
(PMID:8267637)
GO_REF:0000024
RGD
UniProt
PMID:8267637 GO_REF:0000024 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) RGD PMID:16020505 MGI:3719947 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857478 (MGI:3038547|PMID:15039234)
Ensembl
RGD
PMID:15039234 GO_REF:0000107 MGI:3038547 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha acts_upstream_of_or_within ISO (MGI:2183839|PMID:12115603) RGD PMID:12115603 MGI:2183839 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha acts_upstream_of_or_within ISO (MGI:2675215|PMID:12944463) RGD PMID:12944463 MGI:2675215 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta involved_in ISO (PMID:21172653) RGD PMID:21172653 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485
JBrowse link
G Ret ret proto-oncogene involved_in ISO (PMID:10921886) RGD PMID:10921886 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Srpx sushi-repeat-containing protein, X-linked acts_upstream_of_or_within ISO MGI:3706175 (MGI:3703665|PMID:17088259) RGD PMID:17088259 MGI:3703665 NCBI chr  X:12,676,984...12,751,296
Ensembl chr  X:12,566,645...12,747,882
JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of_or_within ISO (MGI:67124|PMID:8206089) RGD PMID:8206089 MGI:67124 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Unc5b unc-5 netrin receptor B involved_in IMP PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537
JBrowse link
G Wwox WW domain-containing oxidoreductase acts_upstream_of_or_within ISO (MGI:3851310|PMID:19366691) RGD PMID:19366691 MGI:3851310 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
JBrowse link
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1b bone morphogenetic protein receptor type 1B acts_upstream_of_or_within ISO MGI:1927616|MGI:95484 (MGI:3819026|PMID:18363966) RGD PMID:18363966 MGI:3819026 NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368
JBrowse link
G Faf1 Fas associated factor 1 acts_upstream_of_or_within ISO (MGI:77677|PMID:8524870) RGD PMID:8524870 MGI:77677 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977
JBrowse link
G Mal mal, T-cell differentiation protein acts_upstream_of_or_within ISO (MGI:3687876|PMID:12776198) RGD PMID:12776198 MGI:3687876 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 acts_upstream_of_or_within ISO (MGI:3687663|PMID:10588860) RGD PMID:10588860 MGI:3687663 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:15705586) RGD PMID:15705586 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO (MGI:84500|PMID:8940094) RGD PMID:8940094 MGI:84500 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO
IEA
(PMID:9391078)
GO_REF:0000107
RGD
Ensembl
PMID:9391078 GO_REF:0000107 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Skil SKI-like proto-oncogene acts_upstream_of_or_within ISO MGI:2387096 (MGI:1858539|PMID:10811619) RGD PMID:10811619 MGI:1858539 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
JBrowse link
G Stk3 serine/threonine kinase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104798|MGI:1928487|MGI:1929004 (MGI:4420852|PMID:20080598)
Ensembl
RGD
PMID:20080598 GO_REF:0000107 MGI:4420852 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
JBrowse link
G Stk4 serine/threonine kinase 4 acts_upstream_of_or_within ISO MGI:104798|MGI:1928487 (MGI:4420852|PMID:20080598) RGD PMID:20080598 MGI:4420852 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:18726995) RGD PMID:18726995 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Trps1 transcriptional repressor GATA binding 1 acts_upstream_of_or_within ISO MGI:107191|MGI:95484 (MGI:3819026|PMID:18363966) RGD PMID:18363966 MGI:3819026 NCBI chr 7:81,916,668...82,142,733
Ensembl chr 7:81,921,601...82,141,905
JBrowse link
G Zswim2 zinc finger, SWIM-type containing 2 acts_upstream_of_or_within ISO (MGI:3692348|PMID:16522193) RGD PMID:16522193 MGI:3692348 NCBI chr 3:68,993,422...69,015,441
Ensembl chr 3:68,995,027...69,015,411
JBrowse link
positive regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 involved_in ISO (PMID:24939851) RGD PMID:24939851 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:19962668) RGD PMID:19962668 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 involved_in ISO
IEA
(PMID:19962668)
GO_REF:0000107
RGD
Ensembl
PMID:19962668 GO_REF:0000107 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
regulation of extrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl5 acyl-CoA synthetase long-chain family member 5 involved_in ISO (PMID:17681178) RGD PMID:17681178 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
JBrowse link
G Bcl2l12 Bcl2 like 12 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991
JBrowse link
G Bcl2l14 Bcl2-like 14 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
JBrowse link
G Dbh dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857556 (MGI:3587974|PMID:15849236)
Ensembl
RGD
PMID:15849236 GO_REF:0000107 MGI:3587974 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein involved_in ISO (PMID:19446321) RGD PMID:19446321 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
JBrowse link
G Madd MAP-kinase activating death domain involved_in ISO (PMID:11577081) RGD PMID:11577081 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO (MGI:72948|PMID:7743522) RGD PMID:7743522 MGI:72948 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Traf1 TNF receptor-associated factor 1 involved_in ISO (PMID:10692572) RGD PMID:10692572 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO MGI:2176216|MGI:2181474 (MGI:3608262|PMID:16207751), (MGI:3775898|PMID:18191119) RGD PMID:16207751 PMID:18191119 MGI:3608262 MGI:3775898 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fem1b fem-1 homolog B involved_in ISO (PMID:10542291) RGD PMID:10542291 NCBI chr 8:63,265,301...63,278,577
Ensembl chr 8:63,265,301...63,278,577
JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:8692888) RGD PMID:8692888 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Madd MAP-kinase activating death domain involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:9115275)
UniProt
Ensembl
RGD
PMID:9115275 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701
JBrowse link
G Sp100 SP100 nuclear antigen involved_in ISO (PMID:17245429) RGD PMID:17245429 NCBI chr 9:86,310,990...86,377,036
Ensembl chr 9:86,311,032...86,377,034
JBrowse link
G Stx4 syntaxin 4 involved_in ISO (PMID:20956541) RGD PMID:20956541 NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979
JBrowse link
G Tmc8 transmembrane channel-like 8 involved_in ISO (PMID:23429285) RGD PMID:23429285 NCBI chr10:103,000,038...103,010,601
Ensembl chr10:102,998,402...103,010,590
JBrowse link
TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07018323.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Casp8 caspase 8 involved_in ISO (PMID:21785459) RGD PMID:21785459 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Fadd Fas associated via death domain involved_in IBA
ISO
PMID:21873635
(PMID:21785459)
RGD PMID:21785459 PMID:21873635 RGD:13792537 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Spi1 Spi-1 proto-oncogene acts_upstream_of_positive_effect ISO (PMID:28362429) RGD PMID:28362429 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b involved_in ISO
IBA
(PMID:19090789), (PMID:21785459)
PMID:21873635
RGD PMID:19090789 PMID:21785459 PMID:21873635 RGD:13792537 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:198,802,513...198,824,049
Ensembl chr 1:198,802,971...198,823,418
JBrowse link
G Zdhhc3 zinc finger DHHC-type palmitoyltransferase 3 involved_in ISO (PMID:22240897) RGD PMID:22240897 NCBI chr 8:122,725,206...122,773,519
Ensembl chr 8:122,715,111...122,773,529
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20094
    signaling 7674
      signal transduction 7105
        apoptotic signaling pathway 638
          extrinsic apoptotic signaling pathway 241
            B cell receptor apoptotic signaling pathway 1
            death-inducing signaling complex assembly + 3
            extrinsic apoptotic signaling pathway in absence of ligand + 79
            extrinsic apoptotic signaling pathway via death domain receptors + 85
            fibroblast growth factor receptor apoptotic signaling pathway 1
            negative regulation of extrinsic apoptotic signaling pathway + 106
            positive regulation of extrinsic apoptotic signaling pathway + 60
            regulation of extrinsic apoptotic signaling pathway + 171
            ripoptosome assembly involved in extrinsic apoptotic signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 20094
    cellular process 18691
      cell death 2260
        programmed cell death 2066
          apoptotic process 2009
            apoptotic signaling pathway 638
              extrinsic apoptotic signaling pathway 241
                B cell receptor apoptotic signaling pathway 1
                death-inducing signaling complex assembly + 3
                extrinsic apoptotic signaling pathway in absence of ligand + 79
                extrinsic apoptotic signaling pathway via death domain receptors + 85
                fibroblast growth factor receptor apoptotic signaling pathway 1
                negative regulation of extrinsic apoptotic signaling pathway + 106
                positive regulation of extrinsic apoptotic signaling pathway + 60
                regulation of extrinsic apoptotic signaling pathway + 171
                ripoptosome assembly involved in extrinsic apoptotic signaling pathway 0
paths to the root